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刺激的攀冰运动为什么冒险爱好者开始热衷于这项运动?

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空中英语教室（高级版．彭蒙惠英语） 2024年第8期 6-8,38,39页

作者： lila seidman 不详

哐!哐!砰!挥动了几下之后,我紧紧抓着的锋利的冰镐牢固地卡进结冻的瀑布里。从冰镐插人处爆开的碎冰打在我的脸上,我尝到了血的味道。但至少支撑点看起来很稳固。我抬起一只脚,将鞋钉插进乳白色的冰面上,然后起另一只脚。

关键词：结冻碎冰支撑点

Abaca Fiber as a Potential Reinforcer for Acoustic Absorption Material at Middle-High Frequencies

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Journal of Renewable Materials 2024年第5期12卷 909-921页

作者： Susilo Indrawati lila Yuwana Suyatno Mochamad Zainuri Darminto Department of Physics Faculty of Science and Data AnalyticsInstitut Teknologi Sepuluh NopemberSurabaya60111Indonesia

Recently,abacaﬁbers have become the focus of specialized research due to their intriguing characteristics,with their outstanding mechanical properties being a particularly *** the conducted study,the abacaﬁbers underwent a preliminary treatment process involving an alkaline solution,which was composed of 0.5%sodium hydroxide(NaOH)and 50%acetic acid(CH3COOH).This process entailed immersing eachﬁber in the solution for a period of one *** treatment led to a 52.36%reduction in lignin content compared to the levels before treatment,resulting in a dramatic decrease in the full width at half maximum(FWHM)in the XRD spectra from 1.13 to *** change indicates that theﬁbers became more crystalline following the *** abacaﬁbers were also characterized using BET(Brunauer Emmett Teller)measurements,which revealed that the aver-age pore length ranged from 33–49 nm and the surface area was between 13–28 m^(2)·g^(-1).The morphology of the abacaﬁber after alkali an hydrolisis treatment(AFAH)appeared rougher and more *** measurements revealed a signiﬁcant rise in the storage modulus of the singleﬁber post-treatment,with dependencies on both frequency and *** exhibited an optimal absorption coefﬁcient ofα=0.9 for frequencies above 2500 *** combined effect of alkalization and hydrolyzation treatments,while resulting in an enhancement in the mechanical properties of theﬁbers,also reduced high-intensity noise produced by sources such as machin-ery,aircraft takeoffs and landings,etc.,across a broader working frequency range.

关键词： Abacaﬁber alkalization mechanical property acoustic characteristics middle frequency

Clinical Insights:Prevalence of β-Thalassemia Mutations(IVSI-5,FSC8/9,and CD41/42)in the Swat District

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Journal of Bio-X Research 2024年第1期7卷 1-7页

作者： Sumaia Saif Shah lila Gulalai Ghani Murad Ali Rahat Akhtar Rasool Muhammad Israr Department of Forensic Sciences University of SwatKhyber PakhtunkhwaPakistan Centre for Animal Sciences and Fisheries University of SwatKhyber PakhtunkhwaPakistan

Background:Thalassemia is a prevalent condition characterized by decreased production or absence of hemoglobin globin *** are 2 types of thalassemia,alpha thalassemia and beta thalassemia(β-thalassemia),classified according to defects in the alpha or beta protein chain.β-Thalassemia results from a diverse range of mutations in theβsubunit of the hemoglobin gene(HBB).This results in severe reductions in erythrocyte and hemoglobin ***,more than 40,000 babies are born withβ-thalassemia *** are approximately 80 millionβ-thalassemia *** Pakistan,the annual birth rate ofβ-thalassemia major carriers is approximately 6,000,and 50,000 to 100,000 patients suffer from this common inherited ***-1,IVSI-5(G>C),Fr 8/9(+G),Fr 41/42(-TTCT),and del 619 are the 5 most common mutations that account for 90%ofβ-thalassemia cases in *** study aimed to investigate the prevalence ofβ-thalassemia mutations(IVSI-5,Fr 41/42,and Fr 8/9)in the Swat district and to analyze the blood morphology of different mutant thalassemia blood ***:A cross-sectional study was performed at the Forensic Research Lab University of Swat from December 2021 to March *** study included a total of 150 blood *** analysis of blood morphology through microscopy was carried out on samples from patients with differentβ-thalassemia mutations and normal *** DNA extraction was performed according to the Sambrook protocol,and DNA was quantified via agarose gel *** mutations were detected by amplification refractory mutation system(ARMS)-polymerase chain reaction(PCR).The frequencies of differentβ-thalassemia mutations were ***:Thalassemia blood cells were more hypochromic and microcytic than normal blood cells,although no differences were detected in the morphology of IVSI-5,Fr 8/9,or CD41/42 mutant blood *** IVSI-5,Fr 8/9,and CD41/42 mutations were analyzed through agarose ge

关键词： Thalassemia annually Pakistan

The functional role of miRNAs in colorectal cancer: insights from a large population-based study

