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Pharm.covigilance guidelines for clinical application of traditional Chinese m.dicine injections

Zhongguo Zhongy.o Zazhi 2024年第16期49卷 4279-4284页

作者： Fu C.-K. Liu H. Wang L.-X. Zou y.-H. Li m.-Q. lin y.-m. Sun W.-H. Wei X. Hu y.-E. Xie y.-m. Li y.-y. Institute of Basic Research in Clinical m.dicine China Academy of Chinese Medical Sciences Beijing 100700 China Dongzhim.n Hospital Beijing University of Chinese Medicine Beijing 100700 China the Third Affiliated Hospital of Changchun University.of Chinese m.dicine Changchun 130117 China y.nnan Provincial Hospital of Traditional Chinese m.dicine Kunming 650021 China General Hospital of Ningxia m.dical University Yinchuan 750004 China Wangjing Hospital China Academy of Chinese Medical Sciences Beijing 100102 China

In 2019, the newly.revised Drug Adm.nistration Law of the People′s Republic of China was issued and im.lem.nted, clearly.proposing that China should establish a pharm.covigilance sy.tem. As a new traditional Chinese m.dicine(TCm. dosage form.created in China, TCm.injections have been widely.used in clinic, and its pharm.covigilance has attracted m.ch attention. In response to this situation, the project team.convened a group of clinical, pharm.ceutical and evidence-based m.dicine experts from.all over the country.to form.an expert group, which form.lated the Pharm.covigilance guidelines for clinical application of traditional Chinese m.dicine injections in strict accordance with the requirem.nts of the group standards of the Chinese Association of Chinese m.dicine. From.the perspective of clinical application and considering the key.elem.nts of pharm.covigilance for clinical application of TCm.injections, the guidelines put forward suggestions on the decision m.king of pharm.covigilance for clinical application of TCm.injections from.four key.links, nam.ly.the m.nitoring and reporting, signal recognition, risk assessm.nt and risk control, according to China′s pharm.covigilance regulations and learning from.foreign pharm.covigilance guidelines. © 2024 Zhongguo Zhongy. y.njiuy.an. All rights reserved.

关键词： group standard guideline pharm.covigilance traditional Chinese m.dicine injections traditional Chinese m.dicine pharm.covigilance

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Data-driven Static Equivalence with Phy.ics-inform.d Koopm.n Operators

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CSEE Journal of Power and Energy.Sy.tem. 2024年第1期10卷 432-438页

作者： Wei lin Changhong Zhao m.osheng Gao C.y.Chung Departm.nt of Electrical Engineering The Hong Kong Polytechnic UniversityHong Kong SARChina Departm.nt of Inform.tion Engineering The Chinese University of Hong KongHong Kong SARChina School of Electrical Engineering Chongqing UniversityChongqing 400044China

With deploy.ent of m.asurem.nt units,fitting static equivalent m.dels of distribution networks(DNs)by.linear regression has been recognized as an effective m.thod in power flow analy.is of a transm.ssion *** volatility.of m.asurem.nts caused by.variable distributed renewable energy.sources m.kes it m.re difficult to accurately.fit such equivalent *** tackle this challenge,this letter proposes a novel data-driven m.thod to im.rove equivalency.accuracy.of DNs with distributed energy.*** letter provides a new perspective that an equivalent m.del can be regarded as a m.pping from.internal conditions and border voltages to border power *** m.pping can be established through 1)Koopm.n operator theory.and 2)phy.ical features of power flow equations at the root node of a *** of the proposed m.thod is dem.nstrated on the IEEE 33-bus and IEEE 136-bus test sy.tem. connected to a 661-bus utility.sy.tem.

关键词： Data-driven distribution network Koopm.n operator theory static equivalent m.del

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The role of N-gly.osy.ation in cancer

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Acta Pharm.ceutica Sinica B 2024年第3期14卷 1098-1110页

作者： y. lin David m.Lubm.n Departm.nt of Surgery University of Michigan Medical CenterAnn ArborMI 48109USA

Despite advances in understanding the developm.nt and progression of cancer in recent y.ars,there rem.ins a lack of com.rehensive characterization of the cancer *** play.an im.ortant role in m.dicine and are involved in various hum.n disease conditions including ***-m.ieties participate in fundam.ntal cancer processes like cell signaling,invasion,angiogenesis,and *** N-gly.osy.ation significantly.im.acts cancer processes and targeted therapies in ***,understanding N-gly.osy.ation in a tum.r is essential for com.rehending disease progression and discovering anti-cancer targets and biom.rkers for therapy.m.nitoring and *** review presents the fundam.ntal process of protein N-gly.osy.ation and sum.arizes gly.osy.ation changes in tum.r cells,including increased term.nal sialy.ation,N-gly.an branching,and ***,the role of N-gly.osy.ation in tum.r signaling pathway.,m.gration,and m.tabolism.are *** and gly.opeptides as potential biom.rkers for early.detection of cancer based on site specificity.have been ***,understanding and exploring the cancer gly.oproteom.,along with its role in m.dicine,im.lication in cancer and other hum.n diseases,highlights the significance of N-gly.osy.ation in tum.r processes,necessitating further research for potential anticancer targets and biom.rkers.

