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Fatty acid intake in relation to reproductive hormones and testicular volume among young healthy men

Asian Journal of Andrology 2017年第2期19卷 184-190页

作者： lidia minguez-alarcon Jorge E Chavarro JJaime Mendiola Manuela Roca Cigdem Tanrikut Jesus Vioque Niels Jorgensen Alberto M Torres-Cantero Department of Environmental Health Harvard School of Public Health Boston Massachusetts USA Department of Health and Social Sciences Division of Preventive Medicine and Public Health University of Murcia School of Medicine IMIB-Arrixaca Espinardo (Murcia) Spain Department of Nutrition Harvard School of Public Health Boston Massachusetts USA Department of Epidemiology Harvard School of Public Health Boston Massachusetts USA Channing Division of Network Medicine Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts USA Roca Fertility Advanced Clinic Management SLU Murcia Spain Department of Urology Massachusetts General Hospital Boston Massachusetts USA Department of Surgery Harvard Medical School Boston Massachusetts USA ClBER Epidemiology and Public Health (ClBERESP) Institute of Health Ill (ISClII) Madrid Spain Department of Public Health Miguel Hernandez University EIche-Alicante Spain Department of Growth and Reproduction University of Copenhagen Rigshospitalet Copenhagen Denmark Regional Campus of International Excellence 'Campus Mare Nostrum' University of Murcia Murcia Spain

Emerging evidence suggests that dietary fats may influence testicular function. However, most of the published literature on this field has used semen quality parameters as the only proxy for testicular function. We examined the association of fat intake with circulating reproductive hormone levels and testicular volume among healthy young Spanish men. This is a cross-sectional study among 209 healthy male volunteers conducted between October 2010 and November 2011 in Murcia Region of Spain. Participants completed questionnaires on lifestyle, diet, and smoking, and each underwent a physical examination, and provided a blood sample. Linear regression was used to examine the association between each fatty acid type and reproductive hormone levels and testicular volumes. Monounsaturated fatty acids intake was inversely associated with serum blood levels of calculated free testosterone, total testosterone, and inhibin B. A positive association was observed between the intake of polyunsaturated fatty acids, particularly of omega-6 polyunsaturated fatty acids, and luteinizing hormone concentrations. In addition, the intake of trans fatty acids was associated with lower total testosterone and calculated free testosterone concentrations （Ptrend = 0.01 and 0.02, respectively）. The intake of omega-3 polyunsaturated fatty acids was positively related to testicular volume while the intake of omega-6 polyunsaturated fatty acids and trans fatty acids was inversely related to testicular volume. These data suggest that fat intake, and particularly intake of omega 3, omega 6, and trans fatty acids, may influence testicular function.

关键词： fat intake reproductive health reproductive hormones trans fatty acids young healthy men

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室内空气污染造成的疾病负担及为什么我们要了解它

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Science Bulletin 2024年第9期69卷 1161-1164页

作者： lidia Morawska International Laboratory for Air Quality and Heath(ILAQH) WHO Collaborating Centre for Air Quality and HealthSchool of Earth and Atmospheric SciencesQueensland University of TechnologyBrisbane QLD 4001Australia Global Centre for Clean Air Research(GCARE) School of SustainabilityCivil and Environmental EngineeringFaculty of Engineering and Physical SciencesUniversity of SurreyGuildford GU27XHUK

Ask a scientist from basically any area of science what they think about the immense scientific complexity of indoor air and its impacts,and they seem *** of black holes—yes,complexity of the human genome—yes,but of indoor air?To scientists who investigate indoor air it is incomprehensible that this area of science attracts so little interest from the broader scientific community,the public,and frankly,anyone.

