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Bioinformatic identification of key candidate genes and pathways in axon regeneration after spinal cord injury in zebrafish

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Neural Regeneration Research 2020年第1期15卷 103-111页

作者： Jia-He Li Zhong-Ju shi Yan Li Bin Pan shi-Yang Yuan lin-lin shi Yan Hao Fu-Jiang Cao shi-Qing Feng Department of Orthopedics Tianjin Medical University General HospitalTianjinChina Department of Orthopedics the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Tianjin Neurological Institute Key Laboratory of Post-Neuroinjury Neurorepair and Regeneration in Central Nervous SystemMinistry of Education and Tianjin CityTianjinChina

Zebrafish and human genomes are highly homologous;however,despite this genomic similarity,adult zebrafish can achieve neuronal proliferation,regeneration and functional restoration within 6–8 weeks after spinal cord injury,whereas humans *** analyze differentially expressed zebrafish genes between axon-regenerated neurons and axon-non-regenerated neurons after spinal cord injury,and to explore the key genes and pathways of axonal regeneration after spinal cord injury,microarray GSE56842 was analyzed using the online tool,GEO2R,in the Gene Expression Omnibus *** ontology and protein-protein interaction networks were used to analyze the identified differentially expressed ***,we screened for genes and pathways that may play a role in spinal cord injury repair in zebrafish and mammals.A total of 636 differentially expressed genes were obtained,including 255 up-regulated and 381 down-regulated differentially expressed genes in axon-regenerated *** Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment results were also obtained.A protein-protein interaction network contained 480 node genes and 1976 node *** also obtained the 10 hub genes with the highest correlation and the two modules with the highest *** results showed that spectrin may promote axonal regeneration after spinal cord injury in *** growth factor beta signaling may inhibit repair after spinal cord injury in *** adhesion or tight junctions may play an important role in the migration and proliferation of some cells,such as Schwann cells or neural progenitor cells,after spinal cord injury in *** analysis identified key candidate genes and pathways in axonal regeneration after spinal cord injury in zebrafish,providing targets for treatment of spinal cord injury in mammals.

关键词： axonal regeneration differentially expressed genes focal adhesions Gene Ontology Kyoto Encyclopedia of Genes and Genomes neural regeneration protein-protein interaction network signaling pathway spectrin tight junctions transforming growth factor beta Wnt signaling pathway

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Preoperative prediction of macrotrabecular-massive hepatocellular carcinoma through dynamic contrast-enhanced magnetic resonance imaging-based radiomics

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World Journal of Gastroenterology 2023年第13期29卷 2001-2014页

作者： Yang Zhang Dong He Jing Liu Yu-Guo Wei lin-lin shi Cancer Center Department of RadiologyZhejiang Provincial People's HospitalAffiliated People's HospitalHangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina Precision Health Institution General Electric HealthcareHangzhou 310014Zhejiang ProvinceChina Department of Gastroenterology Zhejiang Hospital of Integrated Traditional Chinese and Western MedicineHangzhou 310005Zhejiang ProvinceChina

BACKGROUND Macrotrabecular-massive hepatocellular carcinoma(MTM-HCC)is closely related to aggressive phenotype,gene mutation,carcinogenic pathway,and immunohistochemical markers and is a strong independent predictor of early recurrence and poor *** the development of imaging technology,successful applications of contrast-enhanced magnetic resonance imaging(MRI)have been reported in identifying the MTM-HCC ***,as an objective and beneficial method for tumour evaluation,is used to convert medical images into high-throughput quantification features that greatly push the development of precision *** To establish and verify a nomogram for preoperatively identifying MTM-HCC by comparing different machine learning *** This retrospective study enrolled 232(training set,162;test set,70)hepatocellular carcinoma patients from April 2018 to September 2021.A total of 3111 radiomics features were extracted from dynamic contrast-enhanced MRI,followed by dimension reduction of these *** regression(LR),K-nearest neighbour(KNN),Bayes,Tree,and support vector machine(SVM)algorithms were used to select the best radiomics *** used the relative standard deviation(RSD)and bootstrap methods to quantify the stability of these five *** algorithm with the lowest RSD represented the best stability,and it was used to construct the best radiomics *** logistic analysis was used to select the useful clinical and radiological features,and different predictive models were ***,the predictive performances of the different models were assessed by evaluating the area under the curve(AUC).RESULTS The RSD values based on LR,KNN,Bayes,Tree,and SVM were 3.8%,8.6%,4.3%,17.7%,and 17.4%,***,the LR machine learning algorithm was selected to construct the best radiomics signature,which performed well with AUCs of 0.766 and 0.739 in the training and test sets,*** the mul

关键词： Hepatocellular carcinoma Macrotrabecular-massive subtype Algorithms Radiomics Models Nomogram

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无模型SISO时滞系统的PID参数稳定域研究

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控制理论与应用 2009年第4期26卷 443-445页

