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Systemic therapy in gastrointestinal stromal tumors

Oncology and Translational Medicine 2024年第3期10卷 110-118页

作者： Shaoli Li Hui Wang Xiaogang Wang Rui Bai Qunan sun Sujing Jiang lifeng sun Youping Wang Ying Dong Department of Medical Oncology the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Cancer Institute Key Laboratory of Cancer Prevention and InterventionMinistry of Educationthe Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Cancer Center Zhejiang UniversityHangzhou 310009China Department of Pathology the Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)Institute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou 310022China Department of Pathology the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Department of Respiratory and Critical Care Medicine the Fourth Affiliated Hospital of Zhejiang University School of MedicineYiwuChina Colorectal Surgery and Oncology the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China.

Gastrointestinal stromal tumors(GISTs)are the most common type of soft tissue sarcoma in the gastrointestinal *** GISTs have been attributed to activated gain-of-function mutations in either KIT or platelet-derived growth factor receptorα,making these molecular features essential targets for therapeutic *** surgery is the standard treatment for localized GISTs,patients often experience relapse and disease progression even after *** recent years,targeted therapy has significantly improved the prognosis of patients with advanced *** mesylate,a KIT inhibitor,is the first-line treatment for advanced GISTs and has revolutionized the treatment of this ***,drug resistance remains a major issue with imatinib treatment,as a significant majority of patients become resistant to imatinib either after initiation or after 2–3 years of ***,novel tyrosine kinase inhibitors such as sunitinib,regorafenib,ripretinib,and avapritinib have been introduced to address drug *** has emerged as a potential approach for the treatment of advanced *** review comprehensively summarizes the pathogenesis of GISTs and the development of targeted therapies and immunotherapies,provides an overview of the emergence of drug resistance in advanced GISTs,and discusses the challenges and prospects associated with the treatment of GISTs.

关键词： Gastrointestinal stromal tumors Pathogenesis Systemic therapy Drug resistance

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基础设施PPP+REITs项目合规审查和交易结构搭建

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当代农村财经 2024年第1期 44-47页

作者：孙立峰天津大学管理与经济学部

通过基础设施不动产投资信托基金(REITs),可以盘活政府和社会资本合作(PPP)项目存量资产,在更大范围内吸引社会投资者参与基础设施项目。根据国家发展改革委和财政部关最新颁发的《关于规范实施政府和社会资本合作新机制的指导意见》,对... 详细信息

通过基础设施不动产投资信托基金(REITs),可以盘活政府和社会资本合作(PPP)项目存量资产,在更大范围内吸引社会投资者参与基础设施项目。根据国家发展改革委和财政部关最新颁发的《关于规范实施政府和社会资本合作新机制的指导意见》,对PPP项目底层资产的合规性进行深入审查和合理搭建REITs交易结构是成功发行REITs的关键。

关键词：政府和社会资本合作不动产投资信托基金交易结构

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家电产品能效信息认知对消费者绿色购买行为的影响——一个有调节的中介模型

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济宁学院学报 2024年第4期45卷 45-55页

作者：梅蕾孙洋孙立峰内蒙古科技大学经济与管理学院内蒙古包头014010

购买绿色节能家电有助于降低家庭能耗、控制碳排放,也有助于促进制造企业生产的绿色转型。以家电产品的能效标识为研究对象,参照ABC态度模型构建了一个有调节的中介模型,重点考察绿色价值和感知付出在能效信息认知与绿色购买行为之间的... 详细信息

购买绿色节能家电有助于降低家庭能耗、控制碳排放,也有助于促进制造企业生产的绿色转型。以家电产品的能效标识为研究对象,参照ABC态度模型构建了一个有调节的中介模型,重点考察绿色价值和感知付出在能效信息认知与绿色购买行为之间的中介作用以及自然联结感的调节作用。研究发现:能效信息认知正向影响消费者的绿色购买行为,绿色价值和感知付出对消费者绿色购买行为起部分中介作用;绿色价值和感知付出在能效信息认知与绿色购买行为之间起链式中介作用;自然联结感正向调节能效信息认知与绿色价值之间的关系,而对能效信息认知与感知付出的关系起不到调节作用。基于研究结果,从增强公众对能效标识的认知,提升消费者绿色价值感知,注重培养公众的自然联结感等方面提出对策建议,可以为政府推进绿色消费政策和家电企业营销管理提供参考。

关键词：能效信息认知绿色价值感知付出绿色购买行为自然联结感

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中国儿童幽门螺杆菌感染流行病学与耐药现状及其治疗进展

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国际儿科学杂志 2024年第5期51卷 297-301页

作者：公金铭孙立锋山东第一医科大学附属省立医院儿科、山东省儿童健康与疾病临床医学研究中心济南250021

中国幽门螺杆菌感染率一直处于较高水平。尽管随着社会经济发展, 我国儿童幽门螺杆菌感染率已经有所降低, 但由于抗生素在儿童群体中的广泛应用等原因, 耐药菌株不断出现, 既往的幽门螺杆菌根除方案根除率有所下降, 儿童幽门螺杆菌根除... 详细信息

