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High-Pressure Behavior of Ferromagnesite(Mg_(0.81)Fe_(0.19))CO_(3)by Synchrotron X-Ray Diffraction and Raman Spectroscopy up to 53 GPa

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Journal of Earth Science 2024年第2期35卷 525-535页

作者： lin liang Guibin Zhang Shengxuan Huang Jingjing Niu Dongzhou Zhang Jingui Xu Wen liang Shan Qin Key Laboratory of Orogenic Belts and Crustal Evolution MOEand School of Earth and Space SciencesPeking UniversityBeijing100871China CAS Center of Excellence in Tibetan Plateau Earth Sciences and Key Laboratory of Continental Collision and Plateau Uplift Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing100101China Hawai’i Institute of Geophysics and Planetology School of Ocean and Earth Science and TechnologyUniversity of Hawai’i at ManoaHawai’i96822USA Key Laboratory of High Temperature and High Pressure Study of the Earth’s Interior Institute of GeochemistryChinese Academy of SciencesGuiyang550081China

Ferromagnesite(Mg,Fe)CO_(3)with 20 mol%iron is a potential host mineral for carbon transport and storage in the Earth mantle.The high-pressure behavior of synthetic ferromagnesite(Mg_(0.81)Fe_(0.19))CO_(3)up to 53 GPa was investigated by synchrotron X-ray diffraction(XRD)and Raman spectroscopy.The iron bearing carbonate underwent spin transition at around 44–46 GPa accompanied by a volume collapse of 1.8%,which also demonstrated a variation in the dνi/dP slope of the Raman modes.The pressure-volume data was fitted by a third-order Birch-Murnaghan equation of state(BM-EoS)for the high spin phase.The best-fit K_(0)=108(1)GPa and K_(0)'=4.2(1).Combining the dνi/dP and the K_(0),the mode Grüneisen parameters of each vibrational mode(T,L,ν4 andν1)were calculated.The effects of iron concentration on the Mg_(1−x)Fe_(x)CO_(3)system related to high-pressure compressibility and vibrational properties are discussed.These results expand the knowledge of the physical properties of carbonates and provide insights to the potential deep carbon host.

关键词： ferromagnesite synchrotron XRD Raman spectroscopy high pressure geochemistry mineral

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Molecular Dynamics Simulation of Shock Response of CL-20 Co-crystals Containing Void Defects

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Defence Technology（防务技术） 2024年第1期31卷 364-374页

作者： Changlin Li Wei Yang Qiang Gan Yajun Wang lin liang Wenbo Zhang Shuangfei Zhu Changgen Feng State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China School of Materials Science&Engineering Beijing Institute of TechnologyBeijing 100081China

To investigate the effect of void defects on the shock response of hexanitrohexaazaisowurtzitane(CL-20)co-crystals,shock responses of CL-20 co-crystals with energetic materials ligands trinitrotoluene(TNT),1,3-dinitrobenzene(DNB),solvents ligands dimethyl carbonate(DMC) and gamma-butyrolactone(GBL)with void were simulated,using molecular dynamics method and reactive force field.It is found that the CL-20 co-crystals with void defects will form hot spots when impacted,significantly affecting the decomposition of molecules around the void.The degree of molecular fragmentation is relatively low under the reflection velocity of 2 km/s,and the main reactions are the formation of dimer and the shedding of nitro groups.The existence of voids reduces the safety of CL-20 co-crystals,which induced the sensitivity of energetic co-crystals CL-20/TNT and CL-20/DNB to increase more significantly.Detonation has occurred under the reflection velocity of 4 km/s,energetic co-crystals are easier to polymerize than solvent co-crystals,and are not obviously affected by voids.The results show that the energy of the wave decreases after sweeping over the void,which reduces the chemical reaction frequency downstream of the void and affects the detonation performance,especially the solvent co-crystals.

关键词： CL-20 co-crystals Molecular dynamics simulation Reactive forcefield Impact response Hot spot Void defect

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Harnessing cytokine-induced killer cells to accelerate diabetic wound healing: an approach to regulating post-traumatic inflammation

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Regenerative Biomaterials 2024年第2期3卷 88-99页

作者： Yixi Yang Cheng Zhang Yuan Jiang Yijun He iawei Cai lin liang Zhaohuan Chen Sicheng Pan Chu Hua Keke Wu Le Wang Zhiyong Zhang Translational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University Guangdong Province Engineering Research Center for Biomedical EngineeringState Key Laboratory of Respiratory DiseaseDepartment of Orthopaedic SurgeryMedical Technology and Related Equipment Research for Spinal Injury TreatmentCity Key LaboratoryThe Third Affliated Hospital of Guangzhou Medical UniversitySchool of Biomedical EngineeringGuangzhou MedicalUniversityGuangzhouGuangdong510150P.R.China Department of Osteoarthropathy and Sports Medicine Panyu Central HospitalGuangzhou 511400P.R.China

