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Poly(meta-phenylene) Derivative with Rigid Twisted Biphenyl Units in Backbone:Synthesis,Structural Characterization,Photophysical Properties and Electroluminescence

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Chemical Research in Chinese Universities 2007年第6期23卷 720-725页

作者： ZHENG Yan yang Bing ZHANG Hai-quan LU Ping SHEN Fang-zhong LIU lin-lin XU Hai yang Guang-di MA Yu-guang Key Lab for Supramolecular Structure and Materials of Ministry of Education Jilin University Changchun 130012 P. R. China

A soluble poly（meta-phenylene） derivative with rigid twisted biphenyl unit was synthesized by the Yamamoto coupling reaction. The polymer is soluble in common organic solvents, and the number-average molecular weight is about 6500. The UV-Vis and quantum chemical calculation indicate that the different conformation segments named ＂conformers＂ exist in the polymer backbones; it was also further confirmed by the single crystal X-ray diffraction study of the dimeric model compound. The π-π^＊ transition of biphenyl segments of twisted and planar conformations made the polymer exhibit a strong absorption around 256 nm and a weak absorption at about 300 nm. Furthermore, the polymer exhibits a strong UV photoluminescence at 372 nm when the excitation wavelengths are longer than 300 run. The ultraviolet-emitting electroluminescence（EL） device with the single layer structure shows EL λmax of the derivative at 370 nm.

关键词： Poly(phenylene) Conformation UV light-emitting

Combination therapy(toripalimab and lenvatinib)-associated toxic epidermal necrolysis in a patient with metastatic liver cancer:A case report

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World Journal of Clinical Cases 2022年第11期10卷 3478-3484页

作者： Kai-Kai Huang Shan-Shan Han Li-Ya He lin-lin yang Bao-Ying Liang Qing-Yu Zhen Zi-Bo Zhu Cai-Yun Zhang Hong-Yi Li Ying lin Department of Dermatology the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Department of Dermatology the Second Clinical Medical College of Guangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases Guangzhou 510120Guangdong ProvinceChina

BACKGROUND Both programmed cell death-1(PD-1)inhibitors and lenvatinib,which have a synergistic effect,are promising drugs for tumor *** is generally believed that combination therapy with a PD-1 inhibitor and lenvatinib is safe and ***,we report a case of toxic epidermal necrolysis(TEN),a grade 4 toxicity,after this combination *** SUMMARY A 39-year-old male presented with erythema,blisters and erosions on the face,neck,trunk and limbs 1 wk after receiving combination therapy with lenvatinib and toripalimab,a PD-1 *** skin injury covered more than 70%of the body surface *** was previously diagnosed with liver cancer with cervical vertebra ***,prominent necrotic keratinocytes,hyperkeratosis,liquefaction of basal cells and acantholytic bullae were observed in the *** vessels in the dermis were infiltrated by lymphocytes and *** immunofluorescence staining was ***,the diagnosis was confirmed to be TEN(associated with combination therapy with toripalimab and lenvatinib).Full-dose and long-term corticosteroids,high-dose intravenous immunoglobulin and targeted antibiotic drugs were *** rashes gradually faded;however,as expected,the tumor ***, sorafenib and regorafenib were given in succession, and the patient was still alive at the10-mo *** attention should be given to rashes that develop after combination therapy with PD-1inhibitors and lenvatinib. Large-dose and long-course glucocorticoids may be crucial for thetreatment of TEN associated with this combination treatment.

