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A New Maleamide Bridged Carbazole Chromogenic-sensor Based on Proton Transfer Signaling Mode

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Chemical Research in Chinese Universities 2008年第3期24卷 263-265页

作者： WANG Yue-hong lin Hai SHAO Jie lin hua-kuan Department of Chemistry for Absorption and Separation of Ministry of Education Nankai University Tianjin 300071 P R. China Key Laboratory of Functional Polymer Materials for Absorption and Separation of Ministry of Education Nankai University Tianjin 300071 P R. China

A Maleamide bridged carbazole receptor was designed and synthesized, the interactions between the receptor and anions, such as Ac-, H2PO4-, OH-, F-, Cl-, Br- and I- in DMSO were investigated by UV-Vis spectroscopy and 1H NMR titration. The results of UV-Vis spectral studies indicate that interactions existed between receptor and anions, which induced remarkable color changes. The 1H NMR titration indicated amide moiety of the receptor was deprontonated first when a small quantity of anions such as Ac-, H2PO4-, F- were added; however, the carbazole N―H was gradually deprontonated upon the addition of anions.

关键词： Anion receptor Colorimetric Supramolecular chemistry

Potential hydraulic connectivity of coal mine aquifers based on statistical analysis of hydrogeochemistry

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Water Science and Engineering 2022年第4期15卷 285-293页

作者： Xiang Zhao Wei-hua Peng Kai Chen Xin-yi Qiu lin-hua Sun School of Resources and Civil Engineering Suzhou UniversitySuzhou 234000China School of Earth and Environment Anhui University of Science and TechnologyHuainan 232001China Key Laboratory of Mine Water Resource Utilization of Anhui Higher Education Institutes Suzhou UniversitySuzhou 234000China

Mining activities interfere with the natural groundwater chemical environment,which may lead to hydrogeochemical changes of aquifers and mine water inrush *** study analyzed the hydrochemical compositions of 80 water samples in three aquifers and developed a water source identification model to explore the control factors and potential hydraulic connection of groundwater chemistry in a coal *** results showed that the hydrochemical types of the three aquifers were *** main hydrochemical compositions of the loose-layer,coal-bearing,and limestone aquifers were HCO_(3)·Cl-Na,SO_(4)·HCO_(3)-Na,and SO_(4)-Na·Ca,*** correlation,Unmix,and factor an-alyses showed that the hydrochemical composition of groundwater was controlled by the dissolution of soluble minerals(such as calcite,dolomite,gypsum,and halite)and the weathering of silicate *** factor score plot combined with Q-mode cluster analysis demon-strated no remarkable hydraulic connection among the three aquifers in the study *** water source identification model effectively identified the source of inrush ***,the mixing ratio model rationally quantified the contributions of the three aquifers to inrush water.

关键词： Groundwater Water chemistry Factor analysis Hydraulic connection Mathematical statistics

Microfluidic synthesis of thiourea modified chitosan microsphere of high specific surface area for heavy metal wastewater treatment

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Chinese Chemical Letters 2017年第3期28卷 633-641页

作者： Yong Zhu Zhi-Shan Bai hua-lin Wang State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process East China University of Science and TechnologyShanghai 200237China

An improved biosorbent of thiourea modified chitosan microsphere（TMCM） with high specific surface,favorable mechanical strength and excellent adsorption performance had been synthesized via microfluidic technology. Polyethylene glycol was used as a significant component added in aqueous solution of chitosan to produce such microspheres through droplets forming, chemical crosslinking and pores creating. For the improvement of adsorption capacity, thiourea was considered as an excellent choice in increasing amino functional group by graft modification. The SEM, FTIR and EDS were employed to detect distinct features of TMCM. Copper（Ⅱ） was used to test the adsorption performance of TMCM. The experimental results indicated that TMCM exhibited higher adsorption capacity（q_e= 60.6 mg g_（-1）） and faster adsorption rate than that non-modified chitosan microsphere（NMCM）.The adsorption kinetic was described well by the pseudo-second order kinetic model, which suggested that chemical adsorption along with electrons transferring was dominant in adsorption process.

关键词： Thiourea modification Chitosan microsphere High specific surface area Microfluidic technology Adsorption

一种氟化纳米给药系统通过抑制阿霉素外排逆转MCF-7/ADR细胞耐药性的研究

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Male size does not correlate with fertilization success in two bufonid toads that show size-assortative mating

中国药理学通报 2024年第6期40卷 1124-1130页

作者：孙怀涛林银花孙雨蓉陈乔陈硕曹煜安徽中医药大学科研技术中心安徽中医药大学新安医学教育部重点实验室安徽合肥 230038 安徽中医药大学附属第一医院安徽合肥 230031 安徽中医药大学科研技术中心安徽中医药大学新安医学教育部重点实验室安徽合肥 230038 食药用菌功能活性与资源利用安徽省联合共建学科重点实验室安徽合肥 230038

