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Ammonia Diffusion Phenomena through Nalophan<sup>TM</sup>Bags Used for Olfactometric Analyses

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Journal of Environmental Protection 2014年第11期5卷 949-961页

作者： Selena Sironi lidia eusebio Laura Capelli Emanuela Boiardi Renato Del Rosso Jean-Michel Guillot Department of Chemistry Materials and Chemical Engineering “Giulio Natta” Politecnico di Milano Milano Italy Laboratory of Industrial Environment Engineering Ecole des Mines d’Alès Alès cedex France

The ammonia loss through NalophanTM bags has been studied. Ammonia was chosen as target compound in order to be representative of odorous molecules of small dimensions. The losses observed for storage conditions and times as allowed by the reference standard for dynamic olfactometry (EN 13725:2003) indicate that odour concentration values due to the presence of small molecules may be significantly underestimated if samples are not analysed immediately after sampling. The diffusion coefficient of ammonia through the NalophanTM film was evaluated using the Fick’s law, and it turned out to be equal to 2.38E-12 (m2/s). The results and their theoretical interpretation indicate that concentration losses due to ammonia diffusion through the NalophanTM film can be decreased by using large bags and filling them up to their maximum capacity.

关键词： Sampling Bag Diffusion Odour Sampling Ammonia Nalophan

Anticoagulation in elderly patients at high risk of atrial fibrillation without documented arrhythmias

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Journal of Geriatric Cardiology 2017年第3期14卷 166-168页

作者： Manuel Martinez-Selles eusebio Garcia-Izquierdo Jaen Ignacio Fernandez Lozano Servicio de Cardiologia Hospital General Universitario Gregorio Maranon Universidad Complutense CIBERCV Madrid Spain Servieio de Cardiologia Hospital Universitario Puerta de Hierro Majadahonda Madrid Spain

Recent studies have suggested that patients with high CHA2DS2VASc-score [Congestive Heart failure, hyperten- sion, Age ≥ 75 years （doubled）, Diabetes, Stroke （doubled）, Vascular disease, Age 65-74 years, Sex category （female sex）] thromboembolic complications occurred irrespective of the presence of atrial fibrillation （AF） and anticoagulant therapy may be initiated irrespective of documented AF.

关键词： Anticoagulation Atrial fibrillation Interatrial block Prognosis

Reconstructing pre-erosion topography using spatial interpolation techniques： A validation-based approach

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Journal of Geographical Sciences 2015年第2期25卷 196-210页

作者： Rafaello BERGONSE eusebio REIS Center for Geographical Studies University of Lisbon Portugal

Understanding the topographic context preceding the development of erosive landforms is of major relevance in geomorphic research, as topography is an important factor on both water and mass movement-related erosion, and knowledge of the original surface is a condition for quantifying the volume of eroded material. Although any reconstruction implies assuming that the resulting surface reflects the original topography, past works have been dominated by linear interpolation methods, incapable of generating curved surfaces in areas with no data or values out- side the range of variation of inputs. In spite of these limitations, impossibility of validation has led to the assumption of surface representativity never being challenged. In this paper, a validation-based method is applied in order to define the optimal interpolation technique for reconstructing pre-erosion topography in a given study area. In spite of the absence of the original surface, different techniques can be nonetheless evaluated by quantifying their ca- pacity to reproduce known topography in unincised locations within the same geomorphic contexts of existing erosive landforms. A linear method （Triangulated Irregular Network, TIN） and 23 parameterizations of three distinct Spline interpolation techniques were compared using 50 test areas in a context of research on large gully dynamics in the South of Portugal. Results show that almost all Spline methods produced smaller errors than the TIN, and that the latter produced a mean absolute error 61.4% higher than the best Spline method, clearly establishing both the better adjustment of Splines to the geomorphic context considered and the limitations of linear approaches. The proposed method can easily be applied to different interpolation techniques and topographic contexts, enabling better calculations of eroded volumes and denudation rates as well as the investigation of controls by antecedent topographic form over erosive processes.

关键词： pre-erosion topography surface reconstruction spatial interpolation spline interpolation triangulated irregular networks erosive landforms gully erosion

Drag reduction via turbulent boundary layer flow control

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Science China(Technological Sciences) 2017年第9期60卷 1281-1290页

作者： ABBAS Adel BUGEDA Gabriel FERRER Esteban FU Song PERIAUX Jacques PONS-PRATS Jordi VALERO eusebio ZHENG Yao School of Aeronautics Escuela Tecnica Superior de lngenierla Aeronautica y del Espacio de la Universidad Politecnica de Madrid (ETS1.4E-UPM) Universidad Politecnica de Madrid Pza. Cardenal Cisneros 3 Madrid E-28040 Spain International Center for Numerical Methods in Engineering (CIMNE) Gran Capita s/n Campus Nord UPC Barcelona 08034 Spain Civil and Environmental Department Universitat Politecnica de Catalunya. BarcelonaTech Gran Capita s/n Campus Nord UPC Barcelona 08034 Spain Centre for Computational Simulation-UPM Scientific and Technological Park (Campus Montegancedo) 28223 Pozuelo de Alarcon Spain School of Aerospace Engineering Tsinghua University Beijing 100084 China School of Aeronautics andAstronautics Zhejiang University Hangzhou 310027 China

