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Plasmablastic lymphoma of the small intestine:Case report and literature review

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World Journal of Gastroenterology 2012年第45期18卷 6677-6681页

作者： Hong-Wei Wang Wen Yang Jun-Zhong sun Jiang-Yang Lu Min Li lin sun Department of Pathology the First Affiliated Hospital of General Hospital of People's Liberation Army Department of Gynaecology and Obstetrics the General Hospital of People's Liberation Army Department of Pathology Peking University Health Science Center

Plasmablastic lymphoma(PBL) is a rare aggressive B-cell lymphoproliferative disorder,which has been characterized by the World Health Organization as a new *** PBL is most commonly seen in the oral cavity of human immunodeficiency virus(HIV)-positive patients,it can also be seen in extraoral sites in immunocompromised patients who are *** we present a rare case of PBL of the small intestine in a 55-year-old HIV-negative *** examination of the excisional lesion showed a large cell lymphoma with plasmacytic differentiation diffusely infiltrating the small intestine and involving the surrounding *** neoplastic cells were diffusely positive for CD79a,CD138 and CD10 and partly positive for CD38 and epithelial membrane *** 80% of the tumor cells were positive for Ki-67.A monoclonal rearrangement of the kappa light chain gene was *** patient died approximately 1.5 mo after diagnosis in spite of receiving two courses of the CHOP chemotherapy *** a review of the literature,this is the first case report of PBL with initial presentation in the small intestine without HIV and Epstein-Barr virus infection,and a history of hepatitis B virus infection and radiotherapy probably led to the iatrogenic immunocompromised state.

关键词： Plasmablastic lymphoma Small intestine Human immunodeficiency virus Differential diagnosis

Effects of metal binder on the microstructure and mechanical properties of Al2O3-based micro-nanocomposite ceramic tool material

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International Journal of Minerals,Metallurgy and Materials 2017年第7期24卷 826-832页

作者： Xiu-ying Ni Jun Zhao Jia-lin sun Feng Gong Zuo-li Li Key Laboratory of High Efficiency and Clean Mechanical Manufacture of the Ministry of Education Shandong University Jinan 250061 China

The Al_2O_3-（W,Ti）C composites with Ni and Mo additions varying from 0vol% to 12vol% were prepared via hot pressing sintering under 30 MPa. The microstructure was investigated via X-ray diffraction（XRD） and scanning electron microscopy（SEM） equipped with energy dispersive spectrometry（EDS）. Mechanical properties such as flexural strength, fracture toughness, and Vickers hardness were also measured. Results show that the main phases A12O3 and（W,Ti）C were detected by XRD. Compound Mo Ni also existed in sintered nanocomposites. The fracture modes of the nanocomposites were both intergranular and transgranular fractures. The plastic deformation of metal particles and crack bridging were the main toughening mechanisms. The maximum flexural strength and fracture toughness were obtained for 9vol% and 12vol% additions of Ni and Mo, respectively. The hardness of the composites reduced gradually with increasing content of metals Ni and Mo.

关键词： ceramic matrix nanocomposite metal phase microstructure mechanical properties

Reinforcing effect of graphene on the mechanical properties of Al2O3/TiC ceramics

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International Journal of Minerals,Metallurgy and Materials 2017年第12期24卷 1403-1411页

作者： Zuo-li Li Jun Zhao Jia-lin sun Feng Gong Xiu-ying Ni Key Laboratory of High Efficiency and Clean Mechanical Manufacture of Ministry of Education School of Mechanical EngineeringShandong UniversityJinan 250061China

Multilayer graphene(MLG)-reinforced Al_2O_3/TiC ceramics were fabricated through hot pressing sintering, and the reinforcing effect of MLG on the microstructure and mechanical properties of the composites was investigated by experiment and simulation. The simulation of dynamic crack initiation and propagation was investigated based on the cohesive zone method. The results show that the composite added with 0.2 wt% MLG has excellent flexural strength and high fracture toughness. The major reinforcing mechanisms are the synergistic effect by strong and weak bonding interfaces, MLG pull-out, and grain refinement resulting from the addition of MLG. In addition, the aggravating of crack deflection, branching, blunting, and bridging have indispensable contribution to the improvement of the as-designed materials.