关键词：室内空气污染疾病负担 black

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Stem cell technology for antitumor drug loading and delivery in oncology

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Oncology Research 2024年第3期32卷 433-437页

作者： FRANCESCO PETRELLA ENRICO MARIO CASSINA lidia LIBRETTI EMANUELE PIRONDINI FEDERICO RAVEGLIA ANTONIO TUORO Department of Thoracic Surgery Fondazione IRCCSS an Gerardo dei TintoriMonza20900Italy

The main aim of antineoplastic treatment is to maximize patient benefit by augmenting the drug accumulation within affected organs and tissues,thus incrementing drug effects and,at the same time,reducing the damage of non-involved tissues to cytotoxic *** stromal cells(MSC)represent a group of undifferentiated multipotent cells presenting wide self-renewal features and the capacity to differentiate into an assortment of mesenchymal family *** the last year,they have been proposed as natural carriers for the selective release of antitumor drugs to malignant cll,s thus optimizing cytotoxic action on cancer cll,while significantly reducing adverse side efect on healthy *** chemotherapeutic drug loading and delivery is an encouraging new area of cell therapy for several tumors,especially for those with unsatisfactory prognosis and limited treatment options *** some experim ental models have been sucesfuly developed,phase I dinical studies are needed to confirm this potential application of cell therapy,in particular in the case of primary and secondary lung cancers.

关键词： Mesenchymal stromal cell Drug loading Drug delivery Mesothelioma Melanoma Glioblastoma Pancreatic ductal adenocarcinoma Multiple myeloma

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Phytoremediation capacity of the hyperaccumulator Solanum nigrum *** Solanum lycopersicum *** at the flowering stage in cadmium-polluted soil

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Pedosphere 2024年第3期34卷 676-680页

作者： Jibao JIA Huiping DAI Shuhe WEI lidia SKUZA Jianming XUE Rong LI Quan SUN School of Agriculture Ningxia UniversityYinchuan 750021(China) School of Biological Science and Engineering Shaanxi University of TechnologyHanzhong 723001(China) Key Laboratory of Pollution Ecology and Environment Engineering Institute of Applied EcologyChinese Academy of SciencesShenyang 110016(China) Institute of Biology Centre for Molecular Biology and BiotechnologyUniversity of SzczecinSzczecin 71-415(Poland) New Zealand Forest Research Institute(Scion) POB 29237Christchurch 8440(New Zealand)

Dear Editor,Remediation of cadmium(Cd)-contaminated soil is a popular topic in global environmental *** using hyperaccumulators or certain plants to accumulate and remove Cd from polluted soils is a promising *** et al.(2005)first described Solanum nigrum *** a Cd ***,various aspects of ***,including the protective effects on proline,physiological and biochemical responses,earthworms,arbuscular mycorrhizal fungi,and fertilizers and the intercropping with Solanum photeinocarpum,have been extensively studied(Xu et al.,2009;Khan et al.,2014;Wang et al.,2015;Tang et al.,2017;Yang et al.,2019).

关键词： soil cultivar cadmium

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Insights into the origin of precipitation moisture for tropical cyclones during rapid intensification process

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Tropical Cyclone Research and Review 2024年第2期13卷 72-87页

作者： Albenis Perez-alarcon Jose C.Fernandez-Alvarez Ricardo M.Trigo Raquel Nieto Luis Gimeno Centro de Investigacion Mari~na Universidade de VigoEnvironmental Physics Laboratory(EPhysLab)Campus As Lagoas s/nOurenseSpain Departamento de Meteorología Instituto Superior de Tecnologías y Ciencias AplicadasUniversidad de La HabanaLa HabanaCuba Instituto Dom Luiz(IDL) Facultade de Ci^enciasUniversidade de LisboaLisboaPortugal Departamento de Meteorologia Universidade Federal do Rio de JaneiroRio de JaneiroBrazil

In this study,we identiﬁed the moisture sources for the precipitation associated with tropical cyclones(TCs)during the rapid intensiﬁcation(RI)process from 1980 to 2018 by applying a Lagrangian moisture source diagnostic *** detected sixteen regions on a global scale for RI events distributed as follows:four in the North Atlantic(NATL),two in the Central and East Paciﬁc Ocean(NEPAC),the North Indian Ocean(NIO)and South Indian Ocean(SIO),and three in the South Paciﬁc Ocean(SPO)and the Western North Paciﬁc Ocean(WNP).The moisture uptake(MU)mostly was from the regions where TCs underwent *** Western NATL,tropical NATL,Caribbean Sea,the Gulf of Mexico and the Central America and Mexico landmass supported~85.4%of the precipitating moisture in the NATL,while the latter source and the eastern North Paciﬁc Ocean provided the higher amount of moisture in NEPAC(~84.3%).The Arabian Sea,the Bay of Bengal and the Indian Peninsula were the major moisture sources in NIO,contributing approximately 81.3%.The eastern and western parts of the Indian Ocean supplied most of the atmospheric humidity in SIO(~83.8%).The combined contributions(~87.9%)from the western and central SPO and the Coral Sea were notably higher in ***,TCs in the WNP basin mostly received moisture from the western North Paciﬁc Ocean,the Philippine Sea and the China Sea,accounting for 80.1%.The remaining moisture support in each basin came from the summed contributions of the remote ***,RI TCs gained more moisture up to 2500 km from the cyclone centre than those slow intensiﬁcation(SI)and the total MU was approximately three times higher during RI than ***,the patterns of the MU differences respond to the typical pathways of moisture transport in each basin.

