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Microfacies and diagenetic alteration in a semi-deep to deep lacustrine shale: The Yanchang Formation in the Ordos Basin, China

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Petroleum Science 2024年第3期21卷 1524-1538页

作者： Bin Bai Jing-Yue Hao ling fu Yu-Xi Liu Jian-Peng Wang Lan Wang Kevin GTaylor Lin Ma PetroChina Research Institute of Petroleum Exploration and Development Beijing100083China Department of Earth and Environmental Sciences University of ManchesterM139PLUK College of Earth Sciences Jilin UniversityChangchun130061jilinChina Department of Chemical Engineering University of ManchesterM139PLUK

The mineralogical development and diagenetic sequence of lacustrine shales in the Chang 7 Member of the Yanchang Formation in the Ordos Basin are detailed studied.A model of their depositional system and a diagenetic diagram are proposed in this *** detailed petrographic,mineralogical,and elemental analyses,four distinct shale types are identified:argillaceous shale,siliceous shale,calcareous shale,and carbonate,clay,and silt-bearing *** main diagenetic process in argillaceous shale is the transformation of illite to smectite,negatively impacting shale *** shale undergoes carbonate cementation and quartz dissolution,contributing to increased porosity,particularly in *** shale experiences diagenesis characterised by carbonate formation and dissolution,with a prevalence of *** carbonate,clay,and silt-bearing shale,the dissolution of K-feldspar contributes to illitization of *** shale,characterised by more clay minerals and lower mesopore volume,is identified as a potential hydrocarbon *** shale,with the highest pore volume and abundant inter-mineral pores,emerges as a promising shale oil *** findings contribute to a comprehensive understanding of shale properties,aiding in the prediction of shale oil exploration potential in the studied area.

关键词： Ordos Basin Yanchang Formation Chang 7 Member Diagenesis Microfacies

Enhancing layered perovskite ferrites with ultra-high-density nanoparticles via cobalt doping for ceramic fuel cell anode

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Journal of Energy Chemistry 2024年第9期96卷 39-48页

作者： Shuo Zhai Rubao Zhao Hailong Liao ling fu Senran Hao Junyu Cai Yifan Wu Jian Wang Yunhong Jiang Jie Xiao Tao Liu Heping Xie State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering Shenzhen University&Sichuan UniversityShenzhen 518060GuangdongChina National and Local Joint Engineering Research Center for Lithium-ion Batteries and Materials Preparation Technology Key Laboratory of Advanced Battery Materials of Yunnan ProvinceFaculty of Metallurgical and Energy EngineeringKunming University of Science and TechnologyKunming 650093YunnanChina School of Energy and Environment City University of Hong KongKowloon 999077Hong KongChina

Nanoparticles anchored on the perovskite surface have gained considerable attention for their wide-ranging applications in heterogeneous catalysis and energy conversion due to their robust and integrated structural ***,we employ controlled Co doping to effectively enhance the nanoparticle exsolution process in layered perovskite ferrites *** alloy nanoparticles with ultra-high-density are exsolved on the(PrBa)_(0.95)(Fe_(0.8)Co_(0.1)Nb_(0.1))2O_(5+δ)(PBFCN_(0.1))surface under reducing atmosphere,providing significant amounts of reaction sites and good durability for hydrocarbon *** a reducing atmosphere,cobalt facilitates the reduction of iron cations within PBFCN_(0.1),leading to the formation of CoFe alloy *** formation is accompanied by a cation exchange process,wherein,with the increase in temperature,partial cobalt ions are substituted by ***,Co doping significantly enhance the electrical conductivity due to the stronger covalency of the Cosingle bondO bond compared with Fesingle bondO bond.A single cell with the configuration of PBFCN_(0.1)-Sm_(0.2)Ce_(0.8)O_(1.9)(SDC)|SDC|Ba_(0.5)Sr_(0.5)Co_(0.8)Fe_(0.2)O_(3−δ)(BSCF)-SDC achieves an extremely low polarization resistance of 0.0163Ωcm^(2)and a high peak power density of 740 mW cm^(−2)at 800℃.The cell also shows stable operation for 120 h in H_(2)with a constant current density of 285 mA cm^(−2).furthermore,employing wet C_(2)H_(6)as fuel,the cell demonstrates remarkable performance,achieving peak power densities of 455 mW cm^(−2)at 800℃and 320 mW cm^(−2)at 750℃,marking improvements of 36%and 70%over the cell with(PrBa)_(0.95)(Fe_(0.9)Nb_(0.1))_(2)O_(5+δ)(PBFN)-SDC at these respective *** discovery emphasizes how temperature influences alloy nanoparticles exsolution within doped layered perovskite ferrites materials,paving the way for the development of high-performance ceramic fuel cell anodes.

