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Serum bile acid and unsaturated fatty acid profiles of non-alcoholic fatty liver disease in type 2 diabetic patients

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World Journal of Diabetes 2024年第5期15卷 898-913页

作者： Su-Su Feng Si-Jing Wang lin Guo Pan-Pan Ma Xiao-Long ye Ming-lin Pan Bo Hang Jian-Hua Mao Antoine M Snijders Yi-Bing Lu Da-Fa Ding Department of Endocrinology The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011Jiangsu ProvinceChina Biological Systems and Engineering Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720United States

BACKGROUND The understanding of bile acid(BA)and unsaturated fatty acid(UFA)profiles,as well as their dysregulation,remains elusive in individuals with type 2 diabetes mellitus(T2DM)coexisting with non-alcoholic fatty liver disease(NAFLD).Investigating these metabolites could offer valuable insights into the pathophy-siology of NAFLD in *** To identify potential metabolite biomarkers capable of distinguishing between NAFLD and *** A training model was developed involving 399 participants,comprising 113 healthy controls(HCs),134 individuals with T2DM without NAFLD,and 152 individuals with T2DM and *** validation encompassed 172 *** patients were divided based on liver fibrosis *** analytical approach employed univariate testing,orthogonal partial least squares-discriminant analysis,logistic regression,receiver operating characteristic curve analysis,and decision curve analysis to pinpoint and assess the diagnostic value of serum *** Compared to HCs,both T2DM and NAFLD groups exhibited diminished levels of specific *** UFAs,particular acids exhibited a positive correlation with NAFLD risk in T2DM,while theω-6:ω-3 UFA ratio demonstrated a negative *** ofα-linolenic acid andγ-linolenic acid were linked to significant liver fibrosis in *** validation cohort substantiated the predictive efficacy of these biomarkers for assessing NAFLD risk in T2DM *** This study underscores the connection between altered BA and UFA profiles and the presence of NAFLD in individuals with T2DM,proposing their potential as biomarkers in the pathogenesis of NAFLD.

关键词： Bile acid Non-alcoholic fatty liver disease Type 2 diabetes mellitus Unsaturated fatty acid

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Cardiac remodeling in patients with atrial fibrillation reversing bradycardia-induced cardiomyopathy:A case report

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World Journal of Clinical Cases 2024年第7期12卷 1339-1345页

作者： De-Kui Gao Xiang-lin ye Zhen Duan Hong-Yang Zhang Tao Xiong Zheng-Hong Li Hai-Feng Pei Department of Cardiology Jiangyou Second People's HospitalJiangyou 621701Sichuan ProvinceChina Department of Cardiology The General Hospital of Western Theater CommandChengdu 610083Sichuan ProvinceChina Department of Clinical Medicine Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Special Inspection Jiangyou Second People's HospitalJiangyou 621701Sichuan ProvinceChina

BACKGROUND Bradycardia-induced cardiomyopathy(BIC),which is a disease resulting from bradycardia,is characterized by cardiac chamber enlargement and diminished cardiac *** correction of bradycardia can allow for significant improvements in both cardiac function and structure;however,this disease has been infrequently *** this case,we conducted a longitudinal followup of a patient who had been enduring BIC for more than 40 years to heighten awareness and prompt timely diagnosis and rational *** SUMMARY A woman who presented with postactivity fatigue and dyspnea was diagnosed with bradycardia at the age of *** she had no obvious symptoms,she did not receive any treatment to improve her bradycardia during the 42-year follow-up,except for the implantation of a temporary pacemaker during labor induction *** time progressed,the patient's heart gradually expanded due to her low ventricular rate,and she was diagnosed with *** 2014,the patient developed atrial fibrillation,her ventricular rate gradually increased,and her heart shape gradually returned to *** report describes the cardiac morphological changes caused by the heart rate changes in BIC patients older than 40 years,introduces another possible outcome of BIC,and emphasizes the importance of early intervention in treating *** BIC can induce atrial fibrillation,causing an increased ventricular rate and leading to positive cardiac remodeling.

关键词： Bradycardia cardiomyopathy Heart rate Atrial fibrillation Cardiac dilatation Case report

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Artificial intelligence in the anterior segment of eye diseases

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1743-1751页

作者： Yao-Hong Liu lin-Yu Li Si-Jia Liu Li-Xiong Gao Yong Tang Zhao-Hui Li Zi ye School of Medicine Nankai UniversityTianjin 300071China Medical School of Chinese PLA Beijing 100039China Department of Ophthalmology Chinese PLA General HospitalBeijing 100039China Chinese PLA General Hospital Medicine Innovation Research Department Beijing 100039China

