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Adaptive Event-Triggered Time-Varying Output Group Formation Containment Control of Heterogeneous Multiagent Systems

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1398-1409页

作者： lihong Feng Bonan Huang Jiayue sun Qiuye sun Xiangpeng Xie College of Information Science and Engineering Northeastern UniversityShenyang 110819China College of Automation and College of Artificial Intelligence Nanjing University of Posts and TelecommunicationsNanjing 210023China IEEE

In this paper,a class of time-varying output group formation containment control problem of general linear hetero-geneous multiagent systems(MASs)is investigated under directed topology.The MAS is composed of a number of tracking leaders,formation leaders and followers,where two different types of leaders are used to provide reference trajectories for movement and to achieve certain formations,respectively.Firstly,compen-sators are designed whose states are estimations of tracking lead-ers,based on which,a controller is developed for each formation leader to accomplish the expected formation.Secondly,two event-triggered compensators are proposed for each follower to evalu-ate the state and formation information of the formation leaders in the same group,respectively.Subsequently,a control protocol is designed for each follower,utilizing the output information,to guide the output towards the convex hull generated by the forma-tion leaders within the group.Next,the triggering sequence in this paper is decomposed into two sequences,and the inter-event intervals of these two triggering conditions are provided to rule out the Zeno behavior.Finally,a numerical simulation is intro-duced to confirm the validity of the proposed results.

关键词： Adaptive control event-triggered mechanisms for-mation containment(FC) heterogeneous multiagent systems time-varying group formation.

A multiple-target mRNA-LNP vaccine induces protective immunity against experimental multi-serotype DENV in mice

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Virologica Sinica 2022年第5期37卷 746-757页

作者： lihong He Wenqiang sun Limin Yang Wenjun Liu Jing Li CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing100101China Institute of Infectious Diseases Shenzhen Bay LaboratoryShenzhenGuangdong518000China University of Chinese Academy of Sciences Beijing100049China Institute of Microbiology Center for Biosafety Mega-ScienceChinese Academy of SciencesBeijing100101China

Dengue virus(DENV)is a mosquito-borne virus with a rapid spread to humans,causing mild to potentially fatal illness in hundreds of millions of people each year.Due to the large number of serotypes of the virus,there remains an unmet need to develop protective vaccines for a broad spectrum of the virus.Here,we constructed a modified mRNA vaccine containing envelope domain III(E-DIII)and non-structural protein 1(NS1)coated with lipid nanoparticles.This multi-target vaccine induced a robust antiviral immune response and increased neutralizing antibody titers that blocked all four types of DENV infection in vitro without significant antibodydependent enhancement(ADE).In addition,there was more bias for Th1 than Th2 in the exact E-DIII and NS1-specific T cell responses after a single injection.Importantly,intramuscular immunization limited DENV transmission in vivo and eliminated vascular leakage.Our findings highlight that chimeric allogeneic structural and non-structural proteins can be effective targets for DENV vaccine and that they can prevent the further development of congenital DENV syndrome.

关键词： Dengue virus(DENV) mRNA vaccine Envelope domain III(E-DIII) Non-structural protein 1(NS1) Multi-serotype Immune response

Ultrasound-induced biophysical effects in controlled drug delivery

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Science China(Life Sciences) 2022年第5期65卷 896-908页

作者： Lulu Zhang Zhuohua Lin Lan Zeng Fan Zhang lihong Sun Suhui sun Ping Wang Menghong Xu Jinxia Zhang Xiaolong Liang Huiyu Ge Department of Ultrasound Peking University Third HospitalBeijing 100191China

Ultrasound is widely used in biomedical engineering and has applications in conventional diagnosis and drug delivery.Recent advances in ultrasound-induced drug delivery have been summarized previously in several reviews that have primarily focused on the fabrication of drug delivery carriers.This review discusses the mechanisms underlying ultrasound-induced drug delivery and factors affecting delivery efficiency,including the characteristics of drug delivery carriers and ultrasound parameters.Firstly,biophysical effects induced by ultrasound,namely thermal effects,cavitation effects,and acoustic radiation forces,are illustrated.Secondly,the use of these biophysical effects to enhance drug delivery by affecting drug carriers and corresponding tissues is clarified in detail.Thirdly,recent advances in ultrasound-triggered drug delivery are detailed.Safety issues and optimization strategies to improve therapeutic outcomes and reduce side effects are summarized.Finally,current progress and future directions are discussed.

