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Cardiovascular health awareness,risk perception,behavioural intention and INTERHEART risk stratification among middle-aged adults in Malaysia

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Asian Pacific Journal of Tropical Medicine 2024年第2期17卷 61-70页

作者： Siew-Keah Lee Ang-lim Chua Clement Heng Yew Fong Ban Hao Brian Cong Wen Ling Ng Jing Feng Kong Yik-Ling Chew kai Bin Liew Yang Shao M.Kandiah Faculty of Medicine and Health Sciences Universiti Tunku Abdul RahmanMalaysia Faculty of Medicine Universiti Teknologi MARAMalaysia Faculty of Pharmaceutical Sciences UCSI UniversityMalaysia Faculty of Pharmacy University of CyberjayaMalaysia The First Affiliated Hospital of Hainan Medical University China

Objective:To investigate the interrelationship between cardiovascular health awareness,risk perception,behavioural intention,and INTERHEART risk stratification in a middle-aged adult population in ***:A cross-sectional survey with convenience sampling was conducted during November 2022 and January *** completed validated questionnaires assessing cardiovascular health awareness,risk perception of cardiovascular diseases,behavioural intention towards adopting healthy habits,and INTERHEART risk stratification score(IHRS)based on established risk factors.A total of 602 respondents were included in the final *** were analysed with independent t-test/one-way ANOVA or Mann-Whitney/Kruskal-Wallis to test the differences,Pearson correlation or linear regression test to analyze the association of independent and dependent ***:There was a significant positive correlation between medical knowledge related to cardiovascular disease(CVD)and knowledge related to CVD risk prevention,risk perception,behavioural intention and IHRS(P<0.05,Pearson correlation).Notably,individuals with higher IHRS tended to have lower knowledge related to CVD and CVD risk prevention,risk perception,and behavioural ***,laborers,active/former smokers,individuals with lower household income and educational levels,those involved in occupations not related to the healthcare sector,and those who did not receive the CVD health brochure or are unaware of health self-assessment tools are likely to have lower levels of knowledge,risk perception,and poorer behavioural intention regarding cardiovascular health(P<0.05,one-way ANOVA).While educational level,smoking status,awareness about CVD poster,self-assessment tools were repeatedly significantly associated with knowledge related to CVD and CVD risk prevention,risk perception,behavioral intention and/or IHRS(P<0.05,linear regression).Conclusions:These findings underscore the importance of promoting car

关键词： Cardiovascular risk Knowledge Risk perception Behavioural intention INTERHEART Middle-aged Lifestyle Physical activity Psychosocial stress

Elastic catenary cable element considering frictional slip effect

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Science China(Technological Sciences) 2012年第6期55卷 1489-1495页

作者： CAI JianGuo lim James FENG Jian XU YiXiang WANG kai Key Laboratory of Concrete and Prestressed Concrete Structures of Ministry of Education Southeast UniversityNanjing 210096China National Prestress Engineering Research Center Southeast UniversityNanjing 210096China School of Planning Architecture and Civil EngineeringQueen's University Belfast BT95AGUK Department of Civil Engineering Strathclyde UniversityGlasgow G128QQUK

Conventional analysis methods of cable structures do not consider sliding of cables inside the joint,which may lead to inaccuracy of the theoretical behavior of the *** order to develop an effective method for cable sliding,a two-node cable element based on the analytical solution for an elastic catenary was *** cable sliding stiffness and the effect of friction were *** validate the proposed numerical method,analyses of two examples given in the literature were *** results demonstrated that the method given in this paper is accurate and effective,and can take into account cable sliding in cable *** addition,it was shown that the effect of cable sliding on the behavior of cable structures is *** was also shown that the friction at the support hampers the flow of the cable force,leading to unequal cable tensions on both sides of the support.

