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Coordinated regulation of the mitochondrial retrograde response by circadian clock regulators and ANAC017

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Plant Communications 2023年第1期4卷 250-271页

作者： Yanqiao Zhu Reena Narsai Cunman He Yan Wang Oliver Berkowitz James Whelan lim chee liew College of Life Science Zhejiang UniversityHangzhouZhejiang 310058P.R.China Department of Animal Plant and Soil ScienceARC Centre of Excellence in Plant Energy BiologyLa Trobe UniversityBundooraVIC 3086Australia

Mitochondrial retrograde signaling(MRS)supports photosynthetic function under a variety of *** of mitochondrial dysfunction with myxothiazol(a specific inhibitor of the mitochondrial bc1 complex)or antimycin A(an inhibitor of the mitochondrial bc1 complex and cyclic electron transport in the chloroplast under light conditions)in the light and dark revealed diurnal control of *** was evidenced by(1)significantly enhanced binding of ANAC017 to promoters in the light compared with the dark in Arabidopsis plants treated with myxothiazol(but not antimycin A),(2)overlap in the experimentally determined binding sites for ANAC017 and circadian clock regulators in the promoters of ANAC013 and AOX1a,(3)a diurnal expression pattern for ANAC017 and transcription factors it regulates,(4)altered expression of ANAC017-regulated genes in circadian clock mutants with and without myxothiazol treatment,and(5)a decrease in the magnitude of LHY and CCA1 expression in an ANAC017-overexpressing line and protein–protein interaction between ANAC017 and *** study also shows a large difference in transcriptome responses to antimycin A and myxothiazol in the dark:these responses are ANAC017 independent,observed in shoots and roots,similar to biotic challenge and salicylic acid responses,and involve ERF and ZAT transcription *** suggests that antimycin A treatment stimulates a second MRS pathway that is mediated or converges with salicylic acid signaling and provides a merging point with chloroplast retrograde signaling.

关键词： mitochondria chloroplast retrograde signaling diurnal circadian clock ANAC017

Safety and efficacy of Kaffes intraductal self-expanding metal stents in the management of post-liver transplant anastomotic strictures

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World Journal of Transplantation 2024年第2期14卷 88-98页

作者： chee lim Jonathan Ng Babak Sarraf Rhys Vaughan Marios Efthymiou Leonardo Zorron Cheng Tao Pu Sujievvan Chandran Department of Gastroenterology and Hepatology Austin HealthMelbourne HeidelbergVIC 3084Australia Melbourne Medical School The University of MelbourneMelbourne ParkvilleVIC 3052Australia

BACKGROUND Endoscopic management is the first-line therapy for post-liver-transplant anas-tomotic *** the optimal duration of treatment with plastic stents has been reported to be 8-12 months,data on safety and duration for metal stents in this setting is *** to limited access to endoscopic retrograde cholan-giopancreatography(ERCP)during the coronavirus disease 2019 pandemic in our centre,there was a change in practice towards increased usage and length-of-stay of the Kaffes biliary intraductal self-expanding stent in patients with suitable *** was mainly due to the theoretical benefit of Kaffes stents allowing for longer indwelling periods compared to the traditional plastic *** Adult liver transplant recipients aged 18 years and above who underwent ERCP were retrospectively identified during a 10-year period through a database *** admissions post-Kaffes stent insertion were identified manually through electronic and scanned medical *** main outcome was the incidence of complications when stents were left indwelling for 3 months vs 6 *** efficacy was calculated via rates of stricture recurrence between patients that had stenting courses for≤120 d or>120 *** During the study period,a total of 66 ERCPs with Kaffes insertion were performed in 54 patients throughout their stenting *** 33 ERCPs,the stent was removed or exchanged on a 3-month *** pancreatitis,perfor-ations or deaths *** post-ERCP complications were similar between the 3-month(abdominal pain and intraductal migration)and 6-month(abdominal pain,septic shower and embedded stent)groups-6.1%vs 9.1%respectively,P=*** strictures resolved at the end of the stenting course,but the stenting course was variable from 3 to 22 *** recurrence rate for stenting courses lasting for up to 120 d was 71.4%and 21.4%for stenting courses of 121 d or over(P=0.03).There were 28 patients that were treated with a sin

关键词： Liver transplantation Cholangiopancreatography Endoscopic retrograde Constriction Pathologic Self expandable metallic stents Bile duct diseases Cholestasis

Cardiovascular health awareness,risk perception,behavioural intention and INTERHEART risk stratification among middle-aged adults in Malaysia

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Asian Pacific Journal of Tropical Medicine 2024年第2期17卷 61-70页

作者： Siew-Keah Lee Ang-lim Chua Clement Heng Yew Fong Ban Hao Brian Cong Wen Ling Ng Jing Feng Kong Yik-Ling Chew Kai Bin liew Yang Shao M.Kandiah Faculty of Medicine and Health Sciences Universiti Tunku Abdul RahmanMalaysia Faculty of Medicine Universiti Teknologi MARAMalaysia Faculty of Pharmaceutical Sciences UCSI UniversityMalaysia Faculty of Pharmacy University of CyberjayaMalaysia The First Affiliated Hospital of Hainan Medical University China

