检索结果-南通市图书馆

Different types of drug abusers prefrontal cortex activation patterns and based on machine-learning classification

Journal of Innovative Optical Health Sciences 2022年第2期15卷 83-92页

作者： Banghua yang Xuelin Gu Shouwei Gao lin feng yan Ding Xu Wen Wang School of Mechanical and Electrical Engineering and Automation Shanghai University Shanghai 200444P.R.China Shanghai Drug Rehabilitation Administration Bureau Shanghai 200080 P.R.China Department of Radiology&Functional and Molecular Imaging Key Lab of Shaanxi Province Tangdu Hospital Fourth Military Medical University Xi'anShaanxi 710038P.R.China Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of Education ShanghaiP.R.China Shanghai Intelligent Engineering Technology Research Center for Addiction and Rehabilitation Minhang District 200240 ShanghaiP.R.China

Drug addiction can cause abnormal brain activation changes,which are the root cause of drug craving and brain function *** study enrolled drug abusers to determine the effects of different drugs on brain activation.A functional near-infrared spectroscopy(fNIRS)device was used for the *** study was designed with an experimental paradigm that included the induction of resting and drug addiction *** collected the fNIRS data of 30 drug users,including 10 who used heroin,10 who used Methamphetamine,and 10 who used mixed ***,using Statistical Analysis,the study analyzed the activations of eight functional areas of the left and right hemispheres of the prefrontal cortex of drug addicts who respectively used heroin,Methamphetamine,and mixed drugs,including Left/Right-Dorsolateral prefrontal cortex(L/R-DLPFC),Left/Right-Ventrolateral prefrontal cortex(L/R-VLPFC),Left/Right-Fronto-polar prefrontal cortex(L/R-FPC),and Left/Right Orbitofrontal Cortex(L/R-OFC).Second,referencing the degrees of activation of oxyhaemoglobin concentration(HbO2),the study made an analysis and got the specific activation patterns of each group of the ***,after taking out data which are related to the addicts who recorded high degrees of activation among the three groups of addicts,and which had the same channel numbers,the paper classified the different drug abusers using the data as the input data for Convolutional Neural Networks(CNNs).The average three-class accuracy is 67.13%.It is of great significance for the analysis of brain function errors and personalized rehabilitation.

关键词： Drug addiction fNIRS machine-learning di®erent drug users brain regions activation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Platinum nanoparticles promote breast cancer cell metastasis by disrupting endothelial barrier and inducing intravasation and extravasation

引用

Nano Research 2022年第8期15卷 7366-7377页

作者： De-Ping Wang Jing Shen Chuan-Yue Qin Yong-Mei Li Li-Juan Gao Jian Zheng yan-lin feng Zi yan Xin Zhou Ji-Min Cao Key Laboratory of Cellular Physiology at Shanxi Medical University Ministry of Educationand the Department of PhysiologyShanxi Medical UniversityTaiyuan 030001China Department of Medical Imaging Shanxi Medical UniversityTaiyuan 030001China

Breast cancer is a common malignancy in women with disappointing prognosis especially the triple-negative ***,nanomedicine becomes a promising therapeutic strategy for breast cancer,such as platinum nanoparticles(PtNPs).Despite the promising anticancer effects of PtNPs,the safety of PtNPs remains to be fully ***,a series of cell and animal experiments demonstrate that PtNPs facilitate breast cancer metastasis by damaging the vascular endothelial *** disrupt endothelial cell proliferation,migration and tube-like structure formation,destruct endothelial adhesions junctions and induce endothelial barrier leakiness in vitro most likely by stimulating intracellular reactive oxygen species(ROS)generation and altering the expression and conformation of endothelial junctional proteins,thus promoting intravasation and extravasation of the implanted 4T1 breast cancer cells and leading to cancer metastasis in female BALB/c nude mice in *** addition,smaller PtNPs(5 nm)are more potent than larger PtNPs(70 nm)in exerting the above *** study provides the first evidence that PtNPs can promote breast cancer metastasis by damaging endothelial *** unexpected detrimental effects of PtNPs should be considered in future nanomedicine designs for the treatment of breast cancer.

