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Irritable bowel syndrome and functional constipation management with integrative medicine: A systematic review

World Journal of Clinical Cases 2019年第21期7卷 3486-3504页

作者： Liang Dai linda ld zhong Guang Ji Institute of Digestive Diseases Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China School of Chinese Medicine Hong Kong Baptist UniversityHong KongChina

BACKGROUND Irritable bowel syndrome(IBS)and functional constipation(FC)are two commonly encountered functional gastrointestinal disorders in clinical practice and are usually managed with Western medicines in cooperation with traditional Chinese medicine(TCM)*** clinical practice guidelines(CPGs)have been developed to assist clinicians with their decisions,there are still gaps in management with regard to integrative medicine(IM)*** To comprehensively review the currently available CPGs and to provide a reference for addressing the gaps in IBS and FC *** We searched mainstream English and Chinese databases and collected data from January 1990 to January *** search was additionally enriched by manual searches and the use of publicly available *** on the development method,the guidelines were classified into evidence-based(EB)guidelines,consensus-based(CB)guidelines,and consensus-based guidelines with no comprehensive consideration of the EB(CB-EB)*** regard to the recommendations,the strength of the interventions was uniformly converted to a 4-point grading *** Thirty CPGs met the inclusion criteria and were captured as data extraction *** Western medicine(WM)CPGs were developed as EB *** TCM CPGs and most IM CPGs were identified as CB *** the 2011 IBS and IM CPG was a CB-EB set of *** and peppermint oil for pain,loperamide for diarrhea,and linaclotide for constipation polyethylene glycol and lactulose as osmotic laxatives,bisacodyl and sodium picosulfate as stimulant laxatives,lubiprostone and linaclotide as prosecretory agents,and prucalopride were strongly recommended or recommended in *** interventions were suggested based on pattern differentiation,while the recommendation level was considered to be weak or *** WM CPGs generally provide a comprehensive management algorithm,although there are still s

关键词： Irritable bowel disease Functional constipation Clinical practice guideline Integrative medicine Systematic review

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Outcome of the efficacy of Chinese herbal medicine for functional constipation:A systematic review and meta-analysis

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World Journal of Clinical Cases 2022年第15期10卷 4856-4877页

作者： Zipan Lyu Yibo Fan Yang Bai Tao Liu linda ld zhong Hui-Feng Liang Teaching and Research Division School of Chinese MedicineHong Kong Baptist UniversityHong Kong SAR 99977China Department of Cardiology Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China Department of Digestive Endoscope Center Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China School of Chinese Medicine Hong Kong Baptist UniversityHong Kong 999077China The Institute for Science Technology and HumanitiesShanghai University of Traditional Chinese MedicineShanghai 201203China

BACKGROUND Functional constipation(FC)is a common and chronic gastrointestinal disease and its treatment remains *** To evaluate the efficacy and safety of Chinese herbal medicine(CHM)on efficacy rate,global symptoms,bowel movements and the Bristol Stool Scale score in patients with FC by summarizing current available randomized controlled trials(RCTs).METHODS RCTs with CHM to treat FC were identified by a systematic search of six databases from inception to October 20,*** independent reviewers assessed the quality of the included articles and extracted ***-analyses were performed to odds ratio(OR),mean differences(MD)and 95%confidence interval(CI)using random-effects *** analyses and sensitivity analyses were used to explore and interpret the sources of *** funnel plot,Begg’s test and Egger’s test were used to detect publication *** Ninety-seven studies involving 8693 patients were included in this *** was significantly associated with a higher efficacy rate(OR:3.62,95%CI:3.19-4.11,Pld not be reached because of the poor quality of the included *** trials with higher quality are required.

