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Chemical Composition,Anticancer,Anti-neuroinflammatory,and Antioxidant Activities of the Essential Oil of Patrinia scabiosaefolia

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Chinese Journal of Integrative Medicine 2018年第3期24卷 207-212页

作者： lin Jing CAI Qiao-yan XU Wen lin jiu-mao PENG Jun Academy of Integrative Medicine Biomedical Research Center Fujian University of Traditional Chinese Medicine Fujian Key Laboratory of Integrative Medicine on Geriatrics Fujian University of Traditional Chinese Medicine Department of Pharmacology Fujian University of Traditional Chinese Medicine

Objective：To study the chemical composition,anticancer,anti-neuroinflammatory,and antioxidant activities of the essential oil of Patrinia scabiosaefolia（EO-PS）.Methods：Patrinia scabiosaefolia was analyzed by gas chromatography-mass *** human carcinoma cell lines,including SGC-7901,AGS,Hep G2,HT-29,HCT-8,5-FU/HCT-8,He La,and MDA-MB-231,were assessed by methylthiazolyldiphenyltetrazolium bromide（MTT） ***-neuroinflammatory activity was assessed by production of interleukin（IL）-1β and IL-6 induced by lipopolysaccharide in BV-2 cells（microglia from mice）.The antioxidant activity was evaluated with a 2,2-diphenyl-1-picrylhydrazyl（DPPH） scavenging ***：Forty-four components,representing 83.919% of the total oil,were identified in the *** major constituents were caryophyllene oxide（12.802%）,caryophyllene（6.909%）,α-caryophyllene（2.927%）,β-damascenone（3.435%）,calarene（5.621%）,and phenol（3.044%）.The MTT assay showed that the EO-PS exhibited significant dose-dependent growth inhibition in the 50–200 μg/m L dilution *** EO-PS exhibited a dose-dependent scavenging activity against the DPPH radical,with an half of maximal inhibitory concentration 1.455 mg/m ***：The EO-PS possesses a wide range of antitumor,anti-neuroinflammatory and antioxidant activities,suggesting that it may be a good candidate for further investigations of new bioactive substances.

关键词： Patrinia scabiosaefolia essential oil anti-neuroinflammatory anticancer antioxidant caryophyllene oxide

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Scutellaria barbata *** Inhibits Colorectal Cancer Growth via Suppression of Wnt/β-Catenin Signaling Pathway

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Chinese Journal of Integrative Medicine 2017年第11期23卷 858-863页

作者： WEI Li-hui lin jiu-mao CHU Jian-feng CHEN Hong-wei LI Qing-yu PENG Jun Academy of Integrative Traditional Chinese Medicine.Medicine Fujian University of Fuzhou(350122)China Fujian Key Laboratory of Integrative Medicine on Geriatrics Fujian University of Traditional Chinese MedicineFuzhou(350122)China

Objective： To investigate the effect of the ethanol extract of Scutellaria barbata D. Don（EESB） on colorectal cancer（CRC） growth and Wnt/β-catenin signaling pathway in vivo and in vitro. Methods： In vivoexperiment, CRC xenograft mouse model was constructed with injection of HT-29 cells. Following xenograft implantation, twenty mice were randomly divided into EESB-treated group（n=10） and control group（n=10） by a random number table, and were given with intra-gastric administration of 2 g/kg EESB or saline, 5 days a week for 16 days, respectively. At the end of experiment, tumors were removed and weighed by electronic scales. The proliferation biomarker Ki-67 of tumor was evaluated by immunohistochemistry（IHC） assay. In vitro study, HT-29 cells were treated with 0, 0.5, 1.5, 2.5 mg/m L EESB for 24 h. At the end of the treatment, the viability and survival of HT-29 cells were determined by methylthiazolyldiphenyl-tetrazolium bromide（MTT） assay and colony formation assay, respectively. The m RNA expression of c-Myc, Survivin and adenomatous polyposis coli（APC） was examined by reverse transcription-polymerase chain reaction（RT-PCR） both in tumor tissues of CRC xenograft mice and HT-29 cells. Protein expression of c-Myc, Survivin, APC, and β-catenin as well as β-catenin phosphorylation level were evaluated by IHC assay or Western blotting. Results： EESB significantly reduced tumor weight in CRC xenografts mice, compared with the control group（P〈0.05）. IHC assay showed that EESB significantly inhibited protein expression of Ki-67 in tumor tissues（P〈0.05）. MTT assay showed that EESB significantly reduced HT-29 cell viability in a dose-dependent manner（P〈0.05）. Colony formation assay showed that EESB dose-dependently decreased the survival of HT-29 cells（P〈0.05）. In addition, RT-PCR assay showed that EESB decreased the m RNA expression of c-Myc and Survivin and increased APC expression, both in tumor tissues of CRC xenograft mice and HT-29 cells（P〈0.05）. IHC assay or Western