关键词： mechanical properties ceramics graphene simulation interface

Competition Between Self-birth and Catalyzed Death in Aggregation Growth with Catalysis Injection

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Communications in Theoretical Physics 2009年第12期52卷 1139-1148页

作者： CHEN Dan lin Zhen-Quan sun Yun-Fei KE Jian-Hong Department of Physics Wenzhou University Wenzhou 325027 China

We propose two irreversible aggregation growth models of aggregates of two distinct species （.4 and B） to study the interactions between virus aggregates and medicine efficacy aggregates in the virus-medicine cooperative evolution system. The A-species aggregates evolve driven by self monomer birth and B-species aggregate-catalyzed monomer death in model I and by self birth, catalyzed death, and self monomer exchange reactions in model II, while the catalyst B-species aggregates are assumed to be injected into the system sustainedly or at a periodic time-dependent rate. The kinetic behaviors of the A-species aggregates are investigated by the rate equation approach based on the mean-field theory with the self birth rate kernel IA（k） = Ik, catalyzed death rate kernel JAB（k） = Jk and self exchange rate kernel KA （k, l） = Kkl. The kinetic behaviors of the A-species aggregates are mainly dominated by the competition between the two effects of the self birth （with the effective rate I） and the catalyzed death （with the effective rate JB0）, while the effects of the self exchanges of the A-species aggregates which appear in an effective rate KAo play important roles in the cases of I 〉 JBo and I = JBo. The evolution behaviors of the total mass M1^A（t） and the total aggregate number MA（t） are obtained, and the aggregate size distribution ak（t） of species A is found to approach a generalized scaling form in the case of I ≥ JBo and a special modified scaling form in the case of I 〈 JB0. The periodical evolution of the B-monomers concentration plays an exponential form of the periodic modulation.

关键词： evolution behavior aggregation growth scaling rate equation

Shear-thickening behavior of Fe-ZSM5 zeolite slurry and its removal with alumina/boehmites

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International Journal of Minerals,Metallurgy and Materials 2018年第6期25卷 682-688页

作者： Xiao-guang Liu Yan Li Wen-dong Xue Jia-lin sun Qian Tang Department of Inorganic Nonmetallic Materials School of Materials Science and Engineering University of Science and Technology Beijing Atmospheric Environment Department Chinese Academy for Environmental Planning

A cryogenic scanning electron microscopy（cryo-SEM） technique was used to explore the shear-thickening behavior of Fe-ZSM5 zeolite pastes and to discover its underlying mechanism. Bare Fe-ZSM5 zeolite samples were found to contain agglomerations, which may break the flow of the pastes and cause shear-thickening behaviors. However, the shear-thickening behaviors can be eliminated by the addition of halloysite and various boehmites because of improved particle packing. Furthermore, compared with pure Fe-ZSM5 zeolite samples and its composite samples with halloysite, the samples with boehmite（Pural SB or Disperal） additions exhibited network structures in their cryo-SEM images; these structures could facilitate the storage and release of flow water, smooth paste flow, and avoid shear-thickening. By contrast, another boehmite（Versal 250） formed agglomerations rather than network structures after being added to the Fe-ZSM5 zeolite paste and resulted in shear-thickening behavior. Consequently, the results suggest that these network structures play key roles in eliminating the shear-thickening behavior.

关键词： Fe-ZSM5 zeolite cryogenic scanning electron microscopy shear-t^ickening behavior zeta potential boel^nite

Effect of manganese sulfide on the precipitation behavior of tin in steel

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International Journal of Minerals,Metallurgy and Materials 2014年第7期21卷 654-659页

作者： Gui-lin sun Bo Song ling-zhi Yang Su-fen Tao Yong Yang State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing School of Metallurgical and Ecological Engineering University of Science and Technology Beijing Department of Metallurgical Technology

Tramp elements such as tin are considered harmful to steel because of hot brittleness they induce at high temperatures. Because tramp elements retained in steel scrap will be enriched in new steel due to the difficultly of their removal, studies on the precipitation behavior of tin are essential. In this study, the effects of different inclusions on the precipitation behavior of tin in steel were studied. The results show that the tin-rich phase precipitates at austenite grain boundaries in an Fe-5%Sn alloy without MnS precipitates, whereas Sn precipitates at the boundaries of MnS inclusions in steel that contains MnS precipitates. MnS is more effective than silicon dioxide or aluminum oxide as a nucleation site for the precipitation of the tin phase, which is consistent with the disregistry between the lattice parameters of the tin phase and those of the inclusions.