作者：林示麟欧林林俞立浙江工业大学信息工程学院浙江杭州310032

针对无精确模型的单输入单输出(SISO)时滞系统,利用频率响应数据,给出确定PID参数稳定域的解析方法.首先通过继电反馈频域辨识法得到系统的频率响应数据,然后基于该数据确定控制参数的奇异边界线和非奇异边界线,并判断边界线的哪一侧具... 详细信息

针对无精确模型的单输入单输出(SISO)时滞系统,利用频率响应数据,给出确定PID参数稳定域的解析方法.首先通过继电反馈频域辨识法得到系统的频率响应数据,然后基于该数据确定控制参数的奇异边界线和非奇异边界线,并判断边界线的哪一侧具有更少的不稳定极点,从而给出能使闭环系统稳定的控制参数区域.该方法避免了模型辨识的复杂计算过程,为无模型SISO时滞系统的PID控制器设计和调节提供了一条简单有效的途径.仿真结果验证了方法的有效性。

关键词：单输入单输出系统时滞频率响应 PID参数稳定域

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High Fe‑Loading Single‑Atom Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy

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Nano-Micro Letters 2025年第2期17卷 187-203页

作者： Si Chen Fang Huang Lijie Mao Zhimin Zhang Han lin Qixin Yan Xiangyu Lu Jianlin shi Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic Medicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-atom catalysts(SACs)for medicine still suffer from the limited active site ***,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with *** constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial ***,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading ***,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/*** addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)*** in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound *** work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.

关键词： Nanocatalytic medicine Single-atom catalysts Reactive oxygen species(ROS) High metal loading Oxidase catalysis

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Bidirectional regulation of the brain-gut-microbiota axis following traumatic brain injury

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Neural Regeneration Research 2025年第8期20卷 2153-2168页

作者： Xinyu You lin Niu Jiafeng Fu shining Ge Jiangwei shi Yanjun Zhang Pengwei Zhuang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjinChina Haihe Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina First Teaching Hospital of Tianjin University of Traditional Chinese Medicine TianjinChina National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion TianjinChina

Traumatic brain injury is a prevalent disorder of the central nervous *** addition to primary brain parenchymal damage,the enduring biological consequences of traumatic brain injury pose long-term risks for patients with traumatic brain injury;however,the underlying pathogenesis remains unclear,and effective intervention methods are *** dysfunction is a significant consequence of traumatic brain *** the most densely innervated peripheral tissue in the body,the gut possesses multiple pathways for the establishment of a bidirectional“brain-gut axis”with the central nervous *** gut harbors a vast microbial community,and alterations of the gut niche contribute to the progression of traumatic brain injury and its unfavorable prognosis through neuronal,hormonal,and immune pathways.A comprehensive understanding of microbiota-mediated peripheral neuroimmunomodulation mechanisms is needed to enhance treatment strategies for traumatic brain injury and its associated *** comprehensively reviewed alterations in the gut microecological environment following traumatic brain injury,with a specific focus on the complex biological processes of peripheral nerves,immunity,and microbes triggered by traumatic brain injury,encompassing autonomic dysfunction,neuroendocrine disturbances,peripheral immunosuppression,increased intestinal barrier permeability,compromised responses of sensory nerves to microorganisms,and potential effector nuclei in the central nervous system influenced by gut ***,we reviewed the mechanisms underlying secondary biological injury and the dynamic pathological responses that occur following injury to enhance our current understanding of how peripheral pathways impact the outcome of patients with traumatic brain *** review aimed to propose a conceptual model for future risk assessment of central nervous system-related diseases while elucidating novel insights into the bidirectional effec

关键词： traumatic brain injury brain-gut-microbiome axis gut microbiota neuroimmune immunosuppression host defense vagal afferents bacterial infection dorsal root ganglia nociception neural circuitry

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基于区域划分的声定位算法及精度分析

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吉林大学学报（工学版） 2017年第1期47卷 288-293页

作者：崔林林宋萍石庚辰北京理工大学智能机器人研究所北京100081

针对当前基于TDOA(波达时间差)的空间交汇声定位算法中,在整个定位区域采用单一的定位算法的不足,提出了一种基于区域划分的声定位算法。在定位区域内布设4个六元阵,根据区域误差均值最小的原则,确定基阵的各个参数,并将该区域划分成16... 详细信息

针对当前基于TDOA(波达时间差)的空间交汇声定位算法中,在整个定位区域采用单一的定位算法的不足,提出了一种基于区域划分的声定位算法。在定位区域内布设4个六元阵,根据区域误差均值最小的原则,确定基阵的各个参数,并将该区域划分成16个子区域,每个子区域将采取不同的定位算法。以炮竹作为声源,在北京郊区的一块200m×200m的定位区域中随机选取3个声源点,每个点重复实验3次,每个点的定位误差均小于1m。

