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Severe pediatric COVID‑19:a review from the clinical and immunopathophysiological perspectives

World Journal of Pediatrics 2024年第4期20卷 307-324页

作者： Yi‑Kan Sun Can Wang Pei‑Quan lin Lei Hu Jing Ye Zhi‑Gang Gao Ru lin Hao‑Min Li Qiang Shu Li‑Su huang lin‑hua tan Children's Hospital Zhejiang University School of MedicineHangzhou 310052China The Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310030China Surgical Intensive Care Unit Children’s HospitalZhejiang University School of MedicineHangzhou 310052China Department of General Surgery Children’s HospitalZhejiang University School of MedicineHangzhou 310052China Department of Cardiopulmonary and Extracorporeal Life Support Children’s HospitalZhejiang University School of MedicineHangzhou 310052China Clinical Data Center Children’s HospitalZhejiang University School of MedicineHangzhou 310052China Department of Cardiac Surgery Children’s HospitalZhejiang University School of MedicineHangzhou 310052China National Clinical Research Center for Child Health Children’s HospitalZhejiang University School of MedicineHangzhou 310052China Department of Infectious Diseases Children’s HospitalZhejiang University School of MedicineHangzhou 310052China

Background Coronavirus disease 2019(COVID-19)tends to have mild presentations in ***,severe and critical cases do arise in the pediatric population with debilitating systemic impacts and can be fatal at times,meriting further attention from ***,the intricate interactions between the pathogen virulence factors and host defense mechanisms are believed to play indispensable roles in severe COVID-19 pathophysiology but remain incompletely *** sources A comprehensive literature review was conducted for pertinent publications by reviewers independently using the PubMed,Embase,and Wanfang *** keywords included“COVID-19 in children”,“severe pediatric COVID-19”,and“critical illness in children with COVID-19”.Results Risks of developing severe COVID-19 in children escalate with increasing numbers of co-morbidities and an unvaccinated *** respiratory distress stress and necrotizing pneumonia are prominent pulmonary manifestations,while various forms of cardiovascular and neurological involvement may also be *** immunological processes are implicated in the host response to COVID-19 including the type I interferon and inflammasome pathways,whose dysregulation in severe and critical diseases translates into adverse clinical *** inflammatory syndrome in children(MIS-C),a potentially life-threatening immune-mediated condition chronologically associated with COVID-19 exposure,denotes another scientific and clinical conundrum that exemplifies the complexity of pediatric *** the considerable dissimilarities between the pediatric and adult immune systems,clinical trials dedicated to children are lacking and current management recommendations are largely adapted from adult *** Severe pediatric COVID-19 can affect multiple organ *** dysregulated immune pathways in severe COVID-19 shape the disease course,epitomize the vast functional diversity of the

关键词： Immunopathophysiology MIS-C Pediatric critical care Severe pediatric COVID-19

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Hydrogels of Chemically Cross-linked and Organ-metallic Complexed Interpenetrating PEG Networks

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Chinese Journal of Polymer Science 2016年第5期34卷 637-648页

作者： Meng-jiao Dong Shun-li Liu lin-hua tan 岑莲付国东 School of Chemistry and Chemical Engineering Southeast UniversityJiangning DistrictNanjing 211189China Shanghai Key Laboratory of Multiphase Materials Chemical Engineering Department of Product EngineeringSchool of Chemical EngineeringEast China University of Science and TechnologyShanghai 200237China National Tissue Engineering Center of China Shanghai 200241China