关键词： ultrasound biophysical effects drug delivery systems ultrasound parameters ultrasound-triggered drug delivery

Targeted drug delivery strategies for the treatment of rheumatoid arthritis

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Science China(Life Sciences) 2021年第7期64卷 1187-1189页

作者： Jinxia Zhang Ling Jiang lihong Sun Ping Wang Suhui sun Menghong Xu Lulu zhang Shumin Wang Xiaolong Liang Ligang Cui Department of Ultrasound Peking University Third HospitalBeijing 100191China

A chronic autoimmune disease named rheumatoid arthritis(RA)is characterized mainly by synovitis,which has high morbidity,disability and mortality rates.In addition,the aetiology and pathogenesis of RA have not been fully determined.RA is usually accompanied by persistent arthritic pain,swelling,stiffness,and functional disorders;in severe cases,it may result in cardiovascular,pulmonary,psychological and skeletal diseases(Scott et al.,2010).

关键词： mortality cardiovascular diseases

Flow characteristics and hot workability of a typical low-alloy high-strength steel during multi-pass deformation

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International Journal of Minerals,Metallurgy and Materials 2024年第2期31卷 323-336页

作者： Mingjie Zhao lihong Jiang Changmin Li Liang Huang Chaoyuan sun Jianjun Li Zhenghua Guo School of Aeronautical Manufacturing Engineering Nanchang Hangkong UniversityNanchang 330063China Jiangxi Key Laboratory of Forming and Joining Technology for Aerospace Components Nanchang Hangkong UniversityNanchang 330063China State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China China National Erzhong Group Deyang Wanhang Die Forging Co.LTD. Deyang 618000China Hubei Huangshi Mold Industrial Technology Research Institute Huangshi 435007China

Heavy components of low-alloy high-strength(LAHS) steels are generally formed by multi-pass forging. It is necessary to explore the flow characteristics and hot workability of LAHS steels during the multi-pass forging process, which is beneficial to the formulation of actual processing parameters. In the study, the multi-pass hot compression experiments of a typical LAHS steel are carried out at a wide range of deformation temperatures and strain rates. It is found that the work hardening rate of the experimental material depends on deformation parameters and deformation passes, which is ascribed to the impacts of static and dynamic softening behaviors. A new model is established to describe the flow characteristics at various deformation passes. Compared to the classical Arrhenius model and modified Zerilli and Armstrong model, the newly proposed model shows higher prediction accuracy with a confidence level of 0.98565. Furthermore, the connection between power dissipation efficiency(PDE) and deformation parameters is revealed by analyzing the microstructures. The PDE cannot be utilized to reflect the efficiency of energy dissipation for microstructure evolution during the entire deformation process, but only to assess the efficiency of energy dissipation for microstructure evolution in a specific deformation parameter state.As a result, an integrated processing map is proposed to better study the hot workability of the LAHS steel, which considers the effects of instability factor(IF), PDE, and distribution and size of grains. The optimized processing parameters for the multi-pass deformation process are the deformation parameters of 1223–1318 K and 0.01–0.08 s^(-1). Complete dynamic recrystallization occurs within the optimized processing parameters with an average grain size of 18.36–42.3 μm. This study will guide the optimization of the forging process of heavy components.

关键词： low-alloy high-strength steel work hardening rate constitutive model hot workability multi-pass deformation

Pharmacokinetics of Enrofloxacin and Its Metabolite in Carp (Cyprinus carpio) After a Single Oral Administration in Medicated Feed

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Journal of Ocean University of China 2023年第1期22卷 171-180页

作者： LIU Ying LI Zhaoxin ZHANG Dahai XING lihong sun Weihong sun Xiaojie PENG Jixing ZHANG Yonggang LI Xianguo College of Chemistry and Chemical Engineering Ocean University of ChinaQingdao 266100China Qingdao Fishery Technology Service Station Qingdao 266071China Qingdao Marine Management Support Center Qingdao 266071China Key Laboratory of Testing and Evaluation for Aquatic Product Safety and Quality Laboratory of Quality&Safety Risk Assessment for Aquatic ProductsMinistry of Agriculture and Rural AffairsYellow Sea Fisheries Research InstituteChinese Academy of Fishery SciencesQingdao 266071China

