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Science China Chemistry 2025年

作者： Wenxian Zhang Jiahong Yang Qijun sun Lu Peng Tong lin Shouke Yan Xiaoli sun State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences State Key Laboratory of Separation Membranes and Membrane Processes School of Textile Science and EngineeringTiangong University Key Laboratory of Rubber-Plastics of Ministry of Education Shandong Provincial Key Laboratory of Rubber-PlasticsQingdao University of Science & Technology

Wearable self-powered piezoelectric pressure sensors are attracting tremendous ***,fabricating a high-sensitive elastic piezoelectric sensor for a broad response range remains ***,we assemble polar poly（vinylidene fluoride）(PVDF) microsphere-elastomer composites,achieving high-sensitive and wide-responsive pressure *** polar PVDF microspheres are produced cost-effectively through phase separation,enabling *** piezoelectric composite （PC） film demonstrates low Young’s modulus,and excellent anti-fatigue ***,the PC-based piezoelectric sensor exhibits a rather high sensitivity of 540 mV N-1in a wide sensing range （5–40 N）,240 times greater than the PVDF film-based sensor and comparable to the inorganic piezoelectric *** excellent performance is attributed to the highest average stress concentration on the spherical PVDF coupled with the remarkable deformation of dipoles of spherical PVDF in the flexible *** on excellent performance,this piezoelectric sensor achieves precise recognition of motions and sound *** high-sensitive flexible piezoelectric sensor enabling large area production with ultralow price exerts great potential in smart monitoring and intelligent robots.

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Non-coding RNAs in acute ischemic stroke:from brain to periphery

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Neural Regeneration Research 2025年第1期20卷 116-129页

作者： Shuo Li Zhaohan Xu Shiyao Zhang Huiling sun Xiaodan Qin lin Zhu Teng Jiang Junshan Zhou Fuling Yan Qiwen Deng Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina

Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and *** predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain *** innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding RNAs(ncRNAs)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental *** expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncRNAs can serve as therapeutic targets in acute ischemic ***,distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and *** particular,ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic *** this review,we consolidate the latest progress of research into the roles of ncRNAs(microRNAs,long ncRNAs,and circular RNAs)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncRNAs to act as biomarkers for acute ischemic stroke prediction,diagnosis,and *** from this review will provide novel ideas for the clinical application of ncRNAs in acute ischemic stroke.

关键词： acute ischemic stroke apoptosis blood–brain barrier damage circular RNAs excitatory toxicity long non-coding RNAs microRNAs neuroinflammation non-coding RNAs oxidative stress

Study of LKB1-AMPK-mTOR signaling pathway in lung cancer cells

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Study of LKB1-AMPK-mTOR signaling pathway in lung cancer cel...

基于星敏感器的星光折射卫星自主导航方法研究

中华医学会呼吸病学年会——2011（第十二次全国呼吸病学学术会议）

作者： lin-lin sun,Xia Zhang,Dian-sheng Zhong,Li-xia Dong,Zhe Chen,lin-juan lin Department of Respiratory Diseases,Tianjin Medical University General Hospital,

Lung cancer has the highest incidence and top death rates among human neoplasms in china. Clinically,non-small-cell lung cancer(NSCLC) accounts for about 80%-85%of the total number of lung cancer,with an overall 5-year survival rate of about 15%.Understanding the molecular mechanisms underlying NSCLC development may lead to improvement of lung cancer diagnosis

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系统工程与电子技术 2004年第3期26卷 353-357页

作者：李琳琳孙辉先中国科学院空间科学与应用研究中心北京100080

研究了基于星光折射量测进行自主确定卫星姿态及轨道的方法。这种导航方案利用高精度的CCD星敏感器,结合星光穿越大气的较精确的数学模型,来间接敏感地平,从而实现对卫星的精确定位和定姿。为了说明所提导航方案的有效性,采用推广卡尔... 详细信息

