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Tumor size as a prognostic factor in patients with advanced gastric cancer in the lower third of the stomach

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World Journal of Gastroenterology 2012年第38期18卷 5470-5475页

作者： Hong-Mei Wang, Chang-Ming Huang, Chao-Hui Zheng, Ping Li, Jian-Wei xie, Jia-Bin Wang, Jian-Xian lin, Jun Lu, Department of Gastric Surgery, Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China Author contributions: Wang HM and Huang CM conceived of the study, analyzed the data, and drafted the manuscript Zheng CH, Li P and xie JW helped revise the manuscript critically for important intellectual content Wang JB, lin JX and Lu J helped collect data and design the study and all authors read and approved the final manuscript. Department of Gastric Surgery Affiliated Union Hospital of Fujian Medical University Fuzhou 350001 Fujian Province China.

AIM: To explore the impact of tumor size on outcomes in patients with advanced gastric cancer in the lower third of the stomach. METHODS: We retrospectively analyzed the clinical records of 430 patients with advanced gastric cancer in the lower third of the stomach who underwent distal subtotal gastrectomy and D2 lymphadenectomy in our hospital from January 1998 to June 2004. Receiver-operating characteristic (ROC) curve analysis was used to determine the appropriate cutoff value for tumor size, which was measured as maximum tumor diameter. Based on this cutoff value, patients were divided into two groups: those with large-sized tumors (LSTs) and those with small-sized tumors (SSTs). The correlations between other clinicopathologic factors and tumor size were investigated, and the 5-year overall survival (OS) rate was compared between the two groups. Potential prognostic factors were evaluated by univariate KaplanMeier survival analysis and multivariate Cox's propor-tional hazard model analysis. The 5-year OS rates in the two groups were compared according to pT stage and pN stage. RESULTS: The 5-year OS rate in the 430 patients with advanced gastric cancer in the lower third of the stomach was 53.7%. The mean ± SD tumor size was 4.9 ± 1.9 cm, and the median tumor size was 5.0 cm. ROC analysis indicated that the sensitivity and specificity results for the appropriate tumor size cutoff value of 4.8 cm were 80.0% and 68.2%, respectively (AUC=0.795, 95%CI: 0.751-0.839, P=0.000). Using this cutoff value, 222 patients (51.6%) had LSTs (tumor size ≥ 4.8 cm) and 208 (48.4%) had SSTs (tumor size<4.8 cm). Tumor size was significantly correlated with histological type (P=0.039), Borrmann type (P=0.000), depth of tumor invasion (P=0.000), lymph node metastasis (P=0.000), tumor-nodes metastasis stage (P=0.000), mean number of metastatic lymph nodes (P=0.000) and metastatic lymph node ratio (P=0.000). Patients with LSTs had a significantly lower 5-year OS rate than those with SS

关键词：肿瘤浸润肿瘤患者胃癌晚期预后单因素分析海表温度临床资料

An open-labeled, randomized, multicenter phase Ⅱa study of gambogic acid injection for advanced malignant tumors

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Chinese Medical Journal 2013年第9期126卷 1642-1646页

作者： CHI Yihebali ZHAN Xiao-kai YU Hao xie Guang-ru WANG Zhen-zhong XIAO Wei WANG Yong-gang XIONG Fu-xing HU Jun-feng YANG lin CUI Cheng-xu WANG Jin-wan Department of Medical Oncology Cancer Institute & Hospital Chinese Academy of Medical Sciences Beijing 100021 China Department of Hematology and Oncology Chaoyang HospitalBeijing 100020 China Department of Epidemiology and Biostatistics School of Public Health Nanjing Medical University Nanjing Jiangsu 210029China Department of Oncology Tianjin Tumor Hospital Tianjin 300060China Kanion Pharmaceutical Co. Ltd. Lianyungang Jiangsu 222001China Department of Oncology Qilu Hospital Shandong UniversityJinan Shandong 250012 China Department of Internal Oncology the First Affiliated Hospital of Anhui Medical University Hefei Anhui 230022 China

Background Gambogic acid is a pure active compound isolated from the traditional Chinese medicinal plant gamboge （Garcinia morella Desv.）. Based on the preliminary results of a phase I study, this phase Ila study compared the efficacy and safety of different dosage schedules of gambogic acid in patients with advanced malignant tumors. Methods Patients with advanced or metastases cancer who had not received any effective routine conventional treatment or who had failed to respond to the existing conventional treatment were randomly assigned to receive either 45 mg/m2 gambogic acid intravenously from Days 1 to 5 of a 2-week cycle （Group A）, or 45 mg/m2 every other day for a total of five times during a 2-week cycle （Group B）. The primary endpoint was objective response rate （ORR）. Results Twenty-one patients assigned to Group A and 26 to Group B were included in the final analysis. The ORRs were 14.3% in Group A and 0% in Group B. It was not possible to analyze the significant difference because one of the values was zero. The disease control rates （DCRs） were 76.2% in Group A and 61.5% in Group B （P=0.0456）. The observed adverse reactions were mostly Grades I and II, and occurred in most patients after administration of the trial drug. There was no significant difference in the incidence of adverse reactions between the two arms. Conclusions The preliminary results of this phase Ila exploratory study suggest that gambogic acid has a favorable safety profile when administered at 45 mg/m2. The DCR was greater in patients receiving gambogic acid on Days 1-5 of a 2-week cycle, but the incidence of adverse reactions was similar irrespective of the administration schedule.