The aim of the present work was to prepare a well-defined hydrogel of chemically cross-linked and organ-metallic complexed interpenetrating PEG networks. The hydrogel was synthesized via the reaction of copper（I）- catalyzed 1,3-dipolar azide-alkyne cycloaddition（CuA AC） with poly（ethylene glycol）-dopamine（PEG-DA）（“Click Chemistry”） followed by complexation with Fe-（3＋） ions to crosslink the polymeric network. The chemical composition and morphology of the resulting hydrogels were characterized by Fourier transform infrared spectroscopy（FTIR）, -1H-NMR and scanning electron microscopy（SEM）. Swelling ratio, mechanical strength, conductivity, and degradation behaviors of the hydrogels were also studied. The effect of the polymer chain length on properties of hydrogels was explored. The compressive strength of hydrogels could reach as high as 13.1 MPa with a conductivity of 2.2 × 10^-5 S·cm^-1. The hydrogels also exhibited excellent thermal stability even at a temperature of 300 °C, whereas degradation of the hydrogel after 7 weeks was observed under a physiological condition. In addition, the hydrogel exhibited a good biocompatibility based on its in vivo performance through an in vivo subcutaneous implantation model. No inflammation and no obvious abnormality of the surrounding tissue were observed when the hydrogel was subcutaneously implanted for 2 weeks. This work is a step towards creating a new pathway to synthesize hydrogels of interpenetrating networks which could be of important applications in the future research.

关键词： hydrogel metallic implanted subcutaneous implantation compressive azide chemically polymeric glycol

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Polymyxin for the treatment of intracranial infections of extensively drug-resistant bacteria in children after neurosurgical operation

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World Journal of Pediatrics 2020年第5期16卷 528-532页

作者： Jing Ye lin-hua tan Zhi-Peng Shen Yun-Song Yu Deng-Ming Lai Jie Fan Qiang Shu Department of Surgical ICU Children's HospitalZhejiang University School of MedicineNational Clinical Research Center For Child HealthHangzhou 310052China Department of Neurosurgery Children's HospitalZhejiang University School of MedicineNational Clinical Research Center For Child HealthHangzhou 310052China Department of Infectious Diseases Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310003China Department of Neonatal Surgery Children's HospitalZhejiang University School of MedicineNational Clinical Research Center For Child HealthHangzhouZhejiangChina Department of Surgery University of Pittsburgh School of MedicinePittsburghPAUSA Research and Development Veterans Affairs Pittsburgh Healthcare SystemPittsburghPAUSA McGowan Institute for Regenerative Medicine University of PittsburghPittsburghPAUSA Department of Thoracic and Cardiovascular Surgery Children's HospitalZhejiang University School of MedicineNational Clinical Research Center For Child HealthNo.3333 Bin-Sheng RoadBin-Jiang DistrictHangzhou 310052China

Background Increased meningitis caused by extensively drug-resistant bacillary presents a significant challenge in antibiotic *** aim of our study was to evaluate the efficacy and safety of polymyxin in the treatment of post-neurosurgical meningitis due to the extensively drug-resistant bacillary in *** We performed a retrospective study on post-neurosurgical meningitis caused by the extensively drug-resistant bacillary in children,who were treated with polymyxin for≥3 *** Among five post-neurosurgical meningitis cases that were included,the children were infected by Acinetobacter baumannii(n=3),Klebsiella pneumonia(n=l),and Pseudomonas aeruginosa(n=1).The drug susceptibility test showed that they were extensively drug-resistant *** patients received intravenous polymyxin *** children received intravenous combined with intraventricular injection of polymyxin *** patient infected by Klebsiella pneumonia eventually died of septic *** serious adverse effects of polymyxin were *** Polymyxin is a safe and effective therapy for post-neurosurgical,multidrug-resistant bacillary meningitis in children.

关键词： Drug resistance Meningitis Neurosurgical procedures Polymyxin

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Application of artificial intelligence in pediatrics: past, present and future

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World Journal of Pediatrics 2019年第2期15卷 105-108页

作者： Li-Qi Shu Yi-Kan Sun lin-hua tan Qiang Shu Anthony C.Chang School of Medicine and Health Sciences George Washington UniversityWashingtonD.C.20037USA Faculty of Medicine University of New South WalesSydneyNSW 2052Australia Children's Hospital Zhejiang University School of MedicineHangzhou 310052China The Sharon Disney Lund Medical Intelligence and Innovation Institute(MI3) Children's Hospital of Orange CountyOrangeCA 92868USA

Artificial intelligence (AI) is a very active computer science research field aiming to develop systems that mimic human intelligence and is helpful in many human activities,including ***,it is no surprise that innova... 详细信息

