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CT偶发肾脏肿块的管理--美国放射学院(ACR)偶发病变委员会白皮书

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放射学实践 2018年第2期33卷 141-150页

作者： Brian R.Herts Stuart G.Silverman Nicole M.Hindman Robert G.Uzzo Robert P.Hartman Gary M.Israel Deborah A.Baumgarten lincoln l.berland Pari V.Pandharipande 居胜红龙莉玲沈文孙应实姚晋不详东南大学附属中大医院放射科南京广西医科大学第一附属医院放射科南宁天津市第一中心医院放射科天津北京大学肿瘤医院放射科北京四川大学华西医院放射科成都

美国放射学院(American College of Radiology,ACR)偶发病变委员会(Incidental Findings Committee,IFC)发布了针对CT偶发性肾脏肿块的管理建议。这些建议更新了美国放射学院杂志(JACR)2010年发布的关于肾上腺、肾脏、肝脏及胰腺偶发病... 详细信息

美国放射学院(American College of Radiology,ACR)偶发病变委员会(Incidental Findings Committee,IFC)发布了针对CT偶发性肾脏肿块的管理建议。这些建议更新了美国放射学院杂志(JACR)2010年发布的关于肾上腺、肾脏、肝脏及胰腺偶发病变管理白皮书的肾脏部分内容。肾脏亚组委员会(包括6位腹部放射学家和1位泌尿科医师)制订这份管理流程。这些建议结合已发表的文献和专家意见,通过非正式的反复协商达成共识。文中每张流程图描述需要进一步行影像学检查、随访或转诊治疗的肾脏肿块的影像特征。我们的目的是对偶发性肾脏肿块的管理提供指导建议,从而改善医疗质量。

关键词：肾脏肾脏小肿块囊肿 Bosniak分级偶发病变

CT肝脏偶发病灶管理--美国放射学院(ACR)偶发病变委员会白皮书

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放射学实践 2018年第2期33卷 115-122页

作者： Richard M.Gore Perry J.Pickhardt Koenraad J.Mortele Elliot K.Fishman Jeanne M.Horowitz Claus J.Fimmel Mark S.Talamonti lincoln l.berland Pari V.Pandharipande 宋彬严福华杨正汉叶惠义姜慧杰不详四川大学华西医院放射科成都上海交通大学医学院附属瑞金医院放射科上海首都医科大学附属北京友谊医院放射科北京中国人民解放军总医院放射科北京哈尔滨医科大学附属第二医院放射科哈尔滨

美国放射学院(American College of Radiology,ACR)偶发病变委员会(Incidental Findings Committee,IFC)发布了关于肝脏CT偶发病灶的管理建议。这些建议是对ACR 2010年胰腺、肾上腺、肾脏及肝脏偶发病变管理白皮书中肝脏部分的更新。该... 详细信息

美国放射学院(American College of Radiology,ACR)偶发病变委员会(Incidental Findings Committee,IFC)发布了关于肝脏CT偶发病灶的管理建议。这些建议是对ACR 2010年胰腺、肾上腺、肾脏及肝脏偶发病变管理白皮书中肝脏部分的更新。该方案由肝脏亚组委员会(包括5位腹部影像学专家,1位肝病学专家和1位肝胆外科医生)制定。这些建议结合已发表的文献及专家意见,并最终达成专家共识。该方案主要基于患者特征及影像学特征对肝脏病灶进行分类,评估终点为某种良性诊断或具体的随访建议。该方案适用于大多数病理或临床情况,但并非所有情况均适用。该方案旨在通过提供肝脏偶发病灶管理意见以提升医疗质量。

关键词：偶发病变肝囊肿血管瘤局灶性结节增生肝转移肝细胞癌

胰腺偶发囊肿的管理--美国放射学院(ACR)偶发病变委员会白皮书

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放射学实践 2018年第2期33卷 123-133页

作者： Alec J.Megibow Mark E.Baker Desiree E.Morgan Ihab R.Kamel Dushyant V.Sahani Elliot Newman William R.Brugge lincoln l.berland Pari V.Pandharipande 赵心明曾蒙苏薛华丹刘再毅石喻不详中国医学科学院肿瘤医院影像诊断科北京复旦大学附属中山医院放射科上海北京协和医院放射科北京广东省人民医院放射科广州中国医科大学附属盛京医院放射科沈阳

美国放射学院(American College of Radiology,ACR)偶发病变委员会(Incidental Findings Committee,IFC)发布了CT或MR偶发胰腺囊肿的管理建议。该建议是对美国放射学院杂志(JACR)2010年发布的肾上腺、肾脏、肝脏以及胰腺偶发病变管理白... 详细信息

