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Adjuvant chemotherapy may improve outcome of patients with non-small-cell lung cancer with metastasis of intrapulmonary lymph nodes after systematic dissection of N1 nodes

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Chinese Journal of Cancer Research 2018年第6期30卷 588-595页

作者： Xing Wang Shi Yan Yaqi Wang Xiang Li Chao Lyu Yuzhao Wang Jia Wang Shaolei Li lijian zhang Yue Yang Nan Wu Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Thoracic Surgery IIPeking University Cancer Hospital&InstituteBeijing 100142China

Objective: Survival benefit of adjuvant chemotherapy(AC) of patients with intrapulmonary lymph node(IPLN)metastasis(level 12-14) needs *** evaluated the impact of AC on patients whose metastatic nodes were limited to intrapulmonary levels after systematic dissection of N1 ***: First,155 consective cases of lung cancer confirmed as pathologic N1 were collected and *** received systematic dissection of N2 and N1 *** patients with IPLN metastasis,survival outcomes were compared between those receiving AC and those not receiving ***: In this group,112 cases(72.3%) had IPLN metastasis and 55 cases(35.5%) had N1 involvement limited to level 13-14 without further disease spread to higher *** with IPLN involvement had a better prognosis than that of patients with hilar-interlobar *** the intrapulmonary N1 group(level 12-14-positive,level 10-11-negative or unknown,n=112),no survival benefit was found between the AC group and nonAC group [5-year overall survival(OS): 54.6±1.6 vs.50.4±2.4 months,P=0.177].However,76 of 112 cases for whom harvesting of level-10 and level-11 nodes was done did not show cancer involvement in pathology reports(level 12-14-positive,level 10-11 both negative),oncologic outcome was better for patients receiving AC than those not receiving AC in this subgroup(5-year OS: 57.3±1.5 vs.47.1±3.2 months,P=0.002).Conclusions: Oncologic outcome may be improved by AC for patients with involvement of N1 nodes limited to intrapulmonary levels after complete examination of N1 nodes.

关键词： Intrapulmonary lymph node metastasis adjuvant chemotherapy outcome

一种基于决策融合策略的全天空地基云图云量估计方法

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太阳能学报 2023年第10期44卷 245-254页

作者：方明张利箭长春理工大学人工智能学院长春130022 长春理工大学计算机科学技术学院长春130022 长春理工大学中山研究院中山528403

云量对光伏发电有至关重要的影响。全天空地基云图云量估计的重点在于对全天空图像进行畸变矫正,以及设计准确率高的地基云分割方法。针对这两个问题,提出一种基于决策融合策略的云量估计模型。首先,通过基于多维球切面透视投影模型的... 详细信息

云量对光伏发电有至关重要的影响。全天空地基云图云量估计的重点在于对全天空图像进行畸变矫正,以及设计准确率高的地基云分割方法。针对这两个问题,提出一种基于决策融合策略的云量估计模型。首先,通过基于多维球切面透视投影模型的鱼眼畸变矫正算法,获取多方位的局部复原图像;其次,采用最近邻复原中心的决策融合方法对多维复原图像分割后的数据进行修正,最终获取云量估计值。实验表明:该方法更好地复原了云和天空的比例关系,提高了云量估计的准确性。

关键词：云量估计太阳能畸变校正球面投影决策融合

Quantum verification of NP problems with single photons and linear optics

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Light(Science & Applications) 2021年第9期10卷 1750-1760页

作者： Aonan zhang Hao Zhan Junjie Liao Kaimin Zheng Tao Jiang Minghao Mi Penghui Yao lijian zhang National Laboratory of Solid State Microstructures Key Laboratory of Intelligent Optical Sensing and Manipulation(Ministry of Education)and College of Engineering and Applied SciencesNanjing University210093NanjingChina Collaborative Innovation Center of Advanced Microstructures Nanjing University210093NanjingChina State Key Laboratory for Novel Software Technology Nanjing University210093NanjingChina

Quantum computing is seeking to realize hardware-optimized algorithms for application-related computational ***(nondeterministic-polynomial-time)is a complexity class containing many important but intractable problems like the satisfiability of potentially conflict constraints(SAT).According to the well-founded exponential time hypothesis,verifying an SAT instance of size n requires generally the complete solution in an O(n)-bit *** contrast,quantum verification algorithms,which encode the solution into quantum bits rather than classical bit strings,can perform the verification task with quadratically reduced information about the solution in O~(Õ−−√n)*** we realize the quantum verification machine of SAT with single photons and linear *** using tunable optical setups,we efficiently verify satisfiable and unsatisfiable SAT instances and achieve a clear completeness-soundness gap even in the presence of experimental *** protocol requires only unentangled photons,linear operations on multiple modes and at most two-photon joint *** features make the protocol suitable for photonic realization and scalable to large problem sizes with the advances in high-dimensional quantum information manipulation and large scale linear-optical *** results open an essentially new route toward quantum advantages and extend the computational capability of optical quantum computing.

