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Towards Better Understanding of KSHV Life Cycle: from Transcription and Posttranscriptional Regulations to Pathogenesis

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Virologica Sinica 2019年第2期34卷 135-161页

作者： lijun yan Vladimir Majerciak Zhi-Ming Zheng Ke Lan State Key Laboratory of Virology College of Life Sciences Wuhan University Wuhan 430072 China National Cancer Institute National Institutes of Health Frederick MD 21702 USA

Kaposi’s sarcoma-associated herpesvirus(KSHV), also known as human herpesvirus-8(HHV-8), is etiologically linked to the development of Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s disease. These malignancies often occur in immunosuppressed individuals, making KSHV infection-associated diseases an increasing global health concern with persistence of the AIDS epidemic. KSHV exhibits biphasic life cycles between latent and lytic infection and extensive transcriptional and posttranscriptional regulation of gene expression. As a member of the herpesvirus family, KSHV has evolved many strategies to evade the host immune response, which help the virus establish a successful lifelong infection. In this review, we summarize the current research status on the biology of latent and lytic viral infection, the regulation of viral life cycles and the related pathogenesis.

关键词： Kaposi's sarcoma-associated herpesvirus (KSHV) Human herpesvirus 8 (HHV-8)- Transcription Posttranscriptonal regulation ORF57

Hydrothermally stable metal oxide-zeolite composite catalysts for low-temperature NO_(x) reduction with improved N_(2) selectivity

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Chinese Chemical Letters 2024年第6期35卷 515-523页

作者： lijun yan Shiqi Chen Penglu Wang Xiangyu Liu Lupeng Han Tingting yan Yuejin Li Dengsong Zhang School of Environmental and Chemical Engineering International Joint Laboratory of Catalytic ChemistryCollege of SciencesShanghai UniversityShanghai 200444China BASF Environmental Catalyst and Metal Solutions IselinNJ 08830United States

Development of hydrothermally stable,low-temperature catalysts for controlling nitrogen oxides emissions from mobile sources remains an urgent *** have prepared a metal oxide-zeolite composite catalyst by depositing Mn active species on a mixture support of CeO_(2)/Al_(2)O_(3) and *** composite catalyst is hydrothermally stable and shows improved low-temperature SCR activity and significantly reduced N_(2)O formation than the corresponding metal oxide *** with a Cu-CHA catalyst,the composite catalyst has a faster response to NH_(3) injection and less NH_(3) *** characterization results reveal that such an oxide-zeolite composite catalyst contains more acidic sites and Mn^(3+)species as a result of oxide-zeolite interaction,and this interaction leads to the generation of more NH_(4)^(+)species bound to the Br?nsted acid sites and more reactive NOxspecies absorbed on the Mn ***,we report our mechanistic understanding of the oxide-zeolite composite catalyst and its molecular pathway for improving the low-temperature activity and N_(2) selectivity for NH_(3)-SCR ***,this work may provide an alternative methodology for low-temperature NO_(x) control from diesel vehicles.

关键词： Selective catalytic reduction Mn-based catalysts Hydrothermal stability N_(2) selectivity

Oxidation of Dibenzothiophene in Model Diesel Using Hydroperoxide Generated via In-Situ Reaction of Octane with Oxygen

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China Petroleum Processing & Petrochemical Technology 2018年第1期20卷 116-122页

作者： Guo Erliang Li Jianxin Huang Xiaoqiao Duan Yongshen Zhang Lingcong yan lijun Lu Shuxiang College of Chemical Engineering and Materials Science Tianjin University of Science and TechnologyTianjin 300457 PetroChina Fuel Oil Company Limited Research Institute Beijing 100195 Petrochemical Research Institute PetroChina Company LimitedBeijing 100195