美国放射学院(American College of Radiology,ACR)偶发病变委员会(Incidental Findings Committee,IFC)发布了CT或MR偶发胰腺囊肿的管理建议。该建议是对美国放射学院杂志(JACR)2010年发布的肾上腺、肾脏、肝脏以及胰腺偶发病变管理白皮书中胰腺部分的更新。该管理方案由多位腹部影像医师、1位胃肠道学医师以及1位胰腺外科医师所组成的胰腺亚组委员会制定。该方案参考已发表的文献和专家意见,经反复协商,最终达成共识。该方案的分支成功地根据患者的临床特点及影像特征将胰腺囊肿进行分类,评估终点为良性和/或进展缓慢病变的诊断(足以结束随访)或具体的管理建议。该方案适用于大多数但非全部的病理及临床情况。该方案旨在通过提供胰腺偶发囊肿的管理指导,来提高患者的管理质量。

关键词：胰腺囊肿导管内乳头状黏液瘤偶发病变

Metabolic collaboration between cells in the tumor microenvironment has a negligible effect on tumor growth

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The Innovation 2024年第2期5卷 107-114页

作者： Johan Gustafsson Fariba Roshanzamir Anders Hagnestål Sagar M.Patel Oseeyi I.Daudu Donald F.Becker Jonathan l.Robinson Jens Nielsen Department of life Sciences Chalmers University of TechnologySE-41296 GothenburgSweden Hagnesia AB SE-43854 HindåsSweden Department of Biochemistry and Redox Biology Center University of Nebraska-LincolnLincolnNE 68588USA BioInnovation Institute DK2200 CopenhagenDenmark

The tumor microenvironment is composed of a complex mixture of different cell types interacting under conditions of nutrient deprivation,but the metabolism therein is not fully understood due to difficulties in measuring metabolic fluxes and exchange of metabolites between different cell types in ***-scale metabolic modeling enables estimation of such exchange fluxes as well as an opportunity to gain insight into the metabolic behavior of individual cell ***,we estimated the availability of nutrients and oxygen within the tumor microenvironment using concentration measurements from blood together with a metabolite diffusion *** addition,we developed an approach to efficiently apply enzyme usage constraints in a comprehensive metabolic model of human *** combined modeling reproduced severe hypoxic conditions and the Warburg effect,and we found that limitations in enzymatic capacity contribute to cancer cells’preferential use of glutamine as a substrate to the citric acid ***,we investigated the common hypothesis that some stromal cells are exploited by cancer cells to produce metabolites useful for the cancer *** identified over 200 potential metabolites that could support collaboration between cancer cells and cancer-associated fibroblasts,but when limiting to metabolites previously identified to participate in such collaboration,no growth advantage was *** work highlights the importance of enzymatic capacity limitations for cell behaviors and exemplifies the utility of enzyme-constrained models for accurate prediction of metabolism in cells and tumor microenvironments.

关键词： metabolism effect limitations

Analytical and numerical modeling of optical second harmonic generation in anisotropic crystals using #SHAARP package

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npj Computational Materials 2022年第1期8卷 2343-2354页

作者： Rui Zu Bo Wang Jingyang He Jian-Jun Wang lincoln Weber long-Qing Chen Venkatraman Gopalan Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA16802USA Materials Science Division Lawrence Livermore National LaboratoryLivermoreUSA Department of Engineering Science and Mechanics The Pennsylvania State UniversityUniversity ParkPA16802USA Department of Mathematics The Pennsylvania State UniversityUniversity ParkPA16802USA Department of Physics Pennsylvania State UniversityUniversity ParkPA16802USA

Electric-dipole optical second harmonic generation(SHG)is a second-order nonlinear process that is widely used as a sensitive probe to detect broken inversion symmetry and local polar *** modeling of the SHG polarimetry of a nonlinear optical material is essential to extract its point group symmetry and the absolute nonlinear *** literature on SHG analysis involves numerous approximations and a wide range of(in)*** have developed an open-source package called the Second Harmonic Analysis of Anisotropic Rotational Polarimetry(♯***)which derives analytical and numerical solutions of reflection SHG polarimetry from a single interface(.si)for bulk homogeneous crystals with arbitrary symmetry group,arbitrary crystal orientation,complex and anisotropic linear dielectric tensor with frequency dispersion,a general SHG tensor and arbitrary light polarization.♯*** enables accurate modeling of polarimetry measurements in reflection geometry from highly absorbing crystals or wedge-shaped transparent *** package is extendable to multiple interfaces.