研究了基于星光折射量测进行自主确定卫星姿态及轨道的方法。这种导航方案利用高精度的CCD星敏感器,结合星光穿越大气的较精确的数学模型,来间接敏感地平,从而实现对卫星的精确定位和定姿。为了说明所提导航方案的有效性,采用推广卡尔曼滤波算法,结合模拟的测量数据对自主定轨进行了仿真。仿真结果表明,定轨精度优于100m。还分析比较了采样周期、星敏感器精度、恒星数目等因素对定轨精度的影响。总结了其变化规律,可用于提高卫星自主定轨精度。

关键词：卫星自主导航星敏感器星光折射角推广卡尔曼滤波

Diffusion behavior of Ni in Zr_(48)Cu_(36)Ag_8Al_8 bulk metallic glass within supercooled liquid region

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Transactions of Nonferrous Metals Society of China 2015年第4期25卷 1171-1175页

作者：孙琳琳王军寇宏超唐斌李金山张平祥西北工业大学凝固技术国家重点实验室西安710072 西北有色金属研究院西安710016

Diffusion behavior of Ni in Zr48Cu36Ag8Al8 metallic glass was investigated in the temperature range of 683-723 K by secondary ion mass spectrum(SIMS) and transmission electron microscope(TEM). The diffusivity of Ni in Zr48Cu36Ag8Al8 is reasonably fitted by a single Arrhenius relation with small effective activation energy. The diffusivity of Ni in Zr48Cu36Ag8Al8 is an instantaneous function of annealing time in the supercooled liquid region. In addition, a large number of nano-crystals are detected near the interface of Ni-Zr48Cu36Ag8Al8 diffusion couple, and its width is broader than the Ni diffusion depth determined by SIMS. The results indicate that atomic inter-diffusion is an important factor to promote the formation of nano-crystals within the diffusion zone.

关键词： metallic glasses diffusion behavior interface nano-crystal

Insufficient MIRO1 contributes to declined oocyte quality during reproductive aging

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Science China Life Sciences 2025年

作者： Zhen-Nan Pan Hao-lin Zhang Kun-Huan Zhang Jia-Qian Ju Jing-Cai Liu Shao-Chen sun College of Animal Science and Technology Nanjing Agricultural University Reproductive Medicine Centre The Affiliated Yantai Yuhuangding Hospital of Qingdao University

Mitochondrial Rho-GTPase 1 (MIRO1) is an outer mitochondrial membrane protein which regulates mitochondrial transport and mitophagy in mitosis. In present study, we reported the crucial roles of MIRO1 in mammalian oocyte meiosis and its potential relationship with aging. We found that MIRO1 expressed in mouse and porcine oocytes, and its expression decreased in aged mice. MIRO1 deficiency caused the failure of meiotic resumption and polar body extrusion in both mouse and porcine oocytes, which could be rescued by exogenous MIRO1supplementation. Mass spectrometry data indicated that MIRO1 associated with several cytoskeleton and cell cycle-related proteins, and MIRO1 regulated motor protein Dynein for microtubule-organizing centers (MTOCs) dynamics at germinal vesicle (GV) stage, which determined meiotic resumption. Furthermore, we found that MIRO1 regulated Aurora A and kinesin family member 11 (KIF11) for meiotic spindle assembly in oocytes. Besides, MIRO1 associated with several mitochondria-related proteins dynamic-related protein 1 (DRP1),Parkin and lysosomal-associated membrane protein 2 (LAMP2) for mitochondrial dynamics and mitophagy during oocyte meiosis. Taken together, our results suggested that MIRO1 played pivotal roles in meiotic resumption, spindle assembly and mitochondrial function in mouse and porcine oocytes, and its insufficiency might contribute to the oocyte maturation defects during aging.

