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Neural stem cell activation and glial proliferation in the hippocampal CA3 region of posttraumatic epileptic rats

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Neural Regeneration Research 2011年第16期6卷 1232-1237页

作者： Yuanxiang lin Kun lin Dezhi kang Feng Wang Department of Neurosurgery First Affiliated Hospital of Fujian Medical University Fuzhou 350005 Fujian Province China

The present study observed the dynamic expression of CD133, nuclear factor-κB and glial fibrUlary acidic protein in the hippocampal CA3 area of the experimental posttraumatic epilepsy rats to investigate whether gliosis occurs after posttraumatic epilepsy. CD133 and nuclear factor-κB expression was increased at 1 day after posttraumatic epilepsy, peaked at 7 days, and gradually decreased up to 14 days, as seen by double-irnmunohistochemical staining. Glial fibrillary acidic protein/nuclear factor-EB double-labeled cells increased with time and peaked at 14 days after posttraumatic epilepsy. Results show that activation of hippocampal neural stem cells and glial proliferation after posttraumatic epilepsy-induced oxidative stress increases hippocampal glial cell density.

关键词： posttraumatic epilepsy neural stem cell glial cell CD133 nuclear factor-κB glialfibrillary acidic protein neural regeneration

Impacts of Nutlin-3a and exercise on murine double minute 2-enriched glioma treatment

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Neural Regeneration Research 2025年第4期20卷 1135-1152页

作者： Yisheng Chen Zhongcheng Fan Zhiwen Luo Xueran kang Renwen Wan Fangqi Li Weiwei lin Zhihua Han Beijie Qi Jinrong lin Yaying Sun Jiebin Huang Yuzhen Xu Shiyi Chen Department of Sport Medicine Huashan HospitalFudan UniversityShanghaiChina Department of Orthopedic Surgery Hainan Province Clinical Medical CenterHaikou Affiliated Hospital of Central South University Xiangya School of MedicineHaikouHainan ProvinceChina Department of Basic Medicine Shanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Neurosurgery Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Department of Orthopedics Shanghai General HospitalSchool of Medicine Shanghai Jiao Tong UniversityShanghaiChina Department of Infectious Diseases Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina

Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural *** role of the small ubiquitin-like modifier(SUMO)protein,especially post-exercise,in cancer progression,is gaining attention,as are the potential anti-cancer effects of *** used machine learning to create the exercise and SUMO-related gene signature(ESLRS).This signature shows how physical activity might help improve the outlook for low-grade glioma and other *** demonstrated the prognostic and immunotherapeutic significance of ESLRS markers,specifically highlighting how murine double minute 2(MDM2),a component of the ESLRS,can be targeted by *** underscores the intricate relationship between natural compounds such as nutlin-3 and immune *** comprehensive CRISPR screening,we validated the effects of specific ESLRS genes on low-grade glioma *** also revealed insights into the effectiveness of Nutlin-3a as a potent MDM2 inhibitor through molecular docking and dynamic ***-3a inhibited glioma cell proliferation and activated the p53 *** efficacy decreased with MDM2 overexpression,and this was reversed by Nutlin-3a or *** using a low-grade glioma mouse model highlighted the effect of physical activity on oxidative stress and molecular pathway ***,both physical exercise and Nutlin-3a administration improved physical function in mice bearing tumors derived from MDM2-overexpressing *** results suggest the potential for Nutlin-3a,an MDM2 inhibitor,with physical exercise as a therapeutic approach for glioma *** research also supports the use of natural products for therapy and sheds light on the interaction of exercise,natural products,and immune regulation in cancer treatment.

关键词： exercise and SUMO-related gene signatures(ESLRS) glioblastoma management low-grade glioma natural bioactives neural regeneration physical exercise

Double [5]carbohelicene: facile synthesis, chiroptical properties,isomerization study, and lasing application

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Science China Chemistry 2025年第1期 233-240页

作者： Peipei Liu Yantong Li Meng-Xiang Wu Hao kang Xiao-Li Zhao lin Xu linlin Liu Xiaodong Li Junfeng Fang Zhiwei Fang Ya Cheng Hai-Bo Yang Huakang Yu Xueliang Shi State Key Laboratory of Petroleum Molecular & Process Engineering Shanghai Key Laboratory of Green Chemistry and Chemical ProcessesSchool of Chemistry and Molecular Engineering East China Normal University School of Physics and Optoelectronics South China University of Technology Institute of Polymer Optoelectronic Materials & Devices State Key Laboratory of Luminescent Materials & Devices South China University of Technology School of Physics and Electronic Science Engineering Research Center of Nanophotonics & Advanced Instrument Ministry of EducationEast China Normal University State Key Laboratory of Precision Spectroscopy School of Physics and Electronic Science East China Normal University

