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Evaluation of the intracellular lipid-lowering effect of polyphenols extract from highland barley in HepG2 cells

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Food Science and Human Wellness 2024年第1期13卷 454-461页

作者： Yijun Yao Zhifang li Bowen Qin Xingrong Ju lifeng Wang College of Food Science and Engineering/Collaborative Innovation Centre for Modern Grain Circulation and Safety Nanjing University of Finance and EconomicsNanjing 210023China

Active ingredients from highland barley have received considerable attention as natural products for developing treatments and dietary supplements against obesity.In practical application,the research of food combinations is more significant than a specific food component.This study investigated the lipid-lowering effect of highland barley polyphenols via lipase assay in vitro and HepG2 cells induced by oleic acid(OA).Five indexes,triglyceride(TG),total cholesterol(T-CHO),low density lipoprotein-cholesterol(LDL-C),aspartate aminotransferase(AST),and alanine aminotransferase(ALT),were used to evaluate the lipidlowering effect of highland barley extract.We also preliminary studied the lipid-lowering mechanism by Realtime fluorescent quantitative polymerase chain reaction(q PCR).The results indicated that highland barley extract contains many components with lipid-lowering effects,such as hyperoside and scoparone.In vitro,the lipase assay showed an 18.4%lipase inhibition rate when the additive contents of highland barley extract were 100μg/m L.The intracellular lipid-lowering effect of highland barley extract was examined using 0.25 mmol/L OA-induced HepG2 cells.The results showed that intracellular TG,LDL-C,and T-CHO content decreased by 34.4%,51.2%,and 18.4%,respectively.ALT and AST decreased by 51.6%and 20.7%compared with the untreated hyperlipidemic HepG2 cells.q PCR results showed that highland barley polyphenols could up-regulation the expression of lipid metabolism-related genes such as PPARγand Fabp4.

关键词： Highland barley Polyphenols extract lipid-lowering effect HepG2 cells

Predictability of the 7·20 extreme rainstorm in Zhengzhou in stochastic kinetic-energy backscatter ensembles

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Science China Earth Sciences 2024年第7期67卷 2226-2241页

作者： Min YANG Peilong YU lifeng ZHANG Xiaobing PAN Quanjia ZHONG Yunying li College of Meteorology and Oceanography National University of Defense TechnologyChangsha 410073China Key Laboratory of High Impact Weather(Special) China Meteorological AdministrationChangsha 410073China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters/Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment ChangeNanjing University of Information Science and TechnologyNanjing 210044China Department of Ocean Science Hong Kong University of Science and TechnologyHong Kong 999077China

The scale-dependent predictability of the devastating 7·20 extreme rainstorm in Zhengzhou,China in 2021 was investigated via ensemble experiments,which were perturbed on different scales using the stochastic kinetic-energy backscatter(SKEB)scheme in the WRF model,with the innermost domain having a 3-km grid spacing.The daily rainfall(RAIN24h)and the cloudburst during 1600-1700 LST(RAIN1h)were considered.Results demonstrated that with larger perturbation scales,the ensemble spread for the rainfall maximum widens and rainfall forecasts become closer to the observations.In ensembles with mesoscale or convective-scale perturbations,RAIN1h loses predictability at scales smaller than 20 km and RAIN24h is predictable for all scales.Whereas in ensembles with synoptic-scale perturbations,the largest scale of predictability loss extends to 60 km for both RAIN1h and RAIN24h.Moreover,the average positional error in forecasting the heaviest rainfall for RAIN24h(RAIN1h)was 400 km(50-60)km.The southerly low-level jet near Zhengzhou was assumed to be directly responsible for the forecast uncertainty of RAIN1h.The rapid intensification in low-level cyclonic vorticity,mid-level divergence,and upward motion concomitant with the jet dynamically facilitated the cloudburst.Further analysis of the divergent,rotational and vertical kinetic spectra and the corresponding error spectra showed that the error kinetic energy at smaller scales grows faster than that at larger scales and saturates more quickly in all experiments.Larger-scale perturbations not only boost larger-scale error growth but are also conducive to error growth at all scales through a downscale cascade,which indicates that improving the accuracy of larger-scale flow forecast may discernibly contributes to the forecast of cloudburst intensity and position.