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金属过渡层类型对非晶碳膜结构性能的影响

无机材料学报 2018年第3期33卷 331-338页

作者：李蕾郭鹏刘林林孙丽丽柯培玲汪爱英中国科学院宁波材料技术与工程研究所中国科学院海洋新材料与应用技术重点实验室浙江省海洋材料与防护技术重点实验室宁波315201 中国科学院大学北京100049

采用直流磁控溅射技术制备不同金属过渡层(Cr,Ti,W)的类石墨非晶碳膜(GLC),研究过渡层类型对非晶碳膜微结构的影响,并考察其在人工海水中摩擦性能的变化。研究结果表明:Cr/GLC薄膜sp2杂化键含量最高,沿GLC表面到铬碳界面方向,sp2杂化键... 详细信息

采用直流磁控溅射技术制备不同金属过渡层(Cr,Ti,W)的类石墨非晶碳膜(GLC),研究过渡层类型对非晶碳膜微结构的影响,并考察其在人工海水中摩擦性能的变化。研究结果表明:Cr/GLC薄膜sp2杂化键含量最高,沿GLC表面到铬碳界面方向,sp2杂化键含量逐渐增大,Ti过渡层和W过渡层的sp2杂化键含量变化不明显。Cr/GLC薄膜较高的sp2杂化键含量有助于其在摩擦过程中产生可以充当润滑相的石墨化转化摩擦转移膜。在三种涂层中,Cr/GLC薄膜表现出最高的腐蚀电位–0.16 V和最低的腐蚀电流密度4.42?10–9 A/cm2。因此相较于Ti,W作过渡层的GLC薄膜,Cr/GLC薄膜在海水环境下表现出优异的摩擦学特性。

关键词：海水类石墨非晶碳膜(GLC) 金属过渡层电子能量损失谱(EELS)

Vav1 Protects T Cells from Fas-mediated Apoptosis by Maintaining the Homeostatic Expression of Bcl2

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Vav1 Protects T Cells from Fas-mediated Apoptosis by Maintai...

2008年全国生物化学与分子生物学学术大会

作者： Jie Yin lin-lin sun Ying-chi Zhang Shi-yang Li You-jia Cao (College of Life Sciences,Nankai University.Tianjin,P.R.China)

Vavl is a hematopoietic cell-specifical guanine nucleotide exchange factor (GEF) for Rho-family GTPases and plays important roles in T cell development and *** activation have been reported in cells derived from knock...

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骨髓间充质干细胞治疗脑出血的临床观察

现代预防医学 2011年第23期38卷 5018-5019页

作者：王贵均林麟孙香钰鸿广州中医药大学

[目的]观察通过自体骨髓间充质干细胞移植治疗脑出血的近期临床疗效。[方法]选取神经内科收治住院治疗的280例脑出血患者作为治疗组,行手术血肿清除术后,通过腰椎穿刺蛛网膜下腔注射自体骨髓间充质干细胞悬液3.5ml。选择同期入院300例... 详细信息

[目的]观察通过自体骨髓间充质干细胞移植治疗脑出血的近期临床疗效。[方法]选取神经内科收治住院治疗的280例脑出血患者作为治疗组,行手术血肿清除术后,通过腰椎穿刺蛛网膜下腔注射自体骨髓间充质干细胞悬液3.5ml。选择同期入院300例患者作为对照组。分别于移植前后6个月进行神经功能缺损程度评定(NIHSS评分)和日常生活活动能力评定(Barthel指数),行颅脑MRI、血生化指标,监测干细胞移植的安全性。[结果]治疗组移植6个月后与对照组及移植前比较,NIHSS评分均有显著降低(P﹤0.01),Barthel指数均有显著升高(P﹤0.01)。移植后6个月随访,颅脑MRI及血生化指标均未出现明显异常。[结论]自体骨髓间充质干细胞移植治疗脑出血是安全可行的,且在近期内疗效确定,远期疗效尚待进一步观察。

关键词：骨髓间充质干细胞脑出血移植