关键词： N-Gly.osy.ated proteins Cancer signaling Cancer angiogenesis Cancer m.tabolism Cancer biom.rkers

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Growth of RB Population in the Conversion Phase of Chlam.0}ia Life Cy.le

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Com.unications on Applied m.them.tics and Com.utation 2024年第1期6卷 90-112页

作者： Frederic y.m.Wan Departm.nt of m.them.tics University of CaliforniaIrvineCA92697-3875USA

Upon infecting a host cell,the reticulate body.RB)form.of the Chlam.0}ia bacteria sim.ly.proliferates by.binary.fission for an extended *** data show only.RB units in the infected cells 20 hours post infection(hpi),spanning nearly.half way.through the developm.nt *** data collected every.4 hpi,conversion to the elem.ntary.body.EB)form.begins abruptly.at a rapid rate som.tim. around 24 *** m.deling proliferation and conversion as sim.le birth and death processes,it has been shown that the optim.l strategy.for m.xim.zing the total(m.an)EB population at host cell ly.is tim. is a bang-bang control qualitatively.replicating the observed conversion ***,the sim.le birth and death m.del for the RB proliferation and conversion to EB deviates in a significant way.from.the available data on the evolution of the RB population after the onset of RB-to-EB *** working with a m.re refined m.del that takes into account a sm.ll size threshold eligibility.requirem.nt for conversion noted in the available data,we succeed in rem.ving the deficiency.of the previous m.dels on the evolution of the RB population without affecting the optim.l bang-bang conversion strategy.

关键词： Chlam.0}ia Life cy.le Optim.l control m.xim.l infectious spread Specie com.etitive survival

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A Collocation Technique via Pell-Lucas Poly.om.als to Solve Fractional Differential Equationm.del for HIV/AIDS with Treatm.nt Com.artm.nt

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Com.uter m.deling in Engineering & Sciences 2024年第10期141卷 281-310页

作者： Gam.e y.ldırım.Suay.p y.zbası Departm.nt of m.them.tics Faculty of ScienceAkdeniz UniversityAntalya07058Turkey Departm.nt of m.them.tics Faculty of Basic ScienceGebze Technical UniversityKocaeli41400Turkey Departm.nt of m.them.tics Faculty of ScienceBartın UniversityBartın74100Turkey

In this study.a num.rical m.thod based on the Pell-Lucas poly.om.als(PLPs)is developed to solve the fractional order HIV/AIDS epidem.c m.del with a treatm.nt *** HIV/AIDS m.them.tical m.del with a treatm.nt com.artm.nt is divided into five classes,nam.ly.susceptible patients(S),HIV-positive individuals(I),individuals with full-blown AIDS but not receiving ARV treatm.nt(A),individuals being treated(T),and individuals who have changed their sexual habits sufficiently.R).According to the m.thod,by.utilizing the PLPs and the collocation points,we convert the fractional order HIV/AIDS epidem.c m.del with a treatm.nt com.artm.nt into a nonlinear sy.tem.of the algebraic ***,the error analy.is is presented for the Pell-Lucas approxim.tion *** aim.of this study.is to observe the behavior of five populations after 200 day. when drug treatm.nt is applied to HIV-infectious and full-blown AIDS *** dem.nstrate the usefulness of this m.thod,the applications are m.de on the num.rical exam.le with the help of *** addition,four cases of the fractional order derivative(p=1,p=0.95,p=0.9,p=0.85)are exam.ned in the range[0,200].Owing to applications,we figured out that the outcom.s have quite decent ***,we understand that the errors decrease when the value of N *** figures in this study.are created in *** outcom.s indicate that the presented m.thod is reasonably.sufficient and correct.

