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The local control scheme for switching consensus value in multi-agent systems

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Journal of Control and Decision 2015年第3期2卷 185-202页

作者： miao lin lin-lin Ou Ming Wang lin Zhang Li Yu Department of Information Zhejiang University of TechnologyHangzhouChina

A local control strategy is presented to switch the consensus value for the first-order multi-agent *** the local proportional controller is employed in the multiagent systems,the Laplacian matrix of the system is *** is proved that the changed Laplacian has the same properties as the Laplacian matrix of the original multi-agent system for the *** on this,the parameter of the local controller,which can guarantee that all the agents change the original consensus value into the desired one,is determined in terms of the matrix calculation and the stability *** practice,the control system must be implemented in the discrete ***,the influence of the sampling period on the stability of the discrete multi-agent system with the local controller is *** simulation results show the validity of the proposed method.

关键词： multi-agent system local control consensus value stability

Towards personalized perioperative treatment for advanced gastric cancer

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World Journal of Gastroenterology 2014年第33期20卷 11586-11594页

作者： Ru-lin miao Ai-Wen Wu Key Laboratory of Carcinogenesis and Translational Research Ministry of Education Department of Gastrointestinal Surgery Peking University Cancer Hospital Beijing Cancer Hospital and Institute

Gastric cancer is one of the most frequently diagnosed cancers worldwide. Although the rate of gastric cancer has declined dramatically over the past decades in most developed Western countries, it has not declined in East Asia. Currently, a radical gastrectomy is still the only curative treatment for gastric cancer. Over the last twenty years, however, surgery alone has been replaced by a multimodal perioperative approach. To achieve the maximum benefit from the perioperative treatment, a thorough evaluation of the tumor must first be performed. A complete assessment of gastric cancer is divided into two parts: staging and histology. According to the stage and histology of the cancer, perioperative chemotherapy or radiochemotherapy can be implemented, and perioperative targeted therapies such as trastuzumab may also play a role in this field. However, perioperative treatment approaches have notbeen widely accepted until a series of clinical trials were performed to evaluate the value of perioperative treatment. Although multimodal perioperative treatment has been widely applied in clinical practice, personalization of perioperative treatment represents the next stage in the treatment of gastric cancer. Genomic-guided treatment and efficacy prediction using molecular biomarkers in perioperative treatment are of great importance in the evolution of treatment and may become an ideal treatment method.

关键词： Gastric cancer Pre-therapeutic evaluation Perioperative chemotherapy Perioperative radiochemotherapy Perioperative target therapy

Kerr-Lens Effect and Mode Locking in Ring Cavity Ti:Sapphire Laser

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Chinese Physics Letters 1996年第2期13卷 113-116页

作者： ZHANG Gui-zhong miao lin-shi XIANG Wang-hua Department of Precision Instruments Tianjin UniversityTianjin 300072

This paper presents the results of our numerical shnulation,*** by employing Splitstep Fourier Method,of pulsewidth dependence on the physical quantities in ring cavity Ti:sapphire *** is revealed through the computed results that Kerr-lens effect which is now quantitatively considered plays a doniniaiit role in forming *** pulses and its interaction with dispersion *** determines the duration of the pulse,which sheds light on further theoretical investigation of the mode locking ***,the self-consistent results also provide a giuc/eiine for the experimental alignment of the laser.

关键词： Sapphire alignment dispersion

Development and validation of a predictive model for spinal fracture risk in osteoporosis patients

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World Journal of Clinical Cases 2023年第20期11卷 4824-4832页

作者： Xu-miao lin Zhi-Cai Shi Department of Orthopedics Changhai HospitalShanghai 200433China

BACKGROUND Spinal osteoporosis is a prevalent health condition characterized by the thinning of bone tissues in the spine,increasing the risk of *** its high incidence,especially among older populations,it is critical to have accurate and effective predictive models for fracture ***,clinicians have relied on a combination of factors such as demographics,clinical attributes,and radiological characteristics to predict fracture risk in these ***,these models often lack precision and fail to include all potential risk *** is a need for a more comprehensive,statistically robust prediction model that can better identify high-risk individuals for early *** To construct and validate a model for forecasting fracture risk in patients with spinal *** The medical records of 80 patients with spinal osteoporosis who were diagnosed and treated between 2019 and 2022 were retrospectively *** patients were selected according to strict criteria and categorized into two groups:Those with fractures(n=40)and those without fractures(n=40).Demographics,clinical attributes,biochemical indicators,bone mineral density(BMD),and radiological characteristics were collected and compared.A logistic regression analysis was employed to create an osteoporotic fracture risk-prediction *** area under the receiver operating characteristic curve(AUROC)was used to evaluate the model’s *** Factors significantly associated with fracture risk included age,sex,body mass index(BMI),smoking history,BMD,vertebral trabecular alterations,and prior vertebral *** final risk-prediction model was developed using the formula:(logit[P]=-3.75+0.04×age-1.15×sex+0.02×BMI+0.83×smoking history+2.25×BMD-1.12×vertebral trabecular alterations+1.83×previous vertebral fractures).The AUROC of the model was 0.93(95%CI:0.88-0.96,P<0.001),indicating strong discriminatory *** The fracture risk-pr

