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Chinese Chemical Letters 2009年第2期20卷 158-160页

作者： lin bai Institute of Green Chemistry Experiment and Teaching Lanzhou City University Lanzhou 730070 China

A rapid and heterogeneous Pd/C-catalyzed atom-efficient phenylation of aryl bromides by sodium tetraphenylborate takes place under focused microwave irradiation in water. The palladium catalyst can be easily recovered... 详细信息

关键词： Pd/C Sodium tetraphenylborate Water Focused microwave irradiation

Recurrent CNVs on 1q21.1, 15q13.3 and 16p11.2: shared genetic risk factors for neurodevelopmental and neuropsychiatric disorders

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Journal of Genetics and Genomics 2009年第4期36卷 191-192页

作者： bai-lin Wu Children's Hospital Boston Harvard University Boston MA 02115 USA Institutes of Biomedical Science Fudan University Shanghai 200032 China

In the last couple of years, the discovery and characterization of copy-number variations （CNVs） in the human genome have provided a new research tool for identifying genetic risk factors of common complex diseases, referred to as CNVs based genome-wide association studies （GWAS）. As ever smaller genomic rearrangements have been discovered by high resolution GWAS, both de novo and inheritable CNVs （also referred to as microdeletion/microduplication or genomic imbalances） have emerged as an important type of genetic risk factor associated with complex diseases. Recent studies with large-scale, multiple cohorts have not only demonstrated the clinical significance of CNVs but also provided evidence suggesting that some CNVs may associate with various neurodevelopmental and neuropsychiatric disorders.

关键词： no English key word

Boundary Behaviors for a Continuous-state Nonlinear Neveu’s Branching Process

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Acta Mathematica Sinica,English Series 2024年第8期40卷 2005-2016页

作者： lin Yu bai Xu YANG School of Mathematics and Information Science North Minzu UniversityYinchuan 750021P.R.China

By generalizing a criterion of Mufa Chen for Markov jump processes,we establish the necessary and sufficient conditions for the extinction,explosion and coming down from infinity of a continuous-state nonlinear Neveu... 详细信息

关键词： Continuous-state branching process nonlinear branching Neveu’s branching extinction explosion coming down from infinity

A Hybrid Dissipative Trapped Electron ITG Mode

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Chinese Physics Letters 1995年第12期12卷 743-746页

作者： bai lin QIU Xiaoming HUANG lin Southwestern Institute of Physics P.O.Box 432Chengdu 610041

A simple model for theηi-mode taking account of the dissipative trapped electron effect,which is described by means of the well-known formula of the nonadiabatic electron response,in a sheared slab geometry is *** predicts the existence of a hybrid dissipative trapped electron ion temperature gradient(ITG)*** conclusion is in agreement with the observation in the latest simulated tokamak experiment on the Columbia linear Machine.

关键词： dissipative Electron conclusion

Designing a simple multiplex ligation-dependent probe amplification (MLPA) assay for rapid detection of copy number variants in the genome

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Journal of Genetics and Genomics 2009年第4期36卷 257-265页

作者： Yiping Shen bai-lin Wu Children's Hospital Boston Harvard University Boston MA 02115 USA Institutes of Biomedical Science Fudan University Shanghai 200032 China

Copy number variants （CNVs） are pervasive in the human genome and are responsible for many Mendelian diseases and genomic disorders. The detection of CNVs is an essential element of a complete mutation screening strategy. Many techniques have been developed for gene dosage testing. Multiplex ligation-dependent probe amplification （MLPA） is a robust, easy and flexible technique that can detect both deletions and duplications for more than 40 loci in one assay. It has been widely used in research and diagnostic laboratories. We routinely develop our own MLPA assays for quick validation of array comparative genomic hybridization （CGH） findings. Here we discuss the general principles and critical aspects of MLPA assay development and validation using all synthetic MLPA probes. We believe that MLPA will play important roles in the rapid detection of genomic disorders associated with genomic imbalances, the confirmation of pathogenic mutations involving exonic deletions/duplications, CNV genotyping and population frequency analysis of CNVs.

关键词： CGH CNV genomic disorders microdeletion microduplication MLPA

Trajectory Planning for OTFS-Based UAV Communications

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China Communications 2023年第1期20卷 114-124页

作者： Rui Han Jiahao Ma lin bai Tsinghua Space Center Tsinghua UniversityBeijing 100084China School of Cyber Science and Technology Beihang UniversityBeijing 100191China

Unmanned aerial vehicles(UAVs)have attracted growing research interests in recent years,which can be used as cost-effective aerial platforms to transmit collected data packets to ground access points(APs).Thus,it is crucial to investigate robust airto-ground(A2G)wireless links for high-speed ***,the A2G wireless link is unstable as it suffers from large path-loss and severe Doppler effect due to the high mobility of *** order to meet these challenges,we propose an orthogonal time frequency space(OTFS)-based UAV communication system to relief the Doppler ***,considering that the energy of UAV is limited,we optimize the trajectory planning of UAV to minimize the energy consumption under the constraints of bit error rate(BER)and transmission rate,where the Doppler compensation is taken into *** results show that the performance of OTFS-based UAV system is superior to orthogonal frequency division multiplexing(OFDM)-based UAV systems,which can accomplish transmission tasks over shorter distances with lower energy consumption.