关键词： cable elastic catenary friction cable sliding nonlinear analysis

State of data platforms for connected vehicles and infrastructures

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Communications in Transportation Research 2021年第1期1卷 100-110页

作者： kai Li lim Jake Whitehead Dongyao Jia Zuduo Zheng Dow Centre for Sustainable Engineering Innovation The University of QueenslandBrisbaneQLD4072Australia School of Civil Engineering The University of QueenslandBrisbaneQLD4072Australia

The continuing expansion of connected and electro-mobility products and services has led to their ability to rapidly generate very large amounts of data,leading to a demand for effective data management *** is further catalysed through the need for society to make informed policies and decisions that can properly support their emerging *** data systems and platforms exist,they are often proprietary,being only compatible to the products that they are designed *** the products and services generate energy and spatial-temporal data that can often correlate,a lack of interoperability between these systems would impede decision making,as data from each system must be considered *** studying currently available data platforms and frameworks,this paper weighs the problems that these products address,and identifies necessary gaps for a more cohesive platform to *** is performed through a top-down approach,whereby broader vehicle-toeverything approaches are first studied,before moving to the components that could comprise a data platform to integrate and ingest these various data ***,potential design considerations for a data platform is presented,along with examples of application bene.

关键词： Connected mobility Vehicular networks Data platforms Electric vehicles

ABA Signaling in Guard Cells Entails a Dynamic Protein-Protein Interaction Relay from the PYL-RCAR Family Receptors to Ion Channels

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Molecular Plant 2013年第2期6卷 528-538页

作者： Sung Chul Lee Chae Woo lim Wenzhi Lan kai He Sheng Luan Department of Plant and Microbial Biology University of California Berkeley CA 94720 USA School of Biological Sciences (BK21 Program) Chung-Ang University Seoul 156-756 Korea Plant Molecular Biology Institute and College of Life Sciences Nanjing University China WCU Program Chonnam National University Gwangju Korea

Plant hormone abscisic acid （ABA） serves as an integrator of environmental stresses such as drought to trig-ger stomatal closure by regulating specific ion channels in guard cells. We previously reported that SLAC1, an outward anion channel required for stomatal closure, was regulated via reversible protein phosphorylation events involving ABA signaling components, including protein phosphatase 2C members and a SnRK2-type kinase （OST1）. In this study, we reconstituted the ABA signaling pathway as a protein-protein interaction relay from the PYL/RCAR-type receptors, to the PP2C-SnRK2 phosphatase-kinase pairs, to the ion channel SLAC1. The ABA receptors interacted with and inhibited PP2C phosphatase activity against the SnRK2-type kinase, releasing active SnRK2 kinase to phosphorylate, and activate the SLAC1 channel, leading to reduced guard cell turgor and stomatal closure. Both yeast two-hybrid and bimolecular fluorescence complementation assays were used to verify the interactions among the components in the pathway. These biochemical assays demonstrated activity modifications of phosphatases and kinases by their interaction partners. The SLAC1 channel activity was used as an endpoint readout for the strength of the signaling pathway, depending on the presence of different combinations of signaling components. Further study using transgenic plants overexpressing one of the ABA receptors demonstrated that changing the relative level of interacting partners would change ABA sensitivity.

关键词： abscisic acid ABA receptor protein kinase protein phosphatase SLAC1.

Factors affecting visual outcome of myopic choroidal neovascularization treated with verteporfin photodynamic therapy

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International Journal of Ophthalmology(English edition) 2013年第3期6卷 327-330页

作者： Colin S. Tan Milton C. Chew kai-Hung lim Tock-Han lim National Healthcare Group Eye Institute Tan Tock Seng Hospital Fundus Image Reading Center National Healthcare Group Eye Institute

AIM: To evaluate the visual outcomes of choroidal neovascularization (CNV) secondary to pathological myopia and the impact of novel risk factors affecting the final visual outcome. ·METHODS: Interventional case series of 18 consecutive patients with pathological myopia treated with photodynamic therapy (PDT). Inclusion criteria were spherical equivalent -6D or worse or features of pathological myopia on retinal examination. The main outcome measure was final best -corrected visual acuity (BCVA). ·RESULTS: Of 18 eyes, 13 (72.2%) avoided moderate visual loss (≥3 lines of LogMAR BCVA) and 5 eyes (27.8%) improved by at least 1 line after 1 year. Patients with LogMAR BCVA ≤0.3 (Snellen equivalent 20/40) at one year were younger than those with BCVA >0.3 (mean age 39.0 vs 61.6 years, P =0.001). A higher proportion of eyes with greatest linear dimension (GLD) of ≤1 000μm avoided moderate visual loss (100% vs 50%, P =0.026). Among patients who were treated within 2 weeks of visual symptoms, 88.9% avoided the loss of 3 or more lines compared to 55.6% for those who presented later. The mean improvement in LogMAR BCVA of those with GLD ≤1 000μm was +0.12 compared to a loss of 0.55 LogMAR units for those with GLD >1 000μm (P =0.02). Visual outcomes were not associated with gender or refractive error.·CONCLUSION: Good visual outcome in myopic CNV is associated with younger age, smaller lesion size and earlier initiation of treatment. These factors are relevant for ophthalmologists considering treatment options for myopic CNV.

