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Expression and significance of pigment epithelium-derived factor and vascular endothelial growth factor in colorectal adenoma and cancer

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 670-686页

作者： ye Yang Wu Wen Feng-lin Chen Ying-Jie Zhang Xiao-Cong Liu Xiao-Yan Yang Shan-Shan Hu ye Jiang Jing Yuan Digestive Diseases Chengdu Qingbaijiang District People's HospitalChengdu 610300Sichuan ProvinceChina Digestive Diseases Chengdu Second People’s HospitalChengdu 610000Sichuan ProvinceChina Graduate School Chengdu Medical CollegeChengdu 610000Sichuan ProvinceChina

BACKGROUND The incidence and mortality of colorectal cancer(CRC)are among the highest in the world,and its occurrence and development are closely related to tumor *** the balance between pigment epithelium-derived factors(PEDF)that inhibit angiogenesis and vascular endothelial growth factors(VEGF)that stimulate angiogenesis is broken,angiogenesis is out of control,resulting in tumor ***,it is very necessary to find more therapeutic targets for CRC for early intervention and later *** To investigate the expression and significance of PEDF,VEGF,and CD31-stained microvessel density values(CD31-MVD)in normal colorectal mucosa,adenoma,and *** In this case-control study,we collected archived wax blocks of specimens from the Digestive Endoscopy Center and the General Surgery Department of Chengdu Second People's Hospital from April 2022 to October *** cases of specimen wax blocks were selected as normal intestinal mucosa confirmed by electronic colonoscopy and concurrent biopsy(normal control group),50 cases of specimen wax blocks were selected as colorectal adenoma confirmed by electronic colonoscopy and pathological biopsy(adenoma group),and 50 cases of specimen wax blocks were selected as CRC confirmed by postoperative pathological biopsy after inpatient operation of general surgery(CRC group).An immunohistochemical staining experiment was carried out to detect PEDF and VEGF expression in three groups of specimens,analyze their differences,study the relationship between the two and clinicopathological factors in CRC group,record CD31-MVD in the three groups,and analyze the correlation of PEDF,VEGF,and CD31-MVD in the colorectal adenoma group and the CRC *** F test or adjusted F test is used to analyze measurement data ***-Wallis rank sum test was used between groups for ranked *** chi-square test,adjusted chi-square test,or Fisher's exact test were used to compare the rates betwe

关键词： Pigment epithelium-derived factors Vascular endothelial growth factor Microvessel density Colorectal adenoma Colorectal cancer Targeted therapy

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Restoring force model of assembled piers connected with grouting sleeves and a mortise hybrid joint

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Journal of Traffic and Transportation Engineering(English Edition) 2024年

作者： Shangshun lin Jianshuai Zhang Zhiqing Qin Shiji ye Jinbing Zhao Fujian Provincial Key Laboratory of Advanced Technology and Information in Civil Engineering， Fujian University of Technology Fujian Communications Planning & Design Institute Co.，Ltd. 3. Haoyao Times (Fujian) Group Co.，Ltd.

In order to investigate the simplified calculation method of the rebound model of the grouted sleeve and mortise-and-tenon hybrid-connected assembled reinforced concrete piers， quasi-static tests were conducted on three types of piers: cast-in-place piers (SZT-1)， single-span assembled piers (SG-1)， and double-span assembled piers (SGT-1). It was found that the damage modes and seismic performance of the SGT-1 specimens were similar to those of SG-1， while the seismic performance of the hybrid-connected assembled piers was better than that of SZT-1. Parametric analyses were carried out using experimentally-validated finite-element models to investigate the effects of parameters such as axial compression ratio， slenderness ratio， longitudinal reinforcement ratio， concrete strength， and the dimensions and materials of the protruding tenon and steel pipe on the seismic performance of the piers. In addition， the skeleton curve eigenvalue formula and rebound model are proposed， which can be used for elastic-plastic analysis and calculation of hybrid connection assembled piers.

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Paradoxical herniation associated with hyperbaric oxygen therapy after decompressive craniectomy: A case report

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World Journal of Clinical Cases 2024年第10期12卷 1793-1798页

作者： Zhong-Xing ye Xin-Xin Fu Yang-Zong Wu ling lin Liang-Qi Xie Yu-ling Hu Yi Zhou Zhu-Gui You Hai lin Department of Neurosurgery The Second People's Hospital of Fujian Province(The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine)Fuzhou 350001Fujian ProvinceChina Department of Neurosurgery The Second Hospital of LongyanLongyan 364000Fujian ProvinceChina Department of Neurosurgery Zhangping City HospitalLongyan 364400Fujian ProvinceChina

BACKGROUND Whether hyperbaric oxygen therapy(HBOT)can cause paradoxical herniation is still *** SUMMARY A 65-year-old patient who was comatose due to brain trauma underwent decompressive craniotomy and gradually regained consciousness after *** was administered 22 d after surgery due to speech *** herniation appeared on the second day after treatment,and the patient’s condition worsened after receiving mannitol treatment at the rehabilitation *** timely skull repair,the paradoxical herniation was resolved,and the patient regained consciousness and had a good recovery as observed at the follow-up *** Paradoxical herniation is rare and may be caused by ***,the underlying mechanism is unknown,and the understanding of this phenomenon is *** use of mannitol may worsen this *** skull repair can treat paradoxical herniation and prevent serious complications.

