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Targeted gene sequencing and bioinformatics analysis of patients with gallbladder neuroendocrine carcinoma:A case report

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 239-251页

作者： Yun-Chuan Yang Zhi-Tao Chen Da-Long Wan Hui Tang Mu-lin liu Department of Medical College Jinan UniversityGuangzhou 510000Guangdong ProvinceChina Department of General Surgery The First Affiliated Hospital of Bengbu Medical UniversityBengbu 233000Anhui ProvinceChina Department of Hepatobiliary Surgery Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Department of Pathology The First Affiliated Hospital of Medical School of Zhejiang UniversityHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Gallbladder neuroendocrine carcinoma(NEC)represents a subtype of gallbladder malignancies characterized by a low incidence,aggressive nature,and poor *** its clinical severity,the genetic alterations,mechanisms,and signaling pathways underlying gallbladder NEC remain *** SUMMARY This case study presents a rare instance of primary gallbladder NEC in a 73-year-old female patient,who underwent a radical cholecystectomy with hepatic hilar lymphadenectomy and resection of liver segments IV-B and *** gene sequencing and bioinformatics analysis tools,including STRING,GeneMANIA,Metascape,TRRUST,Sangerbox,cBioPortal and GSCA,were used to analyze the biological functions and features of mutated genes in gallbladder *** mutations(APC,ARID2,IFNA6,KEAP1,RB1,SMAD4,TP53,BTK,GATA1,GNAS,and PRDM3)were identified,and the tumor mutation burden was determined to be 9.52 muts/Mb via targeted gene sequencing.A protein-protein interaction network showed significant interactions among the twelve mutated *** Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were used to assess mutation functions and *** results revealed 40 tumor-related pathways.A key regulatory factor for gallbladder NEC-related genes was identified,and its biological functions and features were compared with those of gallbladder *** Gallbladder NEC requires standardized *** with other gallbladder carcinomas revealed clinical phenotypes,molecular alterations,functional characteristics,and enriched pathways.

关键词： Gallbladder neuroendocrine carcinoma Targeted-gene sequencing Bioinformatics analysis case report Immunocytochemistry Case report

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慢性肌筋膜触发点模型大鼠的尿液代谢组学分析

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中国组织工程研究 2025年第8期29卷 1585-1592页

作者：刘琳刘世轩陆馨悦王侃南京体育学院运动健康学院江苏省南京市210014

背景:慢性肌筋膜触发点通过非靶向代谢组学技术可识别差异性代谢物变化,有助于从内源性小分子代谢物层面理解并进一步探究慢性肌筋膜触发点的病理生理过程和发病机制。目的:以慢性肌筋膜触发点模型大鼠为研究对象,基于尿液代谢组学寻找... 详细信息

背景:慢性肌筋膜触发点通过非靶向代谢组学技术可识别差异性代谢物变化,有助于从内源性小分子代谢物层面理解并进一步探究慢性肌筋膜触发点的病理生理过程和发病机制。目的:以慢性肌筋膜触发点模型大鼠为研究对象,基于尿液代谢组学寻找潜在生物标志物及相关代谢通路。方法:将16只SD大鼠随机分为造模组和正常组,造模组大鼠采用钝性打击结合离心运动(跑台坡度为-16°,跑速为16 m/min,训练时间为90 min/次)方式建立慢性肌筋膜触发点动物模型,每周1次,连续干预8周,休息4周;正常组大鼠不做干预。12周造模结束后,采用代谢笼法收集大鼠造模后24 h尿液,利用液相色谱-质谱联用非靶向代谢组学技术对尿样进行代谢图谱检测,筛选出共同差异代谢物,并进行生物信息学分析。结果与结论:①与正常组相比,造模组有32个差异代谢标志物,其中上调21个、下调11个;依据变量权重值>3,共14个差异代谢物被认定为潜在生物标志物;②京都基因与基因组百科全书富集分析表明,慢性肌筋膜触发点的形成与初级胆汁酸生物合成、花生四烯酸代谢通路密切相关。

关键词：肌筋膜触发点大鼠尿液代谢组学生物信息学生物标志物差异代谢物代谢笼法运动损伤

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A comparative electrochemical investigation of silicon nanowires formation via metal-catalyzed electroless etching

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Science China(Technological Sciences) 2015年第2期58卷 362-368页

作者： liu lin Beijing Key Laboratory of Energy Conversion and Storage Materials Beijing Normal University Key Laboratory of Condition Monitoring and Control for Power Plant Equipment of Ministry of Education North China Electric Power University

In this study, the electrochemical behavior of monocrystalline bare Si and Ag-coated Si in hydrofluoric acid （HF） solutions with and without hydrogen peroxide （H202） was systematically tested with an electrochemical technique. By analyzing the po- larization curves, the corrosion processes were quantified and the etchants which govern the formation of silicon nanowires （SiNWs） were determined. It was discovered that both H202 and Ag enhanced the reduction reactions, irrespective of the con- ductivity type and doping concentration of Si. It is believed that the formation of SiNWs via Metal-Catalyzed Electroless Etching is a process controlled by cathodic reduction reactions.