关键词： Stochastic kinetic-energy backscatter(SKEB) Extreme rainfall Ensemble forecast Predictability

Development of a new cerebral ischemia reperfusion model of Mongolian gerbils and standardized evaluation system

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Animal Models and Experimental Medicine 2024年第1期7卷 48-55页

作者： Ying Wu Caijiao Hu Zhihui li Feiyang li Jianyi Lv Meng Guo Xin liu Changlong li Xueyun Huo Zhenwen Chen lifeng Yang Xiaoyan Du School of Basic Medical Sciences Capital Medical UniversityBeijingChina Laboratory for Clinical Medicine Capital Medical UniversityBeijingChina College of Veterinary Medicine China Agricultural UniversityBeijingChina

Background:The Mongolian gerbil is an excellent laboratory animal for preparing the cerebral ischemia model due to its inherent deficiency in the circle of Willis.However,the low incidence and unpredictability of symptoms are caused by numerous complex variant types of the circle.Additionally,the lack of an evaluation system for the cer-ebral ischemia/reperfusion(I/R)model of gerbils has shackled the application of this model.Methods:We created a symptom-oriented principle and detailed neurobehavioral scoring criteria.At different time points of reperfusion,we analyzed the alteration in locomotion by rotarod test and grip force score,infarct volume by triphenyltetrazo-lium chloride(TTC)staining,neuron loss using Nissl staining,and histological charac-teristics using hematoxylin-eosin(H&E)straining.Results:With a successful model rate of 56%,32 of the 57 gerbils operated by our method harbored typical features of cerebral I/R injury,and the mortality rate in the male gerbils was significantly higher than that in the female gerbils.The suc-cessfully prepared I/R gerbils demonstrated a significant reduction in motility and grip strength at 1 day after reperfusion;formed obvious infarction;exhibited typi-cal pathological features,such as tissue edema,neuronal atrophy and death,and vacuolated structures;and were partially recovered with the extension of reperfu-sion time.Conclusion:This study developed a new method for the unilateral common carotid artery ligation I/R model of gerbil and established a standardized evaluation system for this model,which could provide a new cerebral I/R model of gerbils with more practical applications.

关键词： ischemia/reperfusion Mongolian gerbil standardized model system unilateral carotid occlusion

Structure-based development of potent and selective type-II kinase inhibitors of RIPK1

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Acta Pharmaceutica Sinica B 2024年第1期14卷 319-334页

作者： Ying Qin Dekang li Chunting Qi Huaijiang Xiang Huyan Meng Jingli liu Shaoqing Zhou Xinyu Gong Ying li Guifang Xu Rui Zu Hang Xie Yechun Xu Gang Xu Zheng Zhang Shi Chen lifeng Pan Ying li li Tan Interdisciplinary Research Center on Biology and Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 201210China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Chemical Biology Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Institute of Hepatology National Clinical Research Center for Infectious DiseaseShenzhen Third People’s Hospitalthe Second Affiliated HospitalSchool of MedicineSouthern University of Science and TechnologyShenzhen 518112China Department of Burn and Plastic Surgery Shenzhen Institute of Translational MedicineShenzhen University Medical SchoolShenzhen Second People’s Hospitalthe First Affiliated Hospital of Shenzhen UniversityShenzhen 518035China

Receptor-interacting serine/threonine-protein kinase 1(RIPK1)functions as a key regulator in inflammation and cell death and is involved in mediating a variety of inflammatory or degenerative diseases.A number of allosteric RIPK1 inhibitors(RIPK1i)have been developed,and some of them have already advanced into clinical evaluation.Recently,selective RIPK1i that interact with both the allosteric pocket and the ATP-binding site of RIPK1 have started to emerge.Here,we report the rational development of a new series of type-II RIPK1i based on the rediscovery of a reported but mechanistically atypical RIPK3i.We also describe the structure-guided lead optimization of a potent,selective,and orally bioavailable RIPK1i,62,which exhibits extraordinary efficacies in mouse models of acute or chronic inflammatory diseases.Collectively,62 provides a useful tool for evaluating RIPK1 in animal disease models and a promising lead for further drug development.

关键词： RIPK1 Necroptosis Type-II kinase inhibitors Rational design Lead optimization Structure‒activity relationship Anti-inflammation Preclinical drug discovery

The linkage between Midwinter Suppression of the North Pacific Storm Track and Atmospheric Circulation Features in the Northern Hemisphere

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Advances in Atmospheric Sciences 2022年第3期39卷 502-518页

作者： Minghao YANG Chongyin li Xin li Xiong CHEN lifeng li College of Meteorology and Oceanography National University of Defense TechnologyChangsha 410073China State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China