Ophthalmology is a subject that highly depends on imaging *** intelligence(AI)technology has great potential in medical imaging analysis,including image diagnosis,classification,grading,guiding treatment and evaluating *** combination of the two can realize mass screening of grass-roots eye health,making it possible to seek medical treatment in the mode of“first treatment at the grass-roots level,two-way referral,emergency and slow treatment,and linkage between the upper and lower levels”.On the basis of summarizing the AI technology carried out by scholars and their teams all over the world in the field of ophthalmology,quite a lot of studies have confirmed that machine learning can assist in diagnosis,grading,providing optimal treatment plans and evaluating prognosis in corneal and conjunctival diseases,ametropia,lens diseases,glaucoma,iris diseases,*** paper systematically shows the application and progress of AI technology in common anterior segment ocular diseases,the current limitations,and prospects for the future.

关键词： artificial intelligence anterior segment ocular disease ametropia glaucoma

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A New Micropropagation Technology of Tilia amurensis:In VitroMicropropagation of Mature Zygotic Embryos and the Establishment of a PlantRegeneration System

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Phyton-International Journal of Experimental Botany 2024年第2期93卷 277-289页

作者： Shijie lin Zimo Wang Hongbo Zhu Conghui Wang Hongfeng Wang Dawei Zhang Tianbing Gou Guangdao Bao ye Luo Huaijiang He Zhonghui Zhang Jilin Provincial Academy of Forestry Sciences(Jilin Forestry Biological Control Central Station) Changchun130033China Institute of Forestry Inventory and Planning of Jilin Province Changchun130022China Jilin Forest Tree and Seeding Management Station Changchun130022China

Tilia amurensis is an economically valuable broadleaf tree species in Northeast *** production of *** varieties at commercial scales has been greatly limited by the low germination *** thus a pressing need to develop an organogenesis protocol for in vitro propagation of *** to alleviate ashortage of high-quality *** ***,we established a rapid in vitro propagation system *** from mature zygotic embryos and analyzed the effects of plant growth regulators and culture mediain different *** found that Woody plant medium(WPM)was the optimal primary culture medium formature zygotic *** highest callus induction percentage(68.76%)and number of axillary buds induced(3.2)were obtained in WPM+0.89μmol/L 6-benzyladenine(6-BA)+0.46μmol/L kinetin(KT)+0.25μmol/lindole-3-butryic acid(IBA)+1.44μmol/L gibberellin A_(3)(GA_(3)).The multiple shoot bud development achievedthe highest percentage(83.32%)in the Murashige and Skoog(MS)+2.22μmol/L 6-BA+0.25μmol/L IBA+1.44μmol/L GA_(3).The rooting percentage(96.70%)was highest in 1/2 MS medium+1.48μmol/L *** percentage of transplanting plantlets was 82.22%in soil:vermiculite:perlite(5:3:1).Our study is the firstto establish an effective organogenesis protocol for *** using mature zygotic embryos.

关键词： Tilia amurensis Rupr. mature zygotic embryo micropropagation adventitious bud multiplication rooting

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列宁对马赫主义的意识形态批判及其当代价值

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中南民族大学学报（人文社会科学版） 2024年第2期44卷 172-180,188页

作者：叶林武汉大学马克思主义学院湖北武汉430072

马赫主义在20世纪初的俄国产生了极大的消极影响:一方面作为一种“新哲学”学说,在哲学和自然科学领域造成了极大的思想混乱;另一方面作为一种新的社会思潮,引发了第一次民主革命失败后无产阶级内部的意识形态混乱、革命队伍涣散。为统... 详细信息

马赫主义在20世纪初的俄国产生了极大的消极影响:一方面作为一种“新哲学”学说,在哲学和自然科学领域造成了极大的思想混乱;另一方面作为一种新的社会思潮,引发了第一次民主革命失败后无产阶级内部的意识形态混乱、革命队伍涣散。为统一革命队伍的思想意志,使无产阶级革命运动重新纳入正常的运行轨道,列宁撰写《唯物主义和经验批判主义》,揭露了马赫主义的哲学与政治实质及其危害,对马赫主义作了哲学和政治意识形态批判,以马克思主义为指导,立足俄国革命实际,重构了科学的哲学和政治意识形态体系,清除了反动意识形态对革命者的侵害,统一了布尔什维克全党的意志,为新的革命高潮的到来和无产阶级十月革命的胜利积蓄了力量。列宁对马赫主义的批判,对当前中国认识意识形态领域内的复杂问题具有重要启示:必须绷紧政治意识形态这根弦,坚持马克思主义的指导地位,才能科学辨别各类错误意识形态,消除各种错误意识形态的干扰。