目的通过合成氟化纳米材料完成对阿霉素(doxoru-bicin,dox)的高效负载,并实现纳米药物对抗肿瘤耐药的机制研究.方法评估不同氟化程度(PF4和PF8)的纳米药物(nano dox)的理化性能,筛选出更为优良的氟化nano dox;通过细胞毒性、细胞摄取... 详细信息

目的通过合成氟化纳米材料完成对阿霉素(doxoru-bicin,dox)的高效负载,并实现纳米药物对抗肿瘤耐药的机制研究.方法评估不同氟化程度(PF4和PF8)的纳米药物(nano dox)的理化性能,筛选出更为优良的氟化nano dox;通过细胞毒性、细胞摄取、凋亡以及对抗外排泵P-糖蛋白(P-glycoprotein,P-gp)的研究,考察nano dox对抗肿瘤多药耐药以及体外抗肿瘤活性研究.结果通过考察各种理化指标,PF8相对于PF4显示出更优良的负载dox性能;通过细胞毒性实验证明,nano dox的IC50值只有游离dox IC50值的1/40,显示出nano dox在对抗耐药性方面优良的体外活性;细胞摄取和凋亡研究说明nano dox可以有效提高耐药MCF-7/ADR细胞对dox的摄取并能成功地进入细胞核内,最终导致凋亡诱导的抗癌活性;P-gp的药物外排研究说明nano dox可以有效绕过P-gp外排泵,达到增加耐药细胞对药物的摄取同时减少外排量的双重作用.结论通过氟化nano dox的设计可以有效绕过P-gp对药物的外排作用,增加药物在耐药肿瘤细胞内的摄取,减少其外排,从而达到有效的对抗肿瘤多药耐药效果.

关键词：氟化纳米药物递送 P-糖蛋白体外活性药物外排多药耐药

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Current Zoology 2013年第6期59卷 740-746页

作者： Xiao-Li FAN Zhi-hua lin Xiang JI Jiangsu Key Laboratory for Biodiversity and Biotechnology College of Life Sciences Nanjing Normal University Nanjing210046 Jiangsu China College of Ecology Lishui University Lishui 323000 Zhejiang China

We examined sexual size dimorphism （SSD）, mating pattem, fertilization efficiency and female reproductive traits in two bufonid toads （Bufo gargarizans and Duttaphrynus melanostictus） to test the idea that importance of male body size for egg fertilization success depends on the mating pattern. Female-biased SSD was evident only in D. melanostictus. Female B. gar- garizans laid fewer larger eggs nearly three months earlier than did female D. melanostictus. Fertilization efficieneies on average were higher in B. gargarizans （95%） than in D. melanostictus （91%）. Though differing in the degree of SSD, body size, breeding season, clutch size, egg size and fertilization efficiency, the two toads were similar in four aspects：（1） both showed size-assortative mating; （2） females did not tradeoff egg size against egg number; （3） male size, clutch size and clutch dry mass were greater in male-larger than in female-larger pairs after accounting for female snout-vent length （SVL）; and （4） the ratio of male to female SVL did not affect fertilization efficiency. Our data show that：（1） a female preference for large males is likely not important in terms of egg fertilization success; （2） a male preference for large females is likely important because larger females are more fecund; and （3） size-assortative mating arises from a male preference for large females. Our study demonstrates that male size is not always important for egg fertilization success in anurans that show size-assortative mating.

关键词： Amphibia Bufonidae Bufo gargarizans Duttaphrynus melanostictus Mating pattem Fecundity Reproductiveoutput Body size

Characterization of Phenol Biodegradation by Comamonas testosteroni ZD4-1 and Pseudomonas aeruginosa ZD4-3

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Biomedical and Environmental Sciences 2003年第2期16卷 163-172页

作者： YING-XU CHEN HE LIU hua-lin CHEN Department of Environmental Engineering Zhejiang UniversityHangzhou 310029China

To investigate the characteristic and biochemical mechanism about the phenol biodegradation by bacterial strains ZD 4-1 and ZD 4-3. Methods Bacterial strains ZD 4-1 and ZD 4-3 were isolated by using phenol as the sole source of carbon and energy, and identified by 16S rDNA sequence analysis. The concentrations of phenol and total organic carbon (TOC) were monitored to explore the degradation mechanism. The biodegradation intermediates were scanned at 375 nm by using a uv-vis spectrophotometer. The enzyme assays were performed to detect the activities of dioxygenases. Results Bacterial strains ZD 4-1 and ZD 4-3 were identified as Comamonas testosteroni and Pseudomonas aeruginosa by 16S rDNA sequence analysis, respectively. The growth of the two strains was observed on a variety of aromatic hydrocarbons. The strains ZD 4-1 and ZD 4-3 metabolized phenol via ortho-pathways and meta-pathways, respectively. In addition, the results of enzyme assays showed that the biodegradation efficiency of phenol by meta-pathways was higher than that by ortho-pathways. Finally, the results of induction experiment indicated that the catechol dioxygenases, both catechol 1,2-dioxygenase (C12O) and catechol 2,3-dioxygenase (C23O), were all inducible. Conclusion The strains ZD 4-1 and ZD 4-3 metabolize phenol through ortho-pathways and meta-pathway, respectively. Furthermore, the biodegradation efficiency of phenol by meta-pathways is higher than that by ortho-pathways.