关键词： Toxic epidermal necrolysis Toripalimab Lenvatinib Programmed cell death-1 inhibitor Liver cancer Case report

Treatment of benign ureteral stricture by double J stents using high-pressure balloon angioplasty

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Chinese Medical Journal 2011年第6期124卷 943-946页

作者： YU Hua-liang YE lin-yang lin Mao-hu yang Yu MIAO Rui HU Xiao-juan Department of Urology First Hospital Affiliated to General Hospital of the Chinese People's Liberation Army Beijing 100048China

Background Balloon dilatation angioplasty is a minimally invasive surgery for treating benign ureteral stricture. The aim of this study was to investigate the effect of placing double J （D-J） stents using high-pressure balloon angioplasty in treating benign ureteral *** A total of 42 patients （48 cases） with benign ureteral stricture （42 had benign ureteral stricture） were investigated by inserting dual D-J stents using high-pressure balloon angioplasty. The control group contained 50 patients （57 cases） employing the conventional balloon angioplasty with a single D-J stent inserted for *** The overall effective rate of the treated and control groups was 87.8% （36/41） and 62.7% （32/51）, respectively （P 〈0.05）.Conclusion This new approach produces a better curative effect than the conventional balloon angioplasty with a single D-J stent insertion in treating benign ureteral stricture.

关键词： balloon dilatation angioplasty ureteral stent ureteral stricture

Selection of Minimal Test Points Set for Integer-Coded Fault Wise Table

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Journal of Electronic Science and Technology of China 2009年第4期7卷 312-316页

作者： Shu-lin Tian Cheng-lin yang Bing Long School of Automation engineering University of Electronic Science and Technology of China Chengdu 610054 China

Test points selection for integer-coded fault wise table is a discrete optimization problem. On one hand, traditional exhaustive search method is computationally expensive. On the other hand, the space complexity of traditional exhaustive is low. A tradeoff method between the high time complexity and low space complexity is proposed. At first, a new fault-pair table is constructed based on the integer-coded fault wise table. The fault-pair table consists of two columns： one column represents fault pair and the other represents test points set that can distinguish the corresponding faults. Then, the rows are arranged in ascending order according to the cardinality of corresponding test points set. Thirdly, test points in the top rows are selected one by one until all fault pair are isolated. During the test points selection process, the rows that contain selected test points are deleted and then the dimension of fault-pair table decreases gradually. The proposed test points selection algorithm is illustrated and tested using an integercoded fault wise table derived from a real analog circuit. Computational results suggest show policies are better than the exhaustive strategy.

关键词： Fault-pair table integer-coded fault wise table optimization test points selection.

A study of acupoint selection rules of moxibustion and auricular point therapy in the treatment of urinary retention after anorectal surgery based on data mining

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Asian Toxicology Research 2021年第1期3卷 32-38页

作者： Li-Jiang Ji Jing-Yu Xu Xiao-Jun yang lin-lin yang Mei-ling He Min Zhong Jing Gu The Changshu Affiliated Hospital of Nanjing University of Traditional Chinese Medicine Changshu 215500China The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300193China Tianjin University of Traditional Chinese Medicine Tianjin301617China

Based on the Traditional Chinese Medicine Inheritance Support System(V2.5),we explored the compatibility rules of moxibustion and auricular point prescriptions in the treatment of urinary retention after anorectal surgery,and further to obtain new ***:We searched CNKI,Wanfang,VIP and CBM databases for the literature of moxibustion and auricular point therapy for urinary retention after anorectal surgery,collecting complete prescriptions and entering them into the Traditional Chinese Medicine Inheritance Support System(V2.5).The acupoint frequency,association rules,and combination rules were analyzed by data mining method of software ***:126 moxibustion prescriptions were selected,and the acupoints for urinary retention after anorectal surgery in the literature were analyzed,including 10 acupoints with frequency≥6,9 acupoint combinations with frequency≥26,5 acupoints with association rules,6 core acupoint combinations and 3 new prescription.124 auricular point prescriptions were selected,and the relevant acupoints in the literature were analyzed,including 10 acupoints with frequency of use≥18,15 acupoint combinations with frequency≥40,12 acupoint combinations with association rules,6 core acupoint combinations,and 3 new *** core points include Qihai(RN6),Sanyinjiao(SP6),Zhongji(RN3),Guanyuan(RN4).The auricular point therapy is more to select the tenderness points and acupoints that have an impact on the urinary system,mainly including“Pangguang”(CO9),“Shenmen”(TF4),“Shen”(CO10),“Sanjiao”(CO17),“Pizhixia”(AT4),“Niaodao”(HX3),“Fei”(CO14),“Jiaogan”(AH6a).Conclusion:Moxibustion for the treatment of urinary retention is mainly based on invigorating“Primordial Qi”and regulating the functions of“Middle Jiao”(refers to the area of the body just below the diaphragm and above the navel that helps produce delicate nutrients).The entropic clustering of complex systems excavated new prescriptions for the treatment of urinary retenti