中国幽门螺杆菌感染率一直处于较高水平。尽管随着社会经济发展, 我国儿童幽门螺杆菌感染率已经有所降低, 但由于抗生素在儿童群体中的广泛应用等原因, 耐药菌株不断出现, 既往的幽门螺杆菌根除方案根除率有所下降, 儿童幽门螺杆菌根除治疗面临着巨大挑战。该文对中国儿童幽门螺杆菌的感染、耐药状况及治疗进展进行综述, 以期为儿童幽门螺杆菌感染的预防控制和根除治疗提供参考。

关键词：儿童幽门螺杆菌流行病学治疗耐药

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Adaptive mixture observation models for multiple object tracking

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Science in China(Series F) 2009年第2期52卷 226-235页

作者： CUI Peng sun lifeng YANG ShiQiang Department of Computer Science Tsinghua University Beijing 10084 China

Multiple object tracking （MOT） poses many difficulties to conventional well-studied single object tracking （SOT） algorithms, such as severe expansion of configuration space, high complexity of motion conditions, and visual ambiguities among nearby targets, among which the visual ambiguity problem is the central challenge. In this paper, we address this problem by embedding adaptive mixture observation models （AMOM） into a mixture tracker which is implemented in Particle Filter framework. In AMOM, the extracted multiple features for appearance description are combined according to their discriminative power between ambiguity prone objects, where the discriminability of features are evaluated by online entropy-based feature selection techniques. The induction of AMOM can help to surmount the incapability of conventional mixture tracker in handling object occlusions, and meanwhile retain its merits of flexibility and high efficiency. The final experiments show significant improvement in MOT scenarios compared with other methods.

关键词： motion tracking mixture tracker particle filter online feature selection

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A retargeting method for stereoscopic 3D video

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Computational Visual Media 2015年第2期1卷 119-127页

作者： Yi Liu lifeng sun Shiqiang Yang Department of Computer Science and Technology Tsinghua UniversityTsinghua NLIST Department of Computer Science and Technology Tsinghua University

We propose a disparity-constrained retargeting method for stereoscopic 3D video, which simultaneously resizes a binocular video to a new aspect ratio and remaps the depth to the perceptual comfort zone. First, we model distortion energies to prevent important video contents from deforming. Then, to maintain depth mapping stability, we model disparity variation energies to constraint the disparity range both in spatial and temporal domains. The last component of our method is a non-uniform, pixel-wise warp to the target resolution based on these energy models. Using this method, we can process the original stereoscopic video to generate new, high-perceptual-quality versions at different display resolutions. For evaluation, we conduct a user study; we also discuss the performance of our method.

关键词： stereoscopic 3D video retargeting disparity manipulation image warping

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清瘟祛毒胶囊治疗成人流行性感冒热毒袭肺证临床疗效及对炎症相关因子水平的影响

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河北中医 2024年第6期46卷 897-900页

作者：孙立峰孙光周孙立媛孙立芳付秀英沧州光周中医门诊部河北沧州061000

目的观察清瘟祛毒胶囊治疗成人流行性感冒热毒袭肺证的临床疗效及对炎症相关因子水平的影响。方法选择沧州光周中医门诊部60例成人流行性感冒热毒袭肺证患者,按照随机数字表法分为2组。对照组30例予磷酸奥司他韦胶囊,治疗组30例在对照... 详细信息

目的观察清瘟祛毒胶囊治疗成人流行性感冒热毒袭肺证的临床疗效及对炎症相关因子水平的影响。方法选择沧州光周中医门诊部60例成人流行性感冒热毒袭肺证患者,按照随机数字表法分为2组。对照组30例予磷酸奥司他韦胶囊,治疗组30例在对照组治疗基础上加清瘟祛毒胶囊,治疗5天。比较2组临床疗效,发热、咳嗽、咽痛、乏力消失时间及病毒转阴时间。比较2组治疗前后白细胞介素6(IL-6)、IL-1β、肿瘤坏死因子α(TNF–α)、C反应蛋白(CRP)水平及咳嗽、口渴、咽痛、目赤、头痛评分。结果治疗组总有效率93.33%(28/30),高于对照组的86.67%(26/30)(P<0.05)。治疗组发热、咳嗽、咽痛、乏力消失时间及病毒转阴时间均早于对照组(P<0.05)。治疗后2组IL-6、IL-1β、TNF-α、CRP水平及咳嗽、口渴、咽痛、目赤、头痛各单项症状评分和总分均较本组治疗前显著下降(P<0.05),且治疗组较对照组更低(P<0.05)。治疗组不良反应发生率3.33%(1/30),低于对照组的16.67%(5/30)(P<0.05)。结论清瘟祛毒胶囊治疗成人流行性感冒热毒袭肺证可缩短发热、咽痛等症状消失的时间及病毒转阴时间,改善临床症状,降低炎症相关因子水平,疗效确切。