关键词： silicon nanowires polarization curve electrochemistry

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Theoretical analysis on capillary adhesion of microsized plates with a substrate

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Acta Mechanica Sinica 2010年第2期26卷 217-223页

作者： Jian lin liu Department of Engineering Mechanics China University of Petroleum 266555 Qingdao China

The stiction of a thin plate induced by the capillary force has attracted much attention in the broad range of applications. A novel method is presented to calculate the capillary adhesion problem of the plate through analytical method. The expressions of the surface energy, the strain energy and the total potential energy of the plate-substrate system have been analyzed and delineated. By means of continuum mechanics and the principle of minimum potential energy, the governing equation of the plate with an arbitrary shape and the corresponding transversality boundary condition due to the moving bound have been derived. Then the critical adhesion radius of the circular plate has been solved according to the supplementary transversality condition. Thus the deflections of the plates are analytically calculated with different critical adhesion radii. The results may be beneficial to the engineering application and the micro/nanomeasurement.

关键词： Surface energy · Principle of least potentialenergy · Transversality condition · Critical adhesion radius·Deflection

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Effect of Cd on matrix structure ordering and aging precipitation evolution in a Mg-Gd-Cd solid-solution alloy

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Journal of Magnesium and Alloys 2023年第8期11卷 2833-2852页

作者： lin-lin liu Wei Sun Cuixiu liu Pengyang Sun Institute of Microstructure and Property of Advanced Materials Beijing University of TechnologyBeijing 100124China

The formation and evolution of Gd-rich precipitates companying with the matrix structure ordering in a Mg_(97)Gd_(2)Cd_(1)(at.%)solid-solution alloy aged at 200℃have been systemically investigated using high-angle annular dark-field scanning transmission electron microscopy(HAADF-STEM).The results show that Gd-rich precipitation dynamics during the aging treatment are noticeably affected by a continuous ordering transformation in the *** ordering transformation process involving mainly re-distribution of Cd atoms was revealed to occur in the following way:random super-saturated solid solution(S.S.S.S.)→B19-type ordered domains→D019-type ordered *** Gd(Cd)-rich precipitates,G.P.Ⅰ zone,G.P.Ⅱ zone,β′andβ_(1)phases,have been observed to be formed in sequence to coexist with the various ordered *** on the HAADF-STEM characterization on the aging microstructures at different aging stages,it can be concluded that the Cd-addition and related matrix structure ordering can play significant roles in modifying the early-stage *** structure,altering the morphology ofβ′precipitates and promoting the forming ability of theβ_(1)precipitate.

关键词： Mg-Gd-Cd alloy Ordering transformation Aging microstructure Precipitation evolution HAADF-STEM

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Germ cells from pluripotent stem cells:mouse versus human

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Science China(Life Sciences) 2015年第2期58卷 205-207页

作者： liu lin State Key Laboratory of Medicinal Chemical Biology College of Life Sciences Nankai University Collaborative Innovation Center for Biotherapy West China Hospital West China Medical School Sichuan University

Currently embryonic stem cells （ESCs） derived from ferti- lized embryos or cloned embryos by somatic cell nuclear transfer and induced pluripotent stem cells （iPSCs） from somatic cells represent two major types of pluripotent stem cells （PSCs）. The naive PSCs functionally can produce all ESC/iPSC mice by tetraploid embryo complementation, and contribute to blastocyst chimeras with germline competency, while primed state PSCs including epiblast stem cells （EpiSCs） are not competent to contribute to blastocyst chi- meras, and yet most human PSCs arguably are analogous to rodent EpiSCs.

