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Journal of Pharmaceutical Analysis 2014年第1期4卷 14-25页

作者： Zheng-Wei Chen ling tong Shu-Ming Li Dong-Xiang Li Ying Zhang Shui-Ping Zhou Yong-Hong Zhu He Sun Department of Pharmaceutical Analysis China Pharmaceutical University Tasly R&D Institute Tianjin Tasly Group Co. Ltd. Center of Drug Metabolism and Pharmacokinetics China Pharmaceutical University

Ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry （UPLC-Q-TOF/MS） was developed to identify the absorbed parent components and metabolites in rat bile, plasma and urine after oral administration of Radix Paeoniae Alba extract （RPAE）. A total of 65 compounds were detected in rat bile, plasma and urine samples, including 11 parent compounds and 54 metabolites. The results indicated that glucuronidation, hydroxylation and methylation were the major metabolic pathways of the components of RPAE. Furthermore, the results of this work demonstrated that UPLC-Q-TOF/MS combined with MetaboLynx？ software and mass defect filtering （MDF） could provide unique high throughput capabilities for drug metabolism study, with excellent MS mass accuracy and enhanced MSE data acquisition. With the MSE technique, both precursor and fragment mass spectra can be simultaneously acquired by alternating between high and low collision energy during a single chromatographic run.

关键词： Radix Paeoniae Alba Metabolite profiling UPLC-Q-TOF/MS Monoterpene glycosides

Top gate engineering of field-effect transistors based on wafer-scale two-dimensional semiconductors

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Journal of Materials Science & Technology 2022年第11期106卷 243-248页

作者： Jingyi Ma Xinyu Chen Yaochen Sheng ling tong Xiaojiao Guo Minxing Zhang Chen Luo lingyi Zong Yin Xia Chuming Sheng Yin Wang Saifei Gou Xinyu Wang Xing Wu Peng Zhou David Wei Zhang Chenjian Wu Wenzhong Bao State Key Laboratory of ASIC and System School of MicroelectronicsFudan UniversityShanghai200433China In Situ Devices Center Shanghai Key Laboratory of Multidimensional Information ProcessingEast China Normal UniversityShanghai 200241China School of Electronic Information Soochow UniversitySuzhou215006China

The investigation of two-dimensional(2D)materials has advanced into practical device applications,such as cascaded logic ***,incompatible electrical properties and inappropriate logic levels remain enormous *** this work,a doping-free strategy is investigated by top gated(TG)MoS_(2) field-effect transistors(FETs)using various metal gates(Au,Cu,Ag,and Al).These metals with different work functions provide a convenient tuning knob for controlling threshold voltage(V_(th))for MoS_(2) *** instance,the Al electrode can create an extra electron doping(n-doping)behavior in the MoS_(2) TG-FETs due to a dipole effect at the gate-dielectric *** this work,by achieving matched electrical properties for the load transistor and the driver transistor in an inverter circuit,we successfully demonstrate wafer-scale MoS_(2) inverter arrays with an optimized inverter switching threshold voltage(V_(M))of 1.5 V and a DC voltage gain of 27 at a supply voltage(V_(DD))of 3 *** work offers a novel scheme for the fabrication of fully integrated multistage logic circuits based on wafer-scale MoS_(2) film.

关键词： Two-dimensional semiconductor MoS_(2) Top gate Field effect transistor Logic inverter

基于梅山傩文化的湖南新化地方特色食品公用品牌设计与应用

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食品与机械 2023年第10期39卷 118-122页

作者：童玲湖南人文科技学院美术与设计学院湖南娄底417000

通过对梅山文化的探寻,发掘梅山傩面文化作为一种本土为主、多元共存的独特文化形态,其特有的艺术特征与文化内涵,借鉴其原始、夸张、诙谐的艺术设计手法,将之应用于新化地方特色食品公用品牌“梅山屶”的设计中。从视觉到内涵的表达,... 详细信息

通过对梅山文化的探寻,发掘梅山傩面文化作为一种本土为主、多元共存的独特文化形态,其特有的艺术特征与文化内涵,借鉴其原始、夸张、诙谐的艺术设计手法,将之应用于新化地方特色食品公用品牌“梅山屶”的设计中。从视觉到内涵的表达,剖析了该公用品牌标志在新化地方特色食品包装中的应用案例,展现了地域特色民俗文化在地方特色食品包装设计中的设计手法。

关键词：梅山文化傩文化地方特色食品公用品牌包装设计

Assembly-oriented reliability analysis method for the top-connection structure of a nuclear fuel assembly

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Nuclear Science and Techniques 2023年第6期34卷 155-170页

作者： Ying-Dong Liu Wen-Qiang Li Jia-Hao Chen Si-tong ling Chang-Fu Wan School of Mechanical Engineering Sichuan UniversityChengdu610065China Innovation Method and Creative Design Key Laboratory of Sichuan Province Chengdu610065China