The potential of carrying out oxidative desulfurization(ODS) using oxygen as an oxidant was explored in this work. n-Octane firstly reacted with oxygen to produce hydroperoxides in-situ, which were then used as oxidants to oxidize the dibenzothiophene(DBT) in the absence of catalysts. The hydroperoxides generated in-situ were effective in oxidizing DBT to its corresponding dibenzothiophene sulfone(DBTO_2) which was characterized by FT-IR and ~1H-NMR. The removal rate of DBT could reached 98.4% under conditions covering a temperaure of 140℃, a rection duration of 4 h, and an oxygen partial pressure of 0.4 MPa. The influences of different hydrocarbon components in diesel on DBT removal were investigated. The results showed that cyclohexane and n-dodecane had no effect on the removal of DBT, but xylene had a slight negative effect on DBT removal. A possible oxidation mechanism was proposed and the concentration of hydroperoxides in both O_2-oxidized octane and model diesel were detected.

关键词： oxidative desulfurization oxygen dibenzothiophene hydroperoxides generated in-situ

Surface Tension Calculation of Undercooled Alloys

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Rare Metals 2001年第1期20卷 58-61页

作者： Zhiyu Qiao, lijun yan, Zhanmin Cao, Guirong Liu (Department of Physical Chemistry, University of Science and Technology Beijing, Beijing 100083, China) Univ Sci & Technol Beijing Dept Phys Chem Beijing 100083 Peoples R China

Based on the Butler equation and extrapolated thermodynamic data of undercooled alloys from those of liquid stable alloys, a method for surface tension calculation of undercooled alloys is proposed. The surface tensions of liquid stable and undercooled Ni-Cu (x(Ni)=0.42) and Ni-Fe (x(Ni)=0.3 and 0.7) alloys are calculated using STCBE (Surface Tension Calculation based on Butler Equation) program. The agreement between calculated values and experimental data is good enough, and the temperature dependence of the surface tension can be reasonable down to 150-200 K under the liquid temperature of the alloys.

关键词： undercooled alloy surface tension Butler equation

Experimental Scaling for Mass Ablation Rate in Planar Targets Irradiated by Smoothed 0.351μm Laser Beam

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Chinese Physics Letters 2003年第6期20卷 877-880页

作者： yanGJia-Min DINGYao-Nan ZHANGBao-Han yanGGuo-Hong ZHENGZhi-Jian ZHANGWen-Hai HUXin WANGYao-Mei ZHANGJi-yan lijun ResearchCenterofLaserFusion ChinaAcademyofEngineeringPhysicsPOBox919-986Mianyang621900

Layered planar targets, consists of Al and Au layers, were irradiated by smoothed 0.351-μm-high power laser with relatively large focus spot on Xingguang II laser facility. The burn-through time of laser ablation to Al sample has been obtained by measuring the delay time of Au N-Band x-ray emission with respect to the Al K-Band x-ray emission. The scaling law of mass ablation rate with the laser flux has been obtained by only varying the laser energy on the target surface on different shots. The experimental scaling law is greatly different from the results of Key et al. [Phys. Fluids 23(1983) 2011] and is in good agreement with the analytical model.

关键词： High power lasers

Hydroisomerization performance of platinum supported on ZSM-22/ZSM-23 intergrowth zeolite catalyst

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维普期刊数据库

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Petroleum Science 2013年第2期10卷 242-250页

作者： Chi Kebin Zhao Zhen Tian Zhijian Hu Sheng yan lijun Li Tianshu Wang Bingchun Meng Xiangbin Gao Shanbin Tan Mingwei Liu yanfeng State Key Laboratory of Heavy Oil Processing China University of Petroleum Petrochemical Research Institute PetroChina Company Limited Dalian Institute of Chemical Physics Chinese Academy of Sciences