Objective:To investigate the interrelationship between cardiovascular health awareness,risk perception,behavioural intention,and INTERHEART risk stratification in a middle-aged adult population in ***:A cross-sectional survey with convenience sampling was conducted during November 2022 and January *** completed validated questionnaires assessing cardiovascular health awareness,risk perception of cardiovascular diseases,behavioural intention towards adopting healthy habits,and INTERHEART risk stratification score(IHRS)based on established risk factors.A total of 602 respondents were included in the final *** were analysed with independent t-test/one-way ANOVA or Mann-Whitney/Kruskal-Wallis to test the differences,Pearson correlation or linear regression test to analyze the association of independent and dependent ***:There was a significant positive correlation between medical knowledge related to cardiovascular disease(CVD)and knowledge related to CVD risk prevention,risk perception,behavioural intention and IHRS(P<0.05,Pearson correlation).Notably,individuals with higher IHRS tended to have lower knowledge related to CVD and CVD risk prevention,risk perception,and behavioural ***,laborers,active/former smokers,individuals with lower household income and educational levels,those involved in occupations not related to the healthcare sector,and those who did not receive the CVD health brochure or are unaware of health self-assessment tools are likely to have lower levels of knowledge,risk perception,and poorer behavioural intention regarding cardiovascular health(P<0.05,one-way ANOVA).While educational level,smoking status,awareness about CVD poster,self-assessment tools were repeatedly significantly associated with knowledge related to CVD and CVD risk prevention,risk perception,behavioral intention and/or IHRS(P<0.05,linear regression).Conclusions:These findings underscore the importance of promoting car

关键词： Cardiovascular risk Knowledge Risk perception Behavioural intention INTERHEART Middle-aged Lifestyle Physical activity Psychosocial stress

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儒家智德思想赋能智能时代大学生道德教育

教育文化论坛 2024年第2期16卷 77-86页

作者：孙雷林志敏拉曼大学中华研究院马来西亚吉隆坡43200 海口经济学院网络学院海南海口571100

人工智能的发展影响着人类社会的各个领域,特别是ChatGPT的出现,给教育领域带来了变革。先进的人工智能技术与海量的数据信息为教育提供了更多与更好的技术支持,然而也给学校的思想道德教育带来了前所未有的挑战。教育是兴邦之本,教育... 详细信息

人工智能的发展影响着人类社会的各个领域,特别是ChatGPT的出现,给教育领域带来了变革。先进的人工智能技术与海量的数据信息为教育提供了更多与更好的技术支持,然而也给学校的思想道德教育带来了前所未有的挑战。教育是兴邦之本,教育承担着人才培养、文化传承与社会服务等历史使命,德育是教育的重中之重。通过分析智能时代大学生的道德教育面临新的挑战,提出以儒家“智德”思想赋能“智能”时代大学生道德教育,从儒家“智德”思想中总结出五重价值:明辨是非,知耻明辱;仁者爱人,以智辅仁;学而知之,崇智明德;仁智并重,从善利他;敬德修业,知行并进。

关键词：智能时代儒家智德大学生道德教育

维普期刊数据库博看期刊

Rapid Repair of Earthquake Damaged RC Interior Beam-wide Column Joints and Beam-wall Joints Using FRP Composites

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四川大学学报（工程科学版） 2009年第3期41卷 258-265页

作者： LI Bing lim chee Leong Inst. for the Environment Nanyang Technological Univ. Singapore

This paper studies the seismic performance of FRP-strengthened RC interior non-seismically detailed beam-wide columns and beam-wall joints after limited seismic *** eccentric and concentric beam-wide column joints and two beam-wall joints,initially damaged in a previous study,were repaired and tested under constant axial loads(0.1fc′Ag and 0.35fc′Ag) and lateral cyclic *** rapid repair technique developed,aimed to restore the original strength and to provide minimum drift *** repair schemes were characterized by the use of:(a) epoxy injections and polymer modified cementitious mortar to seal the cracks and replace spalled concrete;and(b) glass(GFRP) and carbon(CFRP) sheets to enhance the joint *** FRP sheets were effectively prevented against possible debonding through the use of fiber *** between responses of specimens before and after repair clearly indicated reasonable restoration in strength,drift capacity,stiffness and cumulative energy dissipation *** specimens failed with delamination of FRP sheets at beam-column joint *** rapid repair technique developed in this study is recommended for mass upgrading or repair of earthquake damaged beam-column joints.