关键词： Spinal osteoporosis Fracture risk prediction Bone mineral density Vertebral trabecular alterations Previous vertebral fractures

A surgical alternative of fusiform penetrating keratoplasty for the management of severe infectious keratitis

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1431-1436页

作者： Xiao-lin Qi Li-Chao Wang miao-lin Wang Hua Gao Eye Hospital of Shandong First Medical University State Key Laboratory Cultivation BaseShandong Provincial Key Laboratory of OphthalmologyShandong Eye InstituteShandong First Medical University&Shandong Academy of Medical SciencesJinan 250021Shandong ProvinceChina

AIM:To describe the surgical procedure of fusiform penetrating keratoplasty(FPK)using multiple trephines of different sizes for treating patients with severe infectious ***:Fourteen eyes underwent FPK,and 15 eyes received conventional penetrating keratoplasty(PK)were included in the *** best-corrected visual acuity(BCVA),refractive outcomes,endothelial cell density,and postoperative complications were ***:The FPK group was followed for an average of 15.3±2.1mo,whereas the PK group was followed for 16.1±*** corneal ulcers were elliptical-shaped in all 14 eyes in the FPK *** mean BCVA(logMAR,0.26±0.13)showed no statistically significant differences from that in the PK group(logMAR,0.21±0.12,P>0.05)at 1y after *** the mean curvature,mean astigmatism,and mean spherical equivalent in the FPK group were lower than those in the PK group(P<0.05).Peripheral anterior synechia was observed in one patient in the FPK group,whereas 6 patients in the PK *** loosening and neovascularization were observed in 4 and 5 eyes in the PK group,*** graft immune rejection or elevation of intraocular pressure was observed in the two ***:For patients with elliptical-shaped corneas or corneal ulcers,FPK can avoid disrupting of corneal limbus,reduce the risk of postoperative complications,and can result in satisfactory visual quality.

关键词： fusiform penetrating keratoplasty multiple trephines infectious keratitis cornea

Clinical observation of Kuntai capsule combined with Fenmotong in treatment of decline of ovarian reserve function

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World Journal of Clinical Cases 2021年第28期9卷 8349-8357页

作者： Xin-miao lin miao Chen Qiao-ling Wang Xiao-Min Ye Hao-Fan Chen Department of Reproductive Health and Infertility Zhanjiang Central People’s HospitalZhanjiang 524037Guangdong ProvinceChina

BACKGROUND Decreased ovarian reserve function is an ovarian hypofunction disease that occurs in women before 40 years of age,leading to a decline in fertility and perimeno-pausal symptoms,such as irregular menstruation,amenorrhea,infertility,de-creased libido,and autonomic nervous ***(FMT)is a com-pound mixture of estradiol tablets and estradiol didroxyprogesterone tablets,which can improve ovarian reserve function by supplementation of exogenous ***,this treatment has also been shown to cause breast pain,gastrointestinal discomfort,irregular vaginal bleeding,and changes in sexual *** severe cases,FMT can promote the development of breast cancer,endometrial cancer,and venous embolic *** To observe the effects of Kuntai capsules and FMT on endocrine indexes and uterine artery blood circulation in patients with decreased ovarian reserve *** Patients(130)with decreased ovarian reserve function,who were treated in our hospital from May 2018 to May 2020,were divided into two groups:The FMT group,in which patients were treated with FMT,and the observation group,in which patients were treated with Kuntai *** medicine symptom scores,uterine artery blood flow parameters,ovarian ultrasound test indexes,pictorial blood loss assessment chart(PBAC)scores,and hormone levels were recorded,and total effective rates were calculated for both *** The total effective rate in the observation group was higher than that in the FMT group(P<0.05).After treatment,primary symptoms,including low menstrual volume,delayed menstruation,red color and thick consistency of menses,di-zziness,palpitation,weakness at the waist and knee,insomnia and excessive dreaming,irritability,and dryness and astringency of the pudendal canal in the observation group decreased,and scores for primary and secondary symptoms in the observation group were significantly lower than those in the FMT group(P<0.05).The systolic peak flow rate(

关键词： Kuntai capsule Fenmatong Ovarian reserve function decline Endocrine index Blood circulation

A case study on behaviors of composite soil nailed wall with bored piles in a deep excavation

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Journal of Central South University 2013年第7期20卷 2017-2024页