关键词： Tropical cyclones Rapid intensiﬁcation Moisture sources Precipitation Lagrangian moisture tracking

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Appropriateness of Amikacin Dose Prescription, Monitoring and Safety during Hospitalization as an Impact of Clinical Pharmacologist Intervention, in the Israeli Regional Hospital

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Journal of Biosciences and Medicines 2024年第3期12卷 337-354页

作者： Renata Shihmanter Olga Lazar lidia Arcavi Clinical Pharmacology Unit Kaplan Medical Center Rehovot and Hebrew University Hadassah Medical School Jerusalem Israel Department of Medicine Kaplan Medical Center Rehovot and Hebrew University Hadassah Medical School Jerusalem Israel

Background: Use of inappropriate amikacin dose is one of the most important factors in inducing toxicity, prolonged hospitalization as well as in increasing patient’s mortality. Objective: The aims of this study are the analysis of amikacin dose, serum level and the examination of the effectiveness of the clinical pharmacologist (CP) therapeutic drug monitoring (TDM) intervention to guarantee the safety of amikacin use. Methods: This is a one-year retrospective observational chart review study, which evaluates amikacin dose, serum drug level, development of adverse effects in patients on amikacin with or without CP TDM consultation. Results: Amikacin was prescribed for 393 complex patients, with median age 83. Amikacin group (AG) included 140 (32%) courses with CP consultation (AG1) and 292 (68%) courses without CP consultation (AG2). The distribution of most study characteristics in both groups was similar including amikacin dose (9-10 mg/kg/day), renal failure (14%) and mortality (12%). Acceptance for CP consultation was in 46% of amikacin courses and dose changes were done in 63% after CP intervention. Prolonged antibiotic course (4.6 ± 1.5 vs 3.8 ± 1.6 days, p < 0.0001) and the patient’s hemodynamic instability (15% vs 7%, p = 0.01) were more frequent in the AG1 compared to the AG2. There was a strong association between CP consultation and prolonged hospitalization (p = 0.005), while no association between it and amikacin adverse effects, renal failure or mortality. Conclusions: There was no trend to reducing amikacin toxicity, days of hospitaliza tion or mortality in patients with CP consultation. CP TDM intervention was more in the management of complicated clinical situations. However, it is necessary to optimize it.

关键词： Amikacin Therapeutic Drug Monitoring Appropriate Clinical Pharmacologist Safety Adverse Effects

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Dose-response effect of pre-exercise carbohydrates under muscle glycogen unavailability:Insights from McArdle disease

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Journal of Sport and Health Science 2024年第3期13卷 398-408页

作者： Pedro L.Valenzuela Alfredo Santalla lidia B.Alejo Andrea Merlo Asuncion Bustos Laura Castellote-Belles Roser Ferrer-Costa Nicola A.Maffiuletti David Barranco-Gil Tomas Pinos Alejandro Lucia Physical Activity and Health Research Group(“PaHerg”) Research Institute of Hospital“12 de Octubre”(“imas12”)Madrid 28041Spain Department of Systems Biology University of AlcalaMadrid 28871Spain Department of Sport and Computer Science Section of Physical Education and SportsFaculty of SportUniversidad Pablo de OlavideSevilla 41013Spain EVOPRED Research Group Universidad Europea de CanariasTenerife 38300Spain Faculty of Sport Sciences Universidad Europea de MadridMadrid 28670Spain Gait&Motion Analysis Laboratory Sol et Salus HospitalTorre Pedrera di Rimini(RN)47922Italy Department of Clinical Biochemistry Laboratoris ClınicsHospital Universitari Vall d’HebronBarcelona 08035Spain Human Performance Lab Schulthess ClinicZurich 8008Switzerland Biomedical Research Networking Center on Rare Disorders(CIBERER) Barcelona 08035Spain Mitochondrial and Neuromuscular Disorders Unit Vall d’Hebron Institut de RecercaUniversitat Autonoma de BarcelonaBarcelona 08035Spain