关键词： Functional constipation Chinese herbal medicine Efficacy Systematic review Meta-analysis

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A clinical pathway for integrative medicine in the treatment of functional constipation in Hong Kong,China

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Journal of Integrative Medicine 2023年第6期21卷 550-560页

作者： Dong-jue Wei Hui-juan Li Zi-pan Lyu Ai-ping Lyu Zhao-xiang Bian linda ld zhong School of Chinese Medicine Hong Kong Baptist UniversityHong KongChina School of Biological Sciences Nanyang Technological University637551Singapore

Objective:Functional constipation(FC)is a common intestinal disease *** the presence of criteria such as Roman IV,there is no standardized diagnosis and treatment algorithm in Hong Kong that combines both Western and Chinese medicine *** study integrates current effective and safe diagnosis and treatment methods for FC and provides a clear and scientific pathway for clinical professionals and ***:A systematic search of the PubMed,Cochrane Library,and China National Knowledge Infrastructure databases was performed from their inception to June 30th,2022,collecting the current evidence about the efficacious integrative management for *** organized a meeting of professionals in fields relevant to treatment and management of FC to develop a consensus agreement on clinical pathway ***:We developed a clinical pathway for the treatment of FC based on the most recent published guidelines and consultation with *** pathway includes a hierarchy of recommendations for every step of the clinical process,including clinical intake,diagnostic examination,recommended labs,diagnostic flowchart,and guidance for selection of therapeutic ***:This pathway establishes clinical standards for the diagnosis and treatment of FC using Chinese medicine and Western medicine;it will help to provide high-quality medical services in Hong Kong for patients with FC.

关键词： Functional constipation Clinical pathway Hong Kong Integrative medicine

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Comparing the effectiveness of pattern differentiation treatment and fixed formula treatment for perimenopausal syndrome with Chinese herbal medicine:A study protocol

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Journal of Traditional Chinese Medical Sciences 2023年第3期10卷 331-338页

作者： Wingsze Hsu Manhon Chan Sirong Zheng Kingchung Li Kamyin Chan Hoiyi Lam Tammy Tinyan Chu Siufung Chan Yingching Kwok linda ld.zhong HKFTU Workers’Medical Clinics Hong Kong Baptist University Chinese Medicine Clinic cum Training and Research Centre(North District)Hong KongChina School of Chinese Medicine Hong Kong Baptist UniversityHong KongChina School of Biological Sciences Nanyang Technological University637551Singapore

Objective:To further understand and compare the effectiveness of pattern differentiation treatment and fixed prescription treatment in perimenopausal ***:The study will be conducted in the Hong Kong Federation of Trade Unions Workers'Medical Clinics,Hong Kong Baptist University Chinese Medicine Clinic cum Training and Research Centre(Hong Kong,China).One hundred Chinese women,aged 45-55 years,will be *** participants will be randomized into 2 *** intervention group will be administered medication,based on pattern differentiation,by qualified traditional Chinese medicine(TCM)*** each evaluation,TCM practitioners will evaluate and revise the prescription,based on the participants'*** control group will be given the standard formula,i.e.,the Erxian decoction,which contains 6 *** treatment period and the follow-up period will be 8 weeks *** primary assessment outcome measure will be the Kupperman Index,and the secondary outcome measure will be the Menopause-specific Quality of Life Questionnaire ***:Pattern-differentiated treatment is the basic principle of TCM to understand and treat *** study will show the pattern-differentiated treatment is effectiveness than the fixed prescription.

关键词： Pattern differentiation treatment Perimenopausal Chinese herbal medicine Kupperman index Menopause-specific quality of life

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A Systematic Review of Chinese Herbal Medicine for Constipation:From Zheng-based Prescription to Selections of Herbs and Formula

A Systematic Review of Chinese Herbal Medicine for Constipat...

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第十四届全国中药和天然药物学术研讨会

作者： linda ld zhong Guang Zheng Zhao-Xiang Bian Hong Kong Baptist University

＜正＞Constipation is a common functional bowel disorder that affects a significant proportion of *** the unsatisfactory response to current symptomatic treatments,many patients seek help from Chinese Herbal Medicine...

