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Bacterial cellulose/glycolic acid/glycerol composite membrane as a system to deliver glycolic acid for anti-aging treatment

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Journal of Bioresources and Bioproducts 2021年第2期6卷 129-141页

作者： Bricard Mbituyimana Lin Mao Sanming Hu Muhammad Wajid Ullah Kun Chen lina fu Weiwei Zhao Zhijun Shi Guang Yang Department of Biomedical Engineering College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China Department of Head and Neck Surgery&Communication Sciences School of MedicineDuke UniversityDurham 27710United States School of Mechanical and Electronic Engineering Wuhan Universit of TechnologyWuhan 430070China

Glycolic acid(GA),as an anti-aging skincare ingredient,plays a pivotal role in anti-aging ***,its benefits could be overshadowed due to its side effects including skin burning and irritation when *** cellulose(BC)is a highly pure form of cellulose,biosynthesized in the form of a swollen membrane by several kinds of bacteria that was demonstrated to modulate the release of model drugs owing to its porous and 3D fibrous network structure,and glycerol(GL),as a plasticizer,could enhance the controlled drug ***,we report a topical controlled drug delivery system based on BC membrane,GA and GL for controlling sustainable release of GA to reduce its side effects on the skin,while maintaining its prolonged and maximum therapeutic *** results showed that the incorporation of GL increased the malleability and flexibility of BC/GA/GL membrane,as compared with BC/GA *** addition,the GL enhanced the control of the GA delivery,as evidenced by a higher swelling capacity and thereby a slower release of the GA from BC/GA/GL *** importantly,in vitro study indicated that both BC/GA and BC/GA/GL membranes could effectively stimulate endogenous collagen synthesis in NIH3T3 cells owing to the release of GA,and that BC/GA/GL membrane is more conducive to a long-term cell adhesion,spreading,and proliferation of NIH3T3 and HaCaT cells due to its lower and sustainable release of GA than BC/GA *** study suggests the BC/GL/GA composite membrane holds great promise as an appealing platform to control the release of GA to greatly promote renewal of skin cells for effective anti-aging treatment.

关键词： Bacterial cellulose Glycolic acid Glycerol Biocompatibility Controlled drug release

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Study on Land Use Change in Urumqi Based on Remote Sensing Image

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Meteorological and Environmental Research 2013年第11期4卷 47-51页

作者： lina fu Liyu Guo College of Geomatics Xi'an University of Science and Technology

[ Objective] The research aimed to study land use change in Urumqi based on remote sensing image. [ Method] By using TM remote sensing images of Urumqi in 1989 and 2007, the images at two periods were corrected, contrasted, analyzed and calculated, and geographical fac- tor was extracted. Finally, we got land use change image during 1989 -2007. [ Result] Due to anthropogenic and natural factors, farmland and ur- ban land in Urumqi occupied a lot of grass and woodland, the areas of canals and lakes were relatively unchanged, and snow coverage area re- duced. [ Conclusion] When improving the economic efficiency of land use, the reduction of forest and grassland, the increases of saline and desert could not be ignored.

关键词： Land use Remote sensing image Markov model Driving force Urumqi China

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EFFECT OF CROSS DIFfuSION IN A COMPETITION MODEL WITH STAGE STRUCTURE

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International Journal of Biomathematics 2012年第6期5卷 77-94页

作者： lina ZHANG SHENGMAO fu PING HU Department of MathematicsNorthwest Normal UniversityLanzhou 730070 P. R. China

The purpose of this paper is to study the effect of cross diffusion in a competition model with stage structure, under homogeneous Neumann boundary condition. It will be shown that cross diffusion cannot only destabilize a uniform positive equilibrium, it can also help diffusion to induce instability of the uniform positive equilibrium. Moreover, stationary patterns can arise from the effect of cross diffusion.

关键词： Competition model stage structure cross diffusion instability pattern.

