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Photonic Sensors 2021年第4期11卷 377-386页

作者： Xiaocheng ZHANG Shuangshuang LIU Jianzhong ZHANG lijun qiao Tao WANG Shaohua GAO Mingjiang ZHANG Key Laboratory of Advanced Transducers and Intelligent Control System of Ministry of Education Taiyuan University of TechnologyTaiyuan 030024China College of Physics and Optoelectronics Institute of Optoelectronic EngineeringTaiyuan University of TechnologyTaiyuan 030024China

Chaotic Brillouin optical correlation domain analysis(BOCDA)has been proposed and experimentally demonstrated with the advantage of high spatial ***,it faces the same issue of the temperature and strain *** this paper,the simultaneous measurement of temperature and strain can be preliminarily achieved by analyzing the two Brillouin frequencies of the chaotic laser in a large-effective-area fiber(LEAF).A temperature resolution of 1℃ and a strain resolution of 20μξ can be obtained with a spatial resolution of *** actual temperature and strain measurement errors are 0.37℃ and 10μξ,respectively,which are within the maximum measurement errors.

关键词： Brillouin scattering simultaneous strain and temperature measurement chaotic laser BOCDA LEAF

Chaos Raman distributed optical fiber sensing

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Light(Science & Applications) 2023年第10期12卷 2105-2121页

作者： Chenyi Wang Jian Li Xinxin Zhou Zijia Cheng lijun qiao Xiaohui Xue Mingjiang Zhang College of Physics Taiyuan University of TechnologyTaiyuan 030024 ShanxiChina Key Laboratory of Advanced Transducers and Intelligent Control System of Ministry of Education Taiyuan University of TechnologyTaiyuan 030024 ShanxiChina College of Electrical Information and Optical Engineering Taiyuan University of TechnologyTaiyuan030024ShanxiChina Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030032 ShanxiChina

The physics principle of pulse flight positioning is the main theoretical bottleneck that restricts the spatial resolution of the existing Raman distributed optical fiber sensing *** to the pulse width of tens of nanoseconds,the spatial resolution of the existing Raman distributed optical fiber sensing scheme with kilometer-level sensing distance is limited to the meter level,which seriously restricts the development of the optical time-domain reflection *** this paper,a chaos laser is proposed in the context of the physical principle of the Raman scattering effect,and a novel theory of chaos Raman distributed optical fiber sensing scheme is *** scheme reveals the characteristics of chaos Raman scattering light excited by a chaotic signal on the sensing ***,the chaos time-domain compression demodulation mechanism between the temperature variation information and chaos correlation peak is ***,the position of the temperature variation signal is precisely located using the delay time of the chaos correlation peak combined with the chaos pulse flight *** on this novel optical sensing mechanism,an experiment with 10 cm spatial resolution and 1.4 km sensing distance was conducted,and the spatial resolution was found to be independent of the sensing *** the limit of the existing spatial resolution theory,the spatial resolution of the proposed scheme is 50 times higher than that of the traditional *** scheme also provides a new research direction for optical chaos and optical fiber sensing.

关键词： fiber optical scattering

Performance improvement in double-ended RDTS by suppressing the local external physics perturbation and intermodal dispersion

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Chinese Optics Letters 2019年第7期17卷 17-22页

作者： Jian Li Yang Xu Mingjiang Zhang Jianzhong Zhang lijun qiao Tao Wangh Key Laboratory of Advanced Transducers and Intelligent Control System Ministry of Education and Shanxi ProvinceTaiyuan 030024China College of Physics&Optoelectronics Taiyuan University of TechnologyTaiyuan 030024China

We propose and experimentally demonstrate a novel Raman-based distributed fiber-optics temperature sensor(RDTS) for improving the temperature measurement accuracy and engineering applicability. The proposed method is based on double-ended demodulation with a reference temperature and dynamic dispersion difference compensation method, which can suppress the effect of local external physics perturbation and intermodal dispersion on temperature demodulation results. Moreover, the system can omit the pre-calibration process by using the reference temperature before the temperature measurement. The experimental results of dispersion compensation indicate that the temperature accuracy optimizes from 5.6°C to 1.2°C, and the temperature uncertainty decreases from 16.8°C to 2.4°C. Moreover, the double-ended configuration can automatically compensate the local external physics perturbation of the sensing fiber, which exhibits a distinctive improvement.