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Would integrated Western and traditional Chinese medicine have more benefits for stroke rehabilitation? A systematic review and meta-analysis

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Stroke & Vascular Neurology 2022年第1期7卷 77-85页

作者： linda ld zhong Ya Zheng Alexander Y Lau Norman Wong Liang Yao Xingyao Wu Tengteng Shao Zhenxing Lu Huijuan Li Chun Sum Yuen Jianwen Guo Suzanne Lo Janita Chau Kam Wa Chan Bacon Fung Leung Ng Zhaoxiang Bian Edwin Chau-leung Yu Hong Kong Chinese Medicine Clinical Study Centre School of Chinese MedicineHong Kong Baptist UniversityHong Kong SARChina Department of Medicine and Therapeutics and Hong Kong Institute of Integrative Medicine Prince of Wales HospitalFaculty of MedicineThe Chinese University of Hong KongHong Kong SARChina Department of Health Research Methods Evidence and ImpactMcMaster UniversityHamiltonOntarioCanada Clinical Laboratory Shanghai Traditional Chinese Medicine Integrated Institute of Vascular AbnomaliesShanghaiChina Institute of Medical Research Northwestern Polytechnical UniversityXi'anShanxiChina Evidence Based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhouChina School of Chinese medicine Hong Kong Baptist UniversityHong Kong SARChina Brain Center Guangdong Procincial Hospital of Traditional Chinese MedicineGuangdong University of Chinese MedicineGuangzhouChina The Nethersole School of Nuring Faculty of Medicinethe Chinese University of Hong KongHong Kong SARChina Department of Medicine Li Ka Shing Faculty of Medicinethe University of Hong KongHong Kong SARChina Department of Rehabilitation Sciences Hong Kong Polytechnic UniversityHong Kong SARChina Hong Kong Association for Integration of Chinese-Western Medicine Limited Hong Kong SARChina

Background Stroke is a major cause of death or long-term disability *** patients with stroke receive integrative therapy consisting of Western medicine(WM)and routine rehabilitation in conjunction with Chinese medicine(CM),such as acupuncture and Chinese herbal ***,there is no available evidence on the effectiveness of the combined use of WM and CM interventions in stroke *** The purpose of this meta-analysis is to evaluate the results of all individual studies to assess the combined use of CM and WM in stroke rehabilitation compared with WM *** The Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines were ***,EMBASE,Cochrane and China National Knowledge Infrastructure(CNKI)were *** included outcomes were dependency,motor function,depression and swallowing *** analysis was performed,and publication bias was assessed using funnel *** of review 58 studies and 6339 patients were included in the *** analysis revealed that combined therapy comprising both acupuncture and WM had a superior effect on improving dependency and swallowing function compared with standard WM therapy *** superiority of combined therapy comprising CM and WM in improving depression compared with standard WM therapy was also *** Our results indicate that the combined use of CM and WM could be more efficacious in stroke rehabilitation compared with the use of WM therapy ***,most studies were short in duration(2 to 4 weeks)and prone to different types of biases,which prevents making any conclusion regarding the long-term effects and raises concerns regarding true efficacy in context of high likelihood of Hawthorn ***,more randomised controlled trials with more rigorous design and longer duration of treatment and follow-up need to be conducted to compare WM alone versus WM and CM combined.

关键词： acupuncture routine alone

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New perspective on the treatment of rheumatic arthritis based on“strengthening body resistance(FúZhèng)”in the theory of co-inhibitory receptor-regulated T-cell immunity

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Acupuncture and Herbal Medicine 2024年第3期4卷 290-294页

作者： Yifei Xu linda zhong Qianqian Liang Hao Xu Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai University of Traditional Chinese MedicineShanghaiChina Biomedical Sciences and Chinese Medicine School of Biological ScienceNanyang Technological UniversitySingaporeSingapore Spine Institute Shanghai University of Traditional Chinese MedicineShanghaiChina Key Laboratory of Theory and Therapy of Muscles and Bones Ministry of Education(Shanghai University of Traditional Chinese Medicine)ShanghaiChina

Co-inhibitory receptors serve as crucial regulators of T-cell function,playing a pivotal role in modulating the delicate balance between immune tolerance and *** identified in autoimmune disease models,co-inhibitory receptors,including CTLA-4,PD-1,TIM-3,and TIGIT,were found to be integral to immune *** blockade or absence in these models resulted in the induction or exacerbation of autoimmune ***,scholars have observed that co-inhibitory receptors on lymphocytes hold the potential to influence the prognosis in the context of chronic ***,the blocking of co-suppressor receptors has emerged as a novel therapeutic approach for inhibiting refractory inflammatory diseases,particularly rheumatoid *** the standpoint of traditional Chinese medicine(TCM),the treatment of rheumatoid arthritis based on the“strengthening body resistance(FúZhèng)”theory can be construed as the regulation of co-suppressor receptors to modulate the body’s immune function in combating chronic *** article provides a succinct overview of the role of co-suppressor receptors in anti-inflammatory processes and explores the research prospects of co-suppressor receptor intervention in the treatment of rheumatoid *** exploration integrates the“strengthening body resistance(FúZhèng)”theory with relevant Chinese medicine formulations.