关键词：多能干细胞小鼠胚胎生殖细胞人类服务公司克隆胚胎 ESCs 生殖能力

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Fatigue Behaviors of a Ni-free ZrCuFeAlAg Bulk Metallic Glass in Simulated Body Fluid

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Journal of Materials Science & Technology 2014年第6期30卷 622-626页

作者： Yimei Wang Yan liu lin liu School of Materials Science and Engineering State Key Lab for Materials Processing and Die & Mould Technology Huazhong University of Science and Technology

Fatigue behaviors of a biocompatible Ni-free Zr60.14Cu22.31Fe4.85Al9.7Ag3 Zr-based bulk metallic glass （BMG） have been studied under three-point-bending test in a simulated body fluid （SBF） at 37 ℃ and compared with those in air at room temperature （RT）. The BMG shows a high fatigue limit of approximately 366 MPa in SBF, which was slightly lower than that in air （400 MPa）. The fatigue cracks tended to initiate from the defects such as cast-pores, inclusions and corners of the samples and propagate in a similar path in SBF and in air. Three distinct regions, i.e. a crack-initiation region, a stable crack-growth region and an unstable fast-fracture region were clearly observed on the fatigue-fractured surface. Although pitting occurred at the defects where crack initiated, it does not affect significantly the fatigue life of the BMG, because the lifetime in the present BMG is mainly determined by crack propagation. The high corrosion-fatigue limit of the studied BMG results from its excellent corrosion resistance in SBF and intrinsically good toughness.

关键词： Ni-free Zr-based bulk metallic glass Corrosion fatigue Simulated body fluid

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Microstructure and mechanical properties of a hot-extruded Al-based composite reinforced with core–shell-structured Ti/Al3Ti

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International Journal of Minerals,Metallurgy and Materials 2017年第12期24卷 1431-1437页

作者： Li Zhang Bao-lin Wu Yu-lin liu School of Materials Science and Engineering Shenyang Aerospace UniversityShenyang 110136China Liaoning Key Laboratory of Aviation Light Alloy and Processing Technology Shenyang Aerospace UniversityShenyang 110136China

An Al-based composite reinforced with core–shell-structured Ti/Al_3Ti was fabricated through a powder metallurgy route followed by hot extrusion and was found to exhibit promising mechanical properties. The ultimate tensile strength and elongation of the composite sintered at 620°C for 5 h and extruded at a mass ratio of 12.75:1 reached 304 MPa and 14%, respectively, and its compressive deformation reached 60%. The promising mechanical properties are due to the core–shell-structured reinforcement, which is mainly composed of Al_3Ti and Ti and is bonded strongly with the Al matrix, and to the reduced crack sensitivity of Al_3Ti. The refined grains after hot extrusion also contribute to the mechanical properties of this composite. The mechanical properties might be further improved through regulating the relative thickness of Al–Ti intermetallics and Ti metal layers by adjusting the sintering time and the subsequent extrusion process.

关键词： microstructure aluminum-based composites Ti/Al3Ti reinforcements mechanical properties

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A unified analysis of a micro-beam,droplet and CNT ring adhered on a substrate:Calculation of variation with movable boundaries

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Acta Mechanica Sinica 2013年第1期29卷 62-72页

作者： Jian-lin liu Re Xia School of Pipeline and Civil Engineering China University of Petroleum School of Power and Mechanical Engineering Wuhan University

In this study, we developed a general method to analytically tackle a kind of movable boundary problem from the viewpoint of energy variation. Having grouped the adhesion of a micro-beam, droplet and carbon nanotube （CNT） ring on a substrate into one framework, we used the developed line of reasoning to investigate the adhesion behaviors of these systems. Based upon the derived governing equations and transversality conditions, explicit solutions involving the critical parameters and morphologies for the three systems are successfully obtained, and then the parameter analogies and common characteristics of them are thor- oughly investigated. The presented method has been verified via the concept of energy release rate in fracture mechanics. Our analyses provide a new approach for exploring the mechanism of different systems with similarities as well as for understanding the unity of nature. The analysis results may be beneficial for the design of nano-structured materi- als, and hold potential for enhancing their mechanical, chemical, optical and electronic properties.

关键词： Variational theory - Transversality condition Beam adhesion Droplet adhesion Carbon nanotube ring adhesion

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Explicit Solutions of (2+1)-Dimensional Canonical Generalized KP, KdV, and (2+1)-Dimensional Burgers Equations with Variable Coefficients

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Communications in Theoretical Physics 2009年第11期52卷 784-790页

作者： ZHANG lin-lin liu Xi-Qiang School of Mathematical Sciences Liaocheng University Liaocheng 252059 China

In this paper, using the generalized （G1/G）-expansion method and the auxiliary differential equation method, we discuss the （2＋1）-dimensional canonical generalized KP （CGKP）, KdV, and （2＋1）-dimensional Burgers equations with variable coetticients. Many exact solutions of the equations are obtained in terms of elliptic functions, hyperbolic functions, trigonometric functions, and rational functions.

关键词： generalized (G1/G)-expansion method auxiliary equation exact solution

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