关键词：列宁《唯物主义和经验批判主义》哲学意识形态政治意识形态

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全面注册制下投资者保护的制度逻辑与发展方向

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证券市场导报 2024年第6期 3-14,69页

作者：叶林中国人民大学民商事法律科学研究中心/法学院北京100872

证券法无论采用发行核准制抑或注册制,都以保护投资者为立法宗旨。不同于核准制下的父爱主义保护元素,注册制表达的是“卖者尽责”下的“买者自负”理念,提高了资本形成效率,弱化了前端行政审核。全面实行注册制下投资者保护的制度逻辑... 详细信息

证券法无论采用发行核准制抑或注册制,都以保护投资者为立法宗旨。不同于核准制下的父爱主义保护元素,注册制表达的是“卖者尽责”下的“买者自负”理念,提高了资本形成效率,弱化了前端行政审核。全面实行注册制下投资者保护的制度逻辑发生转变,需要根据证券发行市场化的特点,结合证券发行、交易和责任的逻辑关系,重新梳理投资者保护的制度体系,明确投资者保护制度的发展方向:在前端,应当以证券发行信息披露为核心,强化发行人在信息披露中的第一责任人地位,避免证券监管机关过度介入证券发行,督促保荐人等中介机构切实履行“看门人”职责;在中端,应当引入“证券市场透明度”目标,形成“身份透明”“交易前透明”和“交易后透明”的交易机制,夯实证券市场公平交易的基础;在后端,则应完善证券执法结构,提升证券执法效率,提升民事救济措施的有效性。

关键词：注册制投资者保护证券监管证券执法

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Development of Machine Learning Methods for Accurate Prediction of Plant Disease Resistance

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Engineering 2024年第9期40卷 100-110页

作者： Qi Liu Shi-min Zuo Shasha Peng Hao Zhang ye Peng Wei Li yehui Xiong Runmao lin Zhiming Feng Huihui Li Jun Yang Guo-Liang Wang Houxiang Kang State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Zhongshan Biological Breeding Laboratory&Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding Agricultural College of Yangzhou UniversityYangzhou 225009China Hunan Provincial Key Laboratory of Crop Germplasm Innovation and Utilization and College of Agronomy Hunan Agricultural UniversityChangsha 410128China State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China College of Plant Protection Hunan Agricultural UniversityChangsha 410128China Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests Ministry of Education College of Plant ProtectionHainan UniversityHaikou 570228China MARA Key Laboratory of Surveillance and Management for Plant Quarantine Pests Department of Plant BiosecurityCollege of Plant ProtectionChina Agricultural UniversityBeijing 100193China Department of Plant Pathology Ohio State UniversityColumbusOH 43210USA

The traditional method of screening plants for disease resistance phenotype is both time-consuming and *** selection offers a potential solution to improve efficiency,but accurately predicting plant disease resistance remains a *** this study,we evaluated eight different machine learning(ML)methods,including random forest classification(RFC),support vector classifier(SVC),light gradient boosting machine(lightGBM),random forest classification plus kinship(RFC_K),support vector classification plus kinship(SVC_K),light gradient boosting machine plus kinship(lightGBM_K),deep neural network genomic prediction(DNNGP),and densely connected convolutional networks(DenseNet),for predicting plant disease *** results demonstrate that the three plus kinship(K)methods developed in this study achieved high prediction ***,these methods achieved accuracies of up to 95%for rice blast(RB),85%for rice black-streaked dwarf virus(RBSDV),and 85%for rice sheath blight(RSB)when trained and applied to the rice diversity panel I(RDPI).Furthermore,the plus K models performed well in predicting wheat blast(WB)and wheat stripe rust(WSR)diseases,with mean accuracies of up to 90%and 93%,*** assess the generalizability of our models,we applied the trained plus K methods to predict RB disease resistance in an independent population,rice diversity panel II(RDPII).Concurrently,we evaluated the RB resistance of RDPII cultivars using spray *** the predictions with the spray inoculation results,we found that the accuracy of the plus K methods reached 91%.These findings highlight the effectiveness of the plus K methods(RFC_K,SVC_K,and lightGBM_K)in accurately predicting plant disease resistance for RB,RBSDV,RSB,WB,and *** methods developed in this study not only provide valuable strategies for predicting disease resistance,but also pave the way for using machine learning to streamline genome-based crop breeding.