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Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cells

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Protein & Cell 2019年第4期10卷 249-271页

作者： Chen Ling Zunpeng Liu Moshi Song Weiqi Zhang Si Wang Xiaoqian Liu Shuai Ma Shuhui Sun lina fu Qun Chu Juan Carlos Izpisua Belmonte Zhaoxia Wang Jing Qu Yun Yuan Guang-Hui Liu Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China Beijing Institute for Brain Disorders Capital Medical UniversityBeijing 100069China Department of Neurology Peking University First HospitalBeijing 100034China National Laboratory of Biomacromolecules CAS Center for Excellenee in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Gene Expression Laboratory Salk Institute for Biological Studies10010 North Torrey Pines RoadLa JollaCA 92037USA Institute for Stem cell and Regeneration CASBeijing 100101China Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Aging and Regenerative MedicineJinan UniversityGuangzhou 510632China

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy(CADASIL)is a rare hereditary cerebrovascular disease caused by a NOTCH3 ***,the underlying cellular and molecular mechanisms remain ***,we generated non-integrative induced pluripotent stem cells(iPSCs)from fibroblasts of a CADASIL patient harboring a heterozygous NOTCH3 mutation(c.3226C>T,p.R1076C).Vascular smooth muscle cells(VSMCs)differentiated from CADASIL-specific iPSCs showed gene expression changes associated with disease phenotypes,including activation of the NOTCH and NF-kB signaling pathway,cytoskeleton disorganization,and excessive cell *** comparison,these abnormalities were not observed in vascular endothelial cells(VECs)derived from the patients ***,the abnormal upregulation of NF-kB target genes in CADASIL VSMCs was diminished by a NOTCH pathway inhibitor,providing a potential therapeutic strategy for ***,using this iPSCbased disease model,our study identified clues for studying the pathogenic mechanisms of CADASIL and developing treatment strategies for this disease.

关键词： CADASIL iPSC NOTCH NF-kB vascular smooth muscle

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CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs

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Protein & Cell 2017年第5期8卷 365-378页

作者： Lixia Wang Fei Yi lina fu Jiping Yang Si Wang Zhaoxia Wang Keiichiro Suzuki Liang Sun Xiuling Xu Yang Yu Jie Qiao Juan Carlos Izpisua Belmonte Ze Yang Yun Yuan Jing Qu Guang-Hui Liu National Laboratory of Biomacromolecules CAS Center for Excellence in Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China Department of Molecular and Cellular Physiology Stanford University School of Medicine Stanford CA 94305 USA Department of Neurology Peking University First Hospital Beijing 100034 China Gene Expression Laboratory Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla CA 92037 USA Universidad Catolica San Antonio de Murcia (UCAM) Campus de los Jeronimos N 135 Guadalupe 30107 Murcia Spain Department of Gynecology and Obstetrics Peking University Third Hospital Beijing 100191 China Beijing Hospital of the Ministry of Health Beijing 100730 China Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Aging and Regenerative Medicine Jinan University Guangzhou 510632 China Beijing Institute for Brain Disorders Capital Medical University Beijing 100069 China

Amyotrophic lateral sclerosis （ALS） is a complex neu- rodegenerative disease with cellular and molecular mechanisms yet to be fully described. Mutations in a number of genes including SOD1 and fuS are associated with familial ALS. Here we report the generation of induced pluripotent stem cells （iPSCs） from fibroblasts of familial ALS patients bearing SOD1＋1A27~c and fuS＋/GISe6A mutations, respectively. We further gener- ated gene corrected ALS iPSCs using CRISPR/Cas9 system. Genome-wide RNA sequencing （RNA-seq） analysis of motor neurons derived from SOD1＋~A272c and corrected iPSCs revealed 899 aberrant transcripts. Our work may shed light on discovery of early biomarkers and pathways dysregulated in ALS, as well as provide a basis for novel therapeutic strategies to treat ALS.