关键词： Performance improvement double-ended RDTS intermodal dispersion

Longitudinal investigation of mineral composition in human milk and its correlation with infant anthropometric outcomes among Tibetan mother-infant dyads during the first 6 months postpartum

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Food Science and Human Wellness 2024年第5期13卷 2857-2865页

作者： Xiaomei Zhang Yaling Wang Junying Zhao Weicang qiao Yanpin Liu lijun Chen National Engineering Research Center of Dairy Health for Maternal and Child Beijing Sanyuan Foods Co.Ltd.Beijing 100163China Beijing Engineering Research Center of Dairy Beijing Technical Innovation Center of Human Milk ResearchBeijing Sanyuan Foods Co.Ltd.Beijing 100163China

Nutrients in human milk,including minerals,relate growth and development of breast-fed *** mother-infant dyads possess unique characteristics on early nutrition due to their featured long-lasting *** study longitudinally investigated the relationship between the mineral composition in human milk and the Z-scores of infants among Tibetan mother-infant dyads during their first 6 months postpartum through a prospective cohort *** results show that the minerals of Na,Mg,K,Ca,Cu,Zn,and Se were of higher levels in colostrum than other lactation *** minerals were below the recommended values for infants according to Chinese dietary ***,a large proportion of infant Z-scores were below-2 as lactation period *** statistical analysis revealed that classifications and correlations in varying degrees were observed between minerals in human milk and infant *** findings will be advantageous for research upon Chinese early nutrition and progress of tailor-made infant formula.

关键词： Tibetan mother-infant dyads Minerals Z-scores Classification and correlation Breastfeeding

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基础教育课程改革的问题表征与理性反思

教育发展研究 2016年第2期36卷 24-27,34页

作者：乔丽军宁波国家高新区外国语学校宁波315100

对"课改"实践中所表征出来的各种问题进行理性分析,并在问题审视的基础上寻找"课改"深化的"突破点",是我们对"应试教育"背景下课程模式批判的一种呼应。在基础教育"课改"的实践过程中,"学为中心"与"以学代教"、"只学不教"的对立,"模式... 详细信息

对"课改"实践中所表征出来的各种问题进行理性分析,并在问题审视的基础上寻找"课改"深化的"突破点",是我们对"应试教育"背景下课程模式批判的一种呼应。在基础教育"课改"的实践过程中,"学为中心"与"以学代教"、"只学不教"的对立,"模式化建构"与常态化课堂推进的鸿沟,兴趣驱动与价值导引的脱节,"先成熟、后认知"与"先认知、后成熟"的博弈,"以学生为本"、"高度尊重学生"与"自我中心主义"的反差,"减负"初衷与"增负"实际的冲突等一系列问题都需要我们予以进一步的审视反思。

关键词：基础教育课程改革问题反思

Diversity of fungal endophytes in Nothapodytes pittosporoides（Oliv.） Sleum（Icacinaceae） from Guizhou province

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Diversity of fungal endophytes in Nothapodytes pittosporoide...

2D-ultrathin MXene/DOXjade platform for iron chelation chemo-photothermal therapy

中国菌物学会第七届全国会员代表大会暨2017年学术年会

作者： Sixuan Zhou lijun qiao Jichuang Kang Kevin D.Hyde Engineering and Research Center for Southwest Bio-Pharmaceutical Resources of National Education Ministry of China Guizhou University Guizhou Institute of Animal Husbandry and Veterinary Institute of Excellence in Fungal Research and School of Science Mae Fah Luang University

Nothapodytes pittosporoides（Oliv.） Sleum（Icacinaceae） is a traditional chinese medicine（TCM） herbal distributed mainly in southern China which produce camptothecin. Its endophytic fungi have been attracted wide attention. In order to study the endophytic fungi from N. pittosporoides and their secondary metabolites,the fresh plant samples（different parts） were collected from one tree once a season in Guiyang in Guizhou provice. Besides, different trees and parts were collected from Tongren and Zuiyi cities respectively in the same provice. Endophytic fungi were isolated and purified from the samples by traditional methods. A total of 1037 endophytic fungal strains were obtained from1444 samples. Their DNA were extracted and amplified by the primers ITS1/ITS4 then sequenced and analyzed. The result showed that 656 strains were isolated from Guiyang, among which, 151 isolates from spring and 144 isolates from summer, 247 isolates from autumn, 144 isolates from *** 223 isolates were isolated from Tongren and 258 isolated from Zunyi respectively. Based on the sequences analyses of internal transcribed spacer（ITS） regions, the isolates were grouped into 3class ***, Sordariomycetes and Eurotiomycetes which including 31 genera of which Diaporthe, Colletotrichum and Phyllosticta are the dominant genera while Diaporthe account for over half. To the best of our knowledge, this is the first study on the endophytic fungi of ***. The fungal strains would be foundation for further study of their secondary metabolites.