A precise and reliable analytical method of high performance liquid chromatography-tandem mass spectrometry(HPLCMS/MS)was developed to measure trace levels of enrofloxacin(ENR)and its major metabolite ciprofloxacin(CIP)in carp tissues.Optimized chromatographic separation was obtained on a Waters Xterra MS C_(18) reversed-phase column using gradient elution with methanol and 0.1%formic acid aqueous solution including 5mmolL^(-1) of ammonium acetate.The established method was applied to study the pharmacokinetics and distribution of ENR and CIP in tissues of carp following a single oral administration in feed at a dosage of 40mgkg^(-1) bw(body weight).Data were analyzed using DAS 2.0 dynamics software,and the experimental results suggest that ENR was rapidly absorbed and extensively distributed in carp tissues through systemic circulation,and the pharmacokinetic characteristics can be described with a two-compartment model.The elimination half-lives(t_(1/2β))from muscle,liver,gill,plasma and skin were 131,160,104,132 and 310 h,respectively.The areas under the drug concentration-time curves(AUC)for these tissues were 491,972,750,249 and 706hmgkg^(-1),respectively.The maximum concentration(C_(max))values were 13,29,37,9 and 5mgkg^(-1) with peak times(t_(max))of 8,4,4,2 and 4 h,respectively.Ciprofloxacin,the active metabolite of ENR,was also detected in carp tissues,indicating that only 1.54%of de-ethylation of ENR occurs in carp.At a water temperature of 18℃,the drug withdrawal time was determined to be no less than 24 d while the carp was fed at a single dosage of 40mgkg^(-1).

关键词： Cyprinus carpio enrofloxacin ciprofloxacin pharmacokinetics liquid chromatography-tandem mass spectrometry

Efficacy of suspended moxibustion stimulating Shenshu(BL23)and Guanyuan(CV4)on the amygdala-HPA axis in rats with kidney-Yang deficiency symptom pattern induced by hydrocortisone

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Journal of Traditional Chinese Medicine 2023年第1期43卷 113-123页

作者： MIN Youjiang YAO Haihua WANG Zhiqin LUO Kaitao sun Jie YUAN Zheng WU Huiqi CHENG lihong School of Traditional Chinese Medicine Nanchang Medical CollegeNanchang 330053China Traditional Chinese Medicine Department Shanghai Eighth People’s HospitalShanghai 200235China Acupuncture Department Affiliated Hospital of Jiangxi University of Traditional Chinese MedicineNanchang 330006JiangxiChina Acupuncture Department Jiaxing Hospital of Traditional Chinese MedicineJiaxing 314001China

OBJECTIVE:To investigated the effects of suspended moxibustion stimulating Shenshu(BL23)and Guanyuan(CV4)acupoints on the amygdala and HPA axis in our rat model and elucidated the possible molecular mechanisms of moxibustion on kidney-Yang deficiency symptom pattern(KYDS).METHODS:Sixty male Sprague Dawley rats were randomly divided into a control group(n=12)and an experimental group(n=48).Rats in the experimental group were given intramuscular injections of hydrocortisone to establish a KYDS model.The 48 rats successfully modeled were then randomly divided into a model group(model,n=12),a carbenoxolone intraperitoneal injection group(CBX,n=12),a moxibustion group(moxi,n=12),and a moxi+CBX group(n=12).In the moxi,the Shenshu(BL23)and Guanyuan(CV 4)acupoints were treated with moxibustion for 14 d.After treatment,measures were taken of serum levels of corticosterone(CORT),adrenocorticotropic hormone(ACTH),and corticotropinreleasing hormone(CRH).The expression of mineralocorticoid receptors(MRs),glucocorticoid receptors(GRs),11beta-hydroxysteroid dehydrogenase type 1(11β-HSD1),CRH,and ACTH in the rats’amygdala,hypothalamus,or pituitary(as appropriate)was detected.Data were analyzed using one-way analysis of variance.RESULTS:Compared with those of the control group,the serum levels of CRH,ACTH,and CORT;the mRNA and protein expressions of MR,GR,and 11β-HSD1 in the amygdala;the mRNA and protein expressions of 11β-HSD1 in the hypothalamus;the CRH mRNA expression in the amygdala and hypothalamus;and the ACTH mRNA expression in the pituitary of the rats in the model group were all significantly decreased(P<0.05 or 0.01).After treatment with moxibustion,all the aforementioned observation indices except for 11β-HSD1 m RNA expression were ameliorated compared with those in the model group(P<0.05 or 0.01).CONCLUSIONS:Suspended moxibustion can effectively improve the serum levels of ACTH,CRH,and CORT and can up-regulate the mRNA and protein expressions of MR,GR,11β-HSD1,CRH,and ACTH in the amygdala and hypothalamus of KYDS rats