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Cancer Biology & Medicine 2019年第2期16卷 211-219页

作者： lila E.Mullany Martha L.Slattery Department of Internal Medicine University of Utah

Identification of causal microRNAs(miRNAs) in colorectal cancer(CRC) is elusive, due to our lack of understanding of how specific miRNAs affect biological pathways and outcomes. An miRNA can regulate many mRNAs and an mRNA can be associated with many miRNAs;appreciation of these complex networks in which miRNAs operate is necessary to transition from identifying dysregulated miRNAs to identifying individual miRNAs or groups of miRNAs that are suitable for therapeutic purposes. The aim of the paper is to compile results from a population-based study(n = 1,954 cases with matched carcinoma/normal tissue) of miRNAs in CRC. The information gained allows for cohesive and comprehensive insight into miRNAs and CRC in terms of function and impact. Comparison of miRNA expression with mRNA expression from nine signaling pathways in carcinogenic processes allowed us to identify miRNA targets within a biological context. MiRNAs that directly influence mRNA expression may be effective biomarkers or therapeutic targets.

关键词： mRNA miRNA pathways colorectal cancer

Antihydatic and immunomodulatory effects of Punica granatum peel aqueous extract in a murine model of echinococcosis

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Asian Pacific Journal of Tropical Medicine 2016年第3期9卷 208-216页

作者： Moussa Labsi lila Khelifi Dalila Mezioug Imene Soufli Chafia Touil-Boukoffa Laboratory of Cellular and Molecular Biology Department of BiologyUniversity of Sciences and Technology Houari Boumediene

Objective: To investigate the effect of pomegranate peel aqueous extract (PGE) on the development of secondary experimental echinococcosis and on the viability of Echinococcus granulosus protoscoleces, and the immunomodulatory properties of PGE. Methods: Swiss mice were inoculated intraperitoneally with viable protoscoleces. Then, PGE was orally administered daily during cystic echinococcosis development. Cyst development and hepatic damage were macroscopically and histologically analyzed. The production of nitric oxide and TNF-alpha was assessed in plasma and the hepatic expression of iNOS, TNF-alpha, NF-kappa B and CD68 was examined. Moreover, protoscoleces were cultured and treated with different concentrations of PGE. Results: It was observed that in vitro treatment of protoscoleces caused a significant decrease in viability in a PGE-dose-dependent manner. In vivo, after treatment of cystic echinococcosis infected mice with PGE, a significant decrease in nitric oxide levels (P<0.000 1) and TNF-alpha levels (P<0.001) was observed. This decline was strongly related to the inhibition of cyst development (rate of hydatid cyst growth inhibition=63.08%) and a decrease in CD68 expression in both the pericystic layer of hepatic hydatid cysts and liver tissue (P<0.000 1). A significant diminution of iNOS, TNF-alpha and NF-kappa B expression was also observed in liver tissue of treated mice (P<0.000 I). Conclusions: Our results indicate an antihydatic scolicidal effect and immunomodulatory properties of PGE, suggesting its potential therapeutic role against Echinococcus granulosus infection.

关键词： Pomegranate peel aqueous extract Tumor necrosis factor-alpha iNOS Nuclear factor-kappa B

Alzheimer’s disease risk after COVID-19:a view from the perspective of the infectious hypothesis of neurodegeneration

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Neural Regeneration Research 2023年第7期18卷 1404-1410页

作者： Eugenia Olivera Albany Sáez lila Carniglia Carla Caruso Mercedes Lasaga Daniela Durand Instituto de Investigaciones Biomédicas INBIOMED UBA-CONICET Facultad de MedicinaUniversidad de Buenos AiresArgentina

In light of the rising evidence of the association between viral and bacterial infections and neurodegeneration,we aimed at revisiting the infectious hypothesis of Alzheimer’s disease and analyzing the possible implications of COVID-19 neurological sequelae in long-term *** wondered how SARS-CoV-2 could be related to the amyloid-βcascade and how it could lead to the pathological hallmarks of the *** also predict a paradigm change in clinical medicine,which now has a great opportunity to conduct prospective surveillance of cognitive sequelae and progression to dementia in people who suffered severe infections together with other risk factors for Alzheimer’s disease.

关键词： Alzheimer amyloid beta antimicrobial cognitive decline COVID-19 infectious hypothesis long-term sequelae neurodegeneration neuroinflammation neurological symptoms neurotropism SARS-CoV-2

Ecological Consequences of Land Use Change: Forest Structure and Regeneration across the Forest-grassland Ecotone in Mountain Pastures in Nepal

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Journal of Mountain Science 2014年第4期11卷 838-849页

作者： lila Nath SHARMA Ole Reidar VETAAS Ram Prasad CHAUDHARY Inger Elisabeth MREN Department of Geography University of Bergen Bergen 5020 Norway Research Centre for Applied Science and Technology and Central Department of Botany Tribhuvan UniversityKathmandu 977 Nepal