关键词： steelmaking manganese sulfide tin precipitation heterogeneous nucleation

Synthesis of Nitroanilines Catalyzed by Horseradish Peroxidase in the Presence of NaNO2 and H2O2

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Chemical Research in Chinese Universities 2013年第6期29卷 1164-1166页

作者： LIU Cong DAI Rong-ji lin Jie sun Jian-hua CHEN Shi DENG Yu-lin School of Life Science Beijing Institute of Technology Beijing 100081 P.R.China

The synthesis of nitroanilines catalyzed by horseradish peroxidase（HRP） in the presence of sodium nitrite and hydrogen peroxide was investigated, o-Nitroaniline and p-nitroaniline were found in the nitrated products. 2-Aminotoluene and 4-aminotoluene could also be nitrated to give corresponding nitrated products. This protocol has great potentials to open new avenues useful for the synthesis of nitroaniline and its derivatives.

关键词： Nitroaniline Horseradish peroxidase Phenylamine Nitration Enzyme

MicroRNA-506 is up-regulated in the development of pancreatic ductal adenocarcinoma and is associated with attenuated disease progression

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Chinese Journal of Cancer 2016年第12期35卷 666-672页

作者： Run-Fen Cheng Jian Wang Jing-Yi Zhang lin sun Yan-Rui Zhao Zhi-Qiang Qiu Bao-Cun sun Yan sun Department of Pathology Tianjin Medical University Cancer Institute and Hospital Department of Pancreatic Oncology Tianjin Medical University Cancer Institute and Hospital Department of Epidemiology and Biostatistics Tianjin Medical University Cancer Institute and Hospital Department of Pathology Tianjin Medical University

Background: MicroRNA?506(miR?506) has been reported to function in several tumors as a tumor suppressor gene or oncogene. However, the expression and role of miR?506 in pancreatic ductal adenocarcinoma(PDAC) remains unclear. In this study, we aimed to evaluate the phenotype of miR?506 in ***: Using mi RNA in situ hybridization, we examined the expression of miR?506 in 113 PDACs and 87 paired normal pancreatic tissues. We evaluated mi R?506 expression in PDAC cells, normal pancreatic ducts, and acinus/islands, and we analyzed the associations between miR?506 expression and the clinicopathologic characteristics of PDAC ***: miR?506 expression was higher in PDAC than in matched normal pancreatic ductal cells(P < 0.001). On the other hand, the combined group of well and moderately diferentiated PDACs showed higher levels of mi R?506 than the poorly diferentiated ones(P = 0.023). Moreover, mi R?506 expression was negatively associated with pathologic T category(P = 0.004) and lymph node metastasis(P = 0.033), suggesting that mi R?506 might inhibit the progression of ***: Our results suggest that mi R?506 either plays a role as an oncogene in the tumorigenesis and a tumor suppressor in the progression or serves as a house?keeping, tumor?suppressing mi RNA, whose expression can be activated by oncogenic signals in early development to hinder the progression of PDAC.

关键词： Pancreatic ductal adenocarcinoma miR?506 Tumor suppressor Development Progression

Non-coding RNAs in cancers with chromosomal rearrangements:the signatures,causes,functions and implications

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Journal of Molecular Cell Biology 2019年第10期11卷 886-898页

作者： Cai Han lin-Yu sunf Wen-Tao Wang Yu-Meng sun Yue-Qin Chen MOE Key Laboratory of Gene Function and Regulation State Key Laboratory for BiocontrolSun Yat-sen UniversityGuangzhou 510275China

Chromosomal translocation leads to the juxtaposition of two otherwise separate DNA loci,which could result in gene *** rearrangements at the DNA level are catastrophic events and often have causal roles in *** oncogenic DNA messages are transferred to RNA molecules,which are in most cases translated into cancerous fusion *** expression programs and signaling pathways are altered in these cytogenetically abnormal ***,non-toding RNAs have attracted increasing attention and are believed to be tightly associated with chromosome-rearranged *** RNAs not only function as modulators in downstream pathways but also directly affect chromosomal translocation or the associated *** review summarizes recent research advances on the relationship between non-coding RNAs and chromosomal translocations and on diverse functions of non-coding RNAs in cancers with chromosomal rearrangements.

关键词： chromosomal translocation non-coding RNA fusion protein gene regulation non-coding fusion transcript