Impaired immunohomeostasis in diabetic wounds prolongs infiammation and cytokine dysfunction,thus,delaying or pre-venting wound-surface healing.Extensive clinical studies have been conducted on cytokine-induced killer(CIK)cells recently,as they can be easily proliferated using a straightforward,inex-pensive protocol.Therefore,the function of CIK cells in regulat-ing inflammatory environments has been drawing attention for clinical management.Throughout the current investigation,we discovered the regenerative capacity of these cells in the chal-lenging environment of wounds that heal poorly due to diabe-tes.We demonstrated that the intravenous injection of CIK cells can re-establish a proregenerative inflammatory microenviron-ment.promote larizationand.ultimatel accelerateskin healing in diabetic mice.The results indicated that CIK cell treatment affects macrophage polarization and restores the function regenerative cells under hyperglycemic conditions.This novel cellular therapy offers a promising intervention for clinical applic tions through specific inflammatory regulation functions.

关键词： macrophage diabetic wound post-traumatic inflammation cytokine-induced killer cells vascularization

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Design Method of Reversely Switched Dynistor Based Pulse Circuit Without Magnetic Switch

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CSEE Journal of Power and Energy Systems 2023年第1期9卷 306-314页

作者： Yicheng Pi lin liang Xiaoxue Yan State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074China

In the reversely switched dynistor(RSD)-based pulse power circuits,a magnetic switch is usually necessary to be applied together with a main switch.It occupies space and needs a magnetic reset.In this paper,a method of designing a RSD-based pulse circuit without a magnetic switch is proposed.In the pulse circuit,a RBDT(reverse blocking diode thyristor)is used to separate the two capacitors and provide an energy branch.The pre-charge time of the RSD can be guaranteed by the energy conversion between the capacitors and inductors,instead of the saturation of the magnetic switch.In addition,the energy which is reused to trigger the RSD is based on an inductor.The pulse circuit is evaluated by simulations and practical experiments.According to the experimental results,the factors affecting the load pulse current and triggering of the RSD and RBDT are studied.Meanwhile,a method to reduce the current in the trigger switch,which is a potential problem in the pulse circuit,is proposed.

关键词： Magnetic switch pulse power circuit reversely switched dynistor(RSD) reverse blocking diode thyristor(RBDT)

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Bimetallic NiCoP catalysts anchored on phosphorus-doped lignin-based carbon for robust oxygen evolution performance

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Rare Metals 2024年第7期43卷 3084-3095页

作者： ling-Ying-Zi Xiong Bo-Wen Liu Lei Du Yue-Kuan Zhou Xu-liang lin Huan Wang Guangdong Engineering Technology Research Center for Sensing Materials & Devices Guangzhou Key Laboratory of Sensing Materials & DevicesSchool of Chemistry and Chemical EngineeringGuangzhou University School of Chemical Engineering and Light Industry Guangdong University of Technology Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Sustainable Energy and Environment Thrust Function HubThe Hong Kong University of Science and Technology (Guangzhou) Division of Emerging Interdisciplinary Areas Department of Mechanical and Aerospace EngineeringThe Hong Kong University of Science and Technology State Key Lab of Pulp and Paper Engineering South China University of Technology

Oxygen evolution reaction（OER） catalysts are the key core materials that determine the performance of fuel cells,metal-air batteries,electrolytic water decomposition,and other applications.In this work,a green lignin-based non-precious metal OER catalyst was prepared by a simple strategy.Firstly,c arboxylated lignin was used to complex Ni and Co in situ,and then they were placed with sodium hypophosphite in the same tube furnace for upstream and downstream high-temperature calcination to construct a lignin carbon-based Ni-Co bimetallic OER catalyst（NiCoP@C）.The synthesized catalyst is a porous bimetallic phosphide with a three-dimensional network structure and high-density electrochemical active sites.NiCoP@C exhibited favorable catalytic activity for the oxygen evolution reaction（OER） with overpotential of 280 mV at 10 mA·cm-2and a Tafel slope of 77 mV·dec-1.Additionally,it exhibited remarkable durability during usage.Density functional theory（DFT） calculations revealed that by leveraging the distinctive structure of transition metal phosphide nanoparticles incorporated into a reticulated substrate,the NiCoP@C catalyst offered an increased number of active sites for OER catalysis,significantly enhancing its stability during practical applications.The present study broadens the utilization pathways of biomass to "turn waste into treasure," aligning the development concept of green sustainable development.