关键词： Scutellaria barbata D.Don colorectal cancer proliferation Wnt/β-catenin pathway

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Babao Dan Alleviates 5-Fluorouracil-Induced Intestinal Damage via Wnt/β-Catenin Pathway

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Chinese Journal of Integrative Medicine 2022年第11期28卷 1000-1006页

作者： GUI Meng-xuan HUANG Bin PENG Jun CHEN Xi Ragunath Muthu GAO Ying WANG Rui-guo lin jiu-mao Academy of Integrative Medicine Fujian Key Laboratory of Integrative Medicine on GeriatricsFujian University of Traditional Chinese MedicineFuzhou(350122)China Department of Medical Oncology 900 Hospital of the Joint Logistics Team Support ForceFuzhou(350025)China

Objective:To evaluate the protective function of Babao Dan(BBD)on 5-flurouracil(5-FU)-induced intestinal mucositis(IM)and uncover the underlying ***:A total of 18 male mice were randomly divided into 3 groups by a random number table,including control,5-FU and 5-FU combined BBD groups,6 mice in each group.A single intraperitoneal injection of 5-FU(150 mg/kg)was performed in 5-FU and 5-FU combined BBD groups on day *** in 5-FU combined BBD group were gavaged with BBD(250 mg/kg)daily from day 1 to *** in the control group were gavaged with saline solution for 6 *** body weight and diarrhea index of mice were recorded *** the 7th day,the blood from the heart of mice was collected to analyze the proportional changes of immunological cells,and the mice were subsequently euthanized by mild anesthesia with 2% pentobarbital *** lengths and villus heights were ***-cellular apoptosis and proliferation were evaluated by Tunel assay and immunohistochemical staining of proliferating cell nuclear antigen,*** and Western blot were performed to investigate the expressions of components in Wnt/β-catenin pathway(Wnt3,LRP5,β-catenin,c-Myc,LRG5 and CD44).Results:BBD obviously alleviated 5-FU-induced body weight loss and diarrhea,and reversed the decrease in the number of white blood cel s,including monocyte,granulocyte and lymphocyte,and platelet(P<0.01).The shortening of colon caused by 5-FU was also reversed by BBD(P<0.01).Moreover,BBD inhibited apoptosis and promoted proliferation in jejunum tissues so as to reduce the intestinal mucosal damage and improve the integrity of vil us and *** y,the expression levels of Wnt/β-catenin mediators such as Wnt3,LRP5,β-catenin were upregulated by BBD,activating the transcription of c-Myc,LRG5 and CD44(P<0.01).Conclusions:BBD attenuates the adverse effects induced by 5-FU via Wnt/β-catenin pathway,suggesting it may act as a potential agent aga

关键词： 5-flurouracil Babao Dan body weight diarrhea intestinal mucositis Wnt/β-catenin pathway

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以环状RNA为靶点的中药抗肿瘤治疗研究进展

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中国中西医结合杂志 2022年第12期42卷 1520-1524页

作者：刘洁林久茂福建中医药大学中西医结合研究院福州350122 福建省中西医结合老年性疾病重点实验室福州350122 中西医结合基础福建省高等学校重点实验室福州350122

环状RNA(circular RNA,circRNA)是一组分子呈封闭环状结构,且不具有编码功能的转录本。由于其共价闭合的环结构,没有3’和5’末端,因此不易被外切酶降解[1]。与线性RNA比较,它更为保守和稳定,广泛存在于真核细胞的细胞质中。1976年,Sang... 详细信息

环状RNA(circular RNA,circRNA)是一组分子呈封闭环状结构,且不具有编码功能的转录本。由于其共价闭合的环结构,没有3’和5’末端,因此不易被外切酶降解[1]。与线性RNA比较,它更为保守和稳定,广泛存在于真核细胞的细胞质中。1976年,Sanger HL等[2]首次在植物病毒中发现了单链共价闭合circRNA分子。

关键词：植物病毒环状结构编码功能治疗研究进展中药抗肿瘤外切酶转录本

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大肠癌多药耐药机制及中药逆转作用的研究进展

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时珍国医国药 2022年第12期33卷 2996-3000页

作者：陈勇林久茂福建中医药大学中西医结合学院福建福州350122 福建中医药大学中西医结合研究院福建福州350122 福建省中西医结合老年性疾病重点实验室福建福州350122 中西医结合基础福建省高校重点实验室福建福州350122

多药耐药(MDR)是导致大肠癌化疗失败的主要原因之一,也是造成大肠癌患者高死亡率的重要因素,寻找逆转多药耐药的药物成为临床治疗大肠癌的新突破。肿瘤多药耐药的产生机制复杂,具有多基因、多步骤及多因素的特性。中药具有毒性小、多途... 详细信息