Double carbohelicenes have attracted considerable attention due to their aesthetic structures, distinct π-conjugation extension, inherent chirality, and intriguing optical and electronic properties. Herein, the concise de novo synthesis of a new double[5]carbohelicene 1 together with its chiroptical properties, isomerization process and lasing application is presented. 1 was synthesized by a simple protocol involving the formation of a 6,6′-bipentacene as the key intermediate. It is worth noting that1 existed as two diastereomers 1-PP/MM and 1-PM, which were successfully isolated and unambiguously confirmed by Xray crystallography. The optical resolution of the racemic 1-PP/MM was successfully achieved by chiral-phase highperformance liquid chromatography（HPLC）, and 1-PP and 1-MM were characterized by circular dichroism. Interestingly, it was found that 1-PP/MM could be completely isomerized to 1-PM upon heating, and the detailed thermodynamics and kinetics of the isomerization process were systematically investigated. 1-PM exhibited deep-red luminescence with emission maximum at 723 nm and fluorescence quantum yield as high as 32.95%. Consequently, we can showcase the lasing application of 1-PM by doping with epoxy resin to assemble a bottle microlaser spontaneously, which the lasing wavelength is 796.6 nm at a threshold of 0.8 m J cm-2. We believe that our studies, including the facile synthesis methodology, detailed isomerization studies, and lasing application, will shed some light on the design and synthesis of novel carbohelical systems with more functions.

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评价两种消毒剂对IVF实验室微环境和妊娠结局的影响

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中国微生态学杂志 2017年第7期29卷 835-838页

作者：陈素珠郑备红杜生荣林典梁林运鸿康跃凡福建省妇幼保健院福建医科大学附属医院福建省生殖医学中心福建福州350001

目的在辅助生殖体外受精(in vitro fertilization,IVF)实验室的胚胎操作过程中,根据消毒剂对胚胎质量和妊娠结局的影响,评价季铵盐消毒剂是否比75%酒精消毒液更适合用于IVF实验室。方法回顾分析2016年1月至9月在我中心行IVF的619例新鲜... 详细信息

目的在辅助生殖体外受精(in vitro fertilization,IVF)实验室的胚胎操作过程中,根据消毒剂对胚胎质量和妊娠结局的影响,评价季铵盐消毒剂是否比75%酒精消毒液更适合用于IVF实验室。方法回顾分析2016年1月至9月在我中心行IVF的619例新鲜移植周期,根据IVF实验室使用的消毒剂不同分为两组,A组383例为使用75%酒精消毒组,B组236例使用季铵盐组。对比两组的VOC浓度、获卵数、获卵率、受精率、多精率、卵裂率、优质胚胎率、优质囊胚形成率、着床率、临床妊娠率以及流产率。结果相比于A组,B组的VOC浓度显著降低;A、B两组的获卵数、获卵率、受精率、多精率、卵裂率、优质胚胎率、优质囊胚形成率和流产率的差异均不具有统计学意义(P>0.05);但B组的着床率和妊娠率显著高于A组(P<0.05)。结论两组对胚胎的体外培养质量没有显著性的影响,但使用季铵盐组相比于75%酒精组胚胎着床率和妊娠率显著提高。因此,季铵盐消毒剂比75%酒精更适合作为IVF实验室消毒剂。

关键词：体外受精消毒剂季铵盐妊娠结局

Deep-ultraviolet nonlinear optical crystals: concept development and materials discovery

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Light(Science & Applications) 2022年第8期11卷 1718-1729页

作者： Lei kang Zheshuai lin Functional Crystals Lab Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing100190China

Deep-ultraviolet (DUV, wavelength λ < 200 nm) nonlinear optical (NLO) crystal is the core component of frequency conversion to generate DUV laser, which plays an important role in cutting-edge laser technology and fu... 详细信息

Deep-ultraviolet (DUV, wavelength λ linear optical (NLO) crystal is the core component of frequency conversion to generate DUV laser, which plays an important role in cutting-edge laser technology and fundamental science. Significant progress has been made in both experimental exploration and theoretical design in the field of DUV NLO crystals over the past three decades. In-depth insight into “structure-property correlations”, in particular, allows for rigorous and precise identification of DUV NLO crystals. In this article, we reviewed the current experimental and theoretical research progress while elucidating the core concepts and stringent criteria of qualified DUV phase-matched second-harmonic generation crystals. We also discussed the development of the DUV NLO “structure-property correlations” from first principles and how it has sparked interest in related materials, as well as future directions for obtaining potential DUV NLO crystals.

