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Assessing the Applicability of Multi-Source Precipitation Products over the Chinese Mainland and Its Seven Regions

Journal of Tropical Meteorology 2024年第3期30卷 275-288页

作者： TIAN Wei WU Yun-long LIN Chen ZHANG Jing-guo lim kam sian kenny thiam choy School of Computer and Software Nanjing University of Information Science&TechnologyNanjing 210044 China School of Atmospheric Science and Remote Sensing Wuxi UniversityWuxiJiangsu 214105 China

Satellite-based and reanalysis precipitation products provide valuable information for various ***,their performance varies widely across regions due to different data sources and production *** paper evaluated the daily performance of four precipitation products(MSWEP,ERA5,PERsianN,and TRMM)for seven regions of the Chinese mainland,using observations from 2462 ground stations across the country as a *** used four statistical and four classification indicators to describe their spatial and temporal accuracy,and capability to detect precipitation events while analyzing their *** results show that according to the precipitation char-acteristics and accuracy of different types of precipitation products over the Chinese mainland,MSWEP was the most suitable product over the Chinese mainland,having the lowest root mean square error and mean absolute error,along with the highest coefficient of *** was followed by TRMM and ERA5,whereas PERsianN lagged behind in terms of *** terms of different regions,MSWEP still performed well,especially in North China and East *** accuracy of the four precipitation products was relatively low in the summer months,and they all overestimated in the northwest *** other months,MSWEP and TRMM were better than PERsianN and *** four precipitation products had good detection performance over the Chinese mainland,with probability of detection above ***,with the increase of precipitation threshold,the detection capability of the four products decreased,and MSWEP and ERA5 had good detection capability for moderate ***’s detection capability for heavy rain and rainstorms was better than that of the other three products,and PERsianN’s detection capability for moderate rain,heavy rain and rainstorms was relatively poor,with a large deviation.

关键词： precipitation product MSWEP TRMM ERA5 PERsianN

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基于遥感数据与数值模式的浒苔漂移输运预报:以江苏近海为例

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海洋学研究 2024年第1期42卷 69-82页

作者：林连杰董昌明嵇宇翔 lim kam sian kenny thiam choy 李兆鑫蒋星亮曹玉晗高慧王胜强曹茜南京信息工程大学海洋科学学院江苏南京210044 江苏省连云港市气象局江苏连云港222006 无锡学院江苏无锡214105 华东师范大学河口海岸学国家重点实验室上海200241 复旦大学大气与海洋科学系上海200433 江苏海洋大学海洋技术与测绘学院江苏连云港222005

浒苔暴发是影响全球近岸海域最为严重的海洋灾害之一,引起了社会各方的重视。该研究基于大气-波浪-海洋集合模式,根据卫星遥感数据提取浒苔位置,采用拉格朗日漂流模式对浒苔进行追踪并预报其漂移路径。与卫星观测结果对比表明,该集合模... 详细信息

浒苔暴发是影响全球近岸海域最为严重的海洋灾害之一,引起了社会各方的重视。该研究基于大气-波浪-海洋集合模式,根据卫星遥感数据提取浒苔位置,采用拉格朗日漂流模式对浒苔进行追踪并预报其漂移路径。与卫星观测结果对比表明,该集合模式能够较好地预报浒苔的位置、分布及其漂移路径。此外,该研究还讨论了Stokes漂流对于模式预报的影响,结果表明考虑Stokes漂流可以修正浒苔漂移路径,有效提高预报的准确性。

关键词：浒苔模式预报 Stokes漂流江苏近海

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一个中国边缘海的风-浪-流预报系统

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海洋科学进展 2022年第4期40卷 660-683页

作者：董昌明 lim kam sian kenny thiam choy 蒋星亮曹玉晗嵇宇翔王森余洋陆晓婕周书逸韦销蔚 BETHEL Brandon Justin 徐广珺董济海孙文金王海丽单海霞王锦王东霞滕芳园曹茜谢文鸿游志伟王子韵林连杰南京信息工程大学海洋科学学院江苏南京210044 南方海洋科学与工程广东省实验室(珠海) 广东珠海519000 无锡学院江苏无锡214105 复旦大学大气与海洋科学系上海200438 江苏海洋大学海洋技术与测绘学院江苏连云港222005 江苏省连云港市气象局江苏连云港222006 江苏海洋大学海洋资源开发研究院江苏连云港222005 福建省气象台福建福州350007 清华大学地球系统科学系北京100084 广西壮族自治区气象局广西南宁530022 广东海洋大学电子与信息工程学院广东湛江524088 中国科学院南海海洋研究所广东广州510301 中国船舶集团海装风电股份有限公司重庆401123