The nuclear fuel assembly is the core component of a nuclear *** a pressurized water reactor fuel assembly,the top-connection structure connects the top nozzle to the guide *** performance reliability is essential for the stability of the nuclear fuel *** this study,an assembly-oriented reliability analysis method for top-connection structures is presented by establishing an assembly-oriented top-connection structure parameter modeling method and a nonlinear contact gap and penetration correction method.A reliability model of the top-connection assembly structure,including multiple stochastic design variables,was constructed,and the overall reliability of the top-connection assembly structure was obtained via a Kriging model and Monte Carlo *** acquired experimental data were consistent with real-world failure conditions,which verified the practicability and feasibility of the reliability analysis method proposed in this study.

关键词： Assembly Top-connection structure Parametric model Approximation model Structural reliability

Comparative study of type 2 diabetes mellitus-associated gut microbiota between the Dai and Han populations

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World Journal of Diabetes 2023年第12期14卷 1766-1783页

作者： ling-tong Tang Lei Feng Hui-Ying Cao Rui Shi Bei-Bei Luo Yan-Bi Zhang Yan-Mei Liu Jian Zhang Shuang-Yue Li Department of Clinical Laboratory Yan’an Hospital Affiliated to Kunming Medical UniversityKunming 650051Yunnan ProvinceChina Department of Clinical Laboratory Sixth Affiliated Hospital of Kunming Medical UniversityKunming 650051Yunnan ProvinceChina

BACKGROUND The global prevalence of type 2 diabetes mellitus(T2DM)is increasing.T2DM is associated with alterations of the gut microbiota,which can be affected by age,illness,and *** studies revealed that there are discriminating microbiota compositions between the Dai and the Han ***,the specific gut microbiota differences between the two populations have not been *** To compare the gut microbiota differences in subjects with and without T2DM in the Dai and Han *** A total of 35 subjects of the Han population(including 15 healthy children,8 adult healthy controls,and 12 adult T2DM patients)and 32 subjects of the Dai population(including 10 healthy children,10 adult healthy controls,and 12 adult T2DM patients)were enrolled in this *** venous blood samples were collected from all the subjects for biochemical *** samples were collected from all the subjects for DNA extraction and 16S rRNA sequencing,which was followed by analyses of the gut microbiota *** No significant difference in alpha diversity was observed between healthy children and *** diversity of gut microbiota was decreased in T2DM patients compared to the healthy adults in both the Dai and Han populations. There was a significant difference in gut microbiota between healthy children and healthy adults in the Hanpopulation with an increased abundance of Bacteroidetes and decreased Firmicutes in children. However, thisdifference was less in the Dai population. Significant increases in Bacteroidetes in the Han population and Proteobacteriain the Dai population and decreases in Firmicutes in both the Han and Dai population were observed inT2DM patients compared to healthy adults. Linear discriminant analysis Effect Size analysis also showed that thegut microbiota was different between the Han and Dai populations in heathy children, adults, and T2DM *** bacteria were consistently increased and two con

关键词： Gut microbiota Type 2 diabetes mellitus Dai population Han population Genetics Ethnic

敲除大肠杆菌Lpp基因对动脉粥样硬化的抑制作用研究

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青岛大学学报（自然科学版） 2024年第2期37卷 10-14页

作者：王珍珍童凌琳杨帅李欣陈阳张贺朱作斌陈仁金徐州医科大学肿瘤生物治疗研究所徐州221004 徐州医科大学生命科学学院徐州221004

为探究大肠杆菌Lpp基因敲除对动脉粥样硬化作用,取8周龄ApoE^(-/-)小鼠分为Control组、Chow_Lpp^(+/+)(C_Lpp^(+/+))组、Chow_Lpp^(-/-)(C_Lpp^(-/-))组、Western Diet_Lpp^(+/+)(W_Lpp^(+/+))组和Western Diet Lpp^(-/-)(W_Lpp^(-/-))组,每周灌胃3次,持续16周后,取小鼠心脏与主动脉;油红及H&E染色主动脉及心脏,观察脂质沉积及炎性变化。研究结果显示,成功构建了动脉粥样硬化小鼠模型;相较于W_Lpp^(+/+)组,W_Lpp^(-/-)组动脉粥样硬化斑块的面积显著减少;小鼠主动脉根部脂质及炎性细胞浸润程度显著降低。这表明敲除Lpp基因后的大肠杆菌对小鼠动脉粥样硬化具有缓解作用。

关键词：大肠杆菌Lpp基因动脉粥样硬化 ApoE^(-/-)小鼠

OMHT method for weak signal processing of GPR and its application in identification of concrete micro-crack

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Journal of Central South University 2019年第11期26卷 3057-3065页