关键词： platinum nanoparticle endothelium cell junction breast cancer metastasis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

低分子量肝素对妊高征大鼠肾脏病变的保护作用及机制初步探讨

引用

中国应用生理学杂志 2005年第2期21卷 212-215,i006页

作者：于昕林延峰中国医科大学附属第二医院妇产科中国医科大学附属第二医院泌尿外科辽宁沈阳110004

目的:研究低分子量肝素(LMWH)对妊高征大鼠肾脏损伤的作用及其细胞内信号转导机制。方法:采用注射L NAME方法制备妊高征动物模型,将妊娠大鼠随机分为正常妊娠组、妊高征组、LMWH治疗组,测定各组平均动脉压、尿蛋白、血肌酐及血尿素氮,观... 详细信息

目的:研究低分子量肝素(LMWH)对妊高征大鼠肾脏损伤的作用及其细胞内信号转导机制。方法:采用注射L NAME方法制备妊高征动物模型,将妊娠大鼠随机分为正常妊娠组、妊高征组、LMWH治疗组,测定各组平均动脉压、尿蛋白、血肌酐及血尿素氮,观察LMWH对肾脏各指标的影响及肾脏出现的病理学变化;同时采用免疫组化、RT PCR及WesternBlot方法检测ERK1/2在各组的表达变化。结果:LMWH治疗组肾脏组织ERK1/2的蛋白及mRNA表达水平明显低于妊高征组(P<0.01),而妊高征组肾脏组织ERK的蛋白及mRNA表达水平明显高于正常妊娠组(P<0.01),ERK1与ERK2在各组大鼠肾脏中的表达无差异;治疗组平均动脉压及尿蛋白明显低于非治疗组(P<0.05),但仍未达正常妊娠水平;HE染色和PAS染色为治疗组肾小球系膜增生、基底膜增厚较非治疗组明显减轻。ERK蛋白主要分布于肾小球中。结论:LMWH对妊高征大鼠肾脏损伤具有一定的防护作用,其机制可能是通过下调ERK1/2的表达来实现。

关键词：肝素低分子妊高征大鼠肾脏 ERK1 ERK2

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Charged Molecular Alloy Clusters [Pd2As14]4- and [Au2Sb14]4-:Chemical Bonding and σ-Aromaticity

Charged Molecular Alloy Clusters [Pd2As14]4- and [Au2Sb14]4-...

引用

第十三届全国量子化学会议

作者： Xue-Rui You lin-yan feng Rui Li 翟华金 Nanocluster Laboratory Institute of Molecular ScienceShanxi University

We report a computational study on the structures and bonding of a synthetic "charged molecular alloy"[1] D [PdAs](1), as well as a model D [AuSb](2) cluster. Our effort makes use of an array of quantum chemistry tools:canonical molecular orbital analysis,adaptive natural density partitioning (AdNDP), natural bond orbital analysis, orbital composition analysis, and nucleus independent chemical shift calculations. Both clusters

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

引用

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao Xiang feng Gao Yu-Gui Peng Peng Wu Zong-lin Li Xue-feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Impact of apodisation functions on group delay and reflectivity ripple of chirped fiber Bragg gratings

引用

Optoelectronics Letters 2006年第6期2卷 430-432页

作者： WANG lin yan feng-ping LI Yi-fan GONG Tao-rong JIAN Shui-sheng Institute of Lightwave Technology Beijing Jiaotong University Beijing 100044 China

Apodisation technology is introduced to optimize fiber Bragg grating based on the analysis of reflectivity spectrum and group delay response of fiber Bragg gratings. The characteristics of Hamming, Gauss and super-Gauss functions are discussed and the optimization effects of the three apodisation functions on ripple smoothness of reflectivity spectrum,group delay and linear degree are compared respectively. As a result,the optimization effects of Hamming function is better than other two functions. When the bandwidth is less than ldB,Super-Gauss function is the best choice and proper parameters （G and m） of super-Gauss function can be selected expediently for wider bandwidth and better ripple smoothness of reflectivitv soectrum.

关键词：光纤Bragg光栅反射光谱群延迟线性度

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

乳腺癌分子生物学指标与^(18)F-FDG PET-CT SUV_(max)的相关性研究

引用

中国现代医学杂志 2017年第23期27卷 47-51页

作者：李雯冯彦林广东省佛山市第一人民医院核医学科广东佛山528000

目的比较乳腺癌新辅助化疗^(18)F-FDG正电子发射计算机断层显像(PET-CT)最大标准摄取值(SUV_(max))、第一疗程化疗后SUV_(max)变化率(⊿SUV_(max)1%)、第二疗程化疗后SUV_(max)变化率(⊿SUV_(max)2%)与雌激素受体(ER)、孕激素受体(PR)... 详细信息