海洋预报是进行海上活动的安全保障,海洋预报系统技术已经成为现代海洋气象业务的技术支撑。海洋观测、数据同化、数值模拟和高性能计算机等技术的进步极大地推动着海洋业务化预报的发展。采用大气数值模式(WRF)、海洋数值模式(CROCO)... 详细信息

海洋预报是进行海上活动的安全保障,海洋预报系统技术已经成为现代海洋气象业务的技术支撑。海洋观测、数据同化、数值模拟和高性能计算机等技术的进步极大地推动着海洋业务化预报的发展。采用大气数值模式(WRF)、海洋数值模式(CROCO)和海浪数值模式(SWAN)的多模式高分辨率离线耦合方式,添加南京信息工程大学“海洋数值模拟与观测实验室”团队自主研发的一系列海洋模式参数化方案,包括浪致混合参数化方案、亚中尺度参数化方案、海山诱导混合参数化方案以及涡旋诱导的沿等密度面和跨等密度面混合参数化方案,并通过同化技术和最新的人工智能技术与观测资料相结合,构建一种面向中国边缘海的风浪流多参数耦合预报系统,用于海上风电功率的预报和其他海洋灾害预警。实际观测资料的验证表明,该预报系统能较准确地模拟海上风场、海流、海温、波浪、潮汐等海洋气象要素。同时实现了按需实时可视化全景展示。

关键词：海洋预报系统海面风场海面温度波浪海流中国边缘海

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A converged ubiquitin-proteasome pathway for the degradation of TOC and TOM tail-anchored receptors

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Journal of Integrative Plant Biology 2024年第5期66卷 1007-1023页

作者： Meijing Yang Shuai Chen Shey-Li lim Lang Yang Jia Yi Zhong Koon Chuen Chan Zhizhu Zhao kam-Bo Wong Junqi Wang Boon Leong lim School of Biological Sciences University of Hong KongPokfulam 999077Hong KongChina Department of Biology Southern University of Science and TechnologyShenzhen 518055China School of Biomedical Engineering Shenzhen UniversityShenzhen 518060China School of Life Sciences The Chinese Universityof Hong KongShatin 999077HongKongChina State Key Laboratory of Agrobiotechnology The Chinese University of Hong KongShatin 999077Hong KongChina HKU Shenzhen Institute of Research and Innovation Shenzhen 518052China

In plants,thousands of nucleus-encoded proteins translated in the cytosol are sorted to chloroplasts and mitochondria by binding to specific receptors of the TOC(translocon on the outer chloroplast membrane)and the TOM(translocon on the outer mitochondrial membrane)complexes for import into those *** degradation pathways for these receptors are ***,we discovered a converged ubiquitin-proteasome pathway for the degradation of Arabidopsis thaliana TOC and TOM tail-anchored *** receptors are ubiquitinated by E3 ligase(s)and pulled from the outer membranes by the AAA+adenosine triphosphatase CDC48,after which a previously uncharacterized cytosolic protein,transmembrane domain(TMD)-binding protein for tail-anchored outer membrane proteins(TTOP),binds to the exposed TMDs at the C termini of the receptors and CDC48,and delivers these complexes to the 26S proteasome.