多药耐药(MDR)是导致大肠癌化疗失败的主要原因之一,也是造成大肠癌患者高死亡率的重要因素,寻找逆转多药耐药的药物成为临床治疗大肠癌的新突破。肿瘤多药耐药的产生机制复杂,具有多基因、多步骤及多因素的特性。中药具有毒性小、多途径、作用靶点广泛等优势,在逆转肿瘤多药耐药方面取得了一定进展,备受各界关注。文章结合大肠癌多药耐药产生的主要机制,阐述近年来中药逆转大肠癌MDR的作用研究,此将为临床中医药治疗大肠癌及相关研究提供一定的参考。

关键词：大肠癌多药耐药逆转中药

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Shexiang Tongxin Dropping Pill（麝香通心滴丸）Protects against Na2S2O4-Induced Hypoxia-Reoxygenation Injury in H9c2 Cells

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Chinese Journal of Integrative Medicine 2019年第6期25卷 439-445页

作者： lin Shan lin jiu-mao ZHANG ling CHEN Da-xin XIAO Fei CHEN Hong-wei CHEN You-qin ZHU Yu-ling CHU Jian-feng PENG Jun Academy of Integrative Medicine Fujian University of Traditional Chinese Medicine Fuzhou (350122) China Fujian Key Laboratory of Integrative Medicine on Geriatric Fujian University of Traditional Chinese Medicine Fuzhou (350122) China Rainbow Babies Children's Hospital Case Western Reserve University School of Medicine Cleveland OH (44106) USA Inner Mongolia Conba Pharmaceutical Co. Ltd. Shanghai (201318) China CHEN Ke-ji Academic Thought Heritage Studio Fuzhou (350122) China

Objectives: To investigate the protective effects of Shexiang Tongxin Dropping Pill(麝香通心滴丸,STP) on Na2S2O4-induced hypoxia-reoxygenation injury in cardiomyoblast H9c2 cells. Methods: The cell viability and levels of mRNA and protein expression in H9c2 cells were determined following Na2S2O4-induced hypoxia using Hoechst staining, annexin V/propidium iodide(PI) flow cytometry, real-time polymerase chain reaction and Western blot analysis. Results: STP pretreatment signi?cantly increased the viability and inhibited aberrant morphological changes in H9c2 cardiomyoblast cells induced by Na2S2O4 treatment(P<0.05). In addition, STP pretreatment attenuated Na2S2O4-induced hypoxic damage, down-regulated the expression of pro-apoptotic Bax,and up-regulated the expression of anti-apoptotic Bcl-2 in H9c2 cells(P<0.05). Conclusions: STP was strongly cardioprotective in hypoxia-reoxygenation injury by preventing hypoxic damage and inhibiting cellular *** results further support the use of STP as an effective drug for the treatment of ischemic heart disease.

关键词： myocardial ischemia apoptosis Shexiang Tongxin Dropping Pill Chinese medicine Na2S2O4-induced hypoxia-reoxygenation injury

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CaH2-promoted activity of Ni-carbonate interface for CO_(2) methanation

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Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： Jin-Peng Wang Guo-Cui mao Hui-lin Jiang Bao-Xia Dong Yun-Lei Teng School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002JiangsuChina

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO_(2)hydrogenation reaction,involving surface carbonate hydrogenation and CO_(2)***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic CO_(2)*** work demonstrated that the incorporation of CaH_(2)in Ni/CaCO_(3)enhances the CO_(2)methanation activity of the *** CO_(2)conversion for Ni/CaH_(2)-CaCO_(3)reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO_(3)(31.6%) and Ni/CaH_(2)-CaO (42.4%) ***,the Ni/CaH_(2)-CaCO_(3)catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH_(2)played a crucial role in promoting the activity of the Ni-carbonate interface for CO_(2)***_(2)could modify the electronic structure of Ni and tune the structural properties of CaCO_(3)to generate medium basic sites (OH groups),which are favorable for the activation of H2and CO_(2).In-situ Fourier transform infrared spectroscopy (FTIR) analysis combined with density functional theory calculations demonstrated that CO_(2)activation occurs at the hydroxyl group (OH) on the CaH_(2)-modified Ni-carbonate surface,leading to the formation of CO_(3)H****,our study has confirmed that CO_(2)methanation over the Ni/CaH_(2)-CaCO_(3)catalysts proceeds via the formate pathway.

