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MSI/LOH and extron expression of the FHIT gene in gastric carcinoma

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Frontiers of Medicine 2007年第1期1卷 99-103页

作者： XIAO Yuping mao lili HAN Chengbo LI Jinyi XU Lei XIN Yan Cancer Institute the First Affiliated HospitalChina Medical UniversityShenyang 110001China

We detected loss of heterozygosity(LOH)and microsatellite instabilities(MSI),as well as extron expression of the fragile histidine triad(FHIT)gene in gastric carcinoma(GC),in order to evaluate their association with clinicopathological processes in gastric *** and MSI of the FHIT were detected by using PCR at 4 microsatellite loci:D3S 1300,D3S 4103,D3S 1481,D3S 1234 in cancer tissues from 50 patients with primary GC,with normal mucosa acting as matched *** transcripts were detected by nested RT-PCR in 30 cases of GC and their products were *** show that the average frequencies of LOH and MSI of the FHIT gene in GC were 32.4%and 26.4%,*** was no correlation between LOH and MSI of the FHIT gene in GC and the histological characteristics of gastric carcinoma(Bormann’s or Lauren’s classification).LOH of the FHIT gene in GC was related to depth invasiveness,and its frequency in GC where serosa was penetrated was significantly higher than that in GC without serosa penetration(73.5%vs 37.5%,P<0.05).The frequency of MSI in GC without lymph node metastasis was significantly higher than that in GC with lymph node metastasis(66.7%vs 34.3%,P<0.05).Aberrant transcripts were found in 11/30 GC *** analysis of the aberrant fragments found a RT-PCR product missing exons 5–7 in one case of GC,and another product missing exons 4–*** of 10(40.0%)cases of primary GC showed absent or decreased expression of the FHIT protein as compared to their matched normal *** findings in this study suggest that LOH and MSI of FHIT gene may induce aberrant extron expression,which might play a role in gastric carcinogenesis.

关键词： gene expression regulation neoplastic microsatellite instabilities loss of heterozygosity fragile histidine triad protein stomach

Genotypic variance in 13C-photosynthate partitioning and within-plant boll distribution in cotton

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Journal of Cotton Research 2020年第2期3卷 124-133页

作者： NIE Junjun QIN Dulin mao lili LIU Yanhui DONG Hezhong SONG Xianliang SUN Xuezhen State Key Laboratory of Crop Biology College of AgronomyShandong Agricultural UniversityTaian 271018ShandongChina Cotton Research Center Shandong Academy of Agricultural SciencesJinan 250100ShandongChina Technical Guidance Station of Cotton Production in Shandong Province Jinan 250013ShandongChina Qufu Agricultural Bureau Qufu 273100ShandongChina.

Background:Photosynthate partitioning and within-plant boll distribution play an important role in yield formation of cotton;however,if and how they interact to mediate yield remains *** objective of this study was to investigate the genotypic variance in photosynthate partitioning and within-plant boll distribution,with a focus on their interactions with regard to yield and yield components.A field experiment was conducted in the Yellow River region in China in 2017 and 2018 using a randomized complete block design with three *** partitioning of three commercial cultivars(DP 99 B,Lumianyan 21 and Jimian 169),varying in yield potential,to different organs(including bolls)at early flowering,peak flowering,and peak boll-setting stages,as well as withinplant boll distribution at harvest,and their effects on yield formation were ***:Lint yield of Jimian 169 was the highest,followed by Lumianyan 21 and DP 99 *** differences were observed in the number of inner bolls and boll weight among the three cultivars.J169 partitioned significantly more photosynthate to the fruit and fiber than Lumianyan 21 and DP 99 B and allocated over 80%of assimilates to the inner ***,Lumianyan 21 allocated a higher proportion of photosynthate to bolls and fiber,with12.5%–17.6%more assimilates observed in the inner bolls,than DP 99 ***:Genotypic variance in lint yield can be attributed to differences in the number of inner bolls and boll weight,which are affected by photosynthate ***,the partitioning of photosynthate to fiber and inner bolls can be used as an important reference for cotton breeding and cultivation.

关键词： Genotypic variance Within-plant boll distribution Photosynthate partitioning Yield Yield components

Fiber up-taper assisted Mach-Zehnder interferometer for high sensitive temperature sensing

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Frontiers of Optoelectronics 2015年第4期8卷 431-438页

作者： lili mao Qizhen SUN Ping LU Zefeng LAO Deming LIU National Engineering Laboratory for Next Generation Intemet Access System Huazhong University of Science and Technology Wuhan 430074 China College of Optical and electronic information Huazhong University of Science and Technology Wuhan 430074 China College of Electrical and electronic Engineering Huazhong University of Science and Technology Wuhan 430074 China

A new in-line Mach-Zehnder interferometer （MZI） sensor consisting of a stub of multi-mode fiber and an up-taper was proposed and demonstrated. Temperature measurement can be carried out by detecting wavelength shift. Dependency of sensitivity on interferometer length and dip wavelength was discussed. Experimental results showed a maximum temperature sensitivity of 113.6pm/℃ can be achieved, which is superior to most fiber temperature sensors based on in-line MZIs within the range from 20℃ to 80℃, also a good mechanical strength can be obtained. The proposed sensor is a good candidate for temperature measurement, due to the advantages of simple structure, easy fabrication, cost- effective and high sensitivity.

