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developing a framework to inform scale-up success for population health interventions:a critical interpretive synthesis of the literature

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Global Health Research and Policy 2020年第1期5卷 279-289页

作者： duyen Thi kim Nguyen lindsay McLaren Nelly d.Oelke Lynn McIntyre department of Economics Faculty of BusinessUniversity of New Brunswick100 Tucker Park RoadP.O.Box 5050Saint JohnNew Brunswick E2L 4L5Canada School of Epidemiology and Public Health Faculty of MedicineUniversity of Ottawa600 Peter Morand Crescent OttawaOntario K1G 5Z3Canada New Brunswick Health Research Foundation 10 Knowledge Park DriveFrederictonNew Brunswick E3C 2M7Canada department of Community Health Sciences Cumming School of MedicineUniversity of CalgaryTRW33280 Hospital Dr.NWCalgaryAlberta T2N 4Z6Canada O’Brien Institute for Public Health University of CalgaryTRW33280 Hospital Dr.NWCalgaryAlberta T2N 4Z6Canada School of Nursing Faculty of Health and Social DevelopmentUniversity of British Columbia3333 University WayKelownaBritish Columbia V1V 1V7Canada

Background:Population health interventions(PHIs)have the potential to improve the health of large populations by systematically addressing underlying conditions of poor health outcomes(i.e.,social determinants of health)and reducing health ***-up may be one means of enhancing the impact of effective ***,not all scale-up attempts have been *** an attempt to help guide the process of successful scale-up of a PHI,we look to the organizational readiness for change theory for a new perspective on how we may better understand the scale-up *** the change theory,our goal was to develop the foundations of an evidence-based,theory-informed framework for a PHI,through a critical examination of various PHI scale-up experiences documented in the ***:We conducted a multi-step,critical interpretive synthesis(CIS)to gather and examine insights from scale-up experiences detailed in peer-reviewed and grey literatures,with a focus on PHIs from a variety of global *** CIS included iterative cycles of systematic searching,sampling,data extraction,critiquing,interpreting,coding,reflecting,and *** relevant to innovations,complexity,and organizational readiness guided our analysis and ***:We retained and examined twenty different PHI scale-up experiences,which were extracted from 77 documents(47 peer-reviewed,30 grey literature)published between 1995 and ***,we identified three phases(i.e.,Groundwork,Implementing Scale-up,and Sustaining Scale-up),11 actions,and four key components(i.e.,PHI,context,capacity,stakeholders)pertinent to the scale-up *** guiding theories provided explanatory power to various aspects of the scale-up process and to scale-up success,and an alternative perspective to the assessment of scale-up readiness for a ***:Our synthesis provided the foundations of the Scale-up Readiness Assessment *** theoreticallyinformed and rigorous synt

关键词： Population health intervention Scale-up Framework Critical interpretive synthesis Readiness

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Preoperative immunonutrition in patients undergoing liver resection:A prospective randomized trial

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World Journal of Hepatology 2019年第3期11卷 305-317页

作者： kylie Russell Han-Guang Zhang Lyn k GillANders Adam SJR Bartlett Helena L Fisk Philip C Calder Peter J Swan lindsay d Plank Nutrition Services Auckland City Hospital department of Surgery University of Auckland New Zealand Liver Transplant Unit Auckland City Hospital Human development and Health Faculty of Medicine University of Southampton NIHR Southampton Biomedical Research Centre University Hospital Southampton NHS Foundation Trust and University of Southampton

BACkGROUNd Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver *** To evaluate the effects of preoperative nutritional supplementation enriched with arginine and n-3 fatty acids on inflammatory and immunologic markers and clinical outcome in patients undergoing liver *** Thirty-four patients undergoing liver resection were randomized to either five days of preoperative Impact? [1020 kcal/d, immunonutrition(IMN) group], or standard care [no supplementation, standard care(STd) group]. Nutritional status was measured at study entry by subjective global assessment(SGA).Functional assessments(grip strength, fatigue and performance status) were carried out at study entry, on the day prior to surgery, and on postoperative day(POd) 7 and 30. Inflammatory and immune markers were measured at study entry, on the day prior to surgery, and POd 1, 3, 5, 7, 10 and 30. Postoperative complications were recorded prospectively until *** A total of 32 patients(17 IMN and 15 STd) were analysed. All except four patients were SGA class A. The plasma ratio of(eicosapentaenoic acid plus docosahexaenoic acid) to arachidonic acid was higher in IMN patients on the day prior to surgery and POd 1, 3, 5 and 7(P kin(IL)-6 concentrations were elevated in the IMN group(P = 0.017 for POd7). No treatment effect was detected for functional measures, immune response(white cell count and total lymphocytes) or markers of inflammation(C-reactive protein,tumour necrosis factor-α, IL-8, IL-10). There were 10 patients with infectious complications in the IMN group and 4 in the STd group(P = 0.087). Median hospital st