Background:This study aimed to determine the effect of different carbohydrate(CHO)doses on exercise capacity in patients with McArdle disease—the paradigm of“exercise intolerance”,characterized by complete muscle glycogen unavailability—and to determine whether higher exogenous glucose levels affect metabolic responses at the McArdle muscle cell(in vitro)***:Patients with McArdle disease(n=8)and healthy controls(n=9)underwent a 12-min submaximal cycling constant-load bout followed by a maximal ramp test 15 min after ingesting a non-caloric *** a randomized,double-blinded,cross-over design,patients repeated the tests after consuming either 75 g or 150 g of CHO(glucose:fructose=2:1).Cardiorespiratory,biochemical,perceptual,and electromyographic(EMG)variables were ***,glucose uptake and lactate appearance were studied in vitro in wild-type and McArdle mouse myotubes cultured with increasing glucose concentrations(0.35,1.00,4.50,and 10.00 g/L).Results:Compared with controls,patients showed the“classical”second-wind phenomenon(after prior disproportionate tachycardia,myalgia,and excess electromyographic activity during submaximal exercise,all p<0.05)and an impaired endurance exercise capacity(-51%ventilatory threshold and55%peak power output,both p<0.001).Regardless of the CHO dose(p<0.05 for both doses compared with the placebo),CHO intake increased blood glucose and lactate levels,decreased fat oxidation rates,and attenuated the second wind in the ***,only the higher dose increased ventilatory threshold(+27%,p=0.010)and peak power output(+18%,p=0.007).In vitro analyses revealed no differences in lactate levels across glucose concentrations in wild-type myotubes,whereas a doseresponse effect was observed in McArdle ***:CHO intake exerts beneficial effects on exercise capacity in McArdle disease,a condition associated with total muscle glycogen *** of these benefits are dose dependent.

关键词： Endurance Glycogen storage disease Glycogenosis Nutrition Supplement

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Understanding the Link:Emotional Attention in Italian Families and Children’s Social Development

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International Journal of Mental Health Promotion 2024年第9期26卷 709-718页

作者： Catalda Corvasce Juan Pedro Martínez-Ramón Francisco Manuel Morales-Rodríguez lidia Pellicer-García Inmaculada Méndez Cecilia Ruiz-Esteban Liceo Statale“Carlo Cafiero” Barletta(BT)76121Italy Department of Developmental Psychology and Education University of MurciaMurcia30100Spain Department of Developmental Psychology and Education University of GranadaCampus of La CartujaGranadaCP 18071Spain Department of Spanish Language and General Linguistics University of MurciaCampus of La MercedMurciaCP 30001Spain

Background:Emotional attention refers to the capacity to recognize and properly respond to one’s and others’emotional *** another note,family is a primary source of socialization that influences the development of various social *** another line,adolescence is a complex stage that has been associated with emotional difficulties that could be related to competences such as prosociability and *** is inferred that through the family context and the attention that is processed,a series of competencies are transmitted to the youngsters,but this relationship is still *** this reason,the study’s purpose was to examine the relationship between the emotional attention of mothers and fathers and the social and prosocial competencies of their ***:To accomplish this,a cross-sectional study and ex post facto design were *** Trait-Meta Mood Scale(TMMS-24)-to assess emotional attention-,the Strengths and Difficulties Questionnaire(SDQ)-to determine the prosociality dimension-,and the Test on Passing Developmental Tasks in Adolescence(TCS-A)-to measure social inclusionwere *** participants were N=228 families composed of n=114 mothers/fathers(67.5%females)and n=114 daughters/sons(38.5%females)selected through non-probabilistic sampling using a convenience sample in the Bari region of Italy.A descriptive and inferential analysis-Student’s test and Pearson’s correlation-was performed with the statistic package SPSS version 28(significance level p<0.05).Results:The findings showed that the families possessed an adequate background in emotional attention and that their daughters and sons were also generally well-adjusted in social inclusion and *** also found certain signs that the prosocial competence of the children could be related to the behavior of their mothers and ***:In conclusion,social inclusion is related to prosocial behavior,and maybe primarily cultivated within families where paren