Turbulent boundary layer control(TBLC) for skin-friction drag reduction is a relatively new technology made possible through the advances in computational-simulation capabilities,which have improved the understanding of the flow structures of *** in micro-electronic technology have enabled the fabrication of active device systems able to manipulating these *** combination of simulation,understanding and micro-actuation technologies offers new opportunities to significantly decrease drag,and by doing so,to increase fuel efficiency of future *** literature review that follows shows that the application of active control turbulent skin-friction drag reduction is considered of prime importance by industry,even though it is still at a low technology readiness level(TRL).This review presents the state of the art of different technologies oriented to the active and passive control for turbulent skin-friction drag reduction and contributes to the improvement of these technologies.

关键词： turbulent boundary layer flow control drag reduction skin-friction drag reduction

Molecular characterization of polar heteroatom species in oilsands bitumen-derived vacuum residue fractions by Fourier transform ion cyclotron resonance mass spectrometry

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Petroleum Science 2019年第5期16卷 1196-1207页

作者： Fang Zheng Warren Chung eusebio Palmisano Dahai Dong Quan Shi Zhiming Xu Keng H.Chung State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing 102249China Well Resources Inc EdmontonCanada Cenovus Energy Inc CalgaryCanada Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of SciencesQingdao 266101China

A Canadian in situ oilsands bitumen-derived vacuum residue(VR)was subjected to supercritical fluid extraction and fractionation(SFEF)into 13 extractable fractions and an unextractable end-cut and characterized by positive-and negative-ion electrospray ionization(ESI)Fourier transform ion cyclotron resonance mass spectrometry(FT-ICR MS).The results of negative-ion ESI FT-ICR MS showed that the N1 class species was the most abundant and the multifunctional group compounds,such as N1 O1,N1 O2,N1 S1,N1 S2,and N2 class species became abundant as the SFEF fraction became *** positive-ion ESI mode,the relative abundance of N1 class species decreased gradually in the heavy SFEF fractions while that of multifunctional group compounds *** relative abundance of N4 V1 O1 increased dramatically in heavy fractions and the *** distributions of polar heteroatom species of VR derived from oilsands bitumen were similar with those of VR derived from the Venezuela Orinoco extra heavy oil.

关键词： Molecular characterization Canadian oilsands bitumen SFEF ESI FT-ICR MS

System Design for the Event Horizon Imaging Experiment Using the PECMEO Concept

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空间科学学报 2019年第2期39卷 250-266页

作者： KUDRIASHOV Volodymyr MARTIN-NEIRA Manuel BARAT Itziar MARTIN IGLESIAS Pertonilo DAGANZO-eusebio Elena ALAGHA Nader VALENTA Vaclav European Space Research and Technology Centre the European Space Agency

The concept for space interferometry from Polar or Equatorial Circular Medium Earth Orbits(the PECMEO concept) is a promising way to acquire the image of the"shadow"of the event horizon of Sagittarius A*with an angular resolution of circa 5 microarcseconds. The concept is intended to decrease the size of the main reflector of the instrument to about 3 m using a precise orbit reconstruction based on Global Navigation Satellite System (GNSS) navigation, inter-satellite range and range-rate measurements, and data from the Attitude and Orbit Determination System (AODS). The paper provides the current progress on the definition of the subsystems required for the concept on the basis of simulations, radio regulations, and available technology. The paper proposes the requirement for the localization of the phase centre of the main reflector. The paper provides information about the visibility of GNSS satellites and the needed accuracies of the AODS. The paper proposes the frequency plan for the instrument and its Inter-Satellite Links (ISLs).The concepts for measurement of range and range-rate using ISLs (as well as for the data exchange at these ISLs) are presented. The block diagram of the interferometer is described and its sensitivity is estimated. The link budget for both ISLs is given as well as their critical components. The calculated measurement quality factors are given. The paper shows the expected performance of the sub-systems of the interferometer. The requirements for the localization of the main reflectors and the information about the availability of the GNSS satellites are based on the simulations results. The frequency plan is obtained according to the PECMEO concept and taking into account the radio regulations. The existing technology defines the accuracies of the AODS, both the link budgets and the fundamental measurement accuracies for ISLs, and the sensitivity of the instrument. The paper provides input information for the development of the orbit r

关键词： Instrumentation Telescope High angular resolution Interferometer Space VLBI

Recent advances in the molecular genetics of type 2 diabetes mellitus

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World Journal of Diabetes 2014年第2期5卷 128-140页

作者： Antonio Brunetti eusebio Chiefari Daniela Foti Department of Health Sciences University "Magna Græcia" of Catanzaro