目的比较乳腺癌新辅助化疗^(18)F-FDG正电子发射计算机断层显像(PET-CT)最大标准摄取值(SUV_(max))、第一疗程化疗后SUV_(max)变化率(⊿SUV_(max)1%)、第二疗程化疗后SUV_(max)变化率(⊿SUV_(max)2%)与雌激素受体(ER)、孕激素受体(PR)、表皮生长因子受体-2(HER-2)、Ki-67、p53表达的关系,探讨乳腺癌新辅助化疗中氟代脱氧葡萄糖(FDG)代谢与乳腺癌分子生物学指标的内在联系。方法完成新辅助化疗前^(18)F-FDG PET-CT患者211例,完成第1次化疗后PET-CT患者49例,完成第2次化疗后PET-CT患者49例,测量每次的SUV_(max)并计算其变化率,在新辅助化疗前取乳腺肿瘤组织进行ER、PR、HER-2、Ki-67及p53免疫组织化学法检查。结果 ER表达阴性组的SUV_(max)高于ER表达阳性组(P<0.05)。PR表达阴性组的SUV_(max)高于PR表达阳性组(P<0.05)。PR表达阴性组的⊿SUV_(max)2%高于PR表达阳性组(P<0.05)。Ki-67表达阳性组的SUV_(max)、⊿SUV_(max)2%高于Ki-67表达阴性组(P<0.05)。结论 ER、PR阴性患者FDG代谢要高于ER、PR表达阳性患者。PR阴性患者⊿SUV_(max)2%高于PR阳性患者,提示PR阴性患者对化疗更敏感。Ki-67阳性的患者SUV_(max)高于Ki-67阴性患者,提示FDG代谢能一定程度反映乳腺癌的增殖活跃程度。Ki-67阳性的患者有较高的⊿SUV_(max)2%,提示Ki-67阳性患者对化疗更加敏感。

关键词： ^18F-FDG PET-CT 雌激素受体孕激素受体表皮生长因子受体-2 Ki-67

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

引用

Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong Tang Nan Zheng Qingming lin yan You Zheng Gong yangping Zhuang Jiali Wu Yu Wang Hanlin Huang Jun Ke feng Chen Shengli Clinical Medical College of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

哈贝马斯的普遍化原则与欧洲中心主义质疑的反思

引用

武汉理工大学学报（社会科学版） 2020年第2期33卷 146-151页

作者：晏临风武汉大学哲学学院湖北武汉430072

哈贝马斯通过自己的商谈理论来解决多元化社会中如何为规范建立共同基础的问题,进而给出了一种在当代重建普遍主义伦理学的方案。在商谈理论中,规范性的基础是通过对话原则和普遍化原则二者建立起来的。然而学者们对普遍化原则本身的中... 详细信息

哈贝马斯通过自己的商谈理论来解决多元化社会中如何为规范建立共同基础的问题,进而给出了一种在当代重建普遍主义伦理学的方案。在商谈理论中,规范性的基础是通过对话原则和普遍化原则二者建立起来的。然而学者们对普遍化原则本身的中立性产生了一定的质疑,认为它必须预设一种欧洲中心主义式的政治理想,因此并非绝对中立。普遍化原则中暗含的这一实质性内容展现出目前商谈理论存在的一些问题。也正是从这一点出发,晚期商谈理论从一种强版本的、纯粹基于语义学的规范性理论弱化为一种基于现代性的解释理论。即便如此,欧洲中心主义的质疑也依旧无法被彻底消除。

关键词：哈贝马斯普遍化原则商谈理论欧洲中心主义规范性

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Revolutionizing breast cancer detection:Advances in fluorescent probe technology

引用

Nano Research 2025年第1期18卷 653-674页

作者： Qian Gao lin Tang Jun Zhan Yiyuan Xue feng Luo State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan UniversityChengdu 610041China Emergency Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Prosthodontics West China School of StomatologySichuan UniversityChengdu 610041China

With the increasing incidence of breast cancer globally,there is an urgent demand for enhanced diagnostic and therapeutic *** comprehensive review explores advancements in fluorescent probe technology for breast cancer imaging and early *** probes offer unparalleled sensitivity and specificity in detecting cancer biomarkers,enabling early diagnosis and delineation of tumor margins during *** categorize these probes into molecular,nano,ratiometric,the second near-infrared window(NIR-II),and multifunctional varieties,each with unique capabilities for targeting specific cancer *** review highlights recent innovations in probe design,emphasizing their applications in pathogenesis studies,drug development,precision medicine,and fluorescence-guided *** their promising clinical potential,challenges such as safety,biomarker targeting accuracy,system compatibility,and clinical translation *** these hurdles is crucial for the integration of fluorescent probes into standard cancer care,aiming to improve treatment outcomes and patient quality of life.

关键词： breast cancer fluorescent probes imaging early diagnosis biomarker

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：