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Plasma chitinase 3-like 1 is persistently elevated during first month after minimally invasive colorectal cancer resection

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World Journal of Gastrointestinal Oncology 2016年第8期8卷 607-614页

作者： HMC Shantha Kumara David Gaita Hiromichi Miyagaki Xiaohong Yan Sonali AC Hearth linda njoh Vesna Cekic Richard L Whelan Division of Colon and Rectal Surgery Department of Surgery Mount Sinai West Hospital Department of Gastroenterological Surgery Osaka University

AIM: To assess blood chitinase 3-like 1(CHi3L1) levels for 2 mo after minimally invasive colorectal resection(MICR) for colorectal cancer(CRC). METHODS: CRC patients in an Institutional Review Board approved data/plasma bank who underwent elective MICR for whom preoperative(PreO p), early postoperative(PostO p), and 1 or more late PostO p samples [postoperative day(POD) 7-27] available were included. Plasma CHi3L1 levels(ng/m L) were determined in duplicate by enzyme linked immunosorbent assay. RESULTS: PreOp and PostOp plasma sample were available for 80 MICR cancer patients for the study. The median PreOp CHi3L1 level was 56.8 CI: 41.9-78.6 ng/mL(n = 80). Significantly elevated(P < 0.001) median plasma levels(ng/mL) over PreOp levels were detected on POD1(667.7 CI: 495.7, 771.7; n = 79), POD 3(132.6 CI: 95.5, 173.7; n = 76), POD7-13(96.4 CI: 67.7, 136.9; n = 62), POD14-20(101.4 CI: 80.7, 287.4; n = 22), and POD 21-27(98.1 CI: 66.8, 137.4; n = 20, P = 0.001). No significant difference in plasma levels were noted on POD27-41. CONCLUSION: Plasma CHi3L1 levels were significantly elevated for one month after MICR. Persistently elevated plasma CHi3L1 may support the growth of residual tumor and metastasis.

关键词： Colorectal cancer Recurrence Minimally inasive colorectal resection Chitinase 3-like 1 Metastasis

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Plasma monocyte chemotactic protein-1 remains elevated after minimally invasive colorectal cancer resection

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World Journal of Gastrointestinal Oncology 2014年第10期6卷 413-419页

作者： HMC Shantha Kumara Elizabeth A Myers Sonali AC Herath Joon Ho Jang linda njoh Xiaohong Yan Daniel Kirchoff Vesna Cekic Martin Luchtefeld Richard L Whelan Division of Colon and Rectal Surgery Department of Surgery Mount Sinai-Roosevelt Hospital Center New York NY 10019 United States Division of Colon and Rectal Surgery Fer-guson Clinic Grand Rapids MI 49546 United States Icahn School of Medicine at-Mount Sinai New York NY 10029 United States Surgical Oncology Department of Surgery College of Physicians and Surgeons Columbia University New York NY 10032 United States

AIM: To investigate plasma Monocyte Chemotactic Protein-1 levels preoperatively in colorectal cancer(CRC) and benign patients and postoperatively after CRC ***: A plasma bank was screened for minimally invasive colorectal cancer resection(MICR) for CRC and benign disease(BEN) patients for whom preoperative, early postoperative, and 1 or more late postoperative samples(postoperative day 7-27) were available. Monocyte chemotactic protein-1(MCP-1) levels(pg/mL) were determined via enzyme linked immuno-absorbent assay. RESULTS: One hundred and two CRC and 86 BEN patients were studied. The CRC patient's median preoperative MCP-1 level(283.1, CI: 256.0, 294.3) was higher than the BEN group level(227.5, CI: 200.2, 245.2; P = 0.0004). Vs CRC preoperative levels, elevated MCP-1 plasma levels were found on postoperative day 1(446.3, CI: 418.0, 520.1), postoperative day 3(342.7, CI: 320.4, 377.4), postoperative day 7-13(326.5, CI: 299.4, 354.1), postoperative day 14-20(361.6, CI: 287.8, 407.9), and postoperative day 21-27(318.1, CI: 287.2, 371.6; P < 0.001 for all). CONCLUSION: Preoperative MCP-1 levels were higher in CRC patients(vs BEN). After MICR for CRC, MCP-1 levels were elevated for 1 mo and may promote angiogenesis, cancer recurrence and metastasis.

关键词： Colorectal cancer Monocyte chemotactic protein-1 Minimally invasive colorectal resection angio-genesis

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