关键词： 26S proteasome CDC48 SP1 TOC TOM ubiquitination

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Federated Learning with Privacy-preserving and Model IP-right-protection

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Machine Intelligence Research 2023年第1期20卷 19-37页

作者： Qiang Yang Anbu Huang Lixin Fan Chee Seng Chan Jian Han lim kam Woh Ng Ding Sheng Ong Bowen Li WeBank Shenzhen 518057China Hong Kong University of Science and Technology Hong Kong 999077China University of Malaya Kuala Lumpur 50603Malaysia University of Surrey Guildford GU27XHUK University of Aberystwyth Wales SY233DDUK Shanghai Jiao Tong University Shanghai 200240China

In the past decades,artificial intelligence(AI)has achieved unprecedented success,where statistical models become the central entity in ***,the centralized training and inference paradigm for building and using these models is facing more and more privacy and legal *** bridge the gap between data privacy and the need for data fusion,an emerging AI paradigm feder-ated learning(FL)has emerged as an approach for solving data silos and data privacy *** on secure distributed AI,feder-ated learning emphasizes data security throughout the lifecycle,which includes the following steps:data preprocessing,training,evalu-ation,and *** keeps data security by using methods,such as secure multi-party computation(MPC),differential privacy,and hardware solutions,to build and use distributed multiple-party machine-learning systems and statistical models over different data *** data privacy concerns,we argue that the concept of“model”matters,when developing and deploying federated models,they are easy to expose to various kinds of risks including plagiarism,illegal copy,and *** address these issues,we introduce FedIPR,a novel ownership verification scheme,by embedding watermarks into FL models to verify the ownership of FL models and protect model intellectual property rights(IPR or IP-right for short).While security is at the core of FL,there are still many articles re-ferred to distributed machine learning with no security guarantee as“federated learning”,which are not satisfied with the FL definition supposed to *** this end,in this paper,we reiterate the concept of federated learning and propose secure federated learning(SFL),where the ultimate goal is to build trustworthy and safe AI with strong privacy-preserving and *** provide a com-prehensive overview of existing works,including threats,attacks,and defenses in each phase of SFL from the lifecycle perspective.

关键词： Federated learning privacy-preserving machine learning security decentralized learning intellectual property protection

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Proton pump inhibitor use increases mortality and hepatic decompensation in liver cirrhosis

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World Journal of Gastroenterology 2019年第33期25卷 4933-4944页

作者： Marianne Anastasia De Roza lim Kai Jia Wen kam Yiong Huak Chan Andrew Kwek Tiing Leong Ang John Chen Hsiang Department of Gastroenterology and Hepatology Changi General HospitalSinghealth 529889Singapore Clinical Trials and Research Unit Changi General HospitalSinghealth 529889Singapore Biostatistics Unit Yong Loo Lin School of MedicineNational University of SingaporeSingapore 160608Singapore

BACKGROUND Proton pump inhibitors(PPIs)are widely prescribed,often without clear *** are conflicting data on its association with mortality risk and hepatic decompensation in cirrhotic ***,PPI users and PPI exposure in some studies have been poorly defined with many confounding *** To examine if PPI use increases mortality and hepatic decompensation and the impact of cumulative PPI dose *** Data from patients with decompensated liver cirrhosis were extracted from a hospital database between 2013 to *** users were defined as cumulative defined daily dose(cDDD)≥28 within a landmark period,after hospitalisation for hepatic *** regression analysis for comparison was done after propensity score *** risk of hepatic decompensation was analysed by Poisson *** Among 295 decompensated cirrhosis patients,238 were PPI users and 57 were *** users had higher mortality compared to non-users[adjusted HR=2.10,(1.20-3.67);P=0.009].Longer PPI use with cDDD>90 was associated with higher mortality,compared to non-users[aHR=2.27,(1.10-5.14);P=0.038].PPI users had a higher incidence of hospitalization for hepatic decompensation[aRR=1.61,(1.30-2.11);P90 increases the risk of mortality.

关键词： Proton pump inhibitor Liver cirrhosis Mortality Hospitalisation Complications Portal hypertension Variceal bleeding Ascites Spontaneous bacterial peritonitis Hepatic encephalopathy

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Retreatment in locally recurrent nasopharyngeal carcinoma:Current status and perspectives

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Cancer Communications 2021年第5期41卷 361-370页