关键词： Urinary retention after anorectal surgery Moxibustion Auricular point therapy Points combination rules Traditional Chinese Medicine Inheritance Support System

生态因子对人参皂苷合成及其关键酶基因表达的影响

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中草药 2017年第20期48卷 4296-4305页

作者：杨林林张涛杨利民韩梅吉林农业大学中药材学院吉林长春130118

目的研究生态因子和人参皂苷合成关键酶表达对人参皂苷合成、积累的影响。方法以人工栽培的4年生人参为研究对象,用实时荧光定量PCR法对在不同生长时期根组织中8个关键酶基因(HMGR、FPS、SS、SE、DS、β-AS、CYP82D47、CYP716A47)表达... 详细信息

目的研究生态因子和人参皂苷合成关键酶表达对人参皂苷合成、积累的影响。方法以人工栽培的4年生人参为研究对象,用实时荧光定量PCR法对在不同生长时期根组织中8个关键酶基因(HMGR、FPS、SS、SE、DS、β-AS、CYP82D47、CYP716A47)表达量进行测定;采用HPLC法测定根中8种单体皂苷(人参皂苷Rg_1、Re、Rf、Rb_1、Rb_2、Rb_3、Rc、Rd)的量;以小型气象站对人参样地气象数据进行采集;采用SPSS软件进行相关性分析。结果人参皂苷合成关键酶基因在人参皂苷积累的重要时期(开花期至果熟期)的表达高于果后参根生长期和枯萎期,人参皂苷合成关键酶基因的表达相互影响,协同增减,人参根组织中关键酶基因的表达对人参皂苷积累多表现出了正相关关系;人参根中人参皂苷Rg_1、Rb_1、Re、Rc量较高,8种单体皂苷量动态变化趋势并不相同;温度、光合有效辐射、土壤水势是影响根部人参皂苷合成的重要生态因子,温度与人参皂苷Rb_1、Rd显著负相关(P<0.05),光合有效辐射对人参皂苷Rg_1的生成有显著的促进作用(P<0.05),土壤水势与人参皂苷Rb_1显著负相关(P<0.05);灰色关联度分析结果表明温度、光合有效辐射、相对湿度是影响人参皂苷量的主导生态因子,人参皂苷合成关键酶基因的表达是次要因子,在生态因子主导下人参皂苷合成关键酶基因调控人参皂苷的合成与积累。生态因子与关键酶基因的表达共同调控了人参皂苷的合成,对人参皂苷的积累有重要影响。结论明确了人参皂苷合成关键酶基因表达和人参皂苷量在人参中的动态变化,为人参皂苷合成生理生态机制的明晰及对人参药材质量的调控提供了理论依据。

关键词：人参人参皂苷Rg1 人参皂苷Re 人参皂苷Rf 人参皂苷Rb1 人参皂苷Rb2 人参皂苷Rb3 人参皂苷Rc 人参皂苷Rd 生态因子相关性灰色关联度

Fine-tuning the spatial allocation of phytohormones for smart canopy, smart breeding, and smart agriculture

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Science China Life Sciences 2025年第1期 309-310页

作者： Tao Zhou lin Li National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University HuBei HongShan Laboratory

The dual challenges of global climate change and population growth have increased demand for higher crop yields per unit area. The innovative technology of smart agriculture aims to synergize breeding, cultivation, and production through the application of biological and informatics technologies. Historically, the “Green Revolution” introduced semidwarf varieties of certain key crops by utilizing mutations affecting gibberellin pathways, which significantly increased planting densities and yields.