关键词： myopic choroidal neovascularization pathologic myopia photodynamic therapy

Antimicrobial activity and mode of action of terpene linalyl anthranilate against carbapenemase-producing Klebsiella pneumoniae

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Journal of Pharmaceutical Analysis 2021年第2期11卷 210-219页

作者： Shun-kai Yang Khatijah Yusoff Mokrish Ajat Wai-Sum Yap Swee-Hua Erin lim Kok-Song Lai Department of Cell and Molecular Biology Faculty of Biotechnology and Biomolecular SciencesUniversiti Putra Malaysia43400SerdangSelangorMalaysia Department of Microbiology Faculty of Biotechnology and Biomolecular SciencesUniversiti Putra Malaysia43400SerdangSelangorMalaysia Department of Veterinary Preclinical Sciences Faculty of Veterinary MedicineUniversiti Putra Malaysia43400SerdangSelangorMalaysia Department of Biotechnology Faculty of Applied SciencesUCSI University56000CherasKuala LumpurMalaysia Health Sciences Division Abu Dhabi Women’s CollegeHigher Colleges of Technology41012Abu DhabiUnited Arab Emirates

Mining of plant-derived antimicrobials is the major focus at current to counter antibiotic resistance. This study was conducted to characterize the antimicrobial activity and mode of action of linalyl anthranilate(LNA) against carbapenemase-producing Klebsiella pneumoniae(KPC-KP). LNA alone exhibited bactericidal activity at 2.5%(V/V), and in combination with meropenem(MPM) at 1.25%(V/V). Comparative proteomic analysis showed a significant reduction in the number of cytoplasmic and membrane proteins,indicating membrane damage in LNA-treated KPC-KP cells. Up-regulation of oxidative stress regulator proteins and down-regulation of oxidative stress-sensitive proteins indicated oxidative stress. Zeta potential measurement and outer membrane permeability assay revealed that LNA increases both bacterial surface charge and membrane permeability. Ethidium bromide influx/efflux assay showed increased uptake of ethidium bromide in LNA-treated cells, inferring membrane damage. Furthermore, intracellular leakage of nucleic acid and proteins was detected upon LNA treatment. Scanning and transmission electron microscopies again revealed the breakage of bacterial membrane and loss of intracellular materials. LNA was found to induce oxidative stress by generating reactive oxygen species(ROS) that initiate lipid peroxidation and damage the bacterial membrane. In conclusion, LNA generates ROS, initiates lipid peroxidation, and damages the bacterial membrane, resulting in intracellular leakage and eventually killing the KPC-KP cells.

关键词： Comparative proteomic KPC-KP Linalyl anthranilate Membrane damage ROS

Hybrid SDS and WPT-IBBO-DNM Based Model for Ultra-short Term Photovoltaic Prediction

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CSEE Journal of Power and Energy Systems 2023年第1期9卷 66-76页

作者： Hui Hwang Goh Qinwen Luo Dongdong Zhang Hui Liu Wei Dai Chee Shen lim Tonni Agustiono Kurniawan kai Chen Goh School of Electrical Engineering Guangxi UniversityNanningGuangxi 530004China University of Southampton Malaysia Iskandar Puteri 79200Malaysia College of the Environment and Ecology Xiamen UniversityFujian 361102China Department of Technology Management Faculty of Construction Management and BusinessUniversity Tun Hussein Onn Malaysia86400 Parit RajaJohorMalaysia

Accurate photovoltaic(PV)power prediction has been a subject of ongoing study in order to address grid stability concerns caused by PV output unpredictability and *** paper proposes an ultra-short-term hybrid photovoltaic power forecasting method based on a dendritic neural model(DNM)in this *** model is trained using improved biogeography-based optimization(IBBO),a technique that incorporates a domestication operation to increase the performance of classical biogeography-based optimization(BBO).To be more precise,a similar day selection(SDS)technique is presented for selecting the training set,and wavelet packet transform(WPT)is used to divide the input data into many *** is then used to train DNM weights and thresholds for each component ***,each component’s prediction results are stacked and *** suggested hybrid model is used to forecast PV power under various weather conditions using data from the Desert Knowledge Australia Solar Centre(DKASC)in Alice *** results indicate the proposed hybrid SDS and WPT-IBBO-DNM model has the lowest error of any of the benchmark models and hence has the potential to considerably enhance the accuracy of solar power forecasting(PVPF).

