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Self-Organizing Maps for identification of zeolitic diagenesis patterns in closed hydrologic systems on the Earth and its implications for Mars

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International Journal of Sediment Research 2021年第5期36卷 567-576页

作者： Gayantha Roshana Loku kodikara lindsay McHenry Department of Geosciences University of Wisconsin-Milwaukee

We have conducted a survey of zeolite occurrences in saline-alkaline paleolake deposits on Earth to identify the most prominent zeolite alteration patterns and to characterize the most common authigenic minerals and their paragenetic relationships. We collected the bulk mineral assemblages(from previous and our studies) as identified by X-ray diffraction from zeolitic tuff beds and associated sedimentary beds from thirteen paleolake deposits from the USA, Mexico, Greece, and Tanzania. We applied the kohonen Self-Organizing Maps(SOM) to look for interesting patterns in the tuff bed mineral assemblages without prescribing any specific interpretation, and for information reduction and classification. Decision Tree(DT) method was applied to characterize these clusters. We were able to define clear class boundaries between fresh glass, non-analcime zeolites, analcime, and k feldspar. The non-analcime zeolites were further grouped into several classes based on mineral type. We also discuss the potential implications for Mars, showing that the mineral assemblages of diagenetic facies identified by SOM and DT can be used to test or validate the orbital, in situ, or modeling results, while the trained SOM provides a robust generalized ability to classify the new mineral assemblage data into the most common diagenetic facies identified in saline-alkaline paleoenvironments that contain zeolites. The study concludes that generalizing the complex geochemical behaviors using unsupervised statistical learning methods can help to identify the most prominent geochemical behaviors.

关键词： Zeolites Self-Organizing Maps Mars Paleolakes Diagenetic patterns

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Pilfering of western juniper seed caches by scatter-hoarding rodents varies by microsite and canopy type

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Integrative Zoology 2022年第2期17卷 192-205页

作者： lindsay A.DIMITRI William S.LONGLAND Agricultural Research Service Great Basin Rangeland ResearchUSDAUSA

Scatter-hoarding rodents store seeds throughout their home ranges in superficially buried caches which,unlike seeds larder-hoarded in burrows,are difficult to *** seeds are often pilfered by other scatter-hoarders and either re-cached,eaten or *** seed movements can influence seedling recruitment,because only seeds remaining in caches are likely to *** the importance of scatter-hoarding rodents in the dispersal of western juniper seeds has recently been revealed,the level of pilfering that occurs after initial burial is *** traits,soil moisture,and substrate can influence pilfering processes,but less is known about how pilfering varies among caches placed in open versus canopy microsites,or how cache discovery and removal varies among different canopy-types,tree versus *** compared the removal of artificial caches between open and canopy microsites and between tree and shrub canopies at two sites in northeastern California during late spring and *** also used trail cameras at one site to monitor artificial cache removal,identify potential pilferers,and illuminate microsite use by *** of artificial caches was faster in open microsites at both sites during both seasons,and more caches were removed from shrub than tree *** kangaroo rats were the species observed most on cameras,foraging most often in open microsites,which could explain the observed pilfering *** is the first study to document pilfering of western juniper seeds,providing further evidence of the importance of scatter-hoarding rodent foraging behavior in understanding seedling recruitment processes in juniper woodlands.

关键词： Dipodomys californicus Juniperus Perognathus parvus Peromyscus truei seed caching seed dispersal

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2024年的航空售后服务市场的变化

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航空维修与工程 2024年第3期 21-21页

作者： lindsay Bjerregaard 不详

光阴似箭,日月如梭。回首2023年,全球范围内航空业都经历了重振和复苏,并正以前所未有的方式予以展开,航空维修业也不例外。展望未来,2024年航空维修业尽管仍存在很多不确定性,如能源价格、通货膨胀、劳动力资源等,但总体来说,可以确定... 详细信息

光阴似箭,日月如梭。回首2023年,全球范围内航空业都经历了重振和复苏,并正以前所未有的方式予以展开,航空维修业也不例外。展望未来,2024年航空维修业尽管仍存在很多不确定性,如能源价格、通货膨胀、劳动力资源等,但总体来说,可以确定一些典型发展变化和重点发展方向以及可能逐渐淡出人们视野的内容。

关键词：劳动力资源展望未来航空维修业能源价格重点发展方向通货膨胀全球范围航空业

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Safety and success of precut biliary sphincterotomy: Is it linked to experience or expertise?