关键词： FRP 建筑物抗震设计抗震结构

维普期刊数据库

A hybrid Jacobian control for uncalibrated robot visual servoing

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Progress in Natural Science:Materials International 2005年第6期15卷 564-568页

作者： TEO chee-Leong,lim Siak-Piang Department of Mechanical Engineering National University of Singapore Singapore 117576 Department of Mechanical Engineering National University of Singapore Singapore 117576

This paper focuses on the visual servo control of an uncalibrated robotic arm with an eye-in-hand camera. Without a prior knowledge of the kinematics of the robotic arm or camera calibration, the proposed hybrid Jacobian controller can track a moving object using visual feedback and joint-space velocity feedback. The proposed hybrid control method is a combination of the uncalibrated visual servoing and approximate Jacobian feedback control. First, the Jacobian matrix from joint-space to image-space is estimated by recursive least-squares (RLS) algorithm, and then the approximate Jacobian feedback controller is designed by using visual feedback and joint-space velocity feedback. The performances of the proposed control methods are illustrated by computer simulations.

关键词： robot control uncalibrated visual servoing Jacobian control.

Convalescent plasma: A potential therapeutic option for COVID-19 patients

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Asian Pacific Journal of Tropical Medicine 2020年第11期13卷 477-486页

作者： Swee Li Ng Tsuey Ning Soon Wei Hsum Yap Kai Bin liew Ya chee lim Long Chiau Ming Yin-Quan Tang Bey Hing Goh Biofunctional Molecule Exploratory Research Group(BMEX) School of PharmacyMonash University MalaysiaBandar SunwayMalaysia School of Biosciences Faculty of Medical and Health SciencesTaylor’s UniversitySubang JayaSelangorMalaysia Faculty of Pharmacy University of CyberjayaCyberjayaSelangorMalaysia PAP Rashidah Sa'adatul Bolkiah Institute of Health Sciences Universiti Brunei DarussalamGadongBrunei Darussalam College of Pharmaceutical Sciences Zhejiang UniversityHangzhouP.R.China

The new coronavirus disease(COVID-19)outbreak has challenged us to take unprecedented steps to bring this pandemic under *** view of the urgency of this situation,convalescent plasma which was used in previous coronavirus outbreaks has emerged as one of the treatment options in this current *** is mainly due to the fact that convalescent plasma has been studied in a few case series with promising *** addition,on-going large clinical trials aimed to further evaluate the effectiveness,safety,and optimal dosage,duration and timing of administration of convalescent plasma are indeed revealing a certain level of promising ***,this article aims to provide an overview of possible mechanisms of actions of convalescent plasma,its benefits and its level of usage safeness by summarizing the existing evidence on the use of convalescent plasma in COVID-19 patients.

关键词： Coronavirus Convalescent plasma COVID-19 SARS-COV-2 Neutralizing antibody Immunomodulation Convalescent plasma transfusion

Mitochondrial homeostasis in Parkinson＇s disease-a triumvirate rule？

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Neural Regeneration Research 2017年第8期12卷 1270-1272页

作者： chee-Hoe Ng Liting Hang Kah-Leong lim National Neuroscience Institute Singapore Neuroscience & Behavioral Disorders Program Duke-NUSMedical School Singapore Department of Physiology National University of SingaporeSingapore NUS Graduate School for Integrative Sciences and Engineering Singapore

Mitochondrial dysfunction in Parkinson＇s disease：Mitochondria are the primary energy generator of the cell and they are important for cell survival and *** mitochondrial homeostasis is frequently reported in human d... 详细信息

关键词： PPAR PD cell PGC AMPK Mitochondrial homeostasis in Parkinson’s disease-a triumvirate rule

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Potential Economic Value of Chitin and Its Derivatives as Major Biomaterials of Seafood Waste,with Particular Reference to Southeast Asia

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Journal of Renewable Materials 2022年第4期10卷 909-938页

作者： Hsiao Wei Tan Zhi Yin Joan lim Nur Airina Muhamad Fong Fong liew Institute of Research Management and Services Research and Innovation Management ComplexUniversity of MalayaKuala Lumpur50603Malaysia Department of Restorative Dentistry Faculty of DentistryMAHSA UniversitySaujana Putra CampusJenjarum42610Malaysia Institute of Biological Sciences Faculty of ScienceUniversity of MalayaKuala Lumpur50603Malaysia Department of Oral Biology&Biomedical Sciences Faculty of DentistryMAHSA UniversitySaujana Putra CampusJenjarum42610Malaysia

With a growing population,changes in consumerism behavior and trends in consumption in Indo-Pacific Asia,our seafood processing and consumption practices produce a large volume of waste *** are several advantages in regulating and sustaining shellfish processing *** major advantage of waste management is that it leads to better conservation of natural resources in the long *** shell waste contains useful biomaterials,which are still untapped due to inadequate waste disposal and solid waste ***,the major component of shell waste,can be extracted either chemically or *** chemical extraction approaches,which use acids and alkali,could be an environmental *** the other hand,biological methods can be eco-friendly alternatives for shell waste *** this review,recent trends in management of shellfish waste as sources of chitin,conversion of chitin into chitosan,economic aspects of waste treatment and application of chitosan will be discussed.

关键词： Seafood waste waste management chitin chitosan economic value Southeast Asian fisheries