关键词： Application past present

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Toward understanding the microstructure characteristics,phase selection and magnetic properties of laser additive manufactured Nd-Fe-B permanent magnets

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International Journal of Extreme Manufacturing 2024年第1期6卷 277-294页

作者： Bo Yao Nan Kang Xiangyu Li Dou Li Mohamed EL Mansori Jing Chen Haiou Yang hua tan Xin lin State Key Laboratory of Solidiffcation Processing Northwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China Arts et Metiers Institute of Technology MSMPHESAM UniversitéF-51006 Chˆalons-en-ChampagneFrance Key Laboratory of Metal High Performance Additive Manufacturing and Innovative Design MIIT ChinaNorthwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China Texas A&M Engineering Experiment Station Institute for Manufacturing SystemsCollege StationTX 77843United States of America

Nd-Fe-B permanent magnets play a crucial role in energy conversion and electronic *** essential magnetic properties of Nd-Fe-B magnets,particularly coercivity and remanent magnetization,are significantly infuenced by the phase characteristics and *** this work,Nd-Fe-B magnets were manufactured using vacuum induction melting(VIM),laser directed energy deposition(LDED)and laser powder bed fusion(LPBF)*** evolution and phase selection of Nd-Fe-B magnets were then clarified in *** results indicated that the solidification velocity(V)and cooling rate(R)are key factors in the phase *** terms of the VIM-casting Nd-Fe-B magnet,a large volume fraction of theα-Fe soft magnetic phase(39.7 vol.%)and Nd2Fe17Bxmetastable phase(34.7 vol.%)areformed due to the low R(2.3×10-1?C s-1),whereas only a minor fraction of the Nd2Fe14B hard magnetic phase(5.15 vol.%)is *** the LDED-processed Nd-Fe-B deposit,although the Nd2Fe14B hard magnetic phase also had a low value(3.4 vol.%)as the values of V(10-2m s-1)and R(1.45×106?C s-1)in the LPBF process resulted in the substantial formation of the Nd2Fe14B hard magnetic phase(55.8 vol.%)directly from the liquid,while theα-Fe soft magnetic phase and Nd2Fe17Bxmetastable phase precipitation are suppressed in the LPBF-processed Nd-Fe-B ***,crystallographic texture analysis reveals that the LPBF-processedNd-Fe-B magnets exhibit isotropic magnetic ***,the LPBF-processed Nd-Fe-B deposit,exhibiting a coercivity of 656 k A m-1,remanence of 0.79 T and maximum energy product of 71.5 k J m-3,achieved an acceptable magnetic perfor

关键词： laser additive manufacturing(LAM) Nd-Fe-B permanent magnets numerical simulation microstructure magnetic properties

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High shear stress-induced pulmonary hypertension alleviated by endothelial progenitor cells independent of autophagy

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World Journal of Pediatrics 2015年第2期11卷 171-176页

作者： Bi-Jun Xu Jian Chen Xi Chen Xi-Wang Liu Shu Fang Qiang Shu Lei Hu Shan-Shan Shi Li-Zhong Du lin-hua tan Department of Cardiothoracic Surgery Children's HospitalZhejiang University School of Medicine3333 Binsheng RoadHangzhou 310051China Department of Cardiothoracic Surgery Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China The First Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou 310006China Central Laboratory Children's HospitalZhejiang University School of MedicineHangzhou 310051China Department of SICU Children's HospitalZhejiang University School of MedicineHangzhou 310051China