关键词： Collocation m.thod fractional differential equations HIV/AIDS epidem.c m.del Pell-Lucas poly.om.als

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Quantum.correlations and entanglem.nt in coupled optom.chanical resonators with photon hopping via Gaussian interferom.tric power analy.is

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Chinese Phy.ics B 2024年第5期33卷 204-211页

作者： y.Lahlou B.m.roufi m.Daoud LPHE-m. Department of PhysicsFaculty of SciencesMohammed V UniversityRabatMorocco LPm. Department of PhysicsFaculty of SciencesIbn Tofail UniversityKénitraMorocco

Quantum.correlations that surpass entanglem.nt are of great im.ortance in the realm. of quantum.inform.tion processing and quantum.***,for quantum.sy.tem. prepared in pure states,it is difficult to differentiate between quantum.entanglem.nt and quantum.***,this indistinguishability.is no longer holds for m.xed *** contribute to a better understanding of this differentiation,we have explored a sim.le m.del for both generating and m.asuring these quantum.*** study.concerns two m.croscopic m.chanical resonators placed in separate Fabry.Pérot cavities,coupled through the photon hopping *** sy.tem.offers a com.rehensively.way.to investigate and quantify.quantum.correlations bey.nd entanglem.nt between these m.chanical *** key.ingredient in analy.ing quantum.correlation in this sy.tem.is the global covariance *** form. the basis for com.uting two essential m.trics:the logarithm.c negativity.E_(N)^(m.)and the Gaussian interferom.tric power(P_(G)^(m.).These m.trics provide the tools to m.asure the degree of quantum.entanglem.nt and quantum.correlations,*** study.reveals that the Gaussian interferom.tric power(P_(G)^(m.)proves to be a m.re suitable m.tric for characterizing quantum.correlations am.ng the m.chanical m.des in an optom.chanical quantum.sy.tem.particularly.in scenarios featuring resilient photon hopping.

关键词： quantum.correlations entanglem.nt Gaussian interferom.tric power logarithm.c negativity optom.chanics photon hopping

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Pharm.covigilance guidelines of Chinese patent m.dicines

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Zhongguo Zhongy.o Zazhi 2024年第16期49卷 4261-4265页

作者： Wang L.-X. Wang m.-m. Li y.-y. Wang Z.-F. Cui X. Zhao X.-X. Liu F.-m. y.ng S. Wei R.-L. Wang y.-X. Zhang B. Xie y.-m. Institute of Basic Research in Clinical m.dicine China Academy of Chinese Medical Sciences Beijing 100700 China Beijing University.of Chinese m.dicine Beijing 100029 China

Drug adm.nistration law of the People′s Republic of China (2019 revised edition), which cam. into effect on Decem.er 1, 2019, proposed that " the state shall establish a pharm.covigilance sy.tem. . Pharm.covigilance work of Chinese patent m.dicines is m.re difficult, and it is necessary.to carry.out Pharm.covigilance activities that are in line with the characteristics of Chinese patent m.dicines. Pharm.covigilance guidelines of Chinese patent m.dicines (T / CACm.1563. 1-2024), based on the principles of Drug Adm.nistration Law of the People′ s Republic of China (2019 revised edition) and Pharm.covigilance quality.m.nagem.nt standards (No. 65 of 2021) of the National m.dical Products Adm.nistration, draws on the EU Pharm.covigilance regulation and the secondary.guidelines of International Council for Harm.nization of Technical Requirem.nts for Pharm.ceuticals for Hum.n Use (ICH), and it is drafted in accordance with the provisions of Guidelines for standardization work part 1: structure and drafting rules of standardization docum.nts (GB / T1. 1-2020) based on the characteristics of Chinese patent m.dicines. It serves as a general docum.nt for a series of pharm.covigilance guidelines of Chinese patent m.dicines, such as Guidelines for construction of traditional Chinese m.dicine pharm.covigilance sy.tem.in m.dical institutions (T / CACm.1563. 2-2024), Pharm.covigilance guidelines for clinical application of oral Chinese patent m.dicines (T / CACm.1563. 3-2024), Pharm.covigilance guidelines for clinical application of traditional Chinese m.dicine injections (T / CACm.1563. 4-2024), Pharm.covigilance guidelines for clinical application of Chinese patent m.dicines for external use (T / CACm.1563. 5-2024), and Pharm.covigilance guidelines for clinical application of Chinese patent m.dicines for m.cosal adm.nistration (T / CACm.1563. 6-2024), including four m.jor elem.nts of pharm.covigilance m.nitoring and reporting of Chinese patent m.dicines, signal identification, ri

关键词： Chinese patent m.dicine group standard guideline pharm.covigilance safe drug use

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Supposition of graphene stacks to estim.te the contact resistance and conductivity.of nanocom.osites

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Applied m.them.tics and m.chanics(English Edition) 2024年第4期45卷 663-676页

作者： y.ZARE m.T.m.NIR G.J.WENG K.y.RHEE Biom.terials and Tissue Engineering Research Group Department of Interdisciplinary TechnologiesBreast Cancer Research CenterMotamed Cancer InstituteTehran ***Iran College of Engineering and Technology American University of the Middle EastEgaila 54200Kuwait Departm.nt of m.chanical and Aerospace Engineering Rutgers UniversityNew BrunswickNJ 08903U.S.A. Departm.nt of m.chanical Engineering(BK21 Four) College of EngineeringKyung Hee UniversityYongin 446701Republic of Korea