关键词： fiber sensor Mach-Zehnder interferometer(MZI) multimode fiber (MMF) up-taper

用水平土柱估算土壤入渗性能和水分布简化模型方法

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农业机械学报 2011年第1期42卷 49-53,58页

作者：毛丽丽雷廷武中国农业大学水利与土木工程学院北京100083

在对Green-Ampt修正模型研究的基础上,根据水量平衡原理,提出了在水平土柱试验供水量、土壤初始与饱和含水率、土壤含水率线性分布假定的基础上计算土壤入渗性能的简化模型方法。用本研究提出的简化算法计算得到的土壤入渗性能与其他方... 详细信息

在对Green-Ampt修正模型研究的基础上,根据水量平衡原理,提出了在水平土柱试验供水量、土壤初始与饱和含水率、土壤含水率线性分布假定的基础上计算土壤入渗性能的简化模型方法。用本研究提出的简化算法计算得到的土壤入渗性能与其他方法得到的结果非常接近。将该简化方法计算得到的土壤含水率分布与实测值进行比较表明,平均误差为4.18%,证明该方法估算的土壤含水率分布与实测值非常接近。结果表明该方法可以较为准确地估算土壤入渗性能在时间上及含水率在空间上的分布,能方便地应用到相关研究与应用中。

关键词：水平土柱 Green-Ampt入渗模型土壤含水率修正模型

Assessment of HER2 status in extramammary Paget disease and its implication for disitamab vedotin,a novel humanized anti-HER2 antibody-drug conjugate therapy

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Frontiers of Medicine 2024年第3期18卷 565-569页

作者： Jia Jia lili mao Jing Lin Wenyu Li Pei Yuan Lei Guo Jie Dai Caili Li Xue Bai Zhongwu Li Yu Chen Jun Guo Jianming Ying Lu Si State Key Laboratory of Molecular Oncology Department of PathologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100021China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Melanoma and SarcomaPeking University Cancer Hospital&InstituteBeijing100142China Department of Medical Oncology Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhou350014China Department of Pathology Peking University Cancer Hospital&InstituteBeijing100142China

Dear Editor,Extramammary Paget disease(EMPD)is a rare adenocarcinoma that originates in the apocrine gland-rich skin and usually affects the perineal skin(primary EMPD)or represents the intraepithelial spread of an underlying visceral carcinoma(secondary EMPD).Approximately half of EMPD cases are confined to the epidermis,which was defined as intraepithelial EMPD.

关键词： Paget HER2 adenocarcinoma

用修正的Green-Ampt模型确定土壤入渗性能的速算方法

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农业工程学报 2010年第12期26卷 53-57页

作者：毛丽丽雷廷武中国农业大学水利与土木工程学院北京100083 中国科学院水利部水土保持研究所黄土高原土壤侵蚀与旱地农业国家重点实验室杨凌712100

土壤入渗性能的确定对水文过程及其相关研究与应用具有重要的意义。该文在土壤入渗性能的水平土柱测量方法和Green-Ampt修正模型的基础上,推导出了Green-Ampt模型与修正模型之间的比例关系,进而提出了土壤入渗性能的速算模型。该计算模... 详细信息

土壤入渗性能的确定对水文过程及其相关研究与应用具有重要的意义。该文在土壤入渗性能的水平土柱测量方法和Green-Ampt修正模型的基础上,推导出了Green-Ampt模型与修正模型之间的比例关系,进而提出了土壤入渗性能的速算模型。该计算模型在保证土壤入渗性能计算精度的前提下,计算过程较修正Green-Ampt模型有了很大的简化。将3种方法计算得到的土壤入渗率进行了比较,快速方法计算得到的土壤入渗性能与Green-Ampt修正模型计算得到的土壤入渗性能非常接近。在水量平衡原理的基础上得到3种方法计算结果误差分别为11.5%(Green-Ampt模型),0.66%(修正模型)和2.68%(快速计算模型)。表明快速计算方法具有很高的精度。新方法大大简化了修正模型的计算步骤。该文提出的土壤入渗性能速算法与水平土柱试验相结合,可以方便地应用于室内土壤入渗性能的测量,为水文循环/地表产流等相关研究提供便捷的土壤入渗性能计算工具。