Background:Pulmonary hypertension(PH)is a progressive disease characterized by lung endothelial cell dysfunction and Vascular *** progenitor cells(EPCs)have been proved to be a potential therapeutic strategy to treat *** has been found to be protective to hypoxia-induced *** this study,we applied high shear stress(HSS)-induced PH,and examined whether EPCs confer resistance against HSS-induced PH through ***:Pulmonary microvascular endothelial cells(PMVECs)were cultured under HSS with pro-inflammatory factors in an artificial capillary system to mimic the PH *** of p62,a selective autophagy substrate,were quantified by western *** viability was determined by trypan blue exclusion ***:The p62 level in PMVECs was increased at 4 hours after HSS,peaked at 12 hours and declined at 24 *** cell viability gradually *** with PMVECs cultured by empty medium,in cells cultured by EPC-conditioned medium(EPC-CM),the cell viability was significantly higher;however,p62 levels were also significantly higher,suggesting inhibition of autophagy by *** choloquine to suppress autophagy decreased the cell viability of PMVECs under ***:EPC-CM could suppress the autophagic activity of PMVECs in HSS-induced ***,suppression of autophagy leads to ceil *** could fight against PH through cellular or molecular pathways independent of *** it is not proved if induction of autophagy could be a potential strategy to treat HSS-induced PH as hypoxia-induced PH.

关键词： autophagy endothelial progenitor cells pulmonary hypertension

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Hypoxic hepatitis in children after cardiac surgery

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Hepatobiliary & Pancreatic Diseases International 2023年第2期22卷 205-209页

作者： Xia-Di Zhao Jing Ye Yi-Kan Sun Jian-Feng Liang Lei Hu Anthony CChang Li-Zhong Du Hao-Min Li Qiang Shu Xi Chen lin-hua tan Department of Surgical ICU Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Faculty of Medicine University of New South WalesSydneyNSW 2052Australia Department of Medical Statistics Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Children’s Hospital of Orange County Pediatric Heart InstituteOrangeCA 92868USA Key Laboratory of Diagnosis and Treatment of Neonatal Diseases of Zhejiang Province Hangzhou 310052China Department of Clinical Data Center Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Cardiac Surgery Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Central Laboratory Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China

To the Editor: Hypoxic hepatitis(HH), also known as ischemic hepatitis or shock liver, is a liver injury characterized by necrosis of centrilobular hepatocytes with a rapid increase in serum aminotransferase levels. The incidence rate of HH among patients in the intensive care unit(ICU) was found to be 0.9%-11.9% [1]. Occurrence of HH appears to have a significant impact on the clinical outcome.

关键词： hepatitis liver surgery

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UPLC-Q-TOF/MS-Based Serum Metabolomics Reveals Potential Anti-tumor Mechanism of Banxia Xiexin Decoction in Colorectal Cancer Mice

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Chinese Journal of Integrative Medicine 2024年第7期30卷 623-632页

作者： YUE Yin-zi LI Ming-xuan WANG Xiao-hui QIN Yuan-yuan WANG Ya-hui tan Jin-hua SU Lian-lin YAN Shuai Department of General Surgery Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou215009China School of Pharmacy Nanjing University of Chinese MedicineNanjing210023China Department of General Surgery Bayinguoleng Mongolian Autonomous Prefecture People’s HospitalXinjiang Uygur Autonomous RegionKorla841000China Department of Pharmacy Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou215009China Department of Anorectal Surgery Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou215009China

Objective To clarify the potential mechanism of Banxia Xiexin Decoction(BXD)on colorectal cancer(CRC)from the perspective of *** Forty male C57BL/6 mice were randomly divided into normal control(NC),azoxymethane/dextran sulfate sodium(AOM/DSS)model,low-dose BXD(L-BXD),high-dose BXD(H-BXD)and mesalamine(MS)groups according to a random number table,8 mice in each *** cancer model was induced by AOM/*** was administered daily at doses of 3.915(L-BXD)and 15.66 g/kg(H-BXD)by gavage for consecutive 21 days,and 100 mg/kg MS was used as positive *** the entire modeling cycle,colon length of mice was measured and quantity of colorectal tumors were *** spleen and thymus index were determined by calculating the spleen/thymus weight to body *** cytokine and changes of serum metabolites were analyzed by enzyme-linked immunosorbent assay kits and ultra performance liquid chromatography-quadrupole/time-of-flight mass spectrometry(UPLC-Q/TOF-MS),*** Notably,BXD supplementation protected against weight loss,mitigated tumor formation,and diminished histologic damage in mice treated with AOM/DSS(P<0.05 or P<0.01).Moreover,BXD suppressed expression of serum inflammatory enzymes,and improved the spleen and thymus index(P<0.05).Compared with the normal group,102 kinds of differential metabolites were screened in the AOM/DSS group,including 48 potential biomarkers,involving 18 main metabolic *** 18 potential biomarkers related to CRC were identified,and the anti-CRC mechanism of BXD was closely related to D-glutamine and D-glutamate metabolism,phenylalanine,tyrosine and tryptophan biosynthesis,arginine biosynthesis,nitrogen metabolism and so *** BXD exerts partial protective effects on AOM/DSS-induced CRC by reducing inflammation,protecting organism immunity ability,and regulating amino acid metabolism.

