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Interplay between microglia and environmental risk factors in Alzheimer's disease

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Neural Regeneration Research 2024年第8期19卷 1718-1727页

作者： miaoping Zhang Chunmei Liang Xiongjin Chen Yujie Cai lili Cui Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases Affiliated Hospital of Guangdong Medical UniversityZhanjiangGuangdong ProvinceChina

Alzheimer s disease,among the most common neurodegenerative disorders,is chara cterized by progressive cognitive *** present,the Alzheimer’s disease main risk remains genetic ris ks,but major environmental fa ctors are increasingly shown to impact Alzheimer’s disease development and ***,the most important brain immune cells,play a central role in Alzheimer’s disease pathogenesis and are considered environmental and lifestyle"sensors."Factors like environmental pollution and modern lifestyles(e.g.,chronic stress,poor dietary habits,sleep,and circadian rhythm disorde rs)can cause neuroinflammato ry responses that lead to cognitive impairment via microglial functioning and phenotypic ***,the specific mechanisms underlying interactions among these facto rs and microglia in Alzheimer’s disease are ***,we:discuss the biological effects of air pollution,chronic stress,gut micro biota,sleep patterns,physical exercise,cigarette smoking,and caffeine consumption on microglia;consider how unhealthy lifestyle factors influence individual susceptibility to Alzheimer’s disease;and present the neuroprotective effects of a healthy *** intervening and controlling these environmental risk fa ctors at an early Alzheimer’s disease stage,understanding the role of microglia in Alzheimer’s disease development,and to rgeting strategies to to rget microglia,co uld be essential to future Alzheimer’s disease treatments.

关键词： Alzheimer’s disease chronic stress environmental factor gut microbiota microglia particulate matter with diameter<2.5μm

Social Radars: Finding Targets in Cyberspace for Cybersecurity

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 279-282页

作者： lili Fan Changxian Zeng Yutong Wang Jiaqi Ma Fei-Yue Wang School of Information and Electronics Beijing Institute of TechnologyBeijing 100081China School of Science Dalian Minzu UniversityDalian 116600China State Key Laboratory for Management and Control of Complex Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China Department of Civil and Environmental Engineering University of CaliforniaLos AngelesCA 90024 USA IEEE State Key Laboratory for Management and Control of Complex Systems Chinese Academy of SciencesBeijing 100190 Faculty of Innovation Engineering Macao University of Science and TechnologyMacao 999078China

INSPIRED by the insight from American political scientist Lasswell, who summarized the environmental role in societal surveillance [1], Schramm coined the term “social radar” [2] as it resembles the activities of radar in collecting and processing information, playing a crucial role in helping humans perceive changes in the internal and external environment and promptly adjusting adaptive behaviors.

关键词： prompt summarized insight

C2-phenyl-substituted benzimidazolium-based covalent organic framework as efficient catalyst for CO_(2) conversion without solvents,metals,and cocatalysts

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Science China Chemistry 2024年第2期67卷 551-557页

作者： Zhenzhen Wu Jing Wang lili Liu Shang Guo Juan Li Xianming Zhang Shanxi Institute for Functional Food Shanxi Agricultural UniversityTaiyuan030031China Institute of Crystalline Materials Shanxi UniversityTaiyuan030006China Key Laboratory of Interface Science and Engineering in Advanced Materials College of ChemistryTaiyuan University of TechnologyTaiyuan030024China

Covalent organic frameworks(COFs) are a potential platform for carbon dioxide(CO_(2)) conversion owing to their periodic permanent porosity,adjustable structure,and chemical *** good catalytic performance in CO_(2) conversion,collaborative multifunctions should be strategically integrated into the catalytic system design and *** this study,a four-in-one high-efficiency catalyst was synthesized and tested for CO_(2) cycloaddition to form cyclic *** obtained Tp-MPB-BrCOF had a high nitrogen content,which enhanced its CO_(2) affinity through substantial Lewis acid-base or dipole-quadrupole interactions;moreover,the acid(protons transferring from oxygen(–OH) to nitrogen(–NH)),hydrogen bond donor(hydroxyl group),and Br-(nucleophile group) served as three active sites,further improving the catalyst *** results provide a basis for designing efficient and stable CO_(2)-conversion catalysts.