作者： ling tong-hua ZHANG Liang HUANG Fu GU Dan-ping YU Bin ZHANG Sheng School of Civil Engineering Changsha University of Science and TechnologyChangsha 410114China Hunan Province Engineering Laboratory of Bridge Structure Changsha University of Science and TechnologyChangsha 410114China College of Civil Engineering Hunan City UniversityYiyang 413000China

In the light of the problem of weak reflection signals shielded by strong reflections from the concrete surface,the detection and the recognition of hidden micro-cracks in the shield tunnel lining were studied using the orthogonal matching pursuit and the Hilbert transform(OMHT method).First,according to the matching pursuit algorithm and the strong reflection-forming mechanism,and based on the sparse representation theory,a sparse dictionary,adapted to the characteristics of the strong reflection signal,was selected,and a matching decomposition of each signal was performed so that the weak target signal submerged in the strong reflection was displayed more ***,the Hilbert transform was used to extract multiple parameters,such as the instantaneous amplitude,the instantaneous frequency,and the instantaneous phase,from the processed signal,and the ground penetrating radar(GPR)image was comprehensively analyzed and determined from multiple *** results show that the OMHT method can accurately weaken the effect of the strong impedance interface and effectively enhance the weak reflected signal energy of hidden micro-crack in the shield tunnel *** resolution of the processed GPR image is greatly improved,and the reflected signal of the hidden micro-crack is easily visible,which proves the validity and accuracy of the analysis method.

关键词： orthogonal matching pursuit Hilbert transform shield tunnel lining structure hidden micro-crack

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水稻后向散射的模拟、验证及参数敏感性分析

电子科技大学学报 2013年第6期42卷 895-899,925页

作者：贾明权童玲陈彦电子科技大学自动化工程学院成都611731

根据蒙特卡洛方法建立的水稻微波散射模型,针对水稻的生长特征对模型进行了修正,利用散射计实测数据验证了修正后模型模拟结果的准确性。结果表明,基于蒙特卡洛方法建立的水稻后向散射模型能够很好地模拟水稻的后向散射特征。根据水稻... 详细信息

根据蒙特卡洛方法建立的水稻微波散射模型,针对水稻的生长特征对模型进行了修正,利用散射计实测数据验证了修正后模型模拟结果的准确性。结果表明,基于蒙特卡洛方法建立的水稻后向散射模型能够很好地模拟水稻的后向散射特征。根据水稻生长参数实测数据设定模型输入参数的变化范围,模拟不同输入参数对应的水稻后向散射系数,获得了系统参数、稻杆和稻叶等水稻生长参数与后向散射系数之间的定量关系,并针对各类参数进行了敏感性分析。

关键词：后向散射系数蒙特卡洛参数敏感性水稻散射计

Research on the Three-Dimensional Human-Computer Interaction based on the Mobile Internet Terminal

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Research on the Three-Dimensional Human-Computer Interaction...

2011 International Conference on Fuzzy Systems and Neural Computing(FSNC 2011)

作者： Lu Ji xiang Wang Ping tong ling Zhang Bei College of Mechanical &Electrical Engineering Northwestern Polytechnical University School of Telecommunication Engineering Xidian University Xian International Studies University College of Mingde Northwestern Polytechnical University

The Three-dimensional（3D）Human-computer Interaction of the wireless mobile communication is becoming the research highlight in the field of the human-computer *** the terminal products of the Mobile Internet the mobile phones,the tablet PC,and etc directly contact the end users,the modal of the content provided and the comfort level of the users are determined by the human-computer interaction,which also further influence weather the users’satisfaction,therefore the product survival in the *** new virtual human-computer interaction technology of Mobile Internet Terminal（MIT）is explored and studied based on mentioned above in this paper.

关键词： Mobile Internet Human-computer Interaction Mobile Internet Terminal(MIT)

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视频隐私保护技术综述

通信学报 2013年第8期34卷 154-160页

作者：佟玲玲李扬曦黄文廷国家计算机网络应急技术处理协调中心北京100029

互联网的快速发展和各类视频应用的日益普及,使视频个人隐私保护得到广泛关注。如何在保证视频应用的同时使隐私信息不被泄露是目前亟待研究和解决的热点问题。针对这些问题从视频隐私保护技术的研究现状进行综述,从隐私提取、隐私区域... 详细信息

互联网的快速发展和各类视频应用的日益普及,使视频个人隐私保护得到广泛关注。如何在保证视频应用的同时使隐私信息不被泄露是目前亟待研究和解决的热点问题。针对这些问题从视频隐私保护技术的研究现状进行综述,从隐私提取、隐私区域保护及访问权限控制3个方面进行概括、比较和分析。此外,对与视频隐私保护相关的一些问题,如隐私的定义、感知安全性评价等方面进行了讨论。最后总结了视频隐私保护技术面临的挑战,并对其发展趋势进行展望。

关键词：数据隐藏隐私保护隐私区域提取视频加密