关键词： Aromatic compounds Phenol Biodegradation Ortho-pathways Meta-pathways C12O C23O

Long-term hemispheric variation of the flare index

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Research in Astronomy and Astrophysics 2013年第3期13卷 343-350页

作者： Song Feng lin-hua Deng Shi-Chun Xu Computer Technology Application Key Lab of Yunnan Province and Faculty of Information Engineering and Automation Kunming University of Science and Technology Key Laboratory of Solar Activity National Astronomical Observatories Chinese Academy of Sciences National Astronomical Observatories / Yunnan Astronomical Observatory Chinese Academy of Sciences University of Chinese Academy of Sciences Kunming Institute of Physics

The long-term hemispheric variation of the flare index is investigated. It is found that, （1） the phase difference of the flare index between the northern and southern hemispheres is about 6-7 months, which is near the time delay between flare activity and sunspot activity; （2） both the dominant and phase-leading hemisphere of the flare index is the northern hemisphere in the considered time interval, implying that the hemispheric asynchrony of solar activity has a close connection with the N-S asymmetry of solar activity.

关键词： Sun: activity -- Sun: flares -- methods: data analysis

Analysis and Design of Circular Plate MR Fluids Brake

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上海交通大学学报 2004年第z2期38卷 152-154页

作者： Yang Yan lin Chang-hua Li Hui Zhou Jing Department of Mechanic Chongqing Institute of Technology Chongqing 400050 China Department of Mechanic Chongqing Institute of Technology Chongqing 400050 China Department of Material Chongqing Institute of Technology Chongqing 400050 China Department of Mechanic Chongqing Institute of Technology Chongqing 400050 China

A magnetorheological (MR) fluids brake is a device to achieve brake by shear force of MR fluids. A MR rotary brake has the property that its braking torque changes quickly in response to an external magnetic field. In this study, the design method of the circular plate MR fluids brake is investigated theoretically. The equation of the torque transmitted by the MR fluids in the brake is derived to provide the theoretical foundation in the design of the brake. Based on this equation, after mathematically manipulated, the calculations of the volume, thickness and width of the MR fluids within the circular plate MR fluids brake are yield.

关键词： MR fluids brake design method

Interstitial chemotherapy with ricin-loaded thermosensitive hydrogel in pancreatic cancer xenograft

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Hepatobiliary & Pancreatic Diseases International 2009年第4期8卷 418-423页

作者： Chen, Zhi-Kui lin, Li-Wu Weng, Xiu-hua Xue, En-Sheng lin, Yong-hua Fujian Med Univ Union Hosp Dept Ultrasound Fuzhou 350001 Peoples R China Fujian Med Univ Affiliated Hosp 1 Dept Pharm Fuzhou 350001 Peoples R China Fuzhou Gen Hosp Dept Gen Surg Fuzhou 350025 Peoples R China

BACKGROUND: Pancreatic cancer is one of the most aggressive malignancies, and has a poor prognosis. Despite efforts made in multiple fields, there has been little success in improving the disease-free survival rate of patients. This study was undertaken to investigate the effectiveness and feasibility of using intra-tumoral injection of ricin-loaded thermosensitive hydrogel for treatment of pancreatic cancer xenografts, attempting to develop a new treatment for human pancreatic cancer. METHODS: BALB/c-(nu/nu) nude mice were inoculated subcutaneously in the right flank with the human pancreatic cancer cells, SW1990. Fourteen days after inoculation, 32 mice, bearing tumors of volume 1.5-2.0 cm(3), were randomly assigned to one of four groups, and given an intra-tumoral injection of: (1) saline; (2) 23% w/w thermosensitive hydrogel alone; (3) ricin, 10 mu g/kg; or (4) 10 mu g/kg ricin loaded in thermosensitive hydrogel. On day 14 after administration, the tumors were excised to calculate the inhibition rate of tumor growth and perform histopathological examination. Tumor cell apoptosis was detected by flow cytometry, and RT-PCR was performed to evaluate the mRNA expression levels of Bc12 and Bax. RESULTS: Intra-tumoral injection of ricin-loaded thermosensitive hydrogel resulted in remarkable control of tumor growth. The tumor became necrotic by day 14 after administration. The histological results clearly confirmed that the tumor cells were lysed. The percentage of apoptotic cells detected by flow cytometry was higher in the ricin hydrogel group than in the other groups. Semi-quantitative RT-PCR revealed that the mRNA expression level of Bc12 was down-regulated whereas Bax was upregulated. CONCLUSIONS: Intra-tumoral injection of ricin-loaded thermosensitive hydrogel may provide an effective approach for interstitial chemotherapy in pancreatic cancer. Inducing apoptosis by downregulating Bcl2 expression and upregulating Bax expression may be a key molecular mechanism.

关键词： pancreatic neoplasm ricin hydrogel therapeutics drug delivery system