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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： lin-Yan huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

The Initial-Boundary-Value Problems for the Hirota Equation on the Half-line

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Chinese Annals of Mathematics,Series B 2020年第1期41卷 117-132页

作者： lin huang School of Science Hangzhou Dianzi UniversityHangzhou 310018China School of Mathematical Sciences Fudan UniversityShanghai 200433China

An initial boundary-value problem for the Hirota equation on the half-line,00, is analysed by expressing the solution q(x, t) in terms of the solution of a matrix Riemann-Hilbert(RH) problem in the complex k-plane. This RH problem has explicit(x, t) dependence and it involves certain functions of k referred to as the spectral functions. Some of these functions are defined in terms of the initial condition q(x,0) = q0(x), while the remaining spectral functions are defined in terms of the boundary values q(0, t) = g0(t), qx(0, t) = g1(t) and qxx(0, t) = g2(t). The spectral functions satisfy an algebraic global relation which characterizes, say, g2(t) in terms of {q0(x), g0(t), g1(t)}.The spectral functions are not independent, but related by a compatibility condition, the so-called global relation.

关键词： Hirota equation Riemann-Hilbert problem Initial-boundary value problem Global relation

Energy-efficiency maximization for fixed-wing UAV-enabled relay network with circular trajectory

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Chinese Journal of Aeronautics 2022年第9期35卷 71-80页

作者： Chenxiao XIE Xin-lin huang Department of Information and Communication Engineering Tongji UniversityShanghai 201804China

With the development of Unmanned Aerial Vehicles(UAVs), the applications of UAVs have been extensively explored. In the field of wireless communications, the relay nodes are often used to extend network coverage. However, traditional fixed ground relays cannot be flexibly deployed due to their low heights and fixed locations. Hence, deploying UAV as relay node is a promising solution and has become a research hotspot. In this paper, we consider an UAVenabled relaying network in which a fixed-wing UAV is deployed between the Base Station(BS)and Ground Users(GUs). We study the energy-efficiency gap between the link “BS-UAV-GUs”and the link “BS-GUs”, and jointly optimize UAV relay transmission power and flight radius to achieve the highest energy-efficiency. Firstly, the UAV/BS-GUs channels models and the UAV energy consumption model are built. Secondly, the optimization objective function is formulated to maximize the energy-efficiency gap. Then, the solution of the optimization problem is divided into a two-step iteration process, in which the UAV relay transmission power and flight radius are adjusted to maximize the energy-efficiency gap. Finally, the experimental results under different simulation scenarios(such as cities, forests, deserts, oceans, etc.) are shown to illustrate the effectiveness of the proposed algorithm. The results show that the proposed algorithm can always find the optimal UAV relay transmission power and flight radius settings, and achieve the largest energy-efficiency gap. The convergency speed of the proposed algorithm is fast, and can obtain the optimal solution within only a few iterations.

关键词： Circular trajectory Energy efficiency Fixed wing UAV Power allocation UAV relay

Effects of compressibility on the Rayleigh-Taylor instability in Z-pinch implosions

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核聚变与等离子体物理 2006年第2期26卷 87-94页

作者： huang lin JIAN Guang-de Southwestern Institute of Physics Chengdu 61004 1

The effects of compressibility on the Rayleigh-Taylor instability in Z-pinch implosion plasmas are investigated by means of simple slab *** linear mode equation,which includes main steady-state quantities and their gradients,is *** solutions are *** incompressible fluid result is also *** results indicate that the linear growth rate of the Rayleigh-Taylor instability for the compressible magnetohydrodynamic fluid is far larger than one in the incompressible ***,the compressible systems are all more unstable than the incompressible ones.

关键词： Z-pinch Rayleigh-Taylor instability Compressibility Growth rate.

Subunit Characteristics of Pig Pancreas Ferritin Revealed by MALDI-TOF MS and RP-HPLC

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Chemical Research in Chinese Universities 2008年第5期24卷 550-556页

作者： huang lin lin Zhi-cao lin Qing LUO Lian-zhong huang He-qing Key Laboratory of the MOD for Cell Biology and Tumor Cell Engineering School of Life Sciences State Key Laboratory of Physical Chemistry of Solid Surface Key Laboratory of Chemical Biology of Fujian Province College Chemistry ＆ Chemical Engineering Xiamen University Xiamen 361005 P R. China

Pig pancreas ferritin（PPF） was purified by ultra-centrifugation, ion-exchange chromatography, and native gradient polyacrylamide gel electrophoresis（PAGENG）. Sodium dodecyl sulfate（SDS）-PAGE indicates that PPF consists of two subunit types, namely, H（21000） and L（19000） subunits, and its core shows an average element composition of 1698 Fe3＋ and 179 phosphate molecules within the hollow shell, giving a 9.5：1 ratio of Fe3＋ to phosphate. An off line approach combining reversed-phase high-performance liquid chromatography（RP-HPLC） with matrix-assisted laser desorption ionization time of flight mass spectrometry（MALDI-TOF MS） made the decomposition of PPF shell into H and L subunits for the analysis of mass spectrometry（MS）, giving molecular weights of both H（21014.4） and L（18319.9） subunits. Both subunit types were further identified by an approach combining peptide mass fingerprint（PMF） with database search. A ratio of 1H to 2L subunits in PPF was determined by SDS-PAGE, RP-HPLC, and MALDI-TOF MS, respectively. It is well known that the non-covalent interaction of L-L or H-L subunits is stronger than that of H-H subunits in PPF, which may be further used to explain the unclear physiological function between H and L subunits in PPF.