关键词： gambogic acid efficacy toxicity advanced malignant tumor

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低盐驯化对低盐胁迫下大黄鱼转录组的影响

水产学报 2023年第6期47卷 41-52页

作者：曾霖张惠宋炜熊逸飞谢正丽黄伟卿蚌埠学院食品与生物工程学院中国水产科学研究院东海水产研究所浙江海洋大学国家海洋设施养殖工程技术研究中心中国水产科学研究院渔业机械仪器研究所宁德师范学院生命科学学院

为探讨低盐驯化对低盐胁迫下大黄鱼氧化损伤和转录组的影响，本实验将体重为(52.46±1.47) g的大黄鱼暴露在盐度为25或20的水体中7 d，再暴露在盐度为10的水体中24 h。结果显示，低盐胁迫显著增加了活性氧(ROS)和脂质过氧化物(LPO)含量... 详细信息

为探讨低盐驯化对低盐胁迫下大黄鱼氧化损伤和转录组的影响，本实验将体重为(52.46±1.47) g的大黄鱼暴露在盐度为25或20的水体中7 d，再暴露在盐度为10的水体中24 h。结果显示，低盐胁迫显著增加了活性氧(ROS)和脂质过氧化物(LPO)含量。尽管低盐驯化对ROS和LPO不产生影响，但低盐驯化显著降低了低盐胁迫下大黄鱼ROS和LPO含量，表明低盐驯化缓解了低盐胁迫对大黄鱼的氧化损伤。从低盐驯化vs.对照组、低盐胁迫vs.对照组和低盐驯化+低盐胁迫vs.低盐胁迫实验中，分别筛选到356、478和484个差异基因。GO和KEGG分析发现，差异基因显著富集在GnRH信号通路、PPAR信号通路、凋亡、Toll样受体通路和MAPK信号通路等，表明低盐驯化可以通过调节离子和物质运输、脂类代谢、细胞凋亡和非特异性免疫等来提高大黄鱼的低盐胁迫耐受性。研究表明，低盐驯化可以通过调节离子和物质运输、脂类代谢、细胞凋亡和非特异性免疫等来提高大黄鱼的低盐胁迫耐受性。研究结果揭示了低盐驯化改善大黄鱼低盐胁迫耐受性的分子机制，可为今后工厂化和内陆采用淡水或半咸水养殖大黄鱼提供科学依据。

关键词：大黄鱼盐度胁迫转录组毒物兴奋效应信号通路

体外冲击波治疗联合全身振动对脑卒中偏瘫患者下肢痉挛及平衡步态的影响

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中南大学学报（医学版） 2022年第6期47卷 755-761页

作者：肖乐刘超李元邓炎尧谢冰林芳波肖豪长沙市第一医院康复医学科长沙410005

目的:脑卒中患者可能会出现痉挛、肌肉无力或感觉受损等多种感觉运动障碍。痉挛影响了20%~40%的脑卒中患者,出现痉挛的脑卒中患者可能会有疼痛、运动功能受损和活动范围减小等问题,进而导致日常生活能力和质量下降。体外冲击波治疗(extr... 详细信息

目的:脑卒中患者可能会出现痉挛、肌肉无力或感觉受损等多种感觉运动障碍。痉挛影响了20%~40%的脑卒中患者,出现痉挛的脑卒中患者可能会有疼痛、运动功能受损和活动范围减小等问题,进而导致日常生活能力和质量下降。体外冲击波治疗(extracorporeal shock wave therapy,ESWT)是一种能改善脑卒中后痉挛的治疗技术。全身振动(whole body vibration,WBV)治疗作为一种被动的神经肌肉刺激技术,能改善各类疾病人群的姿势控制、肌肉力量和肌肉做功等。目前少有研究将WBV联合ESWT用于治疗脑卒中偏瘫患者。本研究旨在探讨WBV联合ESWT对脑卒中偏瘫患者下肢痉挛及步态功能的影响。方法:选择2020年3月至2021年3月长沙市第一医院康复医学科收治的脑卒中偏瘫患者50例。随机分为对照组与联合组,每组25例。两组患者均进行常规治疗,对照组在常规治疗基础上,进行针对下肢痉挛肌群的ESWT和假WBV,联合组在常规治疗和ESWT后,进行WBV治疗。于治疗前和治疗4周后,采用偏瘫下肢改良Ashworth量表(Modified Ashworth Scale,MAS)、Fugl-Meyer运动功能量表下肢部分(Lower Extremity Portion of the Fugl-Meyer Motor Assessment,FMA-LE)、Berg平衡量表(Berg Balance Scale,BBS)对两组患者进行评分,通过三维步态分析采集两组患者步态的运动学参数(屈髋峰值、屈膝峰值)及时空参数(步速、步频及步幅)。结果:治疗4周后,两组患者MAS评分均低于治疗前(均P0.05);联合组的屈髋峰值、屈膝峰值、步速、步频及步幅均高于治疗前(均P<0.05),且均高于对照组(P<0.05或P<0.001)。结论:ESWT联合WBV可显著改善脑卒中偏瘫患者偏瘫侧下肢肢体的痉挛、下肢运动功能、平衡功能及步态。