关键词： Predicting plant disease resistance Genomic selection Machine learning Genome-wide association study

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功能主义视野下的董事勤勉义务

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环球法律评论 2024年第1期46卷 59-73页

作者：叶林中国人民大学法学院

董事勤勉义务是一个抽象概念,要求董事在执行职务时做到善意、认真、尽职。为了引导董事做到勤勉尽责,新修订的《公司法》列明董事的勤勉义务,并规定董事执行职务时应当达到一般勤勉标准。但让董事概括承受违反勤勉义务所造成的公司损失... 详细信息

董事勤勉义务是一个抽象概念,要求董事在执行职务时做到善意、认真、尽职。为了引导董事做到勤勉尽责,新修订的《公司法》列明董事的勤勉义务,并规定董事执行职务时应当达到一般勤勉标准。但让董事概括承受违反勤勉义务所造成的公司损失,系漠视公司关系复杂性,将产生寒蝉效应或驱离效应,并可能会对经济发展产生一定影响。鉴于此,《公司法》的解释论应进一步明晰董事的行为标准,法官应尊重勤勉义务的一般行为标准,并在个案审判中保持适度宽容,逐渐发展一套合乎商业逻辑的司法审查标准。一个良好的董事勤勉义务体系,应当接纳行为标准和审查标准的二元结构,尊重不同董事之间的功能差异,公司应当概括承受董事履职风险,董事仅在限定条件下承担赔偿责任。

关键词：董事勤勉义务董事功能行为标准审查标准赔偿责任

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Modified hepatic left lateral lobe inversion in laparoscopic proximal gastrectomy: An analysis of 13 cases

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 2853-2859页

作者： Jian-An lin Chu-Ying Wu Kai ye Department of Gastrointestinal Surgery The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina

BACKGROUND In laparoscopic proximal gastrectomy(LPG),the prolapse of the hepatic left lateral lobe near the lesser curvature and esophageal hiatus can obstruct the field of vision and ***,it is necessary to retract or obstruct the hepatic left lateral lobe to ensure a clear field of *** To investigate the safety and clinical efficacy of the modified hepatic left lateral lobe inversion technique for *** A retrospective analysis was conducted on the clinical data of 13 consecutive patients with early-stage upper gastric adenocarcinoma or adenocarcinoma of the esophagogastric junction treated with LPG from January to December 2023 at the Department of Gastrointestinal Surgery,Second Affiliated Hospital of Fujian Medical *** modified hepatic left lateral lobe inversion technique was used to expose the surgical field in all patients,and short-term outcomes were *** In all 13 patients,the modified hepatic left lateral lobe inversion technique was successful during surgery without the need for re-retraction or alteration of the liver traction *** were no instances of esophageal hiatus occlusion,eliminating the need for forceps to assist in *** was no occurrence of intraoperative hepatic hemorrhage,hepatic vein injury,or hepatic *** postoperative digestive complications of Clavien-Dindo grade≥II occurred wi-thin 30 days after surgery,except for a single case of pulmonary *** patients experienced increases in alanine aminotransferase and aspartate aminotransferase levels on the first day after surgery,which significantly decreased by the third day and returned to normal by the seventh day after *** The modified hepatic left lateral lobe inversion technique has demonstrated satisfactory results,offering ad-vantages in terms of facilitating surgical procedures,reducing surgical trauma,and protecting the liver.

关键词： Hepatic left lateral lobe Inversion technique Laparoscopy Proximal gastrectomy Liver injury

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Enhancing pediatric asthma management through multifaceted health education

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World Journal of Clinical Cases 2024年第19期12卷 3708-3716页

作者： Guang-Qun lin Zu-Qiong ye En-Lian Song Yu-Nan lin Department of Pediatrics First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Day Surgery Ward First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Anesthesia&Operation Center First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Pediatric asthma is a significant public health issue that impacts the quality of life of children *** management approaches focus on symptom control and medication adherence but often overlook the comprehensive educational needs of patients and their families.A multifaceted health education approach may offer a more holistic strategy in managing pediatric asthma,especially in outpatient *** To evaluate the efficacy of a comprehensive health education strategy in improving disease management,medication adherence,and quality of life among children with asthma in outpatient *** In total,100 pediatric patients with severe asthma were enrolled from January 2021 to November 2022 and randomly allocated to a control group(n=50)or an observation group(n=50).The control group received standard nursing care,including basic nursing interventions and health education upon *** contrast,the observation group was exposed to a broad spectrum of health education methodologies,including internet-based hospital systems,social media channels,one-on-one verbal education,informational brochures,slide present ations,telephone check-ins,animated videos,and illustrated health education *** on asthma management knowledge,symptom control,quality of life[***’s Respiratory Questionnaire(SGRQ)],treatment adherence,and nursing satisfaction were collected and *** The scores of the observation group in knowledge areas,such as medication,home care,disease understanding,symptom management,prevention strategies,and nutritional guidance,were significantly higher than those of the control group(P<0.05).In addition,the observation group exhibited greater symptom control,improved quality of life based on their SGRQ scores,and higher treatment adherence post-intervention(P<0.05).Nursing satisfaction was also rated higher in the observation group across all evaluated areas(P<0.05).CONCLUSION Implementing a diversified hea

关键词： Multifaceted health education mode Pediatrics Outpatient service Bronchial asthma

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