关键词： arbitrary symmetry harmonic

Drosophila neuronal injury model allows for temporal dissection of neurodegenerative events

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Neural Regeneration Research 2016年第3期11卷 416-417页

作者： Barron l.lincolnⅡ lani C.Keller Department of Biological Sciences Quinnipiac University

Neurodegenerative diseases are extremely prevalent in today’s society and,according to the World Health Organization,are currently listed as the third leading cause of death,following cancer and heart disease（Gammon,2014）.The seminal characteristic of neuro-muscular degeneration is the complete disruption of the circuit between the brain,peripheral neuron,and muscle,

关键词： neuronal degeneration muscular dissection extremely Drosophila disruption currently listed today

A novel diagnostic gene region for distinguishing between two pest fruit flies:Bactrocera tryoni(Froggatt)and Bactrocera neohumeralis(Hardy)(Diptera:Tephritidae)

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Insect Science 2024年第4期31卷 1285-1295页

作者： Melissa l.Starkie Elizabeth V.Fowler Alexander M.Piper Xiaocheng Zhu Pauline Wyatt David Gopurenko Matt N.Krosch Francesca Strutt Karen F.Armstrong Hamish Patrick Mark K.Schutze Mark J.Blacket Department of Agriculture and Fisheries BiosecurityBrisbaneQueenslandAustralia Agriculture Victoria AgriBioBundooraVictoriaAustralia Department of Primary Industries Wagga Wagga Agricultural InstituteWagga WaggaNew South WalesAustralia Forensic Services Group Queensland Police ServiceBrisbaneQueenslandAustralia Department of Pest-management and Conservation Lincoln UniversityLincolnNew Zealand Better Border Biosecurity(B3 B3nz.org.nz)LincolnNew Zealand

Bactrocera tryoni and Bactrocera neohumeralis are morphologically similar sibling pest fruit fly species that possess different biological attributes,geographic distributions,and host *** need to differentiate between the two species is critical for accurate pest status assessment,management,biosecurity,and maintenance of reference *** morphologically similar,adults may be separated based on subtle characters;however,some characters exhibit intraspecific variability,creating overlap between the two ***,there is currently no single molecular marker or rapid diagnostic assay that can reliably distinguish between *** and ***;therefore,ambiguous samples remain *** we report the first molecular marker that can consistently distinguish between *** and *** diagnostic region consists of two adjacent single nucleotide polymorphisms(SNPs)within the pangolin(pan)gene *** confirmed the genotypes of each species are consistent across their distributional range,then developed a tetra-primer amplification refractory mutation system(ARMS)PCR assay for rapid diagnosis of the *** assay utilizes four primers in multiplex,with two outer universal primers,and two internal primers:one designed to target two adjacent SNPs(AA)present in *** and the other targeting adjacent SNPs present in ***(GG).The assay accurately discriminates between the two species,but their SNP genotypes are shared with other nontarget tephritid fruit fly ***,this assay is most suited to adult diagnostics where species confirmation is necessary in determining ambiguous surveillance trap catches;maintaining pure colony lines;and in Sterile Insect Technique management responses.

关键词： ARMS-PCR colony molecular diagnostics pangolin tetra-primer

The formation and catalytic activity of silver nanoparticles in aqueous polyacrylate solutions

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Frontiers of Chemical Science and Engineering 2016年第3期10卷 432-439页

作者： Jie Wang Jianjia liu Xuhong Guo liang Yan Stephen F. lincoln State Key laboratory of Chemical Engineering East China University of Science and Technology Shanghai 200237 China Department of Chemistry University of Adelaide Adelaide SA 5005 Australia

Silver nanoparticles （AgNPs） have been synthesized in the presence of polyacrylate through the reduction of silver nitrate by sodium borohydride in aqueous solution. The AgNO3 and polyacrylate carbox- ylate group concentrations were kept constant at 2.0× 10^-4 and 1.0 × 10^-2 mol·l^-1, respectively, while the ratio of [NaBH4]/[AgNO3] was varied from 1 to 100. The ultra- violet-visible plasmon resonance spectra of these solutions were found to vary with time prior to stabilizing after 27 d, consistent with changes of AgNP size and distribution within the polyacrylate ensemble occurring. These obser- vations, together with transmission electron microscopic results, show this rearrangement to be greatest among the samples at the lower ratios of [NaBH4]/[AgNO3] used in the preparation, whereas those at the higher ratios showed a more even distribution of smaller AgNP. All ten of the AgNP samples, upon a one thousand-fold dilution, catalyze the reduction of 4-nitrophenol to 4-aminophenol in the temperature range 283.2-303.2 K with a substantial induction time being observed at the lower temperatures.