关键词： covalent organic framework C2-phenyl-substituted benzimidazolium CO_(2)conversion four-in-one catalyst

Developing silicon-based photocathodes for CO_(2) conversion

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Science China Chemistry 2024年第6期67卷 1904-1921页

作者： Weijie Zhuang miao Kan Tao Meng Jinlong Zhang Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Feringa Nobel Prize Scientist Joint Research CenterSchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai200237China Shanghai Engineering Research Center for Multimedia Environmental Catalysis and Resource Utilization East China University of Science and TechnologyShanghai200237China

Photoelectrochemical(PEC)conversion of CO_(2) presents a promising avenue for solar-driven chemical fuel production,with silicon emerging as a cost-effective and high-light-absorbing material pivotal to this *** at exploring opportunities for industrializing PEC CO_(2) reduction(PEC-CO_(2)R)by minimizing reaction energy consumption,enhancing reaction efficiency and selectivity,this review summarizes recent advancements in developing Si-based photocathodes for PEC-CO_(2)*** outlines the fundamental principles,advantages,and limitations of Si photocathodes with key performance *** on this understanding,the strategies to enhance the performance of the PEC-CO_(2)R system,including light absorption,charge separation,and catalytic reactions are categorized as the interfacial modification,active site decoration,and protective layer *** design ideas of this advantageous three-layer structure in promoting the efficiency,stability,and selectivity have been ***,this review scrutinizes the influence of the photocathodic chemical *** review consolidates the mechanism insights and notable breakthroughs of various fuel generation processes within Si-based PEC-CO_(2)R *** this wealth of information offers an up-to-date perspective on the dynamic developments in silicon-based PEC-CO_(2) conversion and underscores the promising pathways toward the sustainable fuel synthesis from pollutant CO_(2).

关键词： photoelectrochemistry solar fuels silicon photocathodes carbon dioxide reduction microenvironment

STDNet: A Spatio-Temporal Decomposition Neural Network for Multivariate Time Series Forecasting

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Tsinghua Science and Technology 2024年第4期29卷 1232-1247页

作者： Zhuolun Jiang Zefei Ning Hao miao Li Wang College of Computer Science and Technology(College of Data Science) Taiyuan University of TechnologyJinzhong 030600China

Long-term multivariate time series forecasting is an important task in engineering applications. It helps grasp the future development trend of data in real-time, which is of great significance for a wide variety of fields. Due to the non-linear and unstable characteristics of multivariate time series, the existing methods encounter difficulties in analyzing complex high-dimensional data and capturing latent relationships between multivariates in time series, thus affecting the performance of long-term prediction. In this paper, we propose a novel time series forecasting model based on multilayer perceptron that combines spatio-temporal decomposition and doubly residual stacking, namely Spatio-Temporal Decomposition Neural Network (STDNet). We decompose the originally complex and unstable time series into two parts, temporal term and spatial term. We design temporal module based on auto-correlation mechanism to discover temporal dependencies at the sub-series level, and spatial module based on convolutional neural network and self-attention mechanism to integrate multivariate information from two dimensions, global and local, respectively. Then we integrate the results obtained from the different modules to get the final forecast. Extensive experiments on four real-world datasets show that STDNet significantly outperforms other state-of-the-art methods, which provides an effective solution for long-term time series forecasting.

关键词： time series forecasting multivariate time series spatio-temporal decomposition

A crosstalk-free dual-mode sweat sensing system for naked-eye sweat loss quantification via changes in structural reflectance

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Bio-Design and Manufacturing 2024年第4期7卷 428-438页

作者： Bowen Zhong Hao Xu Xiaokun Qin Lingchen Liu Hailong Wang lili Wang State Key Laboratory for Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China Center of Materials Science and Optoelectronic Engineering University of Chinese Academy of SciencesBeijing 100049China

Sweat loss monitoring is important for understanding the body’s thermoregulation and hydration status,as well as for comprehensive sweat *** recent advances,developing a low-cost,scalable,and universal method for the fabrication of colorimetric microfluidics designed for sweat loss monitoring remains *** this study,we propose a novel laserengraved surface roughening strategy for various flexible *** process permits the construction of microchannels that show distinct structural reflectance changes before and after sweat *** leveraging these unique optical properties,we have developed a fully laser-engraved microfluidic device for the quantification of naked-eye sweat *** sweat loss sensor is capable of a volume resolution of 0.5µL and a total volume capacity of 11µL,and can be customized to meet different performance ***,we report the development of a crosstalk-free dual-mode sweat microfluidic system that integrates an Ag/AgCl chloride sensor and a matching wireless measurement flexible printed circuit *** integrated system enables the real-time monitoring of colorimetric sweat loss signals and potential ion concentration signals without ***,we demonstrate the potential practical use of this microfluidic sweat loss sensor and its integrated system for sports medicine via on-body studies.