关键词： Dendritic neural model improved biogeography-based optimization photovoltaic power forecasting similar day selection wavelet packet transform

First evidence of Bartonella phoceensis and Candidatus Mycoplasma haemomuris subsp. ratti in synanthropic rodents in Malaysia

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Asian Pacific Journal of Tropical Medicine 2020年第2期13卷 94-96页

作者： Van Lun Low Tiong kai Tan Jamaiah Ibrahim Sazaly AbuBakar Yvonne Ai Lian lim Tropical Infectious Diseases Research and Education Centre(TIDREC) University of MalayaMalaysia Department of Parasitology Faculty of MedicineUniversity of MalayaMalaysia Faculty of Medicine and Defence Health National Defence University of MalaysiaMalaysia Department of Medical Microbiology Faculty of MedicineUniversity of MalayaMalaysia Centre of Excellence for Research in AIDS(CERIA) University of MalayaMalaysia

Rodent-borne leptospirosis is by far the most common bacterial zoonosis and it is an important emerging global public health concern in Southeast *** pathogens associated with rodents,especially those that live in close association with humans have been *** fill this knowledge gap,the present study was undertaken to explore other neglected disease agents that can naturally infect synanthropic rodents.

关键词： First evidence of Bartonella phoceensis and Candidatus Mycoplasma haemomuris subsp ratti in synanthropic rodents in Malaysia

Occam’s razor or Hickam’s dictum-COVID-19 is not a textbook aetiology of acute pancreatitis:A modified Naranjo Score appraisal

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World Journal of Gastroenterology 2023年第13期29卷 2050-2063页

作者： Thomas Zheng Jie Teng Branden Qi Yu Chua Puay Khim lim kai Siang Chan Vishal G Shelat Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 308232Singapore Department of General Surgery Tan Tock Seng HospitalSingapore 308433Singapore Surgical Science Training Centre Tan Tock Seng HospitalSingapore 308433Singapore

BACKGROUND Acute pancreatitis(AP)is a disease spectrum ranging from mild to severe *** the coronavirus disease 2019(COVID-19)pandemic,numerous reports of AP have been published,with most authors concluding a causal relationship between COVID-19 and *** case reports or small case series are unable to accurately determine the cause-effect relationship between COVID-19 and *** To establish whether COVID-19 is a cause of AP using the modified Naranjo scoring *** A systematic review was conducted on PubMed,World of Science and Embase for articles reporting COVID-19 and AP from inception to August *** criteria were cases of AP which were not reported to be due to COVID-19 infection,age<18 years old,review articles and retrospective cohort *** original 10-item Naranjo scoring system(total score 13)was devised to approximate the likelihood of a clinical presentation to be secondary to an adverse drug *** modified the original scoring system into a 8-item modified Naranjo scoring system(total score 9)to determine the cause-effect relationship between COVID-19 and AP.A cumulative score was decided for each case presented in the included *** of the modified Naranjo scoring system is as follows:≤3:Doubtful,4-6:Possible,≥7:Probable *** The initial search resulted in 909 articles,with 740 articles after removal of duplicates.A total of 67 articles were included in the final analysis,with 76 patients which had AP reported to be due to *** mean age was 47.8(range 18-94)*** of patients(73.3%)had≤7 d between onset of COVID-19 infection and diagnosis of *** were only 45(59.2%)patients who had adequate investigations to rule out common aetiologies(gallstones,choledocholithiasis,alcohol,hypertriglyceridemia,hypercalcemia and trauma)of *** G4 testing was conducted in 9(13.5%)patients to rule out autoimmune *** 5(6.6%)patients underwent endoscopic ultra

关键词： COVID-19 Infections Pancreatic diseases Pancreatitis Post-acute COVID-19 syndrome