关键词：流感人热毒袭肺证中药疗法炎症

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Adaptive data-driven parallelization of multi-view video coding on multi-core processor

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Science in China(Series F) 2009年第2期52卷 195-205页

作者： PANG Yi HU WeiDong sun lifeng YANG ShiQiang Department of Computer Science and Technology Tsinghua University Beijing 100084 China

Multi-view video coding （MVC） comprises rich 3D information and is widely used in new visual media, such as 3DTV and free viewpoint TV （FTV）. However, even with mainstream computer manufacturers migrating to multi-core processors, the huge computational requirement of MVC currently prohibits its wide use in consumer markets. In this paper, we demonstrate the design and implementation of the first parallel MVC system on Cell Broadband Engine^TM processor which is a state-of-the-art multi-core processor. We propose a task-dispatching algorithm which is adaptive data-driven on the frame level for MVC, and implement a parallel multi-view video decoder with modified H.264/AVC codec on real machine. This approach provides scalable speedup （up to 16 times on sixteen cores） through proper local store management, utilization of code locality and SIMD improvement. Decoding speed, speedup and utilization rate of cores are expressed in experimental results.

关键词： adaptive data-driven multi-view video coding Cell Broadband Engine^TM Processor parallelization

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Strategies of Collaboration in Multi-Swarm Peer-to-Peer Content Distribution

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Tsinghua Science and Technology 2012年第1期17卷 29-39页

作者： Zhi Wang Chuan Wu lifeng sun Shiqiang Yang Tsinghua National Laboratory for Information Science and Technology Department of Computer Science and TechnologyTsinghua UniversityBeijing 100084China Department of Computer Science The University of Hong KongPokfulamHong KongChina

In modern Peer-to-Peer （P2P） content distribution applications, multiple swarms typically exist, each corresponding to the dissemination of one content among interested peers. A common design in the existing P2P applications is to allow peers in one swarm to help each other, while different swarms are only coupled when sharing the upload bandwidth at the dedicated content servers/publishers. In recent years, a number of proposals have emerged which advocate inter-swarm collaboration and resource sharing, where peers in one swarm may contribute their storage and bandwidth resources to help peers in the swarm of another content. Such inter-swarm collaboration can improve content availability and optimize resource uti- lization in the entire system, at the cost of additional overhead for content preloading and inter-swarm coor- dination. This paper presents a survey of studies on effective inter-swarm collaboration mechanisms in the existing literature. This paper first discusses strategies of collaboration in P2P file sharing applications, and then presents multi-channel collaborative design for P2P live and Video-on-Demand （VoD） streaming. In particular, this paper elaborates our recent design of collaboration strategies among multiple streaming channels in a P2P VoD system, and shows that the server cost can be reduced by up to 25% while high streaming qualities are guaranteed in the entire system, even during extreme scenarios such as unexpected flash crowds. This paper also discusses representative approaches to implement inter-swarm collaborations in various P2P content distribution systems.

关键词： Peer-to-Peer (P2P) networks content distribution inter-swarm collaboration media streaming

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Study of highly excited vibrational dynamics of HCP integrable system with dynamic potential methods

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Chinese Physics B 2020年第1期29卷 203-211页

作者： Aixing Wang lifeng sun Chao Fang Yibao Liu Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation East China University of TechnologyNanchang 330013China School of Science East China University of TechnologyNanchang 330013China CNNC High Energy Equipment(Tianjin)Co. LtdTianjin 300300China Lab for High Technology Tsinghua UniversityBeijing 100084China

Highly excited vibrational dynamics of phosphaethyne(HCP)integrable system are investigated based on its dynamic *** into consideration the 2:1 Fermi resonance between H–C–P bending vibrational mode and C–P stretching vibrational mode,it is found that the effects of H–C stretching vibrational mode on vibrational dynamic features of the HCP integrable system are significant and regularly vary with Polyad numbers(P number).The geometrical profiles of the dynamic potentials and the corresponding fixed points are sensitive to the variation of H–C stretching vibrational strength when P numbers are small,but are not sensitive when P numbers become larger and the corresponding threshold values become *** phase space trajectories of different energy levels in a designated dynamic potential(P=28)were studied and the results indicated that the dynamic potentials govern the various dynamic environments in which the vibrational states ***,action integrals of the energy levels contained in dynamic potential(P=28)were quantitatively analyzed and *** was determined that the dynamic environments could be identified by the numerical values of the action integrals of trajectories of phase space,which is equivalent with dynamic potentials.

关键词： phosphaethyne(HCP) highly excited vibrational state fixed point phase space trajectory

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