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Risk factors for postpartum posttraumatic stress disorder after emergency admission

World Journal of Emergency Medicine 2024年第2期15卷 121-125页

作者： Fengxia Du Jun Zha Yan Li lichao fang Shuyu Xia Youjia Yu Department of Obstetrics Suzhou Xiangcheng People’s HospitalSuzhou 215131China Department of Anesthesiology the Second Affiliated Hospital of Wannan Medical CollegeWuhu 241000China Department of Anesthesiology Suzhou Xiangcheng People’s HospitalSuzhou 215131China Department of Emergency and Intensive Care Unit Suzhou Xiangcheng People’s HospitalSuzhou 215131China

BACKGROUND:Postpartum posttraumatic stress disorder(PTSD)can occur in women who give birth after emergency *** identification of risk factors for this condition is crucial for developing effective preventive *** retrospective study aimed to explore the incidence and risk factors for postpartum PTSD in women who give birth after emergency ***:Medical records of women who gave birth after emergency admission were collected between March 2021 and April *** patients’general conditions and perinatal clinical indicators were *** puerperae were divided into PTSD group and control group based on symptom occurrence at six weeks *** logistic regression analysis was performed to identify risk ***:A total of 276 puerperae were included,with a PTSD incidence of 20.3% at six weeks *** logistic regression analysis identified emergency cesarean section(odds ratio[OR]=2.102;95%confidence interval[CI]:1.114-3.966,P=0.022),admission to the emergency department after midnight(12:00 AM)(OR=2.245;95%CI:1.170-4.305,P<0.001),and cervical dilation(OR=3.203;95%CI:1.670–6.141,P=0.039)as independent risk factors for postpartum *** pump use(OR=0.500;95%CI:0.259–0.966,P=0.015)was found to be a protective factor against postpartum ***:Emergency cesarean section,admission to the emergency department after midnight,and cervical dilation were identified as independent risk factors for postpartum PTSD,while analgesic pump use was a protective *** findings provide insights for developing more effective preventive measures for women who give birth after emergency admission.

关键词： Risk factors Posttraumatic stress disorder Emergency Delivery

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Risk factors for early death in severe non-brain- injured trauma patients

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World Journal of Emergency Medicine 2024年第5期15卷 404-406页

作者： Hui Feng Ronghai Shao Zihao Fan Limei Ma Jiake Gao Lijun Liu lichao fang Jianjun Zhu Department of Emergency and Critical Care Medicine the Second Affi liated Hospital of Soochow UniversitySuzhou 215004China Department of Emergency the First People's Hospital of Taicang(Taicang Affi liated Hospital of Soochow University)Suzhou 215400China Center for Emergency and Critical Care Medicine Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Emergency and Intensive Care Unit Suzhou Xiangcheng People’s HospitalSuzhou 215131China

Severe trauma is one of the main causes of premature death,posing a significant challenge to public health systems.[1]At present,there is a lack of universally accepted guidelines for rapid detection of life-threatening severe trauma,[2]and the accuracy of existing prognostic models in predicting early death is limited.[3,4]Severe non-brain-injured trauma(SNT)patients account for approximately 70%of all trauma-related ***,there is a lack of studies on early death in SNT patients.[5]This study aims to identify risk factors associated with early death(≤72 h post-admission)in SNT patients.

关键词： death patients trauma

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Data-driven analysis of process,structure,and properties of additively manufactured Inconel 718 thin walls

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npj Computational Materials 2022年第1期8卷 1168-1182页

作者： lichao fang Lin Cheng Jennifer A.Glerum Jennifer Bennett Jian Cao Gregory J.Wagner Department of Mechanical Engineering Northwestern UniversityEvanstonIL60208USA Department of Materials Science and Engineering Northwestern UniversityEvanstonIL60208USA DMG MORI Hoffman EstatesIL60192USA Department of Mechanical and Materials Engineering Worcester Polytechnic InstituteWorcesterMA01609USA Department of Civil and Mechanical Engineering US Military Acadeemy at West PointWest PointNY10996USA

In additive manufacturing of metal parts,the ability to accurately predict the extremely variable temperature field in detail,and relate it quantitatively to structure and properties,is a key step in predicting part performance and optimizing process *** this work,a finite element simulation of the directed energy deposition(DED)process is used to predict the space-and time-dependent temperature field during the multi-layer build process for Inconel 718 *** thermal model results show good agreement with dynamic infrared images captured in situ during the DED *** relationship between predicted cooling rate,microstructural features,and mechanical properties is examined,and cooling rate alone is found to be insufficient in giving quantitative property *** machine learning offers an efficient way to identify important features from series data,we apply a 1D convolutional neural network data-driven framework to automatically extract the dominant predictive features from simulated temperature *** good predictions of material properties,especially ultimate tensile strength,are obtained using simulated thermal history *** further interpret the convolutional neural network predictions,we visualize the extracted features produced on each convolutional layer and compare the convolutional neural network detected features of thermal histories for high and low ultimate tensile strength cases.A key result is the determination that thermal histories in both high and moderate temperature regimes affect material properties.

关键词： Inconel process additive

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Full title: Longitudinal neurophysiological evidences for brain cognitive function after prolonged exposure to high altitude

Full title: Longitudinal neurophysiological evidences for br...

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第十四届中国医师协会神经外科医师年会

作者： ShengLi Hu Wei Xiong WeiNa Li lichao fang Hua Feng

Background: The longitudinal continuous influences of prolonged stay at high altitude on cognitive performance have been poorly studied. This study investigated longitudinal changes of cognitive functions during prolonged period at high altitude using objective neurophysiological examinations. Materials and Methods: The study was conducted on 100 male military voluntary members who had never gone to plateau. Transcranial doppler sonography（TCD）, auditory evoked potential（AEP）, electroencephalogram（EEG）, and cognitive assessments were performed at 500 m, 3650 m, 3 day, 1 month, and 3 month post arrival at the base camp（4400 m）, and 45 days after coming back to 500 m. Results: High altitude decreased average velocity of brain arteries and they did not return to normal level even after coming back to 500 m altitude. Left and right Ⅰ, Ⅲ, and Ⅴ waves latencies of AEP were prolonged and cognitive functions were impaired at high altitude. However, they all recovered in varying