The midwinter suppression(MWS) of the North Pacific storm track(NPST) has been an active research topic for decades. Based on the daily-mean NCEP/NCAR reanalysis from 1948 to 2018, this study investigates the MWS-related atmospheric circulation characteristics in the Northern Hemisphere by regression analysis with respect to a new MWS index, which may shed more light on this difficult issue. The occurrence frequency of the MWS of the upper-tropospheric NPST is more than 0.8 after the mid-1980 s. The MWS is accompanied by significantly positive sea-level pressure anomalies in Eurasia and negative anomalies over the North Pacific, which correspond to a strengthened East Asian winter monsoon. The intensified East Asian trough and atmospheric blocking in the North Pacific as well as the significantly negative low-level air temperature anomalies, lying upstream of the MNPST, are expected to be distinctly associated with the MWS. However, the relationship between the MWS and low-level atmospheric baroclinicity is somewhat puzzling.From the diagnostics of the eddy energy budget, it is identified that the inefficiency of the barotropic energy conversion related to the barotropic governor mechanism does not favor the occurrence of the MWS. In contrast, weakened baroclinic energy conversion, buoyancy conversion, and generation of eddy available potential energy by diabatic heating are conducive to the occurrence of the MWS. In addition, Ural blocking in the upstream region of the MNPST may be another candidate mechanism associated with the MWS.

关键词： midwinter suppression North Pacific storm track anomalous atmospheric circulation eddy energy budget

Polarization-dependent photoinduced metal–insulator transitions in manganites

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Science Bulletin 2024年第2期69卷 183-189页

作者： lina Deng Weiye Zhang Hanxuan lin lifen Xiang Ying Xu Yadi Wang Qiang li Yinyan Zhu Xiaodong Zhou Wenbin Wang lifeng Yin Hangwen Guo Chuanshan Tian Jian Shen State Key Laboratory of Surface Physics Institute for Nanoelectronic Devices and Quantum Computingand Department of PhysicsFudan UniversityShanghai 200433China Shanghai Research Center for Quantum Sciences Shanghai 201315China Zhangjiang Fudan International Innovation Center Fudan UniversityShanghai 201210China Collaborative Innovation Center of Advanced Microstructures Nanjing 210093China Shanghai Branch CAS Center for Excellence and Synergetic Innovation Center in Quantum Information and Quantum PhysicsShanghai 201315China

In correlated oxides,collaborative manipulation on light intensity,wavelength,pulse duration and polarization has yielded many exotic discoveries,such as phase transitions and novel quantum states.In view of potential optoelectronic applications,tailoring long-lived static properties by light-induced effects is highly desirable.So far,the polarization state of light has rarely been reported as a control parameter for this purpose.Here,we report polarization-dependent metal-to-insulator transition(MIT)in phaseseparated manganite thin films,introducing a new degree of freedom to control static MIT.Specifically,we observed giant photoinduced resistance jumps with striking features:(1)a single resistance jump occurs upon a linearly polarized light incident with a chosen polarization angle,and a second resistance jump occurs when the polarization angle changes;(2)the amplitude of the second resistance jump depends sensitively on the actual change of the polarization angles.linear transmittance measurements reveal that the origin of the above phenomena is closely related to the coexistence of anisotropic micro-domains.Our results represent a first step to utilize light polarization as an active knob to manipulate static phase transitions,pointing towards new pathways for nonvolatile optoelectronic devices and sensors.

关键词： Metal-insulator phase transitions Polarization of light Electronic phase separation Selective domain controllability

Mechanistic investigation on Ag-Cu_(2)O in electrocatalytic CO_(2) to CH_(4) by in situ/operando spectroscopic and theoretical analysis

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Journal of Energy Chemistry 2024年第1期88卷 521-531,I0012页

作者： Min Sun Luxiao Zhang Fuli Tian Jiaxin li Yanqiu Lei Heng Zhang lifeng Han Zhihua Guo Yonghui Gao Fenrong liu Yan Wang Luhui Wang Shanghong Zeng School of Chemistry and Chemical Engineering Inner Mongolia UniversityHohhot 010021Inner MongoliaChina Key Laboratory of Medicinal and Edible Plants Resources of Hainan Province Hainan Vocational University of Science and TechnologyHaikou 571126HainanChina State Key Laboratory of Baiyunobo Rare Earth Resource Research and Comprehensive Utilization Baotou Research Institute of Rare EarthsBaotou 014030Inner MongoliaChina Zhejiang Key Laboratory of Petrochemical Environmental Pollution Control Zhejiang Ocean UniversityZhoushan 316022ZhejiangChina