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World Journal of Gastroenterology 2007年第15期13卷 2183-2186页

作者： lindsay S Robison Shyam Varadarajulu C Mel Wilcox Division of Gastroenterology and Hepatology Pancreaticobiliary Center University of Alabama at BirminghamBirminghamAlabama

AIM： To determine the rates of success and complications of precut biliary sphincterotomy （PBS） based on prior experience and to compare the complication rates between PBS and standard endoscopic sphincterotomy （ES）. METHODS： A retrospective evaluation of prospectively collected non-randomized data at an academic tertiary referral center, The study included all patients in an eight-year period who underwent PBS and ES by a single endoscopist who had no formal training in PBS. The main outcorne measures of the study were success and complications of PBS with a comparison to complications of ES.RESULTS： A total of 2939 endoscopic retrograde chola ngiopancreatographies （ERCPs） were performed during the study period, including 818 （28%） ES and 150 （5%） PBS procedures. Selective biliary cannulation via PBS was successful at the first attempt in 75% of the patients. Cannulation was achieved in an additional 13% of the patients at a subsequent attempt （total 87%）. Complication rate from PBS was 45% higher than ES, but did not differ significantly [7% （10/50） vs 5% （38/818）, P = 0.29]. None of the complications from PBS was severe. A significant trend towards increasing success existed with regard to the endoscopist＇s first attempt at precut （P = 0.0393, Cochran-Armitage exact test for trend, Z = -1.7588）. CONCLUSION： Despite the lack of specific training in this technique, PBS was performed with a high success rate and a complication rate similar to or less than reports from other experienced centers. These results suggest that endoscopic experience and perhaps innate endoscopic skill may play an important role in the outcome of this procedure.

关键词： Biliary sphincterotomy Precut sphincterotomy Complication rate Endoscopic skill

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Unveiling T cell evasion mechanisms to immune checkpoint inhibitors in acute myeloid leukemia

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Cancer Drug Resistance 2023年第3期6卷 674-687页

作者： lindsay Gurska kira Gritsman Department of Cell Biology Albert Einstein College of MedicineBronxNY 10461USA Department of Medical Oncology Montefiore Medical CenterAlbert Einstein College of MedicineBronxNY 10461USA

Acute myeloid leukemia (AML) is a heterogeneous and aggressive hematologic malignancy that is associated with a high relapse rate and poor prognosis. Despite advances in immunotherapies in solid tumors and other hematologic malignancies, AML has been particularly difficult to treat with immunotherapies, as their efficacy is limited by the ability of leukemic cells to evade T cell recognition. In this review, we discuss the common mechanisms of T cell evasion in AML: (1) increased expression of immune checkpoint molecules;(2) downregulation of antigen presentation molecules;(3) induction of T cell exhaustion;and (4) creation of an immunosuppressive environment through the increased frequency of regulatory T cells. We also review the clinical investigation of immune checkpoint inhibitors (ICIs) in AML. We discuss the limitations of ICIs, particularly in the context of T cell evasion mechanisms in AML, and we describe emerging strategies to overcome T cell evasion, including combination therapies. Finally, we provide an outlook on the future directions of immunotherapy research in AML, highlighting the need for a more comprehensive understanding of the complex interplay between AML cells and the immune system.

关键词： Acute myeloid leukemia T cells immune checkpoint immune evasion

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新兴技术在MRO中的发展将远超人工智能技术的应用

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航空维修与工程 2024年第1期 25-25页

作者： lindsay Bjerregaard 赵平(译) 不详

1氢能和电能推进系统随着航空业可持续发展期限的临近,氢能和电能推进系统的发展备受航空业的关注。ZeroAvia、MagniX和Universal Hydrogen等电动和氢能推进系统制造商正与克莱菲尔德大学(Cranfield University)和AeroTEC等伙伴开展技... 详细信息

1氢能和电能推进系统随着航空业可持续发展期限的临近,氢能和电能推进系统的发展备受航空业的关注。ZeroAvia、MagniX和Universal Hydrogen等电动和氢能推进系统制造商正与克莱菲尔德大学(Cranfield University)和AeroTEC等伙伴开展技术合作,共同推广和研发氢能和电能推进系统应于飞机的改装方案。

关键词：人工智能系统制造商氢能可持续发展航空业新兴技术技术的应用改装方案

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DEM Fusion using a modified k-means clustering algorithm

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International Journal of Digital Earth 2016年第12期9卷 1242-1255页

作者： Colleen E.Fuss Aaron A.Berg John B.lindsay Department of Geography University of GuelphGuelphCanada

Digital elevation models(DEMs)are a necessary dataset for modelling the Earth’s surface;however,all DEMs contain *** can reduce this error using DEM fusion techniques since numerous DEMs can be available for a ***,the use of a clustering algorithm in DEM fusion has not been previously *** this study a new DEM fusion algorithm based on a clustering approach that works on multiple DEMs to exploit consistency in the estimates as indicators of accuracy and precision is *** fusion approach includes slope and elevation thresholding,k-means clustering of the elevation estimates at each cell location,as well as filtering and smoothing of the fusion *** of the input DEMs,and the products of each step of the fusion algorithm,with a higher accuracy reference DEM enabled a detailed analysis of the effectiveness of the DEM fusion *** main findings of the research were:the k-means clustering of the elevations reduced the precision which also impacted the overall accuracy of the estimates;the number of final cluster members and the standard deviation of elevations before clustering both had a strong relationship to the error in the k-means estimates.