关键词：通信技术波达时间差空间交汇区域划分六元阵

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Design of multifunctional interfaces on ceramic solid electrolytes for high-performance lithium-air batteries

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Green Energy & Environment 2025年第1期10卷 183-192页

作者： Yunxin shi Ziyang Guo Changhong Wang Mingze Gao Xiaoting lin Hui Duan Yonggang Wang Xueliang Sun College of Energy Material and Chemistry College of Chemistry and Chemical EngineeringInner Mongolia UniversityHohhot010021China Department of Mechanical and Materials Engineering Western UniversityLondonONN6A 5B9Canada Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institute of New EnergyiChEM(Collaborative Innovation Center of Chemistry for Energy Materials)Fudan UniversityShanghai200433China Eastern Institute for Advanced Study Eastern Institute of TechnologyNingboZhejiang315100China

High-energy-density lithium(Li)–air cells have been considered a promising energy-storage system,but the liquid electrolyte-related safety and side-reaction problems seriously hinder their *** address these above issues,solid-state Li–air batteries have been widely ***,many commonly-used solid electrolytes generally face huge interface impedance inLi–air cells and also showpoor stability towards ambient air/Li ***,we fabricate a differentiating surface-regulated ceramic-based composite electrolyte(DSCCE)by constructing disparately LiI-containing polymethyl methacrylate(PMMA)coating and Poly(vinylidene fluoride-co-hexafluoropropylene)(PVDF-HFP)layer on both sides of Li_(1.5)Al_(0.5)Ge_(1.5)(PO_(4))_(3)(LAGP).The cathode-friendly LiI/PMMA layer displays excellent stability towards superoxide intermediates and also greatly reduces the decomposition voltage of discharge products in Li–air ***,the anode-friendly PVDF-HFP coating shows low-resistance properties towards ***,Li dendrite/passivation derived from liquid electrolyte-induced side reactions and air/I-attacking can be obviously suppressed by the uniformand compact composite *** a result,the DSCCE-based Li–air batteries possess high capacity/low voltage polarization(11,836mAh g^(-1)/1.45Vunder 500mAg^(-1)),good rate performance(capacity ratio under 1000mAg^(-1)/250mAg^(-1) is 68.2%)and longterm stable cell operation(~300 cycles at 750 mA g^(-1) with 750 mAh g^(-1))in ambient air.

关键词： Li-air batteries Li_(1.5)Al_(0.5)Ge_(1.5)(PO_(4))_(3) Polymers Composite electrolyte Ambient air

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植物源农药研发及中药材生产中的应用现状

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中国中药杂志 2016年第19期41卷 3579-3586页

作者：张鹏李西文董林林陈士林中国中医科学院中药研究所北京100700

中药农残和重金属超标等问题是制约中药材产业健康发展的瓶颈,与传统化学农药相比,以植物源农药为代表的生物农药安全、环保,有利于中药材的无公害生产和质量提高。目前植物源农药在政策利好和市场需求升温的契机下迎来重大发展机遇,尽... 详细信息

中药农残和重金属超标等问题是制约中药材产业健康发展的瓶颈,与传统化学农药相比,以植物源农药为代表的生物农药安全、环保,有利于中药材的无公害生产和质量提高。目前植物源农药在政策利好和市场需求升温的契机下迎来重大发展机遇,尽管基础研究薄弱,因其低毒安全和生态无污染,未来发展空间巨大。该文综述了中药材生产中植物源农药研发的发展现状,并针对现存的问题和挑战提出了策略性建议。植物源农药的研发有望成为解决中药材农残和重金属超标问题的利器,促进中药产业源头的健康发展。

关键词：植物源农药中药材生产农残植物资源

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Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

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Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： Xihang Chen Zhifeng Chen Menghua Li Weiwei Guo Shuolong Yuan Liangwei Xu Chang lin Xi shi Wei Chen shiming Yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and Balance Science BeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory ***,there are currently no effective pharmacological interventions for patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 d B for 4 *** found that tranylcypromine treatment led to the upregulation of Sestrin2(SESN2)and activation of the autophagy markers light chain 3B and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with *** noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz frequencies compared with the noise exposure group treated with *** findings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3B,and lysosome-associated membrane glycoprotein 1 expression after noise exposure,leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of NOD-like receptor family pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2,which induced autophagy,thereby restricting NLRP3-related inflammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** findings suggest that inhibiting lysine-specific demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine

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一种改进的Web访问日志数据预处理算法

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计算机工程与应用 2006年第A1期42卷 101-104页

作者：林源泽林世平福州大学数学与计算机科学学院福州350002

数据预处理是Web使用挖掘的一个关键环节,其结果直接影响到后续的事务识别、路径分析、关联规则挖掘和序列模式挖掘的结果。提出了一种用户识别的通用算法、路径补充的启发式策略和基于主题规约的方法,并用实验证明了其高效性。

关键词： Web使用挖掘数据预处理用户识别会话识别路径补充主题规约

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