关键词： silver nanoparticles polyacrylates catalysis,mechanism sodium borohydride

Prehospital transdermal glyceryl trinitrate for ultra- acute ischaemic stroke: data from the RIGHT- 2 randomised sham- controlled ambulance trial

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Stroke & Vascular Neurology 2024年第1期9卷 38-49,I0035-I0046页

作者： Jason Philip Appleton lisa J Woodhouse Craig S Anderson Sandeep Ankolekar lesley Cala Mark Dixon Timothy J England Kailash Krishnan Grant Mair Keith W Muir John Potter Christopher I Price Marc Randall Thompson G Robinson Christine Roffe Else C Sandset Jeffrey l Saver Angela Shone Aloysius Niroshan Siriwardena Joanna M Wardlaw Nikola Sprigg Philip M Bath Stroke University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Applied HealthResearch University of Birmingham College of Medical and Dental SciencesBirminghamUK Stroke Trials Unit Mental Health and Clinical NeurosciencesUniversity of NottinghamNottinghamUK Faculty of Medicine The George Institute for Global HealthSydneyNew South WalesAustralia The George Institute China at Peking University Health Science Center BeijingChina Neurology Royal Prince Alfred HospitalSydney Health PartnersSydneyNew South WalesAustralia Department of Neurology King's College Hospital NHS Foundation TrustLondonUK Faculty of Health and Medical Sciences University of Western AustraliaCrawleyWestern AustraliaAustralia East Midlands Ambulance Service NHS Trust NottinghamUK Stroke Queen's Medical CentreNottingham University Hospitals NHS TrustNottinghamUK Centre for Clinical Brain Sciences Dementia Research InstituteUniveristy of EdinburghEdinburghUK Institute of Neurology and Psychology University of GlasgowGlasgowUK Bob Champion Research and Education Building University of East AngliaNorwichUK Institute of Neuroscience Newcastle UniversityNewcastle upon TyneUK Department of Neurology Leeds Teaching Hospitals NHS TrustLeedsUK Department of Cardiovascular Sciences and NIHR leicester Biomedical Research Centre University of LeicesterLeicesterUK Stroke Research in Stoke Institute for Science and Technology in MedicineKeele UniversityStoke-on TrentUK Department of Neurology Oslo University HospitalOsloNorway Research and Development Norwegian Air Ambulance FoundationOsloNorway Department of Neurology and Comprehensive Stroke Center David Geffen School of MedicineUCLALos AngelesCaliforniaUSA Research and Graduate Services University of NottinghamNottinghamUK Community and Health Research Unit University of LincolnLincolnUK

Background The effect of transdermal glyceryl trinitrate(GTN,a nitrovasodilator)on clinical outcome when administered before hospital admission in suspected stroke patients is ***,we assess the safety and efficacy of GTN in the prespecified subgroup of patients who had an ischaemic stroke within the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2(RIGHT-2).Methods RIGHT-2 was an ambulance-based multicentre sham-controlled blinded-endpoint study with patients randomised within 4hours of *** primary outcome was a shift in scores on the modified Rankin scale(mRS)at day *** outcomes included death;a global analysis(Wei-lachin test)containing Barthel Index,EuroQol-5D,mRS,telephone interview for cognitive status-modified and Zung depression scale;and neuroimaging-determined‘brain frailty’*** were reported as n(%),mean(SD),median[IQR],adjusted common OR(acOR),mean difference or Mann-Whitney difference(MWD)with 95%*** 597 of 1149(52%)patients had a final diagnosis of ischaemic stroke;age 75(12)years,premorbid mRS>2107(18%),Glasgow Coma Scale 14(2)and time from onset to randomisation 67[45,108]***‘brain frailty’was common:median score 2[2,3](range 0–3).At day 90,GTN did not influence the primary outcome(acOR for increased disability 1.15,95%CI 0.85 to 1.54),death or global analysis(MWD 0.00,95%CI-0.10 to 0.09).In subgroup analyses,there were non-significant interactions suggesting GTN may be associated with more death and dependency in participants randomised within 1hour of symptom onset and in those with more severe *** In patients who had an ischaemic stroke,ultra-acute administration of transdermal GTN in the ambulance did not improve clinical outcomes in a population with more clinical and radiological frailty than seen in previous in-hospital *** IS AlREADY KNOWN ON THIS TOPIC⇒Transdermal glyceryl trinitrate(GTN)was associat-ed with less death and dependency in those w

关键词： Glasgow nitrate random