关键词：含水率模型入渗水平土柱 Green-Ampt入渗模型修正模型快速方法

IBI310(anti-CTLA-4 antibody)monotherapy or in combination with sintilimab in advanced melanoma or urothelial carcinoma

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The Innovation 2024年第4期5卷 34-40,33页

作者： Chuanliang Cui Juan Li Yue Yang Lu Si Zhihong Chi lili mao Xuan Wang Bixia Tang Xieqiao Yan Siming Li Li Zhou Xiaoting Wei Yuping Shen Qun Guo Shirui Zheng Jun Guo Bin Lian Department of Renal Cancer and Melanoma Peking University Cancer Hospital&InstituteKey laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Beijing 100142China Innovent Biologics Inc.Suzhou 215123China

IBI310 is a recombinant fully human IgG1 antibody against cytotoxic T lymphocyte antigen *** study was conducted to evaluate IBI310 monotherapy or combination therapy with sintilimab in the patients with advanced melanoma or urothelial carcinoma(UC).Patients in phase 1a received IBI310 at 0.3/1/2/3 mg/kg intravenously(IV)every 3 weeks(Q3W)following the accelerated titration and 3+3 escalation *** in phase 1b received IBI310(1/2/3 mg/kg IV,Q3W)plus sintilimab(200 mg IV,Q3W)for four cycles,followed by sintilimab maintenance *** phase 1b expansion of IBI310 plus sintilimab was performed in patients with advanced melanoma or ***,53 patients were enrolled,including 10 patients with melanoma in phase 1a,34 with melanoma,and 9 with UC in phase ***,94.3%of patients(50/53)experienced at least one treatment-related adverse event(TRAE)with most being grade 1–2;26.4%of patients(14/53)experienced grade 3 or higher *** phase 1a,the disease control rate(DCR)was 50.0%(95%confidence interval[CI],18.7%–81.3%).In phase 1b,the objective response rate(ORR)and DCR were 17.6%(95%CI,6.8%–34.5%)and 44.1%(95%CI,27.2%–62.1%),respectively,for melanoma,and were 22.2%(95%CI,2.8%–60.0%)and 66.7%(95%CI,29.9%–92.5%),respectively,for ***310 monotherapy or combination therapy with sintilimab was well tolerated with favorable antitumor activity across patients with advanced melanoma and UC.

关键词： melanoma mono experienced

Mg/Fe-LDHO/PES复合膜吸附材料的制备与除氟性能

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材料导报 2017年第14期31卷 26-30,45页

作者：吴涛毛丽莉王海增中国海洋大学化学化工学院海洋化学工程与技术教育部重点实验室青岛266100

以层状氢氧化镁铁的焙烧产物(Mg/Fe-LDHO)和聚醚砜(PES)为原料,采用共混法制备了Mg/Fe-LDHO/PES复合膜吸附材料,并研究了其对水中氟离子的吸附性能,考察了初始pH值、初始F-浓度、吸附温度、吸附时间以及共存阴离子等因素对吸附效果的影... 详细信息

以层状氢氧化镁铁的焙烧产物(Mg/Fe-LDHO)和聚醚砜(PES)为原料,采用共混法制备了Mg/Fe-LDHO/PES复合膜吸附材料,并研究了其对水中氟离子的吸附性能,考察了初始pH值、初始F-浓度、吸附温度、吸附时间以及共存阴离子等因素对吸附效果的影响。结果表明:在25℃条件下,该复合膜饱和吸附容量为12.34mg/g,能在pH=4~10范围内保持稳定的吸附性能,吸附速率较高,前5min内即可达到平衡吸附容量的75%;低温有利于提高复合膜的吸附性能,吸附过程符合准二级动力学模型。通过傅里叶变换红外光谱仪(FT-IR)和扫描电子显微镜(SEM)对复合膜的形貌及结构进行了表征,采用电位滴定法测得复合膜的零电位点pH值(pHpzc)为9.4。

关键词：层状氢氧化镁铁膜吸附材料除氟水处理

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桑蚕丝纬编针织绸缩水率研究

上海纺织科技 2000年第4期28卷 59-60页

作者：毛莉莉西北纺织工学院 710048

缩水率是衡量桑蚕丝纬编针织绸及其服装的内在品质和技术水平的重要指标之一。文章采用正交试验法对其缩水率进行了研究 ,提出了在原料及织物组织一定的前提下 ,织造的后整理工序中的原料细度、烘箱温度是影响桑蚕丝纬编针织绸纵、横向... 详细信息

缩水率是衡量桑蚕丝纬编针织绸及其服装的内在品质和技术水平的重要指标之一。文章采用正交试验法对其缩水率进行了研究 ,提出了在原料及织物组织一定的前提下 ,织造的后整理工序中的原料细度、烘箱温度是影响桑蚕丝纬编针织绸纵、横向缩水率变化的最显著因素。

关键词：桑蚕丝纬编针织绸 2+2罗纹绸缩水率质量