关键词： colorectal cancer metabolomics ultra performance liquid chromatography-quadrupole/time-of-flight mass spectrometry azoxymethane dextran sulfate sodium Banxia Xiexin Decoction Chinese medicine

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Precise determination of the pole position of the exotic Z_(c)(3900)

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Science China(Physics,Mechanics & Astronomy) 2024年第9期67卷 84-90页

作者： Yun-hua Chen Meng-lin Du Feng-Kun Guo School of Mathematics and Physics University of Science and Technology BeijingBeijing 100083China School of Physics University of Electronic Science and Technology of ChinaChengdu 611731China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Peng huanwu Collaborative Center for Research and Education Beihang UniversityBeijing 100191China

We perform a unified description of the experimental data of the π^(+)π^(-)and J/ψπ^(±)invariant mass spectra for e^(+)e^(-)→J/ψπ^(+)π^(-)and the D^(0)D^(*-)mass spectrum for e^(+)e^(-)→D^(0)D^(*-)π^(+)at e^(+)e^(-)center-of-mass energies 4.23 and 4.26 *** analysis takes into account open-charm meson loops that contain triangle singularities,the J/ψπ-DD^(*)coupled-channel interaction respecting unitarity,and the strong ππ-KK final state interaction using dispersion *** analysis leads to a precise determination of the Z_(c)(3900)pole with the pole mass and width(3880.7±1.7_(stat)±22.4_(syst))MeV and(35.9±1.4_(stat)±15.3_(syst))MeV,respectively,and hints at that the DD^(*)molecular and non-molecular components are of similar importance in the Z_(c)(3900)formation.

关键词： exotic hadrons dispersion relations final state interaction triangle singularity

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Cr-catalyzed allylic C(sp^(3))–H addition to aldehydes enabled by photoinduced ligand-to-metal charge transfer

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Science China Chemistry 2024年第5期67卷 1589-1595页

作者： Xianrong Zeng Feng-hua Zhang Runchen Lai Xiaoyu lin Zhaobin Wang Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province Department of ChemistrySchool of Science and Research Center for Industries of the FutureWestlake UniversityHangzhou 310030China Institute of Natural Sciences Westlake Institute for Advanced StudyHangzhou 310024China Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province Instrumentation and Service Center for Molecular SciencesWestlake UniversityHangzhou 310024China

Photoinduced ligand-to-metal charge transfer(LMCT) has emerged as an effective strategy for synthesizing organic molecules in a sustainable manner. However, the majority of existing reports on selective C(sp^(3))–H bond functionalization via photoinduced LMCT focus on the use of late transition metals or rare-earth metals for radical additions or cross-couplings. In contrast, the utilization of photoinduced LMCT with 3d early transition metals poses a significant challenge. Herein, we describe an unprecedented approach to allylic C(sp^(3))–H addition to aldehydes, employing chromium(Cr) complexes as catalysts through visible-light-induced LMCT. By investigating the reaction pathway through various mechanistic studies, including radical trapping, kinetic isotope effect(KIE) analysis, and transient absorption spectroscopy, valuable insights have been gained. The proposed mechanism suggests the intermediacy of bromine radicals through homolysis of the Cr–Br bond. Notably, this protocol expands our understanding of the photochemical properties of earth-abundant Cr complexes.

关键词： Cr catalysis photoinduced ligand-to-metal charge transfer hydrogen-atom transfer carbonyl addition

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