关键词： ALS CRISPR/Cas9 gene correction,iPSC disease modeling

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地方特色植物资源的保护与应用

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分子植物育种 2023年第23期21卷 7925-7930页

作者：付丽娜郑州工业应用技术学院郑州450000

地方特色植物资源是地球生物多样性的重要组成部分,具有丰富的经济、生态和文化价值。本研究旨在全面探讨地方特色植物资源的保护现状、挑战以及应用潜力。首先,通过调查分析了地方特色植物的分布、种类和特点;然后,评估了现有的保护措... 详细信息

地方特色植物资源是地球生物多样性的重要组成部分,具有丰富的经济、生态和文化价值。本研究旨在全面探讨地方特色植物资源的保护现状、挑战以及应用潜力。首先,通过调查分析了地方特色植物的分布、种类和特点;然后,评估了现有的保护措施的有效性,并识别了主要的威胁和挑战;最后,探讨了地方特色植物在食品、医药、园艺和工业等领域的应用前景,并提出了针对政府、企业和社区的具体建议。本研究为地方特色植物资源的可持续利用和保护提供了科学依据,有助于促进经济发展与生态保护的和谐统一。

关键词：地方特色植物生物多样性资源保护可持续应用生态价值

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A widely adaptable approach to generate integration-free iPSCs from non-invasively acquired human somatic cells

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Protein & Cell 2015年第5期6卷 386-389页

作者： Zhichao Ding lina Sui Ruotong Ren Yanjun Liu Xiuling Xu lina fu Ruijun Bai Tingting Yuan Ying Hao Weiqi Zhang Huize Pan Wensu Liu Han Yu Concepcion Rodriguez Esteban Xiaobing Yu Ze Yang Jian Li Xiaomin Wang Juan Carlos Izpisua Belmonte Guang-Hui Liu Fei Yi Jing Qu National Laboratory of Biomacromolecules Institute of Biophysics University of the Chinese Academy of Sciences Chinese Acad- emy of Sciences Beijing 100101 China Department of Endocrinology 306th Hospital of PLA Beijing100101 China Science and Development Xtem Foshan 528000 China State Key Laboratory of Reproductive Biology Institute of ZoologyChinese Academy of Sciences Beijing 100101 China Beijing Hospital of the Ministry of Health Beijing 100073 China Beijing Institute for Brain Disorders Beijing 100069 China Gene Expression Laboratory Salk Institute for Biological Studies10010 North Torrey Pines Road La Jolla CA 92037 USA Center for Molecular and Translational Medicine Beijing 100101China Department of Molecular and Cellular Physiology StanfordUniversity School of Medicine Stanford CA 94305 USA

Dear Editor Human pluripotent stem cells including human embryonic stem cells （ESCs） and induced pluripotent stem cells （iPSCs） are cells displaying abilities of unlimited self-renewal and differentiation into any somatic cell type. These unique properties make them increasingly attractive for novel applications in disease modeling, drug discovery, and cell therapy （Buganim et al., 2014; Liu et al., 2011; Liu et al., 2012; Sanchez Alvarado and Yamanaka, 2014）. Moreover, iPSCs hold great potential for personalized cell therapy as they avoid some of the ethical concerns as well as the immunological rejection issues ascribed to ESCs.

关键词： adaptable approach generate integration-free iPSCs

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Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs

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Protein & Cell 2016年第3期7卷 210-221页

作者： lina fu Xiuling Xu Ruotong Ren Jun Wu Weiqi Zhang Jiping Yang Xiaoqing Ren Si Wang Yang Zhao Liang Sun Yang Yu Zhaoxia Wang Ze Yang Yun Yuan Jie Qiao Juan Carlos Izpisua Belmonte Jing Qu Guang-Hui Liu National Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China FSU-CAS Innovation Institute Foshan University Foshan 528000 China State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China Gene Expression Laboratory Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla CA 92037 USA Universidad Cato1ica San Antonio de Murcia (UCAIVI) Campus de los Jer6nimos N° 135 Guadalupe 30107 Murcia Spain Beijing Hospital of the Ministry of Health Beijing 100730 China Department of Gynecology and Obstetrics Peking University Third Hospital Beijing 100191 China Department of Neurology Peking University First Hospital Beijing 100034 China Beijing Institute for Brain Disorders Capital Medical University Beijing 100069 China University of Chinese Academy of Sciences Beijing 100049 China