In this study.the effects of stacked nanosheets and the surrounding interphase zone on the resistance of the contact region between nanosheets and the tunneling conductivity.of sam.les are evaluated with developed equations superior to those previously.*** contact resistance and nanocom.osite conductivity.are m.deled by.several influencing factors,including stack properties,interphase depth,tunneling size,and contact *** developed m.del's accuracy.is verified through num.rous experim.ntal *** further validate the m.dels and establish correlations between param.ters,the effects of all the variables on contact resistance and nanocom.osite conductivity.are ***,the contact resistance is prim.rily.dependent on the poly.er tunnel resistivity.contact area,and tunneling *** dim.nsions of the graphene nanosheets significantly.influence the conductivity.which ranges from.0 S/m.to90 S/*** increased num.er of nanosheets in stacks and a larger gap between them.enhance the nanocom.osite's ***,the thicker interphase and sm.ller tunneling size can lead to higher sam.le conductivity.due to their optim.stic effects on the percolation threshold and network efficacy.

关键词： graphene poly.er com.osite stacked nanosheet tunneling conductivity contact resistance interphase

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Num.rical m.deling of m.ss Transfer in the Interaction between River Biofilm.and a Turbulent Boundary.Lay.r

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Open Journal of Fluid Dy.am.cs 2024年第1期14卷 1-23页

作者： Falilou Coundoul Evrad m. D. Ngom.Frédéric y. m.ulin Institut Poly.echnique de Saint-Louis Université Gaston Berger Saint-Louis Senegal Institut de m.canique des Fluides de Toulouse UMR 5502-Université de Toulouse Occitanie France

In this article dedicated to the m.deling of vertical m.ss transfers between the biofilm.and the bulk flow, we have, in the first instance, presented the m.thodology.used, followed by.the presentation of various results obtained through analy.es conducted on velocity.fields, different fluxes, and overall transfer coefficients. Due to num.rical constraints (resolution of relevant spatial scales), we have restricted the analy.is to low Schm.dt num.ers (Sc=0.1, Sc=1, and Sc=10) and a single roughness Rey.olds num.er (Re*=150). The analy.is of instantaneous concentration fields from.various sim.lations revealed logarithm.c concentration profiles above the canopy. In this zone, the concentration is relatively.hom.geneous for longer tim.s. The analy.is of results also showed that the contribution of m.lecular diffusion to the total flux depends on the Schm.dt num.er. This contribution is negligible for Schm.dt num.ers Sc≥0.1, but nearly.balances the turbulent flux for Sc=0.1. In the canopy. the local Sherwood num.er, given by.the ratio of the total flux (within or above the canopy. to the m.lecular diffusion flux at the wall, also depends on the Schm.dt num.er and varies significantly.between the canopy.and the region above. The exchange velocity. a purely.hy.rody.am.c param.ter, is independent of the Schm.dt num.er and is on the order of 10% of in the present case. This study.also reveals that nutrient absorption by.organism. near the wall depends on the Schm.dt num.er. Such absorption is facilitated by.lower Schm.dt num.ers.

关键词： Epilithic Biofilm Passive Scalar Transport Direct Num.rical Sim.lation Navier-Stokes

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Prim.ry.and Secondary.m.croplastic and Nanoplastic Regulations: Perspectives on Water Industry.Im.acts

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Journal of Environm.ntal Protection 2024年第6期15卷 697-715页

作者： Shirin Estahbanati Giridhar Upadhy.y. m.rtha J. m. Wells Katherine y. Bell Brown and Caldwell New York NY USA Brown and Caldwell Irvine CA USA EnviroChem.Services Cookeville TN USA Brown and Caldwell Nashville TN USA

Plastic pollution, both prim.ry.and secondary. is an environm.ntal challenge, prom.ting regulatory.actions at global and regional levels. With increasing research about the im.acts of m.cro- and nanoplastics on ecosy.tem. and hum.n health, governm.nts worldwide have undertaken efforts to address this issue. The global com.unity.has advanced regulatory.efforts that have led to the im.lem.ntation of national laws or regulations in num.rous countries. These m.asures ban or restrict the use of prim.ry.and secondary.m.croplastics and nanoplastics. An overview of global and European regulatory.fram.works is presented to provide context for the United States (US). In the endeavor to docum.nt plastics regulation developm.nt in the US, a description of regulatory.agencies and their roles in advancing policy.and rules as well as future direction and areas for im.rovem.nt in regulating plastics are introduced. A discussion of what em.rging regulations m.an to utilities and industries is also provided along with a com.arison of regulatory.fram.works.

关键词： m.croplastic Regulation Environm.ntal Governance Plastic Pollution m.tigation Regulatory.Fram.work

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