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Chinese Journal of Chemistry 2016年第11期34卷 1177-1182页

作者： lifang fan Xinxin Tian Shaomin Shuang Chuan Dong Institute of Environmental Science Shanxi University Taiyuan Sharnxi 030006 China Department of Chemistry and Chemical Engineering Shanxi University Taiyuan Shanxi 030006 China

A simpe electrochemical sensor for detection of cholic acid （CA） was designed by modifying phosphomolybdate （PMol2） doped polypyrrole （PPy） film on glassy carbon electrode （PMo12-PPy/GCE）. The electrochemical behavior of CA on PMo12-PPy/GCE was investigated by cyclic voltammetry and 0.5 order differential voltammetry. The results indicated that CA had high inhibitory activity toward the peak currents of PMo12-PPy/GCE. The reduction peak currents were linearly related to the logarithmic value of the concentration of CA from 1.0 × 10^- 7 to 1.0 × 10^-3 mol/L with a low detection limit of 1.0 × 10^- 8 mol/L. The developed sensor exhibited excellent sensitivity, selectivity and stability for detection of CA, and it could be successfully applied to detect the level of CA in the urine samples. Moreover, the response mechanism of CA on the PMo12-PPy/GCE was discussed in detail.

关键词： phosphomolybdate polypyprrole cholic acid 0.5 order differential voltammetry

Delivery strategies of amphotericin B for invasive fungal infections

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Acta Pharmaceutica Sinica B 2021年第8期11卷 2585-2604页

作者： Xiaochun Wang Imran Shair Mohammad lifang fan Zongmin Zhao Md Nurunnabi Marwa A.Sallam Jun Wu Zhongjian Chen lifang Yin Wei He Department of Pharmaceutics China Pharmaceutical UniversityNanjing 211198China School of Pharmaceutical Sciences Sun Yat-sen UniversityUniversity TownGuangzhou 510006China Jiangsu Aosaikang Pharmaceutical Co. Ltd.Nanjing 211112China School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA Department of Pharmaceutical Sciences School of PharmacyUniversity of Texas at El PasoEl PasoTX 79902USA Department of Industrial Pharmacy Faculty of PharmacyAlexandria UniversityAlexandria 21521Egypt Department of Geriatric Cardiology Jiangsu Provincial Key Laboratory of Geriatricsthe First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Shanghai Skin Disease Hospital Tongji University School of MedicineShanghai 200443China

Invasive fungal infections(IFIs)represent a growing public concern for clinicians to manage in many medical settings,with substantial associated morbidities and *** many current therapeutic options for the treatment of IFIs,amphotericin B(AmB)is the most frequently used *** is considered as a first-line drug in the clinic that has strong antifungal activity and less *** this review,we summarized the most promising research efforts on nanocarriers for AmB delivery and highlighted their efficacy and safety for treating *** have also discussed the mechanism of actions of AmB,rationale for treating IFIs,and recent advances in formulating AmB for clinical ***,this review discusses some practical considerations and provides recommendations for future studies in applying AmB for combating IFIs.

关键词： Invasive fungal infections Amphotericin B Poor water-solubility Drug delivery Topical administration Nanoparticles Conjugates Toxicity

Liposomes and liposome-like nanoparticles:From anti-fungal infection to the COVID-19 pandemic treatment

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Asian Journal of Pharmaceutical Sciences 2022年第6期17卷 817-837页

作者： Yonglong He Wanting Zhang Qingqing Xiao lifang fan Dechun Huang Wei Chen Wei He School of Pharmacy China Pharmaceutical UniversityNanjing 211198China Jiangsu Aosaikang Pharmaceutical Co. Ltd.Nanjing 211112China School of Engineering China Pharmaceutical UniversityNanjing 210009China Shanghai Skin Disease Hospital Tongji University School of MedicineShanghai 200443China

The liposome is the first nanomedicine transformed into the market and applied to human *** then,such phospholipid bilayer vesicles have undergone technological advancements in delivering small molecular-weight compounds and biological *** investigations about liposome uses were conducted in different treatment fields,including anti-tumor,anti-fungal,anti-bacterial,and clinical analgesia,owing to liposome's ability to reduce drug cytotoxicity and improve the therapeutic efficacy and combinatorial *** particular,two liposomal vaccines were approved in 2021 to combat ***,the clinically used liposomes are reviewed by introducing various liposomal preparations in detail that are currently proceeding in the clinic or on the ***,we discuss the challenges of developing liposomes and cutting-edge liposomal delivery for biological drugs and combination therapy.