关键词： Oxygen evolution reaction Lignin Carbon-based catalyst Nickel–cobalt bimetal Metal phosphide

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Plug-in Gate-loop Compensators for Series-connected IGBT Drivers in a Solid-state Fault Current Limiter

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CSEE Journal of Power and Energy Systems 2022年第1期8卷 165-174页

作者： Rui Wang Yu Chen Jing Chen lin liang Li Peng School of Electrical and Electronic Engineering Huazhong University of Science and TechnologyWuhan 430074China

A solid-state fault current limiter(SSFCL)is the key protective equipment in a direct current distribution network.In order to meet the high voltage requirements and reduce costs,implementing a SSFCL based on series-connected insulated gate bipolar transistors(IGBTs)is a promising approach.However,voltage unbalancing of IGBTs would be introduced if the gateloops of the IGBTs are non-identical.In this paper,a plug-in gate-loop compensator with discrete gate voltage feedback and pulsewidth current compensation is proposed.The main merits are:1)with the plug-in structure,the extra current sources only provide small power to fine-tune the gate-loop without affecting the functions provided by the commercial IGBT gate driver;2)the gate-emitter voltages of IGBTs are compared with the preset thresholds to obtain control criterion,and the pulsewidths of the current sources are controlled for gate-loop compensation,thus both analog-digital and digital-analog converters are avoided;3)the control law is easy to implement in FPGA,and is robust to voltage variation of power-loops.With the proposed compensator,the voltage unbalancing is alleviated immediately at the present switching cycle,and further eliminated cycle-by-cycle during the current limitation process.Experimental results verify the feasibility of the proposed compensator.

关键词： Current limitation direct current distribution network insulated gate bipolar transistors(IGBTs) voltage balancing

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Surgical treatment of bipolar segmental clavicle fracture:A case report

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World Journal of Clinical Cases 2022年第29期10卷 10529-10534页

作者： lin liang Xin-Lei Chen Ye Chen Nian-Nian Zhang Department of Orthopedics Shangyu People’s Hospital of Shaoxing CityShaoxing 312000Zhejiang ProvinceChina Department of Orthopedics Haimen People’s HospitalNantong 226000Jiangsu ProvinceChina

BACKGROUND Shoulder injuries caused by trauma are common,including clavicle fractures.Even so,bipolar segmental fracture of the clavicle is extremely rare and seldom reported.Therefore,there is still a controversial issue about how to treat these bipolar segmental clavicle fractures.CASE SUMMARY A 56-year-old security guard arrived at our emergency room after falling on his electric bicycle.There was no loss of consciousness or other pain.He had no numbness in his fingers.X-rays and 3D computed tomography revealed that the patient’s right shoulder had a bipolar segmental clavicle fracture.The surgical procedure included both open reduction and internal fixation.At the 1-year follow-up,he had a full range of motion and minimal discomfort in the injured shoulder.CONCLUSION We provide a rare case of bipolar clavicle facture in the right clavicle.We hold the opinion that such patients would get better clinical and radiological outcomes by early and correct operation.

关键词： Bipolar segmental clavicle fracture Arm sling Open reduction and internal fixation Acromioclavicular hook plate Case report

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MicroRNA-298 determines the radio-resistance of colorectal cancer cells by directly targeting human dual-specificity tyrosine(Y)-regulated kinase 1A

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1453-1464页

作者： Mei-Zhu Shen Yong Zhang Fang Wu Mei-Zhen Shen Jun-lin liang Xiao-Long Zhang Xiao-Jian Liu Xin-Shu Li Ren-Sheng Wang Department of Radiotherapy The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Radiotherapy People’s Hospital of Guangxi Zhuang Autonomous RegionNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Colorectal Anal Surgery The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Clinical Medicine Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Radiotherapy stands as a promising therapeutic modality for colorectal cancer(CRC);yet,the formidable challenge posed by radio-resistance significantly undermines its efficacy in achieving CRC remission.AIM To elucidate the role played by microRNA-298(miR-298)in CRC radio-resistance.METHODS To establish a radio-resistant CRC cell line,HT-29 cells underwent exposure to 5 gray ionizing radiation that was followed by a 7-d recovery period.The quantification of miR-298 levels within CRC cells was conducted through quantitative RT-PCR,and protein expression determination was realized through Western blotting.Cell viability was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and proliferation by clonogenic assay.Radio-induced apoptosis was discerned through flow cytometry analysis.RESULTS We observed a marked upregulation of miR-298 in radio-resistant CRC cells.MiR-298 emerged as a key determinant of cell survival following radiation exposure,as its overexpression led to a notable reduction in radiation-induced apoptosis.Intriguingly,miR-298 expression exhibited a strong correlation with CRC cell viability.Further investigation unveiled human dual-specificity tyrosine(Y)-regulated kinase 1A(DYRK1A)as miR-298’s direct target.CONCLUSION Taken together,our findings underline the role played by miR-298 in bolstering radio-resistance in CRC cells by means of DYRK1A downregulation,thereby positioning miR-298 as a promising candidate for mitigating radioresistance in CRC.