关键词： quantum optics verify

Effect of grape seed proanthocyanidins on tumor vasculogenic mimicry in liver cancer xenograft model

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The Chinese-German Journal of Clinical Oncology 2014年第12期13卷 572-577页

作者： Yunyan Luan Hongwei Xue lijian zhang Ruyong Yao Hongsheng Yu Department of Oncology The Affiliated Hospital of Qingdao University Department of Central Laboratory The Affiliated Hospital of Qingdao University

Objective: As a novel blood supply pattern, vasculogenic mimicry(VM) has attracted increasingly attention in recent years, which may partly compensate for the absence of feeding and facilitate tumor perfusion. However, anti-angiogenic drugs have little effect on VM. The grape seed proanthocyanidins(GSPs), a kind of promising bioactive phytochemical, has shown anti-carcinogenesis and anti-angiogenic in several tumor models. However, GSPs regulation of VM and its possible mechanisms in a H22 hepatoma carcinoma model remain not clear. The aim of this study was to examine the effects of GSPs on proliferation and VM in a H22 hepatoma carcinoma model and to investigate the underlying mechanism. Methods: Seventy-five mice were divided into the control group and experimental groups treated with different concentration of GSPs. CD34-PAS dual staining was employed to identify the VM structure. The immunohistochemical staining for investigating the expression of VEGF, Eph A2 and MMP-2 protein was performed. Results: Treatment of the H22 model with Endostar(4 mg/kg), 50, 100, 200 mg/kg of the GSPs resulted in 6.87%, 17.81%, 27.43%, 53.52% inhibition in tumor growth, respectively. The mean weight of tumors were significantly lower in GSPs(100 mg/kg) and GSPs(200 mg/kg) groups than in the control group(all P < 0.01). Similarly, compared with the control group, the number of VM channels were significantly reduced in GSPs(100 mg/kg) and GSPs(200 mg/kg) groups(all P < 0.01). Immunohistochemistry showed significant decreases in the expression levels of VEGF, Eph A2 and MMP-2 protein in GSPs(100 mg/kg) and GSPs(200 mg/kg) groups when compared with control group(all P < 0.001). Conclusion: This is the first report providing evidence that GSPs inhibit the VM structure by regulation of the VEGF/Eph A2/MMPs signaling pathway. Therefore, we concluded that GSPs has the potential of being a clinical anti-VM inhibitor.

关键词： vasculogenic mimicry H22 hepatoma carcinoma model grape seed proanthocyanidins VEGF EphA2 MMP-2

Adaptive phase estimation at the shot noise limit with parity measurement

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Adaptive phase estimation at the shot noise limit with parit...

Quantum-enhanced stochastic phase estimation with the Su(1,1)interferometer

第十八届全国量子光学学术会议

作者：郑凯敏 Huichao Xu Aonan zhang lijian zhang 南京大学 College of Engineering and Applied Sciences and School of PhysicsNanjing University

An ab initio phase estimation protocol based on zero-photon measurement and a feedback control is proposed in this paper. Compared to the no-feedback case, we can eliminate the ambiguity when the estimated phases are inferred from the conditional probability distribution. After 100 times measurement, we can saturate the Cramér-Rao bound. By using the feedback control, the ultimate measurement precisions are independent on the true phases. In addition, we employ the rejection filtering Bayesian inference algorithm to realize the Bayesian phase estimation.

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Photonics Research 2020年第10期8卷 1653-1661页

作者： KAIMIN ZHENG MINGHAO MI BEN WANG LANG XU LIYUN HU SHENGSHUAI LIU YANBO LOU JETAI JING lijian zhang National Laboratory of Solid State Microstructures Key Laboratory of lnteligent Optical Sensing and ManipulationCollege of Engineeringand Applied Sciencesand CollaborativeInnovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210083China Center for Quantum Science and Technology Jiangxi Normal UniversityNanchang 330022China State Key Laboratory of Precision Spectroscopy Joint lnstitute of Advanced Science and Technology School of Physics and Electronic ScienceEast China Normal UniversiryShanghai 200062China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China