Silver-copper electrocatalysts have demonstrated effectively catalytic performance in electroreduction CO_(2) toward CH_(4),yet a revealing insight into the reaction pathway and mechanism has remained elusive.Herein,we construct chemically bonded Ag-Cu_(2)O boundaries,in which the complete reduction of Cu_(2)O to Cu has been strongly impeded owing to the presence of surface Ag shell.The interfacial confinement effect helps to maintain Cu^(+)sites at the Ag-Cu_(2)O boundaries.Using in situ/operando spectroscopy and theoretical simulations,it is revealed that CO_(2) is enriched at the Ag-Cu_(2)O boundaries due to the enhanced physisorption and chemisorption to CO_(2),activating CO_(2) to form the stable intermediate^(*)CO.The boundaries between Ag shell and the Cu_(2)O mediate local^(*)CO coverage and promote^(*)CHO intermediate formation,consequently facilitating CO_(2)-to-CH_(4) conversion.This work not only reveals the structure-activity relationships but also offers insights into the reaction mechanism on Ag-Cu catalysts for efficient electrocatalytic CO_(2) reduction.

关键词： Ag shell Interfacial confinement effect Cu~+ Local*CO coverage CO_(2)reduction

Leaching kinetics of fluorine during the aluminum removal from spent li-ion battery cathode materials

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Journal of Environmental Sciences 2024年第4期138卷 312-325页

作者： Shengjie li Jianxin Zhu Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

The high content of aluminum(Al)impurity in the recycled cathode powder seriously affects the extraction efficiency of Nickel,Cobalt,Manganese,and lithium resources and the actual commercial value of recycled materials,so Al removal is crucially important to conform to the industrial standard of spent li-ion battery cathode materials.In this work,we systematically investigated the leaching process and optimum conditions associated with Al removal from the cathode powder materials collected in a wet cathode-powder peeling and recycling production line of spent li-ion batteries(liBs).Moreover,we specifically studied the leaching of fluorine(F)synergistically happened along with the removal process of Al,which was not concerned about in other studies,but one of the key factors affecting pollution prevention in the recovery process.The mechanism of the whole process including the leaching of Al and F from the cathode powder was indicated by using NMR,FTIR,and XPS,and a defluoridation process was preliminarily investigated in this study.The leaching kinetics of Al could be successfully described by the shrinking core model,controlled by the diffusion process and the activation energy was 11.14 kJ/mol.While,the leaching of F was attributed to the dissolution of liPF6and decomposition of PVDF,and the kinetics associated was described by Avrami model.The interaction of Al and F is advantageous to realize the defluoridation to some degree.It is expected that our investigation will provide theoretical support for the large-scale recycling of spent liBs.

关键词： Al removal F leaching Cathode powder Heating alkali leaching Leaching kinetics

Porous framework materials for energy&environment relevant applications:A systematic review

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Green Energy & Environment 2024年第2期9卷 217-310页

作者： Yutao liu liyu Chen lifeng Yang Tianhao Lan Hui Wang Chenghong Hu Xue Han Qixing liu Jianfa Chen Zeming Feng Xili Cui Qianrong Fang Hailong Wang libo li Yingwei li Huabin Xing Sihai Yang Dan Zhao Jinping li College of Chemical Engineering and Technology Shanxi Key Laboratory of Gas Energy Efficient and Clean UtilizationTaiyuan University of TechnologyTaiyuan030024China School of Chemistry and Chemical Engineering South China University of TechnologyGuangzhou510640China Key Laboratory of Biomass Chemical Engineering of Ministry of Education College of Chemical and Biological EngineeringZhejiang UniversityHangzhou310027China Department of Chemistry The University of ManchesterManchesterM139PLUK Department of Chemical and Biomolecular Engineering National University of SingaporeSingapore 117585Singapore ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou311215China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin UniversityChangchun130012China Beijing Key Laboratory for Science and Application of Functional Molecular and Crystalline Materials Department of ChemistryUniversity of Science and Technology BeijingBeijing100083China

Carbon peaking and carbon neutralization trigger a technical revolution in energy&environment related fields.Development of new technologies for green energy production and storage,industrial energy saving and efficiency reinforcement,carbon capture,and pollutant gas treatment is in highly imperious demand.The emerging porous framework materials such as metal–organic frameworks(MOFs),covalent organic frameworks(COFs)and hydrogen-bonded organic frameworks(HOFs),owing to the permanent porosity,tremendous specific surface area,designable structure and customizable functionality,have shown great potential in major energy-consuming industrial processes,including sustainable energy gas catalytic conversion,energy-efficient industrial gas separation and storage.Herein,this manuscript presents a systematic review of porous framework materials for global and comprehensive energy&environment related applications,from a macroscopic and application perspective.

关键词： Porous framework materials Catalysis Separation Gas storage Carbon neutrality