关键词：脑卒中痉挛步态体外冲击波治疗全身振动

长江三角洲地区污染物输送对南京臭氧影响的定量分析

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大气科学学报 2023年第5期46卷 703-712页

作者：龚康佳李琳史之浩谢晓栋胡建林南京信息工程大学江苏省大气环境监测与污染控制高技术研究重点实验室/大气环境与装备技术协同创新中心/环境科学与工程学院江苏南京210044

近年来南京O_(3)污染逐渐加剧,为了了解本地及周边城市排放对南京O_(3)的影响,本研究利用源导向的WRF/CMAQ区域空气质量模型对长三角2018年3—10月O_(3)污染季节的空气质量进行了模拟。通过追踪长三角41个城市的排放,探究了长三角地区... 详细信息

近年来南京O_(3)污染逐渐加剧,为了了解本地及周边城市排放对南京O_(3)的影响,本研究利用源导向的WRF/CMAQ区域空气质量模型对长三角2018年3—10月O_(3)污染季节的空气质量进行了模拟。通过追踪长三角41个城市的排放,探究了长三角地区对南京O_(3)的传输特征以及不同风向下的来源贡献。结果表明:研究期间南京O_(3)非污染日和污染日的本地贡献差异不大,分别为56.8%和49.5%;而污染发生时周边城市对南京O_(3)的贡献由36.4%增加至46.3%,长三角以外地区的贡献由6.8%减少至4.7%。;南京O_(3)污染日江苏省内对其贡献占73.1%,而浙江省、安徽省和上海市分别贡献了10.8%、10.5%和0.95%。污染期间南京本地分别由NO x和VOCs作为前体物生成O_(3)(分别记为O_(3)N和O_(3)V)的贡献比率约为7∶13,说明南京本地VOCs对O_(3)生成贡献较大。污染日期间东南风和东北风占比分别为38.0%和35.9%,当主导风向为东北风时,上风向城市扬州对其贡献达13.6%;主导风向为东南风时,上风向城市常州(7.3%)、镇江(7.0%)和无锡(6.5%)对南京O_(3)的贡献较大。因此,南京O_(3)污染控制应考虑根据不同风向对上风向城市群的区域联防联控控制策略。

关键词： O_(3) 南京区域输送源导向模式

Determination of Residual Chlorothalonil in Textiles

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Determination of Residual Chlorothalonil in Textiles

Up-regulation of GSTT1 in Serous Ovarian Cancer Associated with Resistance to Taxol/Carboplatin

作者： Chengyun Wang Junfeng lin Tangtang xie Huiping Zou Yalei Shen The Testing and Technology Center for Industrial Products Shenzhen Customs

An effective method was established to determine the content of residual chlorothalonil in textiles by gas chromatography/mass spectrometry-selected ion monitoring coupled with ultrasonic extraction technique. Residual chlorothalonil in textiles was ultrasonically extracted using ethyl acetate as the extraction solvent. The extract was condensed and analyzed by gas chromatography/mass spectrometry in selected ion monitoring mode（GC/MS-SIM）. The concentration of chlorothalonil was calibrated by the external standard method. Good linearity existed between the peak area and the mass concentration of chlorothalonil in the mass concentration range from 0.2 μg/m L to 42.8 μg/mL. The equation was A = 95,399ρ-50,848, with a correlation coefficient of 0.9999. The limit of detection was 0.1 mg/kg for chlorothalonil. The blank samples were spiked at three concentration levels, and the spiked average recoveries changed from 81.9% to 95.4% while the relative standard deviation（RSD） changed from 1.8% to 5.2%. The proposed method was simple, rapid, sensitive and the limit of detection could meet the limit requirements of relevant regulations. Commercially available textiles were measured by this method, and chlorothalonil at different concentration levels was detected in some samples.