关键词： Sweat loss sensor Microfluidic design Structural reflectance Dual-mode integration Crosstalk-free

From ore to MOF: A case of MIL-100(Fe) production from iron ore concentrates

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Progress in Natural Science:Materials International 2024年第01期34卷 66-73页

作者： miao Chang Chiyao Tang Chong-Chen Wang Chen Zhao Beijing Key Laboratory of Functional Materials for Building Structure and Environment Remediation School of Environment and Energy Engineering Beijing University of Civil Engineering and Architecture

Within this work, iron ore concentrates instead of elemental iron Fe0and iron salts like Fe（NO3）3and FeCl3were selected as iron source to prepare MIL-100（Fe）(labeled as MIL-100（Fe）-ore). The corresponding synthesis cost is reduced to half of the MIL-100（Fe） produced from elemental iron and iron salts. As well, the unreacted iron ore concentrates can be easily separated from the as-prepared MIL-100（Fe）-ore by magnetic to facilitate the purification process, free of the strong acids to wash the residual iron. The as-obtained MIL-100（Fe）-ore with Langmuir surface area up to 2281.6 m2g-1displayed long-term chemical stability. Furthermore, the sorption capacity of MIL-100（Fe）-ore towards malachite green（MG） is up to 522.3 mg g-1at 25℃ and initial pH = 3.2, higher than that of MIL-100（Fe） yielded by conventional hydrothermal process. Finally, the production cost and life cycle assessment of MIL-100（Fe）-ore were compared with other traditional production procedures. The results revealed that our work greatly reduced the synthesis cost and enhanced the environmental sustainability.

关键词： Metal-organic framework Iron ore concentrates Adsorption Life cycle assessment

Study of poly-disperse aerosols deposition in turbulent flow with different Reynolds numbers

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Particuology 2024年第6期89卷 32-43页

作者： Zhichao Gao Yongzheng Chen Dandi Zhang Peng Chen lili Tong Xuewu Cao School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai200240China China Nuclear Power Technology Research Institute Co. Ltd.Shenzhen518000China

The turbulent deposition mechanism is one of the main mechanisms of aerosol deposition in nuclear power plant *** experimental study of poly-disperse aerosol deposition in a horizontal tube is conducted,where the nominal Reynolds number(Re)is in a range of 3600–200,*** aerosol deposition velocity first increases and then decreases with the increase of Res,and at high Re,particle rebound occurs during aerosol deposition in the *** the Re is low,the aerosol deposition velocity increases with the increase of aerosol *** the Re is greater than 60,000,the deposition velocity first increases and then decreases with the increase of aerosol diameter due to particle surface rebound.A new aerosol deposition model has been developed by establishing the energy conservation equation of the rebounded particles in the viscous *** calculated results of the new model are in good agreement with these experimental results,and the error between the aerosol deposition velocity calculated by the model and experimental results is between−60%and 150%.

关键词： Aerosol Turbulent deposition Rebound High Reynolds number

Research progress on short-term mechanical properties of FRP bars and FRP-reinforced concrete beams

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第2期11卷 245-270页

作者： lili Xing Shengjiang Sun Kuihua Mei Yiping Guo Zhenhong Yang School of Highway Chang'an UniversityXi'an 710064China

Fiber-reinforced polymer(FRP)bars have been increasingly recognized in the field of civil engineering due to their advantages of light weight,high strength and excellent *** bars can replace steel bars in concrete beams and effectively improve the durability of *** this paper,the literature relevant to the short-term mechanical properties of FRP bars and FRP-reinforced concrete beams was reviewed based on previous studies and practical engineering ***,the mechanical properties of FRP bars were *** types of fibers or steel and fibers can be combined to obtain hybrid fiber-reinforced polymer(HFRP)or steel-fiber composite bars(SFCB)with excellent mechanical performance,*** bond performance and bond-slip model between FRP bars and concrete were *** common bond-slip models were usually used to study the bond performance between carbon fiber-reinforced polymer(CFRP)bars or glass fiber-reinforced polymer(GFRP)bars and concrete,but changing the type of FRP bars will lead to larger ***,the experimental studies,theoretical calculation methods and finite element simulation methods of flexural/shear behavior of FRP-reinforced concrete beams were ***,their applications in practical engineering were discussed and the prospects of further research were *** is pointed out that FRP-reinforced ultra-high performance concrete(UHPC)beams,FRP-reinforced geopolymer concrete(GPC)beams,engineered cementitious composites(ECC)-FRP-reinforced concrete beams,prestressed FRP-reinforced concrete beams and steel/FRP hybrid-reinforced concrete beams can effectively improve the deformation resistance and poor ductility of pure FRP-reinforced concrete beams.

关键词： FRP bars Bond performance Flexural/shear behavior Civil engineering