作者： Sharon Shuxian Poh Yoke lim Soong Kiattisa Sommat Chwee Ming lim kam Weng Fong Terence WK Tan Melvin LK Chua Fu Qiang Wang Jing Hu Joseph TS Wee Division of Radiation Oncology National Cancer Centre SingaporeSingapore 169610 Oncology Academic Clinical Programme Duke-NUS Graduate Medical SchoolSingapore 169857 Department of Otorhinolaryngology-Head and Neck Surgery Singapore General HospitalSingapore 169608 Surgery Academic Clinical Programme Duke-NUS Graduate Medical SchoolSingapore 169857

1 Background Nasopharyngeal carcinoma(NPC)arises from the epithelial cells that cover and line the *** it is considered a rare cancer globally,it is commonly observed in South China and a few other ethnically distinct racial *** to its propensity to spread early through the submucosal tissue and the highly infiltrative nature of this disease,NPC spreads easily through areas of lesser resistance within the pharyngobasilar fascia with a tendency for neural infiltration[1-3].

关键词： Nasopharyngeal Carcinoma Radiation Oncology Head and Neck Tumor

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Beta-blocker use and risk of symptomatic bradyarrhythmias： a hospital-based case-control study

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Journal of Geriatric Cardiology 2016年第9期13卷 749-759页

作者： Hou Tee Lu Jiyen kam Rusli Bin Nordin Surinder Kaur Khelae Jing Mein Wang Chun Ngok choy Chuey Yan Lee Clinical School Johor Bahru Jeffrey Cheah School of Medicine and Health Sciences Monash University Malaysia Johor Bahru Johor Malaysia Department of Cardiology Sultanah Aminah Hospital Jalan Masjid Abu Bakar Johor Bahru Johor Malaysia Department of Electrophysiology lnstitut Jantung Negara Jalan Tun Razak Kuala Lumpur Malaysia Department of Pharmacy Sultanah Aminah Hospital Jalan Masjid Abu Bakar Johor Bahru Johor Malaysia

Objective To investigate the risk factors of symptomatic bradyarrhythrnias in relation to β-blockers use. Methods A hospital-based case-control study [228 patients： 108 with symptomatic bradyarrhythmias （cases） and 120 controls] was conducted in Sultanah Aminah Hospital, Malaysia between January 2011 and January 2014. Results The mean age was 61.1 ~ 13.3 years with a majority of men （68.9%）. Cases were likely than control to be older, hypertensive, lower body mass index and concomitant use of rate-controlling drugs （such as digoxin, verapamil, diltiazem, ivabradine or amiodarone）. Significantly higher level of serum potassium, urea, creatinine and lower level of estimated glomerular filtration rate （eGFR） were observed among cases as compared to controls. On univariate analysis among patients on β-blockers, older age （crude OR： 1.07; 95% CI： 1.03-1.11, P = 0.000）, hypertension （crude OR： 5.6; 95% CI： 1.51-20.72, P = 0.010）, lower sodium （crude OR： 0.04; 95% CI： 0.81-0.99, P = 0.036）, higher potassium （crude OR： 2.36; 95% CI： 1.31-4.26, P = 0.004） and higher urea （crude OR： 1.23; 95% CI： 1.11-1.38, P = 0.000） were associated with increased risk of symptomatic bradyarrhythmias; eGFR was inversely and significantly associated with symptomatic bradyarrhythmias in both ＇β-blockers＇（crude OR： 0.97; 95% CI： 0.964）.98, P = 0.000） and ＇non-β-blockers＇（crude OR： 0.99; 95% CI： 0.97-0.99, P = 0.023） arms. However, eGFR was not significantly associated with symptomatic bradyarrhythmias in the final model of both ＇β-blockers＇（adjusted OR： 0.98; 95% CI： 0.96-0.98, P = 0.103） and ＇non-p-blockers＇（adjusted OR： 0.99; 95% CI： 0.97-1.01, P = 0.328） arms. Importantly, older age was a significant predictor of symptomatic bradyarrhythmias in the ＇β-blockers＇ as compared to the ＇non-β-blockers＇ arms （adjusted OR： 1.09; 95% CI： 1.03-1.15, P = 0.003 vs. adjusted OR： 1.03; 95% CI： 0.98-1.09, P = 0.232, respectively）. Conclusion Older age was a significant predictor of symptomatic bradyarr