关键词： moxibustion kidney-Yang deficiency amygdala hypothalamus receptors,mineralocorticoid receptors,glucocorticoid 11-beta-hydroxysteroid dehydrogenase type 1

Surface reconstruction,doping and vacancy engineering to improve the overall water splitting of CoP nanoarrays

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Nano Research 2023年第1期16卷 228-238页

作者： Yongkai sun Wenyuan sun lihong Chen Alan Meng Guicun Li Lei Wang Jianfeng Huang Aili Song Zhenhui Zhang Zhenjiang Li College of Electromechanical Engineering Qingdao University of Science and TechnologyQingdao 266061China College of Materials Science and Engineering Qingdao University of Science and TechnologyQingdao 266042China Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science MOE College of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266042China School of Material Science and Engineering International S&T Cooperation Foundation of Shaanxi ProvinceXi’an Key Laboratory of Green Manufacture of Ceramic MaterialsShaanxi University of Science and TechnologyXi’an 710021China Qingdao Huanghai University Qingdao 266000China

Development of a general regulatory strategy for efficient overall water splitting remains a challenging task.Herein,a simple,costfairness,and general fluorination strategy is developed to realize surface reconstruction,heteroatom doping,and vacancies engineering over cobalt phosphide(CoP)for acquiring high-performance bifunctional electrocatalysts.Specifically,the surface of CoP nanoarrays(NAs)becomes rougher,meanwhile F doped into CoP lattice and creating amounts of P vacancies by fluorination,which caused the increase of active sites and regulation of charge distribution,resulting the excellent electrocatalyst performance of F-CoP NAs/copper foam(CF).The optimized F-CoP NAs/CF delivers a lower overpotential of only 35 mV at 10 mA·cm^(−2)for hydrogen evolution reaction(HER)and 231 mV at 50 mA·cm^(−2)for oxygen evolution reaction(OER),and the corresponding overall water splitting requires only 1.48 V cell voltage at 10 mA·cm^(−2),which are superior to the most state-of-theart reported electrocatalysts.This work provides an innovative and feasible strategy to construct efficient electrocatalysts.

关键词： fluorination surface reconstruction F atom doping P vacancies overall water splitting

qRgls1.06, a major QTL conferring resistance to gray leaf spot disease in maize

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The Crop Journal 2021年第2期9卷 342-350页

作者： Hao sun lihong Zhai Feng Teng Zhihong Li Zuxin Zhang National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070HubeiChina Medical College Hubei University of Arts and ScienceXiangyang 441053HubeiChina Hubei Tenglong Seed Co. LtdXiangyang 441100HubeiChina

Gray leaf spot(GLS)caused by Cercospora zeae-maydis and C.zeina is an extremely devastating leaf disease that limits maize production annually.The use of GLS-resistant maize hybrids is the most cost-effective approach for reducing losses.Resistance to GLS is quantitatively inherited in maize(Zea mays L.)and further sources of resistance remain to be analyzed.Here,we detected qRgls1.06,a major quantitative trait locus for GLS resistance in bin 1.06 that explained approximately 55%of the phenotype variance.Fine mapping over 2 consecutive years localized qRgls1.06 to a 2.38-Mb region.Homozygous qRgls1.06^(WGR/WGR) plants in DZ01 background displayed higher GLS resistance and 100-grain weight than DZ01 plants.The GLS responses of several susceptible elite inbred lines were improved by the introduction of qRgls1.06 by marker-assisted backcrossing.Our findings extend the understanding of the genetic basis of resistance to GLS and provide a set of resistant germplasm for genetic improvement of resistance to GLS in maize.

关键词： Fine mapping Marker assisted selection Quantitative trait locus Yield-related traits Zea mays