Type 2 diabetes mellitus(T2DM) is a complex disease in which both genetic and environmental factors interact in determining impaired β-cell insulin secretion and peripheral insulin resistance. Insulin resistance in muscle, liver and fat is a prominent feature of most patients with T2DM and obesity, resulting in a reduced response of these tissues to insulin. Considerable evidence has been accumulated to indicate that heredity is a major determinant of insulin resistance and T2DM. It is believed that, among individuals destined to develop T2DM, hyperinsulinemia is the mechanism by which the pancreatic β-cell initially compensates for deteriorating peripheral insulin sensitivity, thus ensuring normal glucose tolerance. Most of these people will develop T2DM when β-cells fail to compensate. Despite the progress achieved in this field in recent years, the genetic causes of insulin resistance and T2DM remain *** gene association, linkage and genome-wide association studies have highlighted the role of genetic factors in the development of T2DM. Using these strategies, a large number of variants have been identified in many of these genes, most of which may influence both hepatic and peripheral insulin resistance, adipogenesis and β-cell mass and function. Recently, a new gene has been identified by our research group, the HMGA1 gene, whose loss of function can greatly raise the risk of developing T2DM in humans and mice. Functional genetic variants of the HMGA1 gene have been associated with insulin resistance syndromes among white Europeans, Chinese individuals and Americans of Hispanic ancestry. These findings may represent new ways to improve or even prevent T2DM.

关键词： Genome-wide association study Candidate gene Genetic variants High-mobility group A1 Insulin resistant diabetes

Pharmacogenetics of type 2 diabetes mellitus: An example of success in clinical and translational medicine

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World Journal of Translational Medicine 2014年第3期3卷 141-149页

作者： Antonio Brunetti Francesco S Brunetti eusebio Chiefari Department of Health Sciences University "Magna Gr?cia" of Catanzaro Department of Medical and Surgical Sciences University ‘‘Magna Gr?cia’’ of Catanzaro

The pharmacological interventions currently available to control type 2 diabetes mellitus(T2DM) show a wide interindividual variability in drug response, emphasizing the importance of a personalized, more effective medical treatment for each individual patient. In this context, a growing interest has emerged in recent years and has focused on pharmacogenetics, a discipline aimed at understanding the variability in patients' drug response, making it possible to predict which drug is best for each patient and at what doses. Recent pharmacological and clinical evidences indicate that genetic polymorphisms(or genetic variations) of certain genes can adversely affect drug response and therapeutic efficacy of oral hypoglycemic agents in patients with T2 DM, through pharmacokinetic- and/or pharmacodynamic-based mechanisms that may reduce the therapeutic effects or increase toxicity. For example, genetic variants in genes encoding enzymes of the cytochrome P-450 superfamily, or proteins of the ATP-sensitive potassium channel on the beta-cell of the pancreas, are responsible for the interindividual variability of drug response to sulfonylureas in patients with T2 DM. Instead, genetic variants in the genes that encode for the organic cation transporters of metformin have been related to changes in both pharmacodynamic and pharmacokinetic responses to metformin in metformin-treated patients. Thus, based on the individual's genotype, the possibility, in these subjects, of a personalized therapy constitutes the main goal of pharmacogenetics, directly leading to the development of the right medicine for the right patient. Undoubtedly, this represents an integral part of the translational medicine network.

关键词： Type 2 diabetes Anti-diabetic drugs Personalized therapy Genetic variants Genome-wide association study

Rain Forests in Subtropical Mountains of Dominican Republic

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American Journal of Plant Sciences 2014年第10期5卷 1459-1466页

作者： eusebio Cano Alverto Veloz Ana Cano-Ortiz Botanical National Garden Rafael Ma Moscoso of Santo Domingo Dominican Republic Department of Animal Biology Plant Biology and Ecology (Botany) University of Jaen Jaen Spain Department of Sustainability Interra Resources and Engineering SL Plaza of Spain Salamanca Spain

This article presents a study of the cloud forest dominated by the Prestoea montana (R. Graham) Nichols. This is a hyperhumid forest located in ravines and shaded areas with cloud condensation, and at heights ranging from 350 - 1250 masl. This type of forest is always found in thermal and mesotropical belts, without ever reaching the supratropical belt. This study was based on works published by other authors and on our own field sampling. The article begins by describing the geological, bioclimatic, biogeographic and floristic aspects of the areas in the study, specifically the hyperhumid areas in the central and eastern mountains. Due to the scarcity of phytosociological works on this area, we apply a statistical treatment to compare our communities with other associations described in Cuba. This comparison reveals that these forest groups are floristically quite distant from each other, both with regard to alliance and association species. We therefore propose two new communities: Cyathea furfuracea Baker and Prestoea montana (Grah.) Nichol;Ormosia krugii Urb. and Prestoea montana (Grah.) Nichol.

关键词： Cloud Forest Hispaniola Communitiy Central and Eastern Ranges