关键词： Solid oxide fuel cell Anode Ethane fuel Nanoparticle Exsolution Layered perovskite Ferrites

NLRP3-mediated autophagy dysfunction links gut microbiota dysbiosis to tau pathology in chronic sleep deprivation

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Zoological Research 2024年第4期45卷 857-874页

作者： Na Zhao Xiu Chen Qiu-Gu Chen Xue-Ting Liu Fan Geng Meng-Meng Zhu fu-ling Yan Zhi-Jun Zhang Qing-Guo Ren Department of Neurology School of MedicineSoutheast UniversityNanjingJiangsu 210009China Department of Neurology Affiliated Zhongda HospitalSoutheast UniversityNanjingJiangsu 210009China

Emerging evidence indicates that sleep deprivation(SD)can lead to Alzheimer’s disease(AD)-related pathological changes and cognitive ***,the underlying mechanisms remain *** the present study,we identified the existence of a microbiota-gut-brain axis in cognitive deficits resulting from chronic SD and revealed a potential pathway by which gut microbiota affects cognitive functioning in chronic *** findings demonstrated that chronic SD in mice not only led to cognitive decline but also induced gut microbiota dysbiosis,elevated NLRP3 inflammasome expression,GSK-3βactivation,autophagy dysfunction,and tau hyperphosphorylation in the *** with the“SD microbiota”replicated the pathological and behavioral abnormalities observed in chronic sleep-deprived ***,both the deletion of NLRP3 in NLRP3-/-mice and specific knockdown of NLRP3 in the hippocampus restored autophagic flux,suppressed tau hyperphosphorylation,and ameliorated cognitive deficits induced by chronic SD,while GSK-3βactivity was not regulated by the NLRP3 inflammasome in chronic ***,deletion of NLRP3 reversed NLRP3 inflammasome activation,autophagy deficits,and tau hyperphosphorylation induced by GSK-3βactivation in primary hippocampal neurons,suggesting that GSK-3β,as a regulator of NLRP3-mediated autophagy dysfunction,plays a significant role in promoting tau ***,gut microbiota dysbiosis was identified as a contributor to chronic SD-induced tau pathology via NLRP3-mediated autophagy dysfunction,ultimately leading to cognitive ***,these findings highlight GSK-3βas a regulator of NLRP3-mediated autophagy dysfunction,playing a critical role in promoting tau hyperphosphorylation.

关键词： Chronic sleep deprivation Tau pathology NLRP3 inflammasome Autophagy GSK-3β Microbiota-gut-brain axis

Establishment of a cholangiocarcinoma risk evaluation model based on mucin expression levels

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1344-1360页

作者： Chun-Yuan Yang Li-Mei Guo Yang Li Guang-Xi Wang Xiao-Wei Tang Qiu-Lu Zhang ling-fu Zhang Jian-Yuan Luo Department of Pathology Institute of Systems BiomedicineSchool of Basic Medical Sciences Peking UniversityPeking University Third HospitalPeking University Health Science CenterBeijing 100191China Department of General Surgery Peking University Third HospitalBeijing 100191China Department of Medical Genetics Department of Biochemistry and BiophysicsSchool of Basic Medical Sciences Peking UniversityPeking University Health Science CenterBeijing 100191China

BACKGROUND Cholangiocarcinoma(CCA)is a highly malignant cancer,characterized by frequent mucin ***1 has been identified as a critical oncogene in the progression of ***,the comprehensive understanding of how the mucin family influences CCA progression and prognosis is still *** To investigate the functions of mucins on the progression of CCA and to establish a risk evaluation formula for stratifying CCA *** Single-cell RNA sequencing data from 14 CCA samples were employed for elucidating the roles of mucins,complemented by bioinformatic ***-quent validations were conducted through spatial transcriptomics and *** construction of a risk evaluation model utilized the least absolute shrinkage and selection operator regression algorithm,which was further confirmed by independent cohorts and diverse data *** CCA tumor cells with elevated levels of MUC1 and MUC4 showed activated nucleotide metabolic pathways and increased ***5AC-high cells were found to promote CCA progression through WNT ***5B-high cells exhibited robust cellular oxidation activities,leading to resistance against antitumoral ***13-high cells were observed to secret chemokines,recruiting and transforming macrophages into the M2-polarized state,thereby suppressing antitumor ***16-high cells were found to promote tumor progression through interleukin-1/nuclear factor kappa-light-chain-enhancer of activated B cells signaling upon interaction with *** the expression levels of these mucins,a risk factor evaluation formula for CCA was developed and validated across multiple *** samples with higher risk factors exhibited stronger metastatic potential,chemotherapy resistance,and poorer *** Our study elucidates the functional mechanisms through which mucins contribute to CCA development,and provides tools for risk stratification in CCA.