关键词： optical ultraviolet Deep

国有资产改革对自然资源资产“两权”分离的启示与借鉴

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生态经济 2025年第1期41卷 195-200页

作者：林霖黄志豪康琴陈丹张敏王珂虞舟鲁中国计量大学人文与外语学院浙江杭州310018 浙江数治空间规划设计有限公司浙江杭州310030 浙江省测绘科学技术研究院浙江杭州310007 浙江大学环境与资源学院浙江杭州310058

我国国有资产管理体制经过了从统一到分散再到统一的改革历程。在此过程中,国务院设立国有资产监督管理委员会,并逐步推动国有资产管理方式从以管企业为主向以管资本为主转变,探索了国有资产所有权与监管权“两权”分离的路径。鉴于自... 详细信息

我国国有资产管理体制经过了从统一到分散再到统一的改革历程。在此过程中,国务院设立国有资产监督管理委员会,并逐步推动国有资产管理方式从以管企业为主向以管资本为主转变,探索了国有资产所有权与监管权“两权”分离的路径。鉴于自然资源资产管理与国有资产管理存在较强相似性,国有资产投资运营公司在促进国有资产“两权”分离中的关键作用,为自然资源资产所有权与监管权的分离提供了重要启示和借鉴。自然资源资产管理在完成委托代理机制试点后,建议管理方式由“资源管理”逐步转向“资产管理”,授权设立自然资源投资运营公司,以实现自然资源资产“两权”的有效分离,从“自然资源部门—自然资源资产”的二级管理体制转变为“自然资源部门—自然资源投资运营公司—自然资源资产”的三级管理体制,以期为推进自然资源资产的有效监管和资产增值提供改革思路与参考。

关键词：国有资产改革自然资源资产 “两权”分离投资运营公司

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量子核判别分析算法

郑州大学学报（理学版） 2025年第1期57卷 61-66页

作者：康榕乘余凯张新林崧郭躬德福建师范大学计算机与网络空间安全学院福建福州350117 福建师范大学数字福建环境监测物联网实验室福建福州350117 福建师范大学数学与统计学院福建福州350117

核判别分析法通过核函数扩展了线性判别分析对非线性数据的处理能力,成为模式识别领域中一个重要的分支。然而,随着数据的指数增长,经典核判别分析算法在提取特征时会消耗大量计算资源。针对这一问题,利用量子叠加性和并行性提出了一种... 详细信息

核判别分析法通过核函数扩展了线性判别分析对非线性数据的处理能力,成为模式识别领域中一个重要的分支。然而,随着数据的指数增长,经典核判别分析算法在提取特征时会消耗大量计算资源。针对这一问题,利用量子叠加性和并行性提出了一种量子核判别分析算法。首先,借助量子随机存储器技术与控制旋转操作构造需要的类间矩阵和类内矩阵所对应的密度算子;然后,融入线性方程的求解思路并行获取特征态。理论分析表明,所提算法与经典算法相比具有指数级加速。

关键词：量子机器学习非线性判别分析核函数特征提取量子厄米特链积相位估计

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Influence of coupled characteristics on the internally-staged combustor under low-power operation

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航空动力学报 2017年第1期32卷 42-52页

作者： kang Yao lin Yu-zhen Hunan Aviation Powerplant Research Institute Aero Engine(Group)Corporation of China National Key Laboratory of Science and Technology on Aero-Engine Aero-thermodynamics School of Energy and Power EngineeringBeijing University of Aeronautics and Astronautics

An ultra-low emissions combustor,namely low emission stirred swirl(LESS)combustor was studied,based on a scheme of internally-staged/lean premixed and prevaporized(LPP)*** LESS combustor consists of central pilot stage and outer surrounded coaxially main stage,between which there exists aphysical isolation,namely the step *** existence of step height delayed the pilot and main jets *** and numerical studies were carried out to investigate the influence of the step height on the combustion performance.A single dome rectangular combustor was utilized to conduct the lean lightoff and blowout experiments,and pollutant emission *** experimental results showed that with the increase of step height by 38%,the lean lightoff and blowout fuel air ratio decreased by 57.4% and 37.5%,the NOx emission increased by 35.1%,and the combustion efficiency increased by 1.78%;while the CO,unburned hydrocarbons(UHC)emissions ***,the total pressure loss was kept nearly ***-reacting and reacting flow fields were numerically investigated to analyze the coupled characteristics of pilot and main jets with different step heights.A comparison of flow characteristics,spray structure,and combustion component as well as temperature field with different step heights was *** numerical results showed that the increase of the step height shifted the peak velocity *** enlargement of the primary recirculation zone(PRZ)resulted in the increase of the combustion efficiency and NOx emission,while the CO,UHC emissions decreeased.

关键词：航空动力编辑研究工作

Variable Selection for Varying Coefficient Models Via Kernel Based Regularized Rank Regression

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Acta Mathematicae Applicatae Sinica 2020年第2期36卷 458-470页

作者： kang-ning WANG Lu lin School of Statistics Shandong Technology and Business UniversityYantai 264005China Institute for Financial Studies Shandong UniversityJinan 250100China

A robust and efficient shrinkage-type variable selection procedure for varying coefficient models is proposed,selection consistency and oracle properties are ***,a BIC-type criterion is suggested for shrinkage parameter selection and theoretical property is *** studies and real data analysis also are included to illustrate the finite sample performance of our method.

关键词： rank regression oracle property variable selection asymptotic relative efficiency BIC-type criterion