关键词： Combination of Chinese and Western Medicine Co-inhibitory receptors Rheumatic arthritis T-cell exhaustion

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Raising New Hope for Controlling Seizures in Focal Cortical Dysplasia with Gene Therapy

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Neuroscience Bulletin 2024年第7期40卷 1028-1030页

作者： Yuanzhi Yang Yang Zheng zhong Chen Cenglin Xu Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical SciencesXinhua Hospital of Zhejiang ProvinceThe Second Affiliated Hospital of Zhejiang Chinese Medical UniversityZhejiang Chinese Medical UniversityHangzhou310053China

Focal cortical dysplasia(FCD)is characterized by abnormal cortical development and pharmacoresistant epilepsy,often accompanied by cognitive and behavioral malfunctions[1].According to the International League against Epilepsy(ILAE)classification proposed by Najm,Imad et *** 2022,FCD can be further divided into isolated forms(FCD type Ⅰ and Ⅱ)and another type associated with a principal lesion(FCD type Ⅲ)[2].

关键词： epilepsy al. Therapy

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Recent progress and prospects of electrolytes for electrocatalytic nitrogen reduction toward ammonia

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Chinese Chemical Letters 2024年第4期35卷 3-16页

作者： Sajid Mahmood Haiyan Wang Fang Chen Yijun zhong Yong Hu Key Laboratory of the Ministry of Education for Advanced Catalysis Materials Department of ChemistryZhejiang Normal UniversityJinhua 321004China The Center for Applied Mathematics and Bioinformatics(CAMB) Gulf University for Science and TechnologyMishref 32093Kuwait Hangzhou Institute of Advanced Studies Zhejiang Normal UniversityHangzhou 311231China

Electrochemical nitrogen reduction reaction(ENRR) provides a promising strategy to achieve sustainable synthesis of ammonia. However, despite great efforts devoted to this research field, the problems such as low energy efficiency and weak selectivity still impede its practical implementation. Most of the research to date has been concentrated on creating sophisticated electrocatalysts, and adequate knowledge of electrolytes is still lacking. Herein, the recent progress in electrolytes for ENRR, including alkaline, neutral,acidic, water-in-salt, organic, ionic liquid, and mixed water-organic electrolytes, is thoroughly reviewed to obtain an in-depth understanding of their effects on electrocatalytic performance. Recently developed representative electrocatalysts in various types of electrolytes are also introduced, and future research priorities of different electrolytes are proposed to develop new and efficient ENRR systems.

关键词： Electrocatalytic nitrogen reduction Ammonia Electrolytes Production rate Faradaic efficiency

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From Acupoints to Mylohyoid: Revealing the Neural Circuitry Basis of Electroacupuncture for Dysphagia

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Neuroscience Bulletin 2024年第1期40卷 139-142页

作者： Xiaoli Da Xuhong Jiang Lihong Li Cenglin Xu zhong Chen Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical ScienceZhejiang Chinese Medical UniversityHangzhou 310053China Department of Neurology the First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310003China Department of Acupuncture the Second Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310000China

Acupuncturea representative and historical treatment in traditional Chinese medicine(TCM),has been used to cure diseases for Chinese people in the past *** the late 1990s,acupuncture has been further accepted *** World Health Organization(WHO)proposed Clinical Research Specification for acupuncture in 1995 and the US Food and Drug Administration(FDA)approved acupuncture as a complementary and alternative therapy for various kinds of diseases in 1996,with clinical advantages such as convenience and effectiveness[1].Cumulative evidence has proved that acupuncture could produce different degrees of efficacy for treating various kinds of diseases(such as neuropathic pain,migraine,Parkinson's disease et al.)and alleviate symptoms[2-4].However,unlike its evidence-based efficacies.

关键词： medicine(TCM) acupuncture Acupuncture

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