关键词： Decompressive craniectomy Hyperbaric oxygen therapy Mannitol Paradoxical herniation Case report

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BBX9 forms feedback loops with PIFs and BBX21 to promote photomorphogenic development

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Journal of Integrative Plant Biology 2024年第9期66卷 1934-1952页

作者： Zhaoqing Song Wanying ye Qing Jiang Huan lin Qing Hu Yuntao Xiao yeting Bian Fengyue Zhao Jie Dong Dongqing Xu State Key Laboratory of Crop Genetics&Germplasm Enhancement and Utilization National Center for Soybean ImprovementCollege of AgricultureNanjing Agricultural UniversityNanjing 210095China Institute of Crop Science College of Agriculture and BiotechnologyZhejiang UniversityHangzhou 310058China

Light is one of the most essential environmental factors that tightly and precisely control various physiological and developmental processes in plants.B-box CONTAINING PROTEINs(BBXs)play central roles in the regulation of light-dependent *** this study,we report that BBX9 is a positive regulator of light ***9 interacts with the red light photoreceptor PHYTOCHROME B(phyB)and transcription factors PHYTOCHROME-INTERACTING FACTORs(PIFs).phyB promotes the stabilization of BBX9 in light,while BBX9 inhibits the transcriptional activation activity of *** turn,PIFs directly bind to the promoter of BBX9 to repress its *** the other hand,BBX9 associates with the positive regulator of light signaling,BBX21,and enhances its biochemical ***21 associates with the promoter regions of BBX9 and transcriptionally up-regulates its ***,this study unveiled that BBX9 forms a negative feedback loop with PIFs and a positive one with BBX21 to ensure that plants adapt to fluctuating light conditions.

关键词： Arabidopsis BBX21 BBX9 light signaling photo-morphogenesis phyB PIF

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Sorely reducing emissions of non-methane short-lived climate forcers will worsen compound flood-heatwave extremes in the Northern Hemisphere

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Advances in Climate Change Research 2024年第4期15卷 737-750页

作者： Ying-Fang LI Zhi-Li WANG Ya-Dong LEI Xiao-Chao YU lin LIU Hui-Zheng CHE Xiao-ye ZHANG State Key Laboratory of Severe Weather and Key Laboratory of Atmospheric Chemistry of China Meteorological Administration Chinese Academy of Meteorological SciencesBeijing 100081China University of Chinese Academy of Sciences Beijing 100190China

Non-methane short-lived climate forcer(SLCF)or near-term climate forcer(NTCF)emissions,as a significant driver of climate change,can be reduced to improve air *** reductions may contribute to additional warming of the climate system in the short term,thereby strongly affecting the likelihood of climate ***,there has been no quantitative assessment of the impact of non-methane SLCF mitigation on compound flood-heatwave extremes(CFHEs).This study quantitatively investigates the changes in future(2031-2050 versus 1995-2014)CFHEs and the resulting population exposure in the Northern Hemisphere(NH)due to non-methane SLCF *** used multi-model ensemble simulations under two future scenarios from the Aerosol and Chemistry Model Intercomparison Project(AerChemMIP)in the Coupled Model Intercomparison Project Phase 6(CMIP6).The two future scenarios share the same greenhouse gas(GHG)emissions but have weak(Shared Socioeconomic Pathway(SSP)3-7.0)versus strong(SSP3-7.0-lowNTCF)levels of air quality control *** results show that future non-methane SLCF reductions during 2031-2050 results in about a 7.3%±2.3%increase in grid exposure to CFHEs in the NH relative to the period *** frequency,intensity,and duration of CFHEs increase by varying *** the period 2031-2050,the frequency of CFHEs across the NH increases by 2.9±0.9 events per decade due to non-methane SLCF *** increases in CFHE frequency are more pronounced in East Asia,South Asia,Siberia,and northern and eastern North *** East and South Asia,the in-tensities of both heatwaves and floods corresponding to CFHEs increase markedly,where heatwave magnitude(HWM)increases by 0.3±0.2 K in East Asia and weighted average precipitation(WAP)increases by 18.3%±15.3%and 12.0%±4.5%in East Asia and South Asia,*** other regions,rising temperatures dominate the increase in *** regard to the duration of CFHEs,future reductions in non-methane SLC