Hydroisomerization catalysts Pt/ZSM-22, Pt/ZSM-23, and Pt/ZSM-22/ZSM-23 were prepared by supporting Pt on ZSM-22, ZSM-23, and intergrowth zeolite ZSM-22/ZSM-23, respectively. The typical physicochemical properties of these catalysts were characterized by X-Ray Diffraction （XRD）, N2 absorption-desorption, Pyridine-Fourier Transform Infrared （Py-FTIR）, Transmission Electron Microscopy （TEM）, X-Ray Fluorescence （XRF）, Scanning Electron Microscopy （SEM） and NH3- Temperature Programmed Desorption （NH3-TPD）, and the performance of these catalysts in n-dodecane hydroisomerization was evaluated in a continuous down-flow fixed bed with a stainless steel tubular reactor. The characterization results indicated that the intergrowth zeolite ZSM-22/ZSM-23 possessed the dual structure of ZSM-22 and ZSM-23, and the catalyst Pt/ZSM-22/ZSM-23 had similar pores and weak acidity to Pt/ZSM-22 and Pt/ZSM-23 catalysts. Moreover, Pt/ZSM-22/ZSM-23 catalyst showed a high selectivity in hydroisomerization of long chain n-alkanes to mono-branched isomers. The evaluation results for n-dodecane hydroisomerization indicated that the activity of Pt/ZSM-22/ZSM-23 was the lowest, while the hydroisomerization selectivity was the highest among the three catalysts. The maximum yield of i-dodecane product was 68.3% over Pt/ZSM-22/ZSM-23 at 320 ℃.

关键词： ZSM-22/ZSM-23 intergrowth zeolite platinum catalyst n-dodecane hydroisomerization

Endophtic Fungi from Dalbergia Odorifera T. Chen Inhibits the Growth of Staphylococcus aureus by Damaging the Cell Membrane

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Endophtic Fungi from Dalbergia Odorifera T. Chen Inhibits th...

Characteristics of Quaternary deposits near Songjianghe Town on west slope of Changbai Mountain

中国生物化学与分子生物学会2016年全国学术会议

作者： Yuan Gao lijun yan School of Pharmacy Harbin University of Commerce Institute of Cell and Molecular Biology Harbin University of Commerce

This study investigates the antibacterial effects of the endophtic fungi producing naringenin and the mechanism on Staphylococcus aureus.A fungal endophyte P5 with obvious antibacterial activities was isolated from Dalbergiae and identified as Aspergillus fumigatus by ITS *** double broth dilution method,the minimum inhibition concentration

关键词： ITS MIC MBC DNA permeability SEM

来源： cnki会议评论

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cnki会议

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Journal of Geoscientific Research in Northeast Asia 2004年第2期7卷 143-148页

作者： WANGXi-kui lijun-min ZHANGHong-yan CollegeofEarthSciences JilinUniversityChangchun130061JilinChina

On the basis of field survey, microscope sighting, TL dating and scanning electron microscope analysis, the characteristics of Quaternary deposits near Songjianghe Town on the west slope of Changbai Mountain are analyzed and described. There were two phases of volcanism during Mid-Late Quaternary. One occurred before 15.22×104 aB.P. and the other happened between 14.27×104 aB.P. and 1.41×104 aB.P. Volcanism is a landform-making process which makes the rough relief in the studied area become higher and higher. Flow water is a main erosion agency and it cuts into the basalts making river valleys. The Quaternary fluvial deposits distributed on terraces first come from the weathered debris of basement rocks, then they are transported and deposited by flow water. After 1.41×104 aB.P., the river water quickly cuts into the newly formed basalts making a deep valley. Volcanism in the studied area is a main landform-making event in Mid-Late Quaternary.

关键词： Volcanism fluvial deposits Mid-Late Quaternary Songjiang River

Learning curve of a robotic-assisted bronchoscopy system in sampling peripheral pulmonary nodules

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Chinese Medical Journal 2022年第22期135卷 2753-2755页

作者： Fangfang Xie Qin Zhang Shuaiyang Liu lijun yan Yongzheng Zhou Jiayuan Sun Department of Respiratory Endoscopy Department of Respiratory and Critical Care MedicineShanghai Chest HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200030China Shanghai Engineering Research Center of Respiratory Endoscopy Shanghai 200030China

To the Editor:Computed tomography(CT)has been used for the screening of lung cancer in high-risk populations,with a subsequent reduction in lung cancer-related mortality.[1]However,it has also resulted in a considerab... 详细信息

关键词： lung mortality cancer