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RAM护理干预对肠癌术后肠胃功能恢复与心理状态的影响

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世界华人消化杂志 2017年第7期25卷 632-637页

作者：李秋萍林琳杨丽姜鹏飞杨洋天津医科大学第二医院干部保健科天津市300211 天津医科大学第二医院血液净化科天津市300211 天津医科大学第二医院肿瘤科天津市300211

目的探讨肠癌手术患者采用罗伊适应模式(Roy adaptation model,RAM)护理模式干预后肠胃功能恢复与心理状态的影响,为临床应用提供依据.方法将2014-08/2016-08天津医科大学第二医院收治的120例肠癌患者随机分为观察组和对照组,对照组患... 详细信息

目的探讨肠癌手术患者采用罗伊适应模式(Roy adaptation model,RAM)护理模式干预后肠胃功能恢复与心理状态的影响,为临床应用提供依据.方法将2014-08/2016-08天津医科大学第二医院收治的120例肠癌患者随机分为观察组和对照组,对照组患者采用常规护理方案进行干预,观察组患者采用RAM护理模式进行干预;对两组患者禁食时间、排气时间、肠鸣音恢复时间、排便时间等肠胃功能评价指标进行记录;在患者出院后2 wk复查时使用汉密尔顿抑郁量表(Hamilton depression scale,HAMD)及汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)量表对患者心理状态进行评估,调查术后3 d内患者谵妄发生率并统计患者临床满意度及护理疗效.结果出院后2 wk时观察组患者临床有效率显著高于对照组(P<0.05);手术治疗后观察组患者禁食时间、排气时间、肠鸣音恢复时间及排便时间显著低于对照组(P<0.05);出院后2 wk时观察组患者HAMD及HAMA评分显著优于对照组(P<0.05);观察组患者术后3 d内谵妄发生率显著低于对照组(P<0.05);观察组患者满意度明显优于对照组,且差异存统计学意义(P<0.05).结论肠癌手术患者采用RAM护理模式进行干预后,可有效改善患者肠胃功能及心理状态,具有较高的临床应用价值.

关键词： RAM护理模式肠癌手术肠胃功能心理状态

Interannual variability of boreal summer intraseasonal oscillation over the northwestern Pacific influenced by the Pacific Meridional Mode

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 6-11页

作者： Haoyu Zhou Pang-Chi Hsu lin Chen Yitian Qian Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environmental Change/Collaborative Innovation Center on Forecast and Evaluation of Meteorological DisastersNanjing University of Information Science and TechnologyNanjingChina

During the boreal summer,intraseasonal oscillations exhibit significant interannual variations in intensity over two key regions:the central-western equatorial Pacific(5°S-5°N,150°E-150°W)and the subtropical Northwestern Pacific(10°-20°N,130°E-175°W).The former is well-documented and considered to be influenced by the ENSO,while the latter has received comparatively less attention and is likely influenced by the Pacific Meridional Mode(PMM),as suggested by partial correlation analysis *** elucidate the physical processes responsible for the enhanced(weakened)intraseasonal convection over the subtropical northwestern Pacific during warm(cold)PMM years,the authors employed a moisture budget *** findings reveal that during warm PMM years,there is an increase in summer-mean moisture over the subtropical northwestern *** increase interacts with intensified vertical motion perturbations in the region,leading to greater vertical moisture advection in the lower troposphere and consequently resulting in convective *** a process is pivotal in amplifying intraseasonal convection *** observational findings were further verified by model experiments forced by PMM-like sea surface temperature patterns.

关键词： Boreal summer intraseasonal oscillation Interannual variability Pacific Meridional Mode Moisture budget analysis