关键词： Non-methane SLCFs CHFEs Cleaner air Population exposure

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Efficacy of Ca/ZSM-5 zeolites derived from precipitated calcium carbonate in the methanol-to-olefin process

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Chinese Journal of Structural Chemistry 2024年第4期43卷 31-38页

作者： Xinyu You Xin Zhang Shican Jiang Yiru ye lin Gu Hexun Zhou Pandong Ma Jamal Ftouni Abhishek Dutta Chowdhury College of Chemistry and Molecular Sciences Wuhan UniversityWuhan430072PR China Omya International AG Froschackerstrasse 64622EgerkingenSwitzerland

In the context of heightened environmental consciousness and the growing demand for light olefins,this study explores the promising future prospects for their sustainable production from renewable *** olefins(especially propylene)are a pivotal constituent of the petrochemical industry,and their demand is poised for steady growth driven by various sectors(e.g.,electric mobility,consumer goods and packaging industries),which should not rely solely on traditional petroleum-led ***,sustainable pathways,such as the methanol-to-olefin(MTO)process catalyzed by zeolites,are gaining *** to couple the future olefin demands with the concept of a"methanol economy",this study investigates the synthesis of hierarchical Ca/ZSM-5 zeolites using a cost-effective approach involving Precipitated Calcium Carbonate(PCC)as a hard template,leading to superior catalytic *** characterization techniques are employed to elucidate the cata-lyst's properties,highlighting the dual importance of mesoporosity and calcium species in optimizing its *** spectroscopy provides in-depth insights into its enhanced anti-coking *** research contributes to expanding the catalyst toolkit for zeolite-catalyzed MTO processes,focusing on propylene production,thereby addressing the increasing demand for light olefins while promoting sustainability and circular economy principles.

关键词： Hierarchical zeolite Propylene Precipitated calcium carbonate Methanol-to-olefins Characterization

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Thermally modulated photoelectronic synaptic behavior in HfS_(2)/VO_(2) heterostructure

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Rare Metals 2024年第8期43卷 3798-3809页

作者： Le Wang lin Wang Xiao-Yun ye Xiong-Hu Xu Li-Yan Shang Ya-Wei Li Jin-Zhong Zhang Liang-Qing Zhu Zhi-Gao Hu Technical Center for Multifunctional Magneto-Optical Spectroscopy(Shanghai) Engineering Research Center of Nanophotonics&Advanced Instrument(Ministry of Education)Department of PhysicsSchool of Physics and Electronic ScienceEast China Normal UniversityShanghai 200241China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China

Neuromorphic computing is known for its efficient computational speed,low latency,and reduced power consumption,which is considered a pivotal technology to overcome the von Neumann *** synapses are an indispensable component of neuromorphic computational artificial neural *** guarantee effective and precise processing of optical signals,it must have a high responsivity,detectivity,and the ability to adapt to various ***,a synaptic transistor based on the HfS_(2)/VO_(2) heterojunction with a responsivity of8.6×10^(3) A·W^(-1)and a detectivity of 1.26×10^(14)Jones at405 nm laser was ***,the typical synaptic behavior was successfully simulated,including postsynaptic currents(PSCs),the transition from shortterm plasticity(STP)to long-term plasticity(LTP).When VO_(2) converts from the semiconductor state to the metal state,the HfS_(2)/VO_(2) heterojunction transforms into a Schottky heterojunction from a TypeⅡheterojunction with ***'s important,the heterojunction still exhibits excellent responsivity and detectivity,as well as stability of synaptic *** addition,the classical Pavlovian conditioning experiment is simulated under different laser intensity to study the brain's associative learning *** results demonstrate that the HfS_(2)/VO_(2) heterojunction synapse exhibits significant responsivity and detectivity and is adaptable to high-temperature environments,showing great potential for neuromorphic computational applic ations.

关键词： HfS_(2) VO_(2) Phase transition Photoelectric synapse Heterojunction

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Mitigating Lattice Distortion of High‑Voltage LiCoO_(2)via Core‑Shell Structure Induced by Cationic Heterogeneous Co‑Doping for Lithium‑Ion Batteries

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Nano-Micro Letters 2024年第3期16卷 169-182页

作者： Zezhou lin Ke Fan Tiancheng Liu Zhihang Xu Gao Chen Honglei Zhang Hao Li Xuyun Guo Xi Zhang ye Zhu Peiyu Hou Haitao Huang Department of Applied Physics and Research Institute for Smart Energy The Hong Kong Polytechnic UniversityHong KongPeople’s Republic of China Department of Applied Physics The Hong Kong Polytechnic UniversityHong KongPeople’s Republic of China Institute of Nanosurface Science and Engineering Guangdong Provincial Key Laboratory of Micro/Nano Optomechatronics EngineeringShenzhen UniversityShenzhenPeople’s Republic of China School of Physics and Technology University of JinanJinanShandongPeople’s Republic of China