关键词： MicroRNA-298 Human dual-specificity tyrosine(Y)-regulated kinase 1A Colorectal cancer Radio-resistance p53 binding protein 1

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YWHAH activates the HMGA1/PI3K/AKT/mTOR signaling pathway by positively regulating Fra-1 to affect the proliferation of gastric cancer cells

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Oncology Research 2023年第4期31卷 615-630页

作者： JUNYU HE FENG ZENG XI JIN lin liang MENGXIANG GAO WENTAO LI GUIYUAN LI YANHONG ZHOU NHC Key Laboratory of Carcinogenesis Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha410013China Cancer Research Institute Basic School of MedicineCentral South UniversityChangsha410078China Hunan Key Laboratory of Cancer Metabolism Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha410013China

Fos-related antigen 1(Fra-1)is a nuclear transcription factor that regulates cell growth,differentiation,and apoptosis.It is involved in the proliferation,invasion,apoptosis and epithelial mesenchymal transformation of malignant tumor cells.Fra-1 is highly expressed in gastric cancer(GC),affects the cycle distribution and apoptosis of GC cells,and participates in GC occurrence and development.However,the detailed mechanism of Fra-1 in GC is unclear,such as the identification of Fra-1-interacting proteins and their role in GC pathogenesis.In this study,we identified tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta(YWHAH)as a Fra-1-interacting protein in GC cells using co-immunoprecipitation combined with liquid chromatography-tandem mass spectrometry.Experiments showed that YWHAH positively regulated Fra-1 mRNA and protein expression,and affected GC cell proliferation.Whole proteome analysis showed that Fra-1 affected the activity of the high mobility group AT-hook 1(HMGA1)/phosphatidylinositol-4,5-bisphosphate 3-kinase(PI3K)/protein kinase B(AKT)/mechanistic target of rapamycin(mTOR)signaling pathway in GC cells.Western blotting and flow cytometry confirmed that YWHAH activated HMGA1/PI3K/AKT/mTOR signaling pathway by positively regulating Fra-1 to affect GC cell proliferation.These results will help to discover new molecular targets for the early diagnosis,treatment,and prognosis prediction of GC.

关键词： Gastric cancer Fra-1 YWHAH Signal transduction pathway Cell proliferation

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组织韧性对制造企业产品成本优势的双刃剑效应

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中国流通经济 2024年第1期38卷 115-127页

作者：梁林李妍河北工业大学经济管理学院天津市300401 河北工业大学京津冀发展研究中心天津市300401

组织韧性作为制造企业应对外部冲击和实现可持续发展的重要能力,在对制造企业产品成本优势产生促进作用的同时,也可能产生潜在的消极作用。基于资源保存理论,利用2010—2020年我国沪深A股制造业上市公司数据,实证分析组织韧性对制造企... 详细信息

组织韧性作为制造企业应对外部冲击和实现可持续发展的重要能力,在对制造企业产品成本优势产生促进作用的同时,也可能产生潜在的消极作用。基于资源保存理论,利用2010—2020年我国沪深A股制造业上市公司数据,实证分析组织韧性对制造企业产品成本优势的双刃剑效应,以及环境不确定性和数字技术应用对该效应的调节作用。研究表明:组织韧性对制造企业产品成本优势具有双刃剑效应,二者间关系呈典型的倒U型特征。通过替换核心变量、改变样本区间、变换聚类层级、更换固定效应及采用工具变量进行内生性分析后,仍得到一致结果;在组织韧性与制造企业产品成本优势的关系中,环境不确定性、数字技术应用均发挥负向调节作用;异质性分析表明,组织韧性对制造企业产品成本优势的双刃剑效应具有企业产权异质性、企业规模异质性和地理位置异质性,在国有企业、大型企业和东部地区双刃剑效应更显著。因此,为提升产品成本优势,制造企业应认识到组织韧性是把双刃剑,充分发挥其积极效应,规避潜在的负面效应;正确看待环境不确定性,提升数字技术应用水平。

关键词：组织韧性产品成本优势双刃剑效应环境不确定性数字技术应用

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