关键词： Liposomes Drug delivery Clinical application COVID-19 pandemic

Liposomal codelivery of inflammation inhibitor and collagen protector to the plaque for effective anti-atherosclerosis

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Chinese Chemical Letters 2023年第1期34卷 239-244页

作者： Xiaotong Li Jiayi Gu Qingqing Xiao Ying Liu Ping Zhou lifang fan Xiulian Zhang Xiang Lu Jun Wu Zhengxia Liu Wei He School of Pharmacy China Pharmaceutical UniversityNanjing 211198China Department of Geriatrics The Second Affiliated HospitalNanjing Medical UniversityNanjing 210011China Key Laboratory for Aging&Disease Nanjing Medical UniversityNanjing 210011China Jiangsu Aosaikang Pharmaceutical Co. Ltd.Nanjing 211112China Department of Respiratory Disease Baoshan BranchShuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 200120China Department of Geriatric Cardiology Jiangsu Provincial Key Laboratory of GeriatricsThe First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Geriatrics The Affiliated Sir Run Run Hospital of Nanjing Medical UniversityNanjing 211166China

Plaque plays a central role in atherosclerosis(AS)progression,whereas inflammation and destruction of the plaque microenvironment contribute to plaque *** a result,a therapy regime,which combines anti-inflammation and inhibition-degradation of plaque matrix,appears to be a promising strategy to combat ***,we report a p H-sensitive liposome co-loading with the anti-inflammatory agent(oridonin,ORD)and plaque-collagen protector(marimastat)for anti-AS *** was first conjugated with hyaluronic acid(HA)to target the inflammation contributor,pro-inflammatory ***,the conjugate assembled onto the MATT-loaded *** co-loaded system(150 nm)significantly improved pharmacokinetics over the liposomes without anchoring the conjugate and accumulated effectively in the *** preparation administration allowed efficient anti-AS activities in high-fat diet(HFD)-Apoe-/-mice by decreasing the pro-inflammatory cytokine expression in the serum,lessening the lesion area,alleviating the plaque collagen degradation,promoting macrophage polarization from phenotypic M1 to M2,reducing T helper(Th)17 cells(Th17)/T regulatory cells(Tregs)and Th1/Th2 ratio,***,the serum determination in AS patients demonstrated high expression of the inflammatory cytokines,indicating our finding may offer a potential guideline for clinical practice.

关键词： Atherosclerosis Plaque Inflammation Collagen Macrophages Co-delivery Liposomes

Metal phenolic network-stabilized nanocrystals of andrographolide to alleviate macrophage-mediated inflammation in-vitro

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Chinese Chemical Letters 2023年第1期34卷 225-229页

作者： Kosheli Thapa Magar George Frimpong Boafo Makhloufi Zoulikha Xiaohong Jiang Xiaotong Li Qingqing Xiao Xuyang Xing Xiaochun Wang lifang fan Zhenfeng Wu Wei He School of Pharmacy China Pharmaceutical UniversityNanjing 211198China Jiangsu Aosaikang Pharmaceutical Co. Ltd.Nanjing 211112China Key Laboratory of Modern Preparation of TCM Ministry of EducationJiangxi University of Chinese MedicineNanchang 330004China

Macrophages play a crucial role in initiating,maintaining,and resolving inflammation through the phenotypic shift,inducing or inhibiting the production of inflammatory ***,macrophages are potential targets for treating inflammatory ***(AND)is a potent anti-inflammatory drug that can reduce pro-inflammatory cytokines and suppress NF-κB/MAPK pathway in activated *** AND has many medicinal properties,its lower water solubility and first-pass effect in the liver have hindered its clinical *** this context,by using a metal phenolic network as a stabilizer,we designed and prepared highly stabilized AND nanocrystals(AND-MPN Ns)with high drug loading capacity to facilitate the clinical application of *** findings showed that AND-MPN Ns could be used to enhance the anti-inflammation in-vitro via macrophage polarization,reducing proinflammatory cytokines IL-6 and TNF-α,and suppressing the NF-κB signaling pathway *** results demonstrated the potential of AND-MPN Ns to combat inflammatory diseases effectively.

关键词： Inflammation Macrophages Andrographolide Metal phenolic network Nanocrystals

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中外企业信用评价信息源比较研究

图书情报知识 2007年第6期24卷 96-100页

作者：樊李方武汉大学信息管理学院武汉430072

本文比较了中外企业信用评价综合体系中信息源的建立与特点的异同,分析了目前中国企业信用评价中信息源的缺乏之症结所在。提出了中国企业信用评价信息源体系建设发展的建议。

关键词：企业信用信用评价信用信息源

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发展先进生产力推进社会变革的启示

生产力研究 2005年第6期 83-84,131页

作者：樊丽芳中国人民武装警察部队学院河北廊坊065000

党的十一届三中全会以来,我国社会发生了巨大变化。考察、分析在社会所发生的巨大变化,发现:我国先进生产力是推动社会变革的最根本动力。先进生产力的推动作用贯穿于整个社会变革的全过程。它不仅为社会变革明确了方向,同时为社会变革... 详细信息