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Bioactive Materials 2022年第8期7卷 76-85页

作者： Yunjie Xu Yingwei Wang Jusung An Adam C.Sedgwick Mingle Li Jianlei Xie Weibin Hu Jianlong Kang Sajal Sen Axel Steinbrueck Bin Zhang lijun qiao Swelm Wageh Jonathan F.Arambula Liping Liu Han Zhang Jonathan L.Sessler Jong Seung Kim Shenzhen Engineering Laboratory of Phosphorene and Optoelectronics International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of EducationShenzhen Institute of Translational MedicineDepartment of OtolaryngologyShenzhen Second People’s HospitalThe First Affiliated HospitalCollege of Optoelectronic EngineeringShenzhen UniversityShenzhen518060China Department of Chemistry Korea UniversitySeoul02841South Korea Department of Hepatobiliary and Pancreatic Surgery Shenzhen People’s HospitalSecond Clinical Medical College of Jinan UniversityShenzhen518020China Department of Chemistry The University of Texas at AustinAustinTX78712-1224USA Hunan Key Laboratory of Nanophotonics and Devices School of Physics and ElectronicsCentral South University932 South Lushan RoadChangsha410083China Institute of Translation Medicine Shenzhen Second People’s Hospital First Affiliated Hospital of Shenzhen University Shenzhen518035China Department of Physics Faculty of ScienceKing Abdulaziz UniversityJeddah21589Saudi Arabia

An increased demand for iron is a hallmark of cancer cells and is thought necessary to promote high cell proliferation,tumor progression and *** makes iron metabolism an attractive therapeutic ***,current iron-based therapeutic strategies often lack effectiveness and can elicit off-target *** report here a dual-therapeutic prodrug,DOXjade,that allows for iron chelation chemo-photothermal cancer *** prodrug takes advantage of the clinically approved iron chelator deferasirox(ExJade®)and the topoisomerase 2 inhibitor,doxorubicin(DOX).Loading DOXjade onto ultrathin 2D Ti_(3)C_(2) MXene nanosheets produces a construct,Ti_(3)C_(2)-PVP@DOXjade,that allows the iron chelation and chemotherapeutic functions of DOXjade to be photo-activated at the tumor sites,while potentiating a robust photothermal effect with photothermal conversion efficiencies of up to 40%.Antitumor mechanistic investigations reveal that upon activation,Ti_(3)C_(2)-PVP@DOXjade serves to promote apoptotic cell death and downregulate the iron depletion-induced iron transferrin receptor(TfR).A tumor pH-responsive iron chelation/photothermal/chemotherapy antitumor effect was achieved both in vitro and in *** results of this study highlight what may constitute a promising iron chelation-based phototherapeutic approach to cancer therapy.

关键词： 2D MXene Nanomedicine Prodrug Iron chelation Photothermal therapy

Polycystic ovary syndrome: pathogenic mechanisms and nutritional therapeutic strategies

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Food Science and Human Wellness 2024年

作者： Yanyan Zhao Bin Liu Junying Zhao Yanpin Liu Hang Pan Yuying Yuan Xiaoyan Tian Weicang qiao Zhenzhen Zhang lijun Chen School of Public Health， Shandong Second Medical University National Engineering Research Center of Dairy Health for Maternal and Child， Beijing Sanyuan Foods Co.Ltd. Beijing Engineering Research Center of Dairy， Beijing Technical Innovation Center of Human Milk Research， Beijing Sanyuan Foods Co.Ltd. Key Laboratory of Dairy Science， Ministry of Education， Food Science College， Northeast Agricultural University