Xeroderma pigmentosum （XP） is a group of genetic disorders caused by mutations of XP-associated genes, resulting in impairment of DNA repair. XP patients frequently exhibit neurological degeneration, but the underlying mechanism is unknown, in part due to lack of proper disease models. Here, we generated patientspecific induced pluripotent stem cells （iPSCs） harboring mutations in five different XP genes including XPA, XPB, XPC, XPG, and XPV. These iPSCs were further differentiated to neural cells, and their susceptibility to DNA damage stress was investigated. Mutation of XPA in either neural stem cells （NSCs） or neurons resulted in severe DNA damage repair defects, and these neural cells with mutant XPA were hyper-sensitive to DNA damage-induced apoptosis. Thus, XP-mutant neural cells represent valuable tools to clari the molecular mechanisms of neurological abnormalities in the XP patients.

关键词： xeroderma pigmentosum iPSC disease model neural stem cell. neuron

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创新要素协同、市场化改革与制造业高质量发展

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财经理论与实践 2021年第6期42卷 126-131页

作者：贺灵付丽娜湖南科技大学商学院湖南湘潭411201 湘潭大学商学院湖南湘潭411105

基于2004-2018年30个省级地区的面板数据,运用动态面板数据模型与门槛效应模型,考量创新要素协同对制造业高质量发展的影响机制。结果显示:科技创新、现代金融、人力资源等创新要素协同对制造业高质量发展具有显著的正向效应,且存在明... 详细信息

基于2004-2018年30个省级地区的面板数据,运用动态面板数据模型与门槛效应模型,考量创新要素协同对制造业高质量发展的影响机制。结果显示:科技创新、现代金融、人力资源等创新要素协同对制造业高质量发展具有显著的正向效应,且存在明显的时间差异性和空间异质性;资源配置、产业融合、技术进步及需求升级在创新要素协同促进制造业高质量发展的过程中起到中介作用,市场化改革进程具有调节作用。

关键词：高质量发展市场化配置改革创新要素协同传导机制

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Establishment of a Loop-Mediated Isothermal Amplification Assay for Rapid Detection of Xanthomonas oryzae ***

Establishment of a Loop-Mediated Isothermal Amplification As...

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中国植物病理学会2016年学术年会

作者： ZHANG Xiao-fang fu lina LIU Ya-ting ZHANG Hai-yan LI Xue JI Guang-hai College of Plant Protection Yunnan Agricultural University College of Agronomy And Xbiotechnology Yunnan Agricultural University

A visual loop-mediated isothermal amplification detection of Xanthomonas oryzae ***,the causal agent of bacterial leaf streak disease was developed with SYBR Green I as a fluorescence indicator in this *** special Loop-mediated isothermal amplification primers and two loop primers were designed based on putative glycosyltransferase gene loci which is unique for *** ***-mediated isothermal amplification assay efficiently amplified the target element in less than 60 min at 65 ℃.LAMP assay was evaluated for specificity and sensitivity.A positive colour(Fluorescent Green) was only observed in the presence of Xooc by addition of SYBR Green Ⅰ to amplification,whereas none of other closely related Xanthomonas showed a colour *** lower limit of detection of this LAMP assay was about 100 fg/μL DNA and 3×10Cfu/mL Bacterium Suspension,which was 100 times more sensitive than PCR *** of LAMP provides a new alternative method for onsite quarantining and large-scale monitoring of this pathogen.

关键词： Xanthomonas oryzae pv.oryzicola Loop-mediated isothermal amplification Detection

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