党的十一届三中全会以来,我国社会发生了巨大变化。考察、分析在社会所发生的巨大变化,发现:我国先进生产力是推动社会变革的最根本动力。先进生产力的推动作用贯穿于整个社会变革的全过程。它不仅为社会变革明确了方向,同时为社会变革提供了大量的现实条件。先进生产力的发展推动了我国社会经济、政治、文化文明的进程,促进了社会的进步和人的全面发展。

关键词：当代中国先进生产力发展社会变革启示

保险公估人制度对解决保险市场信息不对称的作用及问题分析

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武汉大学学报（哲学社会科学版） 2007年第6期60卷 874-878页

作者：樊李方武汉大学信息管理学院湖北武汉430072

保险市场存在着诸多的信息不对称,由此引起的"逆向选择"和"道德风险"常常会产生不良后果,投保人对保险条款免赔范围和理赔过程的不了解,也会导致双方的不信任感。基于此而引入的保险公估人制度在保险信息的有效沟通、保险理赔工作的专... 详细信息

保险市场存在着诸多的信息不对称,由此引起的"逆向选择"和"道德风险"常常会产生不良后果,投保人对保险条款免赔范围和理赔过程的不了解,也会导致双方的不信任感。基于此而引入的保险公估人制度在保险信息的有效沟通、保险理赔工作的专业化和保险市场的公正性、增强保险市场双方信用程度等方面缩小了买卖双方信息不对称的差距。但是,保险公估人仍然存在信息不对称的问题,对于这些问题我们应该予以关注。

关键词：信息不对称保险公估人市场

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干细胞基因Musashi-1研究进展

中国肿瘤临床 2014年第4期41卷 269-271页

作者：王颜樊利芳武汉大学基础医学院病理教研室武汉市430071

Musashi家族是一类进化保守的RNA结合蛋白家族,可选择性的表达于神经系统干/祖细胞,包括Musashi-1和Musashi-2成员。Musashi-1是第1个最早发现于果蝇的Musashi家族成员,Musashi-1与Musashi-2蛋白通过抑制其目标蛋白Numb mRNA的翻译过程... 详细信息

Musashi家族是一类进化保守的RNA结合蛋白家族,可选择性的表达于神经系统干/祖细胞,包括Musashi-1和Musashi-2成员。Musashi-1是第1个最早发现于果蝇的Musashi家族成员,Musashi-1与Musashi-2蛋白通过抑制其目标蛋白Numb mRNA的翻译过程,协同激活Notch信号通路,参与干细胞非对称分裂。Musashi-1目前作为一个公认的干细胞候选基因,在参与肿瘤有关信号通路、细胞增殖与凋亡等很多方面都起着重要作用。神经胶质瘤、食管癌、胃癌、结肠癌、乳腺癌等实体肿瘤中均出现Musashi-1基因的高表达,Musashi的研究将对临床肿瘤疾病基因层面的深入研究和诊断治疗提供新途径。本文主要针对Musashi-1的结构、功能及其在肿瘤发生发展中的研究进展进行综述。

关键词： Musashi-1 干细胞基因肿瘤

糖肽类抗菌药物利用评价标准的建立与应用分析

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中国现代应用药学 2019年第1期36卷 103-107页

作者：赵云范丽芳台州恩泽医疗中心集团台州医院

目的建立糖苷类抗菌药物(万古霉素和替考拉宁)的药物利用评价标准,并评价糖肽类抗菌药物临床用药情况。方法以药品说明书为基础,参照相关规范和专家共识,建立万古霉素和替考拉宁药物利用评价标准;采用回顾性研究方法,对2017年1月—6月27... 详细信息

目的建立糖苷类抗菌药物(万古霉素和替考拉宁)的药物利用评价标准,并评价糖肽类抗菌药物临床用药情况。方法以药品说明书为基础,参照相关规范和专家共识,建立万古霉素和替考拉宁药物利用评价标准;采用回顾性研究方法,对2017年1月—6月274例使用万古霉素和替考拉宁的病例进行合理性评价。结果糖肽类抗菌药物治疗有效率为75.91%,用药指征符合率为92.70%,剂量正确率为98.18%,用法正确率为91.24%,疗程合理率为79.93%,联合用药合理率为72.26%。结论建立的万古霉素和替考拉宁药物利用评价标准可用于规范糖肽类抗菌药物的使用,该院万古霉素和替考拉宁的使用基本合理。

关键词：糖肽类抗菌药物万古霉素替考拉宁药物利用评价