关键词： DEM fusion k-means clustering DEM error

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Aflibercept for diabetic macular oedema： a Meta-analysis of randomized controlled trials

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International Journal of Ophthalmology(English edition) 2018年第6期11卷 1002-1008页

作者： Chu Luan Nguyen Andrew lindsay Eugene Wong Michael Chilov University of Sydney Sydney NSW 2000 Australia

AIM： To evaluate the relative efficacy and safety of aflibercept for treatment of diabetic macular oedema （DMO）. METHODS： A comprehensive search in MEDLINE, CENTRAL and EMBASE was undertaken for randomized controlled trials （RCTs） comparing intravitreal anti-vascular endothelial growth factor （anti-VEGF） versus another treatment. Primary outcome measures were proportion of patients with at least 15 letters of gain or loss on a logMAR visual acuity chart, and change in best corrected visual acuity （BCVA） and central macular thickness （CMT） from baseline. Safety outcomes were rates of death, thromboembolic events and any systemic or ocular serious adverse events. The final search was performed on November 2017. RESULTS： Four RCTs were included. Only one trial compared efficacy and safety of aflibercept with bevacizumab and ranibizumab over 1 or 2y. Three trials were included for Meta-analysis comprising 661 patients （331 in the aflibercept, and 330 in the photocoagulation group）. Aflibercept was more efficacious compared to photocoagulation in the proportion of patients with at least 15 letters of improvement and worsening, and in improvement of BCVA and reduction in CMT at 1 or 2y. The safety estimates at 1 or 2y did not differ statistically. CONCLUSION： Aflibercept offers superior benefits over photocoagulation in improving and preserving vision, with no differences in safety. Further comparative effectiveness trials between aflibercept and other anti-VEGF agents will aid ophthalmologists in treatment decisions.

关键词： aflibercept diabetic macular oedema Metaanalysis randomized controlled trial

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Association between high deductible health plan coverage and age at pediatric umbilical hernia repair

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World Journal of Pediatric Surgery 2023年第2期6卷 70-76页

作者： Morgan E Doty lindsay A Gil Jennifer N Cooper The Ohio State University College of Medicine ColumbusOhioUSA Department of Surgery Nationwide Children's HospitalThe Ohio State UniversityColumbusOhioUSA Department of Pediatrics Nationwide Children's HospitalThe Ohio State UniversityColumbusOhioUSA

Background High deductible health plans(HDHPs)are associated with the avoidance of both necessary and unnecessary *** hernia repair(UHR)is a procedure that is frequently unnecessarily performed in young children,contrary to best practice *** hypothesized that children with HDHPs,as compared with other types of commercial health plans,are less likely to undergo UHR before 4 years of age but are also more likely to have UHR delayed beyond 5 years of *** Children aged 0-18 years old residing in metropolitan statistical areas(MSAs)who underwent UHR in 2012-2019 were identified in the IBM Marketscan Commercial Claims and Encounters Database.A quasi-experimental study design using MSA/year-level HDHP prevalence among children as an instrumental variable was employed to account for selection bias in HDHP ***-stage least squares regression modeling was used to evaluate the association between HDHP coverage and age at *** A total of 8601 children were included(median age 5 years,IQR 3-7).Univariable analysis revealed no differences between the HDHP and non-HDHP groups in the likelihood of UHR being performed before 4 years of age(27.7%vs 28.7%,p=0.37)or after 5 years of age(39.8%vs 38.9%,p=0.52).Geographical region,metropolitan area size,and year were associated with HDHP *** variable analysis demonstrated no association between HDHP coverage and undergoing UHR at5 years of age(p=0.87).Conclusions HDHP coverage is not associated with age at pediatric *** studies should investigate other means by which UHRs in young children can be avoided.

关键词： pediatric hernia likely

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Women receive more inpatient resections and ablations for hepatocellular carcinoma than men

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World Journal of Hepatology 2017年第36期9卷 1346-1351页

作者： lindsay Sobotka Alice Hinton Lanla Conteh Department of Internal Medicine the Ohio State University Wexner Medical Center Division of Biostatistics College of Public Health the Ohio State University Section of Hepatology Division of Gastroenterology Hepatology and Nutrition the Hepatocellular Carcinoma Multidisciplinary Clinic the James Comprehensive Cancer Center the Ohio State University Wexner Medical Center

AIM To evaluate disparities in the treatment of hepatocellular carcinoma(HCC) based on *** A retrospective database analysis using the Nationwide Inpatient Sample(NIS) was performed between 2010 and 2013. Adult patients with a primary diagnosis of hepatocellular carcinoma determined by International Classification of Disease 9(ICD-9) codes were included. Univariate analysis and multivariate logistic regressions were performed to analyze differences in treatment, mortality, features of decompensation, and metastatic disease based on the patient's *** The analysis included 62582 patients with 45908 men and 16674 women. Women were less likely to present with decompensated liver disease(OR = 0.84, P k of inpatient mortality when compared to men(OR = 0.75, P kely to receive inpatient resection(OR = 1.31, P kely to undergo an ablation or resection then men. Gender disparities in transplantation have resolved.

关键词： Hepatocellular carcinoma Gender disparities Liver transplantation Liver resection Ablation

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