关键词： orthogonal time frequency space(OTFS) orthogonal frequency division multiplexing(OFDM) unmanned aerial vehicle(UAV) 6G trajectory planning

Optical properties of NaY（MoO4）2:Eu3+ nanophosphors prepared by molten salt method

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Journal of Rare Earths 2019年第12期37卷 1261-1268页

作者： lin bai Qingyu Meng Mingxue Huo Yu Sui Department of Physics Harbin Institute of TechnologyHarbin 150001China School of Physics and Electronic Engineering Harbin Normal UniversityHarbin 150025China Research Center of Basic Space Science Harbin Institute of TechnologyHarbin 150001China

We synthesized NaY(MoO4)2:Eu3+phosphors of different doping concentrations by a molten salt *** facile way possesses advantages such as simple process,lower calcination temperature(350℃)and small particle size(70 nm).The crystal system is tetragonal phase and crystal lattice is body *** photo luminescence measurements including emission spectra,excitation spectra and fluorescence decay curves were carried out,elucidating that NaY(MoO4)2:Eu3+can be effectively excited by near UV and blue ***,it can be concluded that Eu3+energy transfer type is exchange ***-Rhys factor and the critical energy transfer distance(Rc)were calculated to be 0.043 and 0.995 nm,***’s model was used to obtain the intrinsic radiative transition lifetime of5 D0 level(τ0=0.923 ms).Furthermore,a calculation method was used to calculate refractive index n of nontransparent NaY(MoO4)2:1 mol%Eu3+phosphor,and n was obtained to be 1.86.

关键词： Energy transfer Red phosphors Eu^3+ Molybdates Rare earths

Progress,implications,and challenges in using humanized immune system mice in CAR-T therapy-Application evaluation and improvement

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Animal Models and Experimental Medicine 2024年第1期7卷 3-11页

作者： Hanwei Yue lin bai NHC Key Laboratory of Human Disease Comparative Medicine Institute of Laboratory Animal SciencesCAMS and PUMCChao-yang DistrictBeijingChina

In recent years,humanized immune system(HIS)mice have been gradually used as models for preclinical research in pharmacotherapies and cell therapies with major breakthroughs in tumor and other fields,better mimicking the human immune system and the tumor immune microenvironment,compared to traditional immunodeficient *** better promote the application of HIS mice in preclinical research,we se-lectively summarize the current prevalent and breakthrough research and evaluation of chimeric antigen receptor(CAR)-T cells in various antiviral and antitumor *** exploring its application in preclinical research,we find that it can better reflect the actual clinical patient condition,with the advantages of providing high-efficiency detection indicators,even for progressive research and *** believe that it has better clinical patient simulation and promotion for the updated design of CAR-T cell therapy than directly transplanted immunodeficient *** characteristics of the main models are proposed to improve the use defects of the existing models by reducing the limitation of antihost reaction,combining multiple models,and unifying sources and organoid *** study of relapse and toxicity after CAR-T treatment also provides more possibilities for application and development.

关键词： antitumor antiviral CAR-T humanized immune system model humanized mice preclinical research

Impact of finite-range tensor terms in the Gogny force on theβ-decay of magic nuclei

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Nuclear Science and Techniques 2021年第7期32卷 83-89页

作者： Da-Zhuang Chen Dong-Liang Fang Chun-lin bai College of Physics Sichuan UniversityChengdu 610065China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China

Effects of finite-range tensor force onβ-decay of magic and semimagic nuclei of^(34)Si,^(68,78)Ni,and^(132)Sn have been investigated using the self-consistent Hartree–Fock plus random-phase approximation *** tensor force shifts the low-lying Gamow–Teller states downward and systematically improves the calculations of Q and logft ***,it systematically reduces the deviations between the theoretical and experimental data and significantly improves the calculation ofβ-decay *** effect is similar to that of zero-range tensor force.

关键词： tensor decay finite

Genetic architecture, epigenetic influence and environment exposure in the pathogenesis of Autism

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Science China(Life Sciences) 2015年第10期58卷 958-967页

作者： YU Li WU YiMing WU bai-lin Children's Hospital of Fudan University Institutes of Biomedical Science Shanghai Medical College of Fudan University Claritas Genomics Boston Children's Hospital Harvard Medical School

Autism spectrum disorder(ASD) is a spectral neurodevelopment disorder affecting approximately 1% of the population. ASD is characterized by impairments in reciprocal social interaction, communication deficits and restricted patterns of behavior. Multiple factors, including genetic/genomic, epigenetic/epigenomic and environmental, are thought to be necessary for autism development. Recent reviews have provided further insight into the genetic/genomic basis of ASD. It has long been suspected that epigenetic mechanisms, including DNA methylation, chromatin structures and long non-coding RNAs may play important roles in the pathology of ASD. In addition to genetic/genomic alterations and epigenetic/epigenomic influences, environmental exposures have been widely accepted as an important role in autism etiology, among which immune dysregulation and gastrointestinal microbiota are two prominent ones.

关键词： autism spectrum disorder genetic architecture genomie disorder gene mutation copy number variants single nucleotide variants genetic pathways epigenetic influence DNA methylation chromatin remodeling long non-coding RNAs environment exposure immune dysregulation gastrointestinal microbiota