Inactive elemental doping is commonly used to improve the structural stability of high-voltage layered transition-metal oxide ***,the one-step co-doping strategy usually results in small grain size since the low diffusivity ions such as Ti^(4+)will be concentrated on grain boundaries,which hinders the grain *** order to synthesize large single-crystal layered oxide cathodes,considering the different diffusivities of different dopant ions,we propose a simple two-step multi-element co-doping strategy to fabricate core–shell structured LiCoO_(2)(CS-LCO).In the current work,the high-diffusivity Al^(3+)/Mg^(2+)ions occupy the core of single-crystal grain while the low diffusivity Ti^(4+)ions enrich the shell *** Ti^(4+)-enriched shell layer(~12 nm)with Co/Ti substitution and stronger Ti–O bond gives rise to less oxygen ligand ***-situ XRD demonstrates the constrained contraction of c-axis lattice parameter and mitigated structural *** a high upper cut-off voltage of 4.6 V,the single-crystal CS-LCO maintains a reversible capacity of 159.8 mAh g^(−1)with a good retention of~89%after 300 cycles,and reaches a high specific capacity of 163.8 mAh g^(−1)at *** proposed strategy can be extended to other pairs of low-(Zr^(4+),Ta^(5+),and W6+,etc.)and high-diffusivity cations(Zn^(2+),Ni^(2+),and Fe^(3+),etc.)for rational design of advanced layered oxide core–shell structured cathodes for lithium-ion batteries.

关键词： Lithium-ion battery LiCoO_(2) Heterogeneous co-doping Core-shell structure High-voltage stability

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警告刺激对驾驶员接管性能的影响机理研究

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交通运输系统工程与信息 2024年第1期24卷 106-114页

作者：王丹林业天津科技大学机械工程学院天津300457

为研究不同模态警告刺激对接管性能的影响机理,本文重点关注在不同非驾驶相关任务和触发场景下,单一模态和双模态警告刺激对驾驶员的预警效果。搭建不同警告刺激下,驾驶员接管车辆控制权的台架试验,采集49名驾驶员的眼动数据与车辆数据... 详细信息

为研究不同模态警告刺激对接管性能的影响机理,本文重点关注在不同非驾驶相关任务和触发场景下,单一模态和双模态警告刺激对驾驶员的预警效果。搭建不同警告刺激下,驾驶员接管车辆控制权的台架试验,采集49名驾驶员的眼动数据与车辆数据,并开展显著性影响分析。研究结果表明,警告类型对接管时间和首次注视时间有显著影响,从事非驾驶相关任务对驾驶员的接管时间产生负面影响,双模态警告刺激的首次注视时间低于单一模态的首次注视时间。在视觉和触觉警告刺激下,非驾驶相关任务下的最大横向加速度为0.36 m·s^(-2),监控任务下为0.34 m·s^(-2),相对其他警告刺激,横向加速度最小,车辆接管更稳定,接管质量最高。双模态警告刺激的横摆角整体小于单一模态警告刺激,车辆更加稳定,而在单一模态警告刺激下,视觉警告刺激的最大横向加速度为0.45 m·s^(-2),相对其他警告刺激,横向加速度最大,接管绩效最差。不同模态警告刺激对接管方式无显著影响。双模态的警告刺激类型相较于单一模态而言,更加依赖于多种感官效果,提供更全面和更准确的警示信息,特别是与驾驶员身体接触的触觉振动警告方式。

关键词：智能交通警告刺激双因素方差分析人机接管眼动数据车辆动力学

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Emerging multimodal memristors for biorealistic neuromorphic applications

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Materials Futures 2024年第1期3卷 128-141页

作者： Xuanyu Shan Ya lin Zhongqiang Wang Xiaoning Zhao ye Tao Haiyang Xu Yichun Liu Key Laboratory of UV-Emitting Materials and Technology of Ministry of Education Northeast Normal UniversityChangchunPeople’s Republic of China

The integration of sensory information from different modalities,such as touch and vision,is essential for organisms to perform behavioral functions such as decision-making,learning,and *** implementation of human multi-sensory perception using electronic supports is of great significance for achieving efficient human–machine *** to their structural and functional similarity with biological synapses,memristors are emerging as promising nanodevices for developing artificial neuromorphic *** devices can sense multidimensional signals including light,pressure,and *** in-sensor computing architecture represents an ideal platform for efficient multimodal *** review recent progress in multimodal memristive technology and its application to neuromorphic perception of complex stimuli carrying visual,olfactory,auditory,and tactile *** the device level,the operation model and undergoing mechanism have also been ***,we discuss the challenges and prospects associated with this rapidly progressing field of research.

关键词： multimodal memristor neuromorphic perception in-sensor computing

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