关键词： Liver cancer Partial hepatectomy Fish oil Arginine Nutritional status Inflammation

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Neighborhood Effects on Hispanic Young Adult Outcomes

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Psychology Research 2016年第9期6卷 516-529页

作者： Benjamin d. Smith Jacquelyn d. Wiersma-Mosley, lindsay S. Ham Zola k. Moon Arizona State University Tempe USA University of Arkansas Fayetteville USA

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Organotypic Models for Functional drug Testing of Human Cancers

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Biomedical Engineering Frontiers 2023年第1期4卷 103-112页

作者： Yu Ling Huang lindsay k.dickerson Heidi kenerson Xiuyun Jiang Venu Pillarisetty Qiang Tian Leroy Hood Taranjit S.Gujral Raymond S.Yeung division of Human Biology Fred Hutchinson Cancer CenterSeattleWAUSA department of Surgery University of WashingtonSeattleWAUSA National Research Center for Translational Medicine Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Institute for Systems Biology Phenome Health InstituteSeattleWAUSA

In the era of personalized oncology,there have been accelerated efforts to develop clinically relevant platforms to test drug sensitivities of individual *** ideal assay will serve as a diagnostic companion to inform the oncologist of the various treatments that are sensitive and insensitive,thus improving outcome while minimizing unnecessary toxicities and *** date,no such platform exists for clinical use,but promising approaches are on the horizon that take advantage of improved techniques in creating human cancer models that encompass the entire tumor microenvironment,alongside technologies for assessing and analyzing tumor *** review summarizes a number of current strategies that make use of intact human cancer tissues as organotypic cultures in drug sensitivity testing.

关键词： Cancer horizon Human

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Correction to:developing a framework to inform scale-up success for population health interventions:a critical interpretive synthesis of the literature

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Global Health Research and Policy 2020年第1期5卷 208-209页

作者： duyen Thi kim Nguyen lindsay McLaren Nelly d.Oelke Lynn McIntyre department of Economics Faculty of BusinessUniversity of New Brunswick100 Tucker Park RoadP.O.Box 5050Saint JohnNew Brunswick E2L 4 L5Canada School of Epidemiology and Public Health Faculty of MedicineUniversity of Ottawa600 Peter Morand CrescentOttawaOntario K1G 5Z3Canada New Brunswick Health Research Foundation 10 Knowledge Park DriveFrederictonNew Brunswick E3C 2 M7Canada department of Community Health Sciences Cumming School of MedicineUniversity of CalgaryTRW33280 Hospital Dr.NWCalgaryAlberta T2N 4Z6Canada O’Brien Institute for Public Health University of CalgaryTRW33280 Hospital Dr.NWCalgaryAlberta T2N 4Z6Canada School of Nursing Faculty of Health and Social DevelopmentUniversity of British Columbia3333 University WayKelownaBritish Columbia V1V 1 V7Canada

Correction to:Global Health Res Policy(2020)5:18 https://***/10.1186/s41256-020-00141-8 Following the publication of the original article[1],it was noted that due to a typesetting error the Table 3 layout was *** corr... 详细信息

关键词： synthesis critical corrected

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ESR研究介质隔离k3分子动态Jahn-Teller效应的隧穿过程

ESR研究介质隔离K3分子动态Jahn-Teller效应的隧穿过程

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第九届全国化学动力学会议

作者：陈志达 d．M．lindsay 北京大学化学与分子工程学院 department of Chemistry City CollegeCity University NY

＜正＞本工作的ESR研究表明,低温下介质隔离的钾三聚分子k3的两种不同ESR 谱的超精细结构分别来自于k3的Jahn-Teller静态与动态异构体;介质效应造成了k3位能面的三个势阱不对称。动态k3分子在这三个势阱之间的隧道效应是体系的电子运动...

＜正＞本工作的ESR研究表明,低温下介质隔离的钾三聚分子k3的两种不同ESR 谱的超精细结构分别来自于k3的Jahn-Teller静态与动态异构体;介质效应造成了k3位能面的三个势阱不对称。动态k3分子在这三个势阱之间的隧道效应是体系的电子运动与介质振动之间的耦合效应。诱发这种耦合的可能机制有直接的

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冠状动脉CTA影像进行钙化积分的可行性和有效性

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国际医学放射学杂志 2016年第4期 455-455页

作者： C.W.Pavitt k.Harron A.C.lindsay S.Zielke R.Ray d.Gordon 谢秋霞 department of Cardiology Royal Brompton Hospital

摘要目的验证用冠状动脉CTA影像进行钙化积分这一新模型的可行性和有效性。方法根据冠状动脉CTA影像设定阈值以量化钙化,每一病人特异性阈值设定为:冠状动脉血管内平均密度(HU)+2标准差(Sd)。分析335例病人的

关键词：钙化积分冠状动脉 CTA 有效性

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