检索结果-南通市图书馆

Placebo effects and the molecular biological components involved

在线全文

学校读者我要写书评

暂无评论

General Psychiatry 2019年第5期32卷 227-236页

作者： Lei Cai lin he Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders(Ministry of Education)Collaborative Innovation Center of Genetics and DevelopmentShanghai Jiaotong UniversityShanghai 200240China

Pharmacologically inactive substances have been used in medicine for more than 700 years and can trigger beneficial responses in the human body, which is referred to as the placebo effects or placebo responses. This effect is robust enough to influence psychosocial and physiological responses to the placebo and to active treatments in many settings, which has led to increased interest from researchers. In this article, we summarise th history of placebo, the characteristics of placebo effects and recent advancements reported from the studies on placebo effects and highlight placebome studies to identif various molecular biological components associated with placebo effects. Although placebos have a long history, the placebome concept is still in its infancy. Although behavioural, neurobiological and genetic studies have identified that molecules in the dopamine, opioid, serotoni and endocannabinoid systems might be targets of the placebo effect, placebome studies with a no-treatment control (NTC) are necessary to identify whole-genome genetic targets. Although bioinformatics analysis has identified the molecular placebome module, placebome studies with NTCs are also required to validate the related findings.

关键词： enough behaviour finding

Reactor field reconstruction from sparse and movable sensors using Voronoi tessellation-assisted convolutional neural networks

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第5期35卷 173-185页

作者： he-lin Gong Han Li Dunhui Xiao Sibo Cheng Paris Elite Institute of Technology Shanghai Jiao Tong UniversityShanghai 200240China School of Mathematical Sciences Tongji UniversityShanghai 200092China Department of Computing Data Science InstituteImperial College LondonLondon SW72AZUK

The aging of operational reactors leads to increased mechanical vibrations in the reactor *** vibration of the incore sensors near their nominal locations is a new problem for neutronic field *** field-reconstruction methods fail to handle spatially moving *** this study,we propose a Voronoi tessellation technique in combination with convolutional neural networks to handle this *** from movable in-core sensors were projected onto the same global field structure using Voronoi tessellation,holding the magnitude and location information of the *** convolutional neural networks were used to learn maps from observations to the global *** proposed method reconstructed multi-physics fields(including fast flux,thermal flux,and power rate)using observations from a single field(such as thermal flux).Numerical tests based on the IAEA benchmark demonstrated the potential of the proposed method in practical engineering applications,particularly within an amplitude of 5 cm around the nominal locations,which led to average relative errors below 5% and 10% in the L_(2) and L_(∞)norms,respectively.

关键词： Voronoi tessellation Field reconstruction Nuclear reactors Reactor physics On-line monitoring

Thermodynamic modeling of Cr-Al-C and Ni-Al-C systems for low-density steels

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2020年第10期27卷 1190-1199页

作者： Wei-sen Zheng Yan-lin he Xiao-gang Lu State Key Laboratory of Advanced Special Steel Shanghai UniversityShanghai 200444China School of Materials Science and Engineering Shanghai UniversityShanghai 200444China

The so-called low-density steels have generated a lot of interests with their high specific strength and ductility due to the addi-tion of the light element *** order to accelerate the low-density steel design,a thermodynamic database has been developedwithin the present author *** Al-containing systems,i.e.,Cr-Al-Cand Ni-Al-C,were modeled and optimirzed with CALPHAD approach based on the reliable binary *** Cr-Al-C,system,the Gibbs energy of Cr2AlC phasewas described by a temperature-dependent polynomial with the aid of the experimental data on the heat capacity,instead of estimating heat capacity from Ncumann-Kopp *** incongruent melting temperature of Cr2AlC is 1762 K with theinvariant reaction of liquid+Cr3C2+Al4C3→*** phase equilibria between Cr2AlC and binary phases were wellreproduced by using the present model *** Ni-Al-C system,the liquid,fec and bec phases have been optimizedto fit the carbon solubility in these three phases.A good agreement between the calculated and experimental data has beenobtained using the present description of Ni-Al-C *** reliable descriptions of the two ternary systems developedin the present work can be implemented into the thermodynamic database for low-density steels.

关键词： Cr-Al-C system Ni-Al-C system Thermodynamic model CALPHAD Low-density steel

Probing the new strategy for the oral formulations of taxanes:changing the method with the situation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2021年第9期19卷 656-665页

作者： WANG he-lin SUN Jin TIAN Chu-Tong he Zhong-Gui Department of Pharmaceutics Wuya College of InnovationShenyang Pharmaceutical UniversityShenyang 110016China

The first-generation taxanes(including paclitaxel and docetaxel)are widely used for the treatment of various cancers in clinical *** the past decade,a series of new-generation taxanes have been developed which are effective in the inhibition of tumor ***,intravenous(i.v.)infusion is still the only route of administration,and may result in serious adverse reactions with respect to the utilization of Cremophor EL or Tween-80 as ***,the dosing schedule is also ***,oral administration of taxanes is urgently needed to avoid the adverse reactionss and increase dosing *** this review,we first outlined the discovery and development of taxane-based anticancer ***,we summarized the research progress on the oral formulations of taxanes and proposed some thoughts on the future development of oral taxane formulations.