关键词： Mucin Cholangiocarcinoma Single-cell RNA sequencing Spatial transcriptomics Prognosis

Association between sensitivity to thyroid hormones and non-highdensity lipoprotein cholesterol levels in patients with type 2 diabetes mellitus

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World Journal of Diabetes 2024年第10期15卷 2081-2092页

作者： Xiao-Ye Duan Jun-ling fu Li-Na Sun Zhi-Jing Mu Shuang-ling Xiu Department of Endocrinology Beijing Institute of GeriatricsXuanwu HospitalCapital Medical UniversityBeijing 100053China

BACKGROUND Dyslipidemia and type 2 diabetes mellitus(T2DM)are chronic conditions with substantial public health *** management of lipid metabolism in patients with T2DM is ***,there has been insufficient attention given to the relationship between thyroid hormone sensitivity and dyslipidemia in the T2DM population,particularly concerning non-high-density lipoprotein cholesterol(non-HDL-C).AIM To clarify the association between thyroid hormone sensitivity and dyslipidemia in patients with *** In this cross-sectional study,thyroid hormone sensitivity indices,the thyroid feedback quantile-based index(TFQI),the thyroid-stimulating hormone index(TSHI),the thyrotrophic T4 resistance index(TT4RI),and the free triiodothyronine(FT3)/free thyroxine(FT4)ratio were *** regression analysis was performed to determine the associations between those composite indices and non-HDL-C *** forest variable importance and Shapley Additive Explanations(SHAP)summary plots were used to identify the strength and direction of the association between hyper-non-HDL-C and its major *** Among the 994 participants,389(39.13%)had high non-HDL-C *** regression analysis revealed that the risk of hyper-non-HDL-C was positively correlated with the TFQI(OR:1.584;95%CI:1.088-2.304;P=0.016),TSHI(OR:1.238;95%CI:1.034-1.482;P=0.02),and TT4RI(OR:1.075;95%CI:1.006-1.149;P=0.032)but was not significantly correlated with the FT3/FT4 *** relationships between composite indices of the thyroid system and non-HDL-C levels differed according to *** increased risk of hyper-non-HDL-C was associated with elevated TSHI levels in men(OR:1.331;95%CI:1.003-1.766;P=0.048)but elevated TFQI levels in women(OR:2.337;95%CI:1.4-3.901;P=0.001).Among the analyzed variables,the average SHAP values were highest for TSHI,followed by *** Impaired sensitivity to thyroid hormones was associated with high non-HDL-C levels in

关键词： Non-high-density lipoprotein cholesterol Sensitivity to thyroid hormones Type 2 diabetes mellitus Thyroid feedback quantile-based index Free triiodothyronine/free thyroxine ratio

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细长桁架臂卸载反弹动力学行为仿真及实验

华南理工大学学报（自然科学版） 2024年第9期52卷 62-71页

作者：付玲刘洋刘延斌尹莉起重机械关键技术全国重点实验室湖南长沙410013 湖南师范大学工程与设计学院湖南长沙410081

细长桁架臂是桁架臂起重机的关键工作部件,卸载反弹冲击是威胁细长桁架臂起重机结构安全的重要工况。为研究细长桁架臂在卸载冲击下的动力学行为,采用刚柔耦合多体仿真方法和起重机卸载冲击实验方法探讨了桁架臂卸载反弹条件下动应力的... 详细信息

细长桁架臂是桁架臂起重机的关键工作部件,卸载反弹冲击是威胁细长桁架臂起重机结构安全的重要工况。为研究细长桁架臂在卸载冲击下的动力学行为,采用刚柔耦合多体仿真方法和起重机卸载冲击实验方法探讨了桁架臂卸载反弹条件下动应力的变化规律,推算了细长桁架臂卸载冲击动载系数。以装备细长桁架臂的动臂塔机为对象,采用刚柔耦合方法建立了包含载荷模型和结构动态特性模型的动臂塔机精细化仿真模型,分析了桁架臂反弹振动引起的动应力变化,发现了桁架臂卸载反弹动应力的分布规律。根据不同臂长的起重机起升性能表,研究了仰角-动应力关系曲线与起升性能曲线之间的关系,发现起重臂的臂中出现最大动应力所对应的起重机突然卸载工况。根据起重机卸载冲击仿真结果,建立了基于仿真预测的起重机卸载冲击实验方法,实施了细长桁架臂系列载荷卸载反弹实验。桁架臂动应力实验值与仿真值之间的误差小于13%,证明精细化模型仿真是求解桁架臂卸载冲击响应的有效工具。通过模型仿真进一步预测了极限工况下细长桁架臂卸载冲击动载系数,发现起重机设计规范中关于卸载冲击动载系数的相关规定存在缺陷,探讨了桁架臂的长细比对卸载冲击动载系数的影响,为细长桁架臂的结构优化设计提供依据。