关键词： Adverse drug reaction Beta-blocker Bradyarrhythmias Case-control

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Effects of Ginkgo biloba extracts with mirodenafil on the relaxation of corpus cavernosal smooth muscle and the potassium channel activity of corporal smooth muscle cells

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Asian Journal of Andrology 2011年第5期13卷 742-746页

作者： Jung Jun Kim Deok Hyun Han Soo Hyun lim Tae Hun Kim Mee Ree Chae Kyung Jin Chung Sung Chul kam Ju-Hong Jeon Jong Kwan Parks Sung Won Lee Department of Urology Samsung Medical Center Sungkyunkwan University School of Medicine Seou1135-710 Korea Department of Urology Gachon University Gil Hospital Incheon 405-760 Korea Department of Urology Gyeengsang National University College of Medicine Gyeongsangnam-do 660-702 Korea Department of Physiology and Biophysics Seeul National University College of Medicine Seeul 110-799 Korea Department of Urology Medical School Chonbuk National University and Institute for Medical Sciences Chonbuk National University and Research Institute and Clinical Trial Center of Medical Device of Chonbuk National University Hospital Jeonju-si 561-712 Korea

In this study, we investigated the effects of a combination of Ginkgo biloba extracts （GBE） and phosphodiesterase type 5 （PDE-5） inhibitors on the muscular tone of the corpus cavernosum and potassium channel activity of corporal smooth muscle cells. Strips of corpus cavernosum from male New Zealand white rabbits were mounted in organ baths for isometric tension studies. After contraction with 1 × 10^-5 mol I^-1 norepinephrine, GBE （0.01-1 mg ml^-1） and mirodenafil （0.01-100 nmol I^-1） were added together into the organ bath. In electrophysiological studies, whole-cell currents were recorded by the conventional patch-clamp technique in cultured smooth muscle cells of the human corpus cavernosum. The corpus cavemosum was relaxed in response to GBE in a dose-dependent manner （from 0.64%±8.35% at 0.01 mg ml^-1 to 52.28%±11.42% at 1 mg ml^-1）. After pre-treatment with 0.03 mg ml^-1 of GBE, the relaxant effects of mirodenafil were increased at all concentrations, After tetraethylammonium （TEA）（1 mmol I^-1） administration, the increased effects were inhibited （P〈0.01）. Extracellular administration of GBE increased the whole-cell K^＋ outward currents in a dose-dependent fashion. The increase of the outward current was inhibited by I mmol 1-1 TEA. These results suggest that GBE could increase the relaxant potency of mirodenafil even at a minimally effective dose. The K＋ flow through potassium channels might be one of the mechanisms involved in this synergistic relaxation.

关键词： calcium-activated potassium channels erectile dysfunction Ginkgo biloba phosphodiesterase inhibitors smooth muscles

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The Effects of the Pilot's Aptitude Test and Simulated Flight Career on Flight Ability

The Effects of the Pilot's Aptitude Test and Simulated Fligh...

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The 6th Pan-Pacific Conference on Occupational Ergonomics

作者： Byung I.Ko Sung O.choy Hyeon K.lim Department of Safety Engineering Chungbuk National University KOREA The Pilot Aptitude Laboratory Korean Air Force Academy KOREA

These years the Korean Air Force has been paying around 600 thousand dollars to bring up a pilot. However, if he/she fails to be a pilot, it will be a great loss from the national point of view. Therefore, it is quite necessary to catch out characteristics of skillful pilots more quickly, and to screen promising trainees as early as possible. In this research, 20 graduate students and 20 senior students from the Korea Air Force Academy took an aptitude test in the type of the Paper-and-Pencil Test and carried out simulated flights. Their results were analyzed to verify whether the results of them are correlated with the flight ability in real situations. According to Quantification techniques adopted for treating qualitative as well as quantitative attributes, there was no correlationship between scores of the aptitude test and the flight ability, and the former could not anticipate the score in the simulated flight even less that in the real situation. Consequently, there was no statistical evidence that flight ability in the simulated situations could predict that in the real situations, but discussion about the rule of thumb that the experience of the simulated flight would be helpful to manipulate instrumental devices in the real flight was added.

关键词： Aptitude test Simulated flight Quantification methods

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