关键词： Taxanes Oral delivery Oral bioavailability Anti-tumor

New Normally Ordered Four-Mode Squeezing Operator for Standard Squeezing of Four-Mode Quadratures

在线全文

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2007年第1期47卷 135-138页

作者： FAN Hong-Yi CAO he-lin Department of Material Science and Engineering University of Science and Technology of China Hefei 230026 China Department of Physics Shanghai Jiao Tong University Shanghai 200030 China

By virtue of the technique of integration within an ordered product of operators a new four-mode squeezing operator that squeezes the four-mode quadrature operators of light field in the standard way is found. This operator differs from the direct product of two two-mode squeezing operators, It is the exponential operator V≡exp[ir （Q1P2＋Q2P3＋Q3P4＋Q4P1）].The Wigner function of the new four-mode squeezed state is ealculated,which quite differs from that of the direct-product state of two usual two-mode squeezed states.

关键词： four-mode quadrature operator squeezing operator the technique of IWOP Wigner function

The forty years of medical genetics in China

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2018年第11期45卷 569-582页

作者： Lei Cai Lan Alice Zheng lin he Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education)Collaborative Innovation Center for Genetics and DevelopmentShanghai Jiao Tong UniversityShanghai 200240China Shanghai Center for Women and Children's health Shanghai 200062China Stanley Center Broad InstituteCambridgeMA 02142USA

Medical genetics is the newest cutting-edge discipline that focuses on solving medical problems using genetics knowledge and methods. In China, medical genetics research activities initiated from a poor inner basis but a prosperous outer environment. During the 40 years of reform and opening-up policy,Chinese scientists contributed significantly in the field of medical genetics, garnering considerable attention worldwide. In this review, we highlight the significant findings and/or results discovered by Chinese scientists in monogenic diseases, complex diseases, cancer, genetic diagnosis, as well as gene manipulation and gene therapy. Due to these achievements, China is widely recognized to be at the forefront of medical genetics research and development. However, the significant progress and development that has been achieved could not have been accomplished without sufficient funding and a wellconstructed logistics network. The successful implementation of translational and precise medicine sourced from medical genetics will depend on an open ethics policy and intellectual property protection,along with strong support at the national industry level.

关键词： Medical genetics GWAS CRISPR Cancer Monogenic diseases Complex diseases Genetic diagnosis Gene therapy

Versatile MOF-derived cobalt catalyst for the reductive amination

在线全文

学校读者我要写书评

暂无评论

Science China Materials 2017年第12期60卷 1269-1271页

作者： Haihong Wu Chaoren Shen Chungu Xia lin he State Key Laboratory for Oxo Synthesis and Selective Oxidation Suzhou Research Institute of LICP Lanzhou Institute of Chemical Physics (LICP) Chinese Academy of Sciences Lanzhou 730000 China University of Chinese Academy of Sciences Beijing 100049 China

The tunable metal center and the tailorable organic linker of metal-organic framework(MOF)make the characteristic of ultrahigh porosity,controllable pore size,crystalline nature and highly-ordered structures[1].Since its emergence[2,3],it represents one of the most celebrated functional *** to the rich diversity of MOF family,a vast of important applications including the storage of gas,recognition of molecules as well as

关键词： DABCO Co NH MOF TPA

Controllable laning phase for oppositely driven disk systems

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2019年第12期28卷 123-129页

作者： lin Liu Ke Li Xiao-lin Zhou lin-Li he lin-Xi Zhang Department of Physics Zhejiang UniversityHangzhou 310027China Department of Physics Wenzhou UniversityWenzhou 325035China

A two-dimensional binary driven disk system embedded by impermeable tilted plates is investigated through nonequilibrium computer simulations. It is well known that a binary disk system in which two particle species are driven in opposite directions exhibits jammed, phase separated, disordered, and laning states. The presence of tilted plates can not only advance the formation of laning phase, but also effectively stabilize laning phase by suppressing massively drifting behavior perpendicular to the driving force. The lane width distribution can be controlled easily by the interplate distance. The collective behavior of driven particles in laning phase is guided by the funnel-shaped confinements constituted by the neighboring tilted plates. Our results provide the important clues for investigating the mechanism of laning formation in driven system.

关键词： driven system tilted plates laning phase drifting behavior

Liquid-crystal Assembly of Semiflexible-coil/Homopolymer Blends: a Dissipative Particle Dynamics Study

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2018年第10期36卷 1200-1206页

作者： Yan-Yan Wang Qing-Liang Song lin-Li he Department of Physics Wenzhou University

The liquid-crystal assembly of semiflexible-coil diblock copolymers with coil or semiflexible homopolymers is studied by dissipative particle dynamics simulation. Phase diagrams of the blends and orientation ordering parameters among semiflexible blocks are constructed as a function of chain stiffness and homopolymer volume fraction. For semiflexible-coil/coil blends with varying stiffness of semiflexible blocks, we display the rich phase behaviors of the system transited from coil-coil/coil to rod-coil/coil blends. The disorder- lamellae or lamellae-liquid crystalline transition and ＂dry brush＂ phenomenon induced by coil homopolymers are observed. For semiflexible-coil/semiflexible blends, adding semiflexible homopolymers also leads to a disorder-order transition and even a transition between monolayer and bilayer smectic-A phase. The results demonstrate that blending homopolymers into semiflexible copolymers can induce liquid-crystal assembly and even improve the orientation ordering of semiflexible blocks effectively.

关键词： Liquid-crystal assembly Semiflexible-coil Homopolymers Orientation