关键词： CO_(2)methanation Metal hydride Ni catalysts Carbonate Metal-carbonate interface

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Loosening metal nodes in metal-organic frameworks to facilitate the regulation of valence

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Fundamental Research 2025年第1期5卷 158-164页

作者： Li, Yu-Xia Shen, Jia-Xin Diao, Ze-jiu Qi, Shi-Chao Liu, Xiao-Qin Sun, lin-Bing State Key Laboratory of Materials-Oriented Chemical Engineering Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) College of Chemical Engineering Nanjing Tech University Nanjing 210009 China

The valence of metal nodes in metal-organic frameworks (MOFs) determines their performance in applications while developing an efficient approach for valence regulation is challenging. Here we present a strategy to make the valence regulation much easier by loosening metal nodes by thermal pretreatment. The typical MOF, HKUST-1, with the tunable valence of Cu nodes, was used as a proof of concept. Thermal pretreatment (producing HK-T) changes the chemical environment and loosens Cu nodes, endowing them with enhanced reducibility. In the subsequent vapor-induced reduction, the yield of Cu+ from Cu2+ conversion in HK-T (producing HK-T-V) reaches 69%, which is higher than that in pristine HKUST-1 (producing HK-V) with a Cu+ yield of 19% as well as the reported yields of target-valence metal nodes in various MOFs (6∼30%). The obtained HK-T-V possessing abundant Cu+ sites can capture 0.809 mmol/g thiophene in adsorptive desulfurization, 2.5 times higher than HK-V and superior to most reported adsorbents. © 2022

关键词： Adsorption Copper Desulfurization Metal-organic frameworks Valence regulation

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Super-high bed sintering for iron ores:variation and optimization of bed resistance

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Journal of Iron and Steel Research International 2025年第1期32卷 40-51页

作者： Liang-ping Xu lin Xiong Hui-bo Liu Xi-duan Yang Ai-xiang mao Pei-dun Chen Guang-hui Li School of Minerals Processing and Bioengineering Central South UniversityChangsha410083HunanChina Central Research Institute Baosteel Group Co.Ltd.Shanghai201900China Manufacturing Management Department Guangdong Zhongnan Iron and Steel Co.Ltd.Shaoguan512123GuangdongChina Technology and Development Center Shandong Taishan Iron and Steel Group Co.Ltd.Jinan271100ShandongChina

As the bed depth increases,sintering yield increases,but the productivity *** reveal the reasons for the decrease in productivity and explore targeted solutions,the bed resistance of mixtures,wet zone,and combustion zone was analyzed in the *** results showed that the decreased porosity of mixture resulted in the increased bed resistance by 160.56%when the bed depth increased from 600 to 1000 *** improving porosity of 1%by adding loosening bars with optimized size and distribution,the bed resistance decreased,and the productivity increased by 5%.The increase in bed depth increased the thickness of the wet zone from 120 to 680 mm and the resistance from 1.56 to 8.83 *** using a three-stage intensive mixer and pre-adding water for granulation,the moisture of mixture was reduced by 0.6%,and the sintering productivity increased by 4%.Besides,the high bed resistance is mainly caused by the increase in the thickness of the combustion zone from 31.9 to 132.7 mm,and the bed resistance increased from 0.70 to 5.62 *** bed resistance of the combustion zone at 900 mm was increased by 90.51%compared to 700 *** optimization of the distribution of coke breeze,the thickness of combustion zone at the lower layer decreased from 132.7 to 106.84 mm and permeability improved significantly.

关键词： Super-high bed sintering Bed resistance Permeability Productivity Wet zone Combustion zone

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黄芪多糖抗肿瘤作用的研究进展

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中医药通报 2020年第4期19卷 69-72,34页

作者：毛倩倩林久茂福建中医药大学中西医结合研究院福建福州350122 福建省中西医结合老年性疾病重点实验室福建福州350122

黄芪多糖是中药黄芪的提取物,具有抗肿瘤、调节免疫、抗氧化、降血糖等多种作用。近年来,其在抗肿瘤方面的作用备受关注。本文通过阅读近几年国内外黄芪多糖抗肿瘤相关文献,主要从调节肿瘤免疫、抑制肿瘤细胞增殖、抑制肿瘤细胞迁移侵... 详细信息

黄芪多糖是中药黄芪的提取物,具有抗肿瘤、调节免疫、抗氧化、降血糖等多种作用。近年来,其在抗肿瘤方面的作用备受关注。本文通过阅读近几年国内外黄芪多糖抗肿瘤相关文献,主要从调节肿瘤免疫、抑制肿瘤细胞增殖、抑制肿瘤细胞迁移侵袭、诱导肿瘤细胞凋亡、抗血管和淋巴管新生以及联合化疗药物的增效减毒作用几方面展开综述,深入了解黄芪多糖在抗肿瘤方面的作用及机制、研究新进展,为黄芪多糖今后的研究开发和广泛应用提供参考。

关键词：黄芪多糖抗肿瘤综述

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