关键词：刚柔耦合模型虚拟仿真卸载冲击实验动应力极限工况预测

习近平新时代中国特色社会主义思想的世界观和方法论:辩证关系、核心要义与实践指向

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新疆师范大学学报（哲学社会科学版） 2024年第1期45卷 58-66,F0002页

作者：周向军庞付玲山东大学马克思主义学院山东济南250100

把握好习近平新时代中国特色社会主义思想的世界观和方法论,要正确认识和处理世界观和方法论的关系、习近平新时代中国特色社会主义思想的世界观和方法论与马克思主义世界观和方法论的关系、与中华优秀传统文化的关系、与习近平新时代... 详细信息

把握好习近平新时代中国特色社会主义思想的世界观和方法论,要正确认识和处理世界观和方法论的关系、习近平新时代中国特色社会主义思想的世界观和方法论与马克思主义世界观和方法论的关系、与中华优秀传统文化的关系、与习近平新时代中国特色社会主义思想的关系。要从不同维度深刻领悟其核心要义,即必须坚持人民至上、必须坚持自信自立、必须坚持守正创新、必须坚持问题导向、必须坚持系统观念、必须坚持胸怀天下。习近平新时代中国特色社会主义思想的世界观和方法论具有强烈的实践指向性,要在学好用好马克思主义哲学的基础上,在“两个结合”中不断推进马克思主义中国化时代化,为新时代新征程推进中国式现代化提供行动指南。

关键词：习近平新时代中国特色社会主义思想世界观和方法论辩证关系核心要义实践指向

知识分类视角下晚清西学汇编中物理知识的表达与认知

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自然辩证法研究 2024年第2期40卷 110-116页

作者：杨诗敏聂馥玲郭世荣内蒙古师范大学科学技术史研究院呼和浩特010022

如何理解两种文化相遇时“本土”与“域外”之间的知识融通是探讨近代中国西学东渐的重要议题。透过晚清西学汇编对物理知识的本土回应或可发现问题的关键。这些汇编资料再次选择与重述已有西学译书,对传入知识进行二度创造。其中的知... 详细信息

如何理解两种文化相遇时“本土”与“域外”之间的知识融通是探讨近代中国西学东渐的重要议题。透过晚清西学汇编对物理知识的本土回应或可发现问题的关键。这些汇编资料再次选择与重述已有西学译书,对传入知识进行二度创造。其中的知识分类呈现出新知与旧识之间的往还,反映出时人对物理知识的认知。西学汇编对传入物理知识再生产的复杂历史情节,显示晚清中国学者对物理学的认识不止由器物上升到学理,还有着以“艺”描述其知识属性,以“测量”“格物”概括其知识领域的尝试。解析西学汇编对物理知识的调适与回应,也是审视晚清物理学本土化的主旨所在。

关键词：晚清西学汇编知识分类百科全书物理学

中国式现代化语境下的科技自立自强:丰富内涵、现实困境与实践进路

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福州党校学报 2024年第3期 84-91页

作者：付羚中共上海市黄浦区委党校上海200023

科技自立自强是大国崛起的必经之路,是科技革命和产业变革背景下实现中国式现代化的重要支撑。在中国式现代化语境下,以五个特征阐释其深刻要义,同时剖析当前我国科技自立自强面临的四维困境,即科技成果转化、关键核心技术攻关“两重难... 详细信息

科技自立自强是大国崛起的必经之路,是科技革命和产业变革背景下实现中国式现代化的重要支撑。在中国式现代化语境下,以五个特征阐释其深刻要义,同时剖析当前我国科技自立自强面临的四维困境,即科技成果转化、关键核心技术攻关“两重难题”需解决,政府市场“两类主体”需协调,区域一体化错位化“两种形态”需兼顾,国内国际“两种循环”需统筹,从而以多视角探索实现高水平科技自立自强的路径指向。

关键词：中国式现代化科技创新自立自强