作者： ZHU Feng-bin miao lin-chang GU Huan-da CHENG Yue-hong Institute of Geotechnical Engineering Southeast University Nanjing 210096 China School of Civil Engineering Suzhou University of Science and Technology Suzhou 215011 China Sttzhou Erjian Construction Group Co. Ltd Suzhou 215131 China

A complete case of a deep excavation was explored. According to the practical working conditions, a 3D non-linear finite element procedure is used to simulate a deep excavation supported by the composite soil nailed wall with bored piles in soft soil. The modified cam clay model is employed as the constitutive relationship of the soil in the numerical simulation. Results from the numerical analysis are fitted well with the field data, which indicate that the research approach used is reliable. Based on the field data and numerical results of the deep excavation supported by four different patterns of the composite soil nailed wall, the significant corner effect is founded in the 3D deep excavation. If bored piles or soil anchors are considered in the composite soil nailed wall, they are beneficial to decreasing deformations and internal forces of bored piles, cement mixing piles, soil anchors, soil nailings and soil around the deep excavation. Besides, the effects due to bored piles are more significant than those deduced from soil anchors. All mentioned above prove that the composite soil nailed wall with bored piles is feasible in the deep excavation.

关键词： deep excavation 3D non-linear finite element bored pile composite soil nailed wall corner effect deformation internal force

Overexpression of polo-like kinase1 predicts a poor prognosis in hepatocellular carcinoma patients

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World Journal of Gastroenterology 2009年第33期15卷 4177-4182页

作者： Zi-Li He He Zheng Hui lin Xiong-Ying miao De-Wu Zhong Department of Hepatobiliary Surgery Xiangya Second Hospital Central South University Changsha 410011 Hunan Province China

AIM： To elucidate the role of overexpressed polo-like kinasel （PLK1）in hepatocellular carcinoma （HCC）. METHODS： We prospectively collected clinicopathological, immunohistochemical and semi-quantitative reverse transcription-polymerase chain reaction （RT-PCR） data from 135 HCC patients undergoing successful hepatectomy. The correlations between PLK1 mRNA expression and clinicopathologic variables were analyzed by Mann-Whitney U test. Prognostic factors were identified by univariate and multivariate analyses. RESULTS： Immunohistochemical results showed overexpression of PLK1 was mainly found in tumor tissues compared with tumor-free tissue. A similar mRNA result was obtained by semi-quantitative RT-PCR. A total of 111 samples were positive for PLK1 mRNA expression. The positive expression was correlated with venous invasion, tumor nodules and Edmondson grade. Furthermore, 1, 3, 5-year survival rates in the positive expression group were significantly lower than the negative control group. Multivariate analysis showed that positive PLK1 expression was an independent risk factor for HCC. CONCLUSION： PLK1 could be a potential biomarker for diagnosis and therapy for HCC.

关键词： Hepatocellular carcinoma Immunohistochemistry Reverse transcription-polymerase chain reaction Survival analysis Polo-like kinase 1

Emerging roles of long noncoding RNAs in cholangiocarcinoma:Advances and challenges

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Cancer Communications 2020年第12期40卷 655-680页

作者： Yang Yang Xueting Deng Quanpeng Li Fei Wang lin miao Qi Jiang Institute of Digestive Endoscopy and Medical Center for Digestive Diseases Second Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210000P.R.China Nanjing Medical University NanjingJiangsu 210000P.R.China Department of Gastroenterology Dongtai People’s HospitalYanchengJiangsu 224000P.R.China

Cholangiocarcinoma(CCA),a cancer with a relatively low incidence rate,is usually associated with poor *** modalities for the diagnosis and treatment of CCA patients are still far from *** recent years,numerous long noncoding RNAs(lncRNAs)have been identified as crucial players in the development of various cancers,including *** expressed lncRNAs in CCA,regulated by some upstream molecules,significantly influence the biological behavior of tumor cells and are involved in tumor development through various mechanisms,including interactions with functional proteins,participation in competing for endogenous RNA(ceRNA)regulatory networks,activation of cancer-related signaling pathways and epigenetic modification of gene ***,several lncRNAs are closely associated with the clinicopathological features of CCA patients,and are promising biomarkers for diagnosing and prognostication of *** of these lncRNAs play an important role in chemotherapy drug *** addition,lncRNAs have also been shown to be involved in the inflammation microenvironment of CCA and malignant outcome of CCA risk factors,such as cholestatic liver *** view of the difficulty of diagnosing CCA,more attention should be paid to detectable lncRNAs in the serum or *** review summarizes the recent knowledge on lncRNAs in CCA and provides a new outlook on the molecular mechanisms of CCA development from the perspective of ***,we also discussed the limitations of the current studies and differential expression of lncRNAs in different types of CCA.

关键词： bile biomarkers cancer development cholangiocarcinoma long noncoding RNA molecular mechanisms signaling pathways tumor microenvironment