关键词： Educational style coping strategies stress social inclusion emotional attention prosociality

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放牧强度对宁夏盐池荒漠草地土壤与植被恢复的影响

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生态学杂志 2024年第7期43卷 2066-2074页

作者：贾继宝代惠萍刘恒青田超孙权魏树和 lidia Skuza 宁夏大学农学院银川750021 陕西理工大学生物科学与工程学院陕西汉中723001 唐山市自然资源和规划局河北唐山063000 中国科学院沈阳应用生态研究所污染生态与环境工程重点实验室沈阳110016 波兰什切青大学分子生物学和生物技术中心生物学研究所什切青71-415

以宁夏盐池县荒漠草原为研究对象,设置3个放牧强度:围栏封育(NG,no grazing)、中度放牧(MG,moderate grazing)、重度放牧(HG,heavy grazing),运用主成分分析与路径分析对草地质量进行综合评价,比较不同放牧条件下草地植被和土壤理化性... 详细信息

以宁夏盐池县荒漠草原为研究对象,设置3个放牧强度:围栏封育(NG,no grazing)、中度放牧(MG,moderate grazing)、重度放牧(HG,heavy grazing),运用主成分分析与路径分析对草地质量进行综合评价,比较不同放牧条件下草地植被和土壤理化性质的差异,以期为退化草地生态系统恢复与重建提供理论指导。结果表明:NG处理下草地植被生物量较MG和HG处理分别提高10.78%和74.85%,植被高度与盖度显著提高31.21%~131.27%和26.03%~93.29%。NG处理的土壤机械稳性团聚体以粒径>0.25 mm的大团聚体为主,HG处理以0.25 mm的大团聚体占比、表层土壤水稳性团聚体的平均质量直径和几何平均直径大小依次为:NG>MG>HG;NG处理下的土壤供肥潜力、土壤供肥强度和土壤综合质量显著高于HG。综上所述,围栏封育下的草场植被、土壤结构和肥力恢复效果更好,对土壤的综合质量有明显的改善作用,是适合的草地生态恢复措施。

关键词：荒漠草原土壤团聚体土壤肥力生物量

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The effects of different electrode materials on seed germination of Solanum nigrum *** its Cd accumulation in soil

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Journal of Environmental Sciences 2022年第3期34卷 291-299页

作者： Lei Xu Huiping Dai lidia Skuza Shuhe Wei Key Laboratory of Pollution Ecology and Environment Engineering Institute of Applied EcologyChinese Academy of SciencesShenyang 110016China College of Biological Science&Engineering Shaanxi Province Key Laboratory of Bio-resourcesShaanxi University of TechnologyHanzhong 723001China Institute of Biology Centre for Molecular Biology and BiotechnologyUniversity of SzczecinSzczecin 71-415Poland University of Chinese Academy of Sciences Beijing 100039China

The effects of different electrode on Solanum nigrum *** germination were *** result showed that germination percentage(GP)of seeds in treatment T2(titanium elec-trode)was 26.6%higher than in control(CK,without electric field).High potassium and calcium concentrations were beneficial for seed enzymatic activity in treatment T2,which could partly explain the increase in *** accumulation(μg/pot)in *** treated with any electric field was significantly higher(p<0.05)than in CK without electric ***-ically,Cd accumulation under the treatment T3(stainless steel electrode)was the highest both in roots and shoots;this accumulation in shoots and roots were 74.7%and 67.4%higher for stainless steel than in *** increase must have been associated with a higher Cd concentration in plants and did not exert a significant effect on the *** par-ticular,Cd concentrations in roots and shoots under stainless steel treatment were both significantly higher than in CK(p<0.05),which had to be related to the higher available Cd concentration in the soil in the middle ***,it could be attributed to al-tered soil pH and other soil ***,none of the biomasses were significantly affected(p<0.05)by different electrode materials compared to CK.

关键词： Cd contaminated soil Solanum nigrum L. DC electric field Electrode materials Seed germination

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