Polycystic ovary syndrome (PCOS) is the most common endocrine disease afflicting women of childbearing age. It is characterized by irregular menstruation， clinical or biochemical hyperandrogenemia， and polycystic ovary morphology. As a complex endocrine-metabolic syndrome， PCOS shares several endocrine-metabolic features with the metabolic syndrome (MS)， with insulin resistance at the core of their pathogenic mechanisms. PCOS and MS are interrelated and thus have similarities in treatment. Currently， the common treatment modalities for both are lifestyle intervention， medication， and surgery. More studies have shown that lifestyle intervention and regulation of intestinal flora are more effective and sustainable. However， progress towards treatment and cure is hampered by unclear etiology and mechanisms. This review aimed to summarize the relationship between PCOS and MS， the pathogenesis of metabolic disorders， and the current nutritional therapeutic strategies， especially lifestyle modifications and modulation of intestinal flora. Lifestyle interventions combined with the regulation of gut flora can be a new perspective for treatment. This perspective has a positive significance in the early diagnosis， adoption of personalized treatment plans， and prevention of complications in PCOS and MS. The need to prevent the occurrence of MS in patients with PCOS should be emphasized.

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前葡萄膜炎周边视网膜改变的临床观察

中华眼科杂志 2015年第10期51卷 750-753页

作者：郭春英乔丽君杨柳北京大学第一医院眼科视觉损伤与修复教育部重点实验室 100034

目的观察前葡萄膜炎患者周边视网膜的改变.方法回顾性系列病例研究.收集2013年9月至11月就诊于北京大学第一医院眼科的20例（33只）受累眼的前葡萄膜炎患者的临床资料.所有患者均进行常规眼科检查及超广角FFA检查.结果 20例患者中男... 详细信息

目的观察前葡萄膜炎患者周边视网膜的改变.方法回顾性系列病例研究.收集2013年9月至11月就诊于北京大学第一医院眼科的20例（33只）受累眼的前葡萄膜炎患者的临床资料.所有患者均进行常规眼科检查及超广角FFA检查.结果 20例患者中男性13例,女性7例;年龄23 ～ 66岁,平均46岁;双眼反复发作者13例,单眼反复发作7例;病程从数月至30年不等.在所有受累的33只眼中,FFA检查时炎症反应处于活动期20只眼,处于安静期13只眼.共有57.6％（19/33）的患眼出现了周边视网膜血管渗漏,其中活动期眼中75％（15/20）出现了周边视网膜血管不同程度渗漏,而炎症反应处于安静期眼中30.8％（4/13）也出现了周边视网膜血管渗漏.炎症反应活动的20只眼中6只眼出现了视乳头高荧光,另4只眼发现了黄斑囊样水肿,另外2只处于安静期眼发现了周边部视网膜强的点状高荧光及带状高荧光.结论通过超广角FFA检查发现前葡萄膜炎患者周边视网膜血管可出现炎性渗漏,而且传统检查炎症反应处于静止期的患者仍然可能存在周边视网膜的炎症反应.

关键词：葡萄膜炎,前黄斑水肿视网膜血管炎荧光素血管造影术

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糖原贮积型心肌病的诊治现状及进展

临床儿科杂志 2024年第10期42卷 837-842页

作者：傅立军乔钰惠上海交通大学医学院附属上海儿童医学中心心内科上海200127

糖原贮积型心肌病是一类由糖原代谢障碍引起糖原在心肌细胞内过度累积所致的心肌病,其中最常见的类型包括糖原贮积病Ⅱ型(庞贝病)、Danon病及PRKAG2心脏综合征,是儿童肥厚型心肌病的重要病因。糖原贮积型心肌病的主要表现包括心肌肥厚... 详细信息

糖原贮积型心肌病是一类由糖原代谢障碍引起糖原在心肌细胞内过度累积所致的心肌病,其中最常见的类型包括糖原贮积病Ⅱ型(庞贝病)、Danon病及PRKAG2心脏综合征,是儿童肥厚型心肌病的重要病因。糖原贮积型心肌病的主要表现包括心肌肥厚、心律失常、心力衰竭等,甚至可引起早期死亡。早期识别和诊断,并做出精准的干预,有望改善心肌病的症状,提高患者的生存质量。因此,提高临床医师对糖原贮积性心肌病的认识具有重要意义。

关键词：糖原贮积性心肌病庞贝病 Danon病 PRKAG2心脏综合征