Quantum stochastic phase estimation has many applications in the precise measurement of various physical *** to the estimation of a constant phase,there is a standard quantum limit for stochastic phase estimation,which can be obtained with the Mach-Zehnder interferometer and coherent input ***,it has been shown that the stochastic standard quantum limit can be surpassed with nonclassical resources such as squcezed ***,practical methods to achieve quantum enhancement in the stochastic phase estimation remain largely *** we propose a method utilizing the SU(1,1)interferometer and coherent input states to cstimate a stochastic optical *** an example,we investigate the Ornstcin-Uhlenback stochastic *** analyze the performance of this method for three key estimation problems:prediction,tracking,and *** results show significant reduction of the mean square error compared with the Mach-Zehnder interferometer under the same photon number flux inside the *** particular,we show that the method with the SU(1,1)interferometer can achieve fundamental quantum scaling,achieve stochastic Heisenberg scalinga and surpass the precision of the canonical measurement.

关键词： stochastic estimation quantum

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非居民用水超定额累进加价制度的思考与建议

给水排水 2019年第3期45卷 11-16页

作者：张立尖上海市供水管理处上海200081

非居民用水超定额累进加价制度是落实水资源承载力刚性约束指标和强化节约用水管理的重大举措,是我国继居民阶梯水价政策2013年全面实施以后在计划用水管理领域的又一重大政策。简述了我国计划用水管理的主要政策,阐述了计划用水管理与... 详细信息

非居民用水超定额累进加价制度是落实水资源承载力刚性约束指标和强化节约用水管理的重大举措,是我国继居民阶梯水价政策2013年全面实施以后在计划用水管理领域的又一重大政策。简述了我国计划用水管理的主要政策,阐述了计划用水管理与定额管理的主要区别,比较分析了国内部分省市的实施方案,在此基础上,结合实例重点探讨了用水定额值的局限性、不同核定方式的管理问题以及与地方法律法规的抵触等全面推进超定额累进加价制度的难点,最后提出了非居民用水户定额管理的发展方向。

关键词：非居民用水户超定额累进加价用水定额居民阶梯水价

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利润最大化区位理论与广州高房价的根源

统计研究 2008年第9期25卷 16-23页

作者：张立建华南师范大学旅游系讲师

本文利用利润最大化区位理论,建立房价模型,实证研究广州房价持续上涨的根源。发现影响房价的主要因素是住房供给的短缺,次要原因是高成本以及严重的贫富分化。其体制根源在于自由竞争的地产需求市场与计划经济的地产供给市场之间的矛盾... 详细信息

本文利用利润最大化区位理论,建立房价模型,实证研究广州房价持续上涨的根源。发现影响房价的主要因素是住房供给的短缺,次要原因是高成本以及严重的贫富分化。其体制根源在于自由竞争的地产需求市场与计划经济的地产供给市场之间的矛盾,政策根源在于政府变为"经济人",一味经营城市,经济根源在于因竞争和权力垄断所导致的产业分化,社会根源在于广州市民不合理的住房消费习惯。因而,近期来讲,加大土地供给、改革土地出让方式、实行房地产累进累退税是抑制房价的关键,从长远来讲,要建立自由竞争的地产供给市场,变"经济人"政府为服务性政府,优化产业结构,取消"国字头"行业特权。

关键词：利润最大化区位理论房地产贫富分化

两次国际产业转移本质探讨——基于产品生命周期理论视角

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统计研究 2009年第10期26卷 39-46页

作者：张立建华南师范大学旅游系

面对今年日益严重的经济衰退,大多数学者主张摒弃现有发展模式,借鉴发达国家发展道路,摆脱困境。本文运用比较分析法,探讨决定这些国家经济发展模式的背景,即两次国际产业转移的本质区别,发现产业区域化处于国际产业转移生命周期的成熟... 详细信息

面对今年日益严重的经济衰退,大多数学者主张摒弃现有发展模式,借鉴发达国家发展道路,摆脱困境。本文运用比较分析法,探讨决定这些国家经济发展模式的背景,即两次国际产业转移的本质区别,发现产业区域化处于国际产业转移生命周期的成熟阶段,在短期内回归高工资、高资本技术构成、高劳动生产率、高价格和高人均GDP状态,仅仅让发达国家的人们享受工业文明的好处,表现为典型的贵族化特点;产业全球化处于标准化阶段,长期性的低工资、低资本技术构成、低劳动生产率、低价格和低人均GDP,让越来越多的发展中国家的人们,享受到越来越多的工业文明的实惠,表现为典型的平民化特点。为此,中国未来仍然应延续低成本、低工资的发展战略,适当的产业升级为辅,避免重蹈西方产业空心化的覆辙。

关键词：国际产业转移产品生命周期理论贵族化平民化比较分析法