The ecotone, the spatial transition zone between two vegetation communities, is claimed to have more species than the adjoining communities. However, empirical studies do not always confirm higher richness at the ecotone. The ecotone position and structure are dynamic over time and space and it is driven by the changes in climate, land use or their interaction. In this context, we assessed the forest- grassland ecotone of temperate mountains in central Nepal by i） comparing species composition and richness across the ecotone, ii） analyzing if the forestgrassland ecotone is shifting towards the grassland center by colonizing them with trees, and iii） discussing the consequence of changed disturbance regime in the dynamics of this ecotone and the surrounding grasslands. We analyzed vegetation data sampled from belt transects laid across the forest- grassland ecotone in semi-natural grassland patches. Vegetation data consisting of species richness and composition, and size structure and regeneration of the two most dominant tree species, namely Rhododendron arboreum and Abies spectabilis, from the transects, were used to analyze the trend of the forest-grassland ecotone. Forest and grasslands were different in terms of floristic composition and diversity. Vascular plant speciesrichness linearly increased while moving from forest interior to grassland center. Spatial pattern of tree size structure and regeneration infers that forest boundary is advancing towards the grasslands at the expense of the grassland area, and tree establishment in the grasslands is part of a suceessional process. Temporally, tree establishment in grasslands started following the gradual decline in disturbance. We argue that local processes in terms of changed land use may best explain the phenomenon of ecotone shift and consequent forest expansion in these grasslands. We underpin the need for further research on the mechanism, rate and spatial extent of ecotone shift by using advaneed tools to

关键词： Ecotone shift Grasslands Forest Landuse change Rhododendron

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数字经济时代装备制造业企业高质量发展研究

现代工业经济和信息化 2024年第2期14卷 75-76,79页

作者：许明昊赵雅慧张李啦黄振河南职业技术学院河南郑州450046 湖南工业职业技术学院湖南长沙410017

以数字经济时代为背景,探讨了我国装备制造业企业的发展现状、存在的问题和高质量发展的创新路径。当下我国装备制造业企业在创新驱动、融合发展和安全可控方面取得了一定的成绩,但仍然面临着核心技术创新能力不足、数字化转型步伐不够... 详细信息

以数字经济时代为背景,探讨了我国装备制造业企业的发展现状、存在的问题和高质量发展的创新路径。当下我国装备制造业企业在创新驱动、融合发展和安全可控方面取得了一定的成绩,但仍然面临着核心技术创新能力不足、数字化转型步伐不够快、产业链供应链安全稳定性不强等问题,应通过加快核心技术攻关,加速数字化转型,加强产业链供应链优化,加强数字人才的培养和引进等创新措施,实现装备制造业企业的高质量发展。

关键词：数字经济装备制造业高质量发展

Polyphenols isolated from Acacia mearnsii bark with anti-inflammatory and carbolytic enzyme inhibitory activities

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Chinese Journal of Natural Medicines 2017年第11期15卷 816-824页

作者： XIONG Jia GRACE Mary H ESPOSITO Debora KOMARNYTSKY Slavko WANG Fei lila Mary Ann Department of Chemical Engineering Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals Nanjing Forestry University Plants for Human Health Institute Department of Food Bioprocessing and Nutrition Sciences North Carolina State UniversityNorth Carolina Research Campus

The present study was designed to characterize the polyphenols isolated from Acacia mearnsii bark crude extract(B) and fractions(B1-B7) obtained by high-speed counter-current chromatography(HSCCC) and evaluate their anti-inflammatory and carbolytic enzymes(α-glucosidase and α-amylase) inhibitory activities. Fractions B4, B5, B6, B7(total phenolics 850.3, 983.0, 843.9, and 572.5 mg·g^(-1)), respectively; proanthocyanidins 75.7, 90.5, 95.0, and 44.8 mg·g^(-1)), respectively) showed significant activities against reactive oxygen species(ROS), nitric oxide(NO) production, and expression of pro-inflammatory genes interleukin-1β(IL-1β) and inducible nitric oxide synthase(iNOS) in a lipopolysaccharide(LPS)-stimulated mouse macrophage cell line RAW 264.7. All the extracts suppressed α-glucosidase and α-amylase activities, two primary enzymes responsible for carbohydrate digestion. A. mearnsii bark samples possessed significantly stronger inhibitory effects against α-glucosidase enzyme(IC_(50) of 0.4-1.4 μg·mL^(-1)) than the pharmaceutical acarbose(IC_(50) 141.8 μg·mL^(-1))). B6 and B7(IC_(50) 17.6 and 11.7 μg·mL^(-1), respectively) exhibited α-amylase inhibitory activity as efficacious as acarbose(IC_(50) 15.4 μg·mL^(-1))). Moreover, B extract, at 25 μg·mL^(-1), significantly decreased the non-mitochondrial oxidative burst that is often associated with inflammatory response in human monocytic macrophages.

关键词： acacia mearnsii Proanthocyanidins Anti-inflammatory α-Amylase α-Glucosidase