关键词： Ferritin Pig pancreas Subunit structure Proteomic MALDI-TOF MS RP-HPLC

H_∞ CONTROL OF NETWORKED MULTI-AGENT SYSTEMS

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Journal of Systems Science & Complexity 2009年第1期22卷 35-48页

作者： Zhongkui LI Zhisheng DUAN lin huang State Key Lab for Turbulence and Complex Systems and Department of Mechanics and Aerospace Engineering College of Engineering Peking University Beijing 100871 China.

This paper concerns the disturbance rejection problem arising in the coordination control of a group of autonomous agents subject to external disturbances. The agent network is said to possess a desired level of disturbance rejection, if the H∞ norm of its transfer function matrix from the disturbance to the controlled output is satisfactorily small. Undirected graph is used to represent the information flow topology among agents. It is shown that the disturbance rejection problem of an agent network can be solved by analyzing the H∞ control problem of a set of independent systems whose dimensions are equal to that of a single node. An interesting result is that the disturbance rejection ability of the whole agent network coupled via feedback of merely relative measurements between agents will never be better than that of an isolated agent. To improve this, local feedback injections are applied to a small fraction of tile agents in the network. Some criteria for possible performance improvement are derived in terms of linear matrix inequalities. Finally, extensions to the case when communication time delays exist are also discussed.

关键词： Coordination control graph theory H∞ control linear matrix inequality (LMI) pinning control.

A Hybrid Dissipative Trapped Electron ITG Mode

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Chinese Physics Letters 1995年第12期12卷 743-746页

作者： BAI lin QIU Xiaoming huang lin Southwestern Institute of Physics P.O.Box 432Chengdu 610041

A simple model for theηi-mode taking account of the dissipative trapped electron effect,which is described by means of the well-known formula of the nonadiabatic electron response,in a sheared slab geometry is *** predicts the existence of a hybrid dissipative trapped electron ion temperature gradient(ITG)*** conclusion is in agreement with the observation in the latest simulated tokamak experiment on the Columbia linear Machine.

关键词： dissipative Electron conclusion

Electroless plating of Ni-Zn(Fe)-P alloy on carbon steel sheets

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中国有色金属学会会刊：英文版 2004年第z1期14卷 157-161页

作者： WANG Sen-lin WU Hui-huang College of Materials Science and Engineering Huaqiao University Quanzhou 362021 China State Key Laboratory for Physical Chemistry of Solid Surface Department of ChemistryXiamen University Xiamen 361005 China State Key Laboratory for Physical Chemistry of Solid Surface Department of ChemistryXiamen University Xiamen 361005 China

The autocatalytic deposition of Ni-Zn(Fe)-P alloys were carried out on carbon steel sheets from bath containing nickel sulfate, zinc sulfate, sodium hypophosphite, sodium citrate and boric acid. The effects of pH and mole ratio of NiSO4/ZnSO4 on the deposition rate and the composition of deposit were studied. It is found that the presence of zinc sulfate in the bath has an inhibitory effect on the alloy deposition. As a consequence, the mole fraction of zinc in the deposits never reaches high value, which is less than 18.0%. The structure and surface morphology of Ni-Zn(Fe)-P coatings were charactered by XRD and SEM. The alloys plated at all conditions consist of amorphous phase coexisting with a crystalline cubic Ni phase. The surface morphology of coating is dependent on the deposition parameters.

关键词： electroless plating nickel zinc

Lamellar Spacing Selection in Regular Eutectic Solidification at Low Velocity

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Journal of Materials Science & Technology 2007年第6期23卷 851-854页

作者： Guanghui MENG Xin lin Weidong huang State Key Laboratory of Solidification Processing Northwestern Polytechnical University Xi＇an 710072 China

Based on the Jackson and Hunt＇s analysis, the selection of lamellar spacing in regular eutectics was reexamined at low velocity. The isothermal assumption was released and the effective interface undercooling was determined by the weighted average of the eutectic phases. It is found that the lamellar spacing minimized the effective interface undercooling depends only on the intrinsic characteristics of a given system at a fixed velocity. In addition, the selection of lamellar spacing is related to the relationship between the average interracial undercoolings of the eutectic phases and the lamellar spacing. The selected lamellar spacing obviously deviated from that predicted by the Jackson and Hunt＇s analysis if the variation of the average interracial undercoolings of the solid phases with the lamellar spacing was markedly different at a constant growth rate.

关键词： Solidification Eutectic Lamellar spacing Undercooling