关键词： Chlorothalonil Textile Ultrasonic Extraction GC/MS-SIM

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Up-regulation of GSTT1 in Serous Ovarian Cancer Associated w...

2021年中国肿瘤标志物学术大会暨第十五届肿瘤标志物青...

作者： Jing Zhang Suhong xie Lei Zhou Renquan Lu lin Guo Fudan University Shanghai Cancer Center

Serous ovarian cancer（SOC） is the most common women cancer and the leading cause of cancer-related mortality among the gynaecological malignancies. Although effective chemotherapeutics combined with surgery are developed for the treatment, the five-year survival rate is unsatisfactory due to chemoresistance. To overcome this shortcoming of chemotherapy, we established taxol and carboplatin resistant SOC cell lines for the understandings of the molecular and cellular mechanisms of chemoresistance. Here, we found that these chemoresistant cell lines showed less viability and proliferation, due to more cells arrested at G0/G1 phase. Glutathione-S-transferases-theta1（GSTT1）was significantly upregulated in these chemoresistant cells, along with other chemoresistant ***, GSTT1 expression was also significantly upregulated in the SOC patient tissues after taxol treatment, indicating this upregulation was physiologically relevant to chemotherapy. Further,suppression of GSTT1 expression by shRNA in SOC cell lines led to more sensitivity to drug treatment, through increasing divided cells and promoting cell death. Moreover, the expression of DNA topoisomerase 1（Topo I） was in synergy with that of GSTT1 in the chemoresistant cells, and GSTT1 can bind to Topo I in vitro, which suggested GSTT1 could function through DNA repair mechanism during chemoresistance. In summary, our data imply that GSTT1 may be a potential biomarker or indicator of drug resistance in serous ovarian cancer.

关键词： GSTT1 Serous Ovarian Cancer Drug resistance Topo I

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“奔”“奔着”的句法语义特征及语法化

辽东学院学报（社会科学版） 2022年第5期24卷 78-84页

作者：谢洁林海云湖南师范大学文学院湖南长沙410000

在定量的语料分析基础上,考察“奔”和“奔着”在句法语义上的差异,追溯“奔”“奔着”的语法化历程和机制。研究发现,“奔”和“奔着”在句法语义上有差异,它们的语法化过程也不相同。介词“奔”是由表示“逃亡”意义的动词“奔”虚化... 详细信息

在定量的语料分析基础上,考察“奔”和“奔着”在句法语义上的差异,追溯“奔”“奔着”的语法化历程和机制。研究发现,“奔”和“奔着”在句法语义上有差异,它们的语法化过程也不相同。介词“奔”是由表示“逃亡”意义的动词“奔”虚化而来,在“奔着”的介词用法出现之前开始虚化。“奔着”出现在明清之际,由动词“奔”加体助词虚化而来。在现代汉语中,“奔着”的介词用法随着使用频率和句法结构的作用逐渐固定,有进一步虚化的趋势。

关键词：奔奔着语法化

口腔固定修复金属材料对MRI成像伪影及种植体周围组织健康的影响

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上海口腔医学 2023年第4期32卷 428-431页

作者：谢淑娟王林虎周荣华中国科学院大学武汉存济口腔医院VIP诊疗中心湖北武汉430021

目的探讨口腔固定修复金属材料对MRI成像伪影及种植体周围组织健康的影响。方法选择2018年5月—2020年6月口腔固定修复患者153例,按照随机数字表法分为A组(钴铬合金,n=31)、B组(镍铬合金,n=32)、C组(钛合金,n=28)、D组(纯钛,n=29)和E组... 详细信息

目的探讨口腔固定修复金属材料对MRI成像伪影及种植体周围组织健康的影响。方法选择2018年5月—2020年6月口腔固定修复患者153例,按照随机数字表法分为A组(钴铬合金,n=31)、B组(镍铬合金,n=32)、C组(钛合金,n=28)、D组(纯钛,n=29)和E组(金合金,n=33)。比较5组金属全冠伪影最大面积和涉及层数;评估修复后6个月的牙周探诊深度(probing depth,PD)、改良菌斑指数(modified plaque index,mPLI)、改良龈沟出血指数(modified sulcus bleeding index,mSBI)和龈乳头指数(papilla index,PI)。采用SPSS 22.0软件包对数据进行统计学分析。结果单因素方差分析显示,5组金属全冠伪影最大面积和涉及层数相比,差异有统计学意义(P0.05);两两比较显示,A组与B、C、D、E组的PD、mPLI、mSBI和PI相比,差异无统计学意义(P>0.05)。结论口腔固定修复金属材料产生的伪影与材料类型密切相关,其中,钴铬合金产生的伪影最大,金合金产生的伪影最小。采用金属材料进行口腔固定修复,不会对种植体周围组织健康造成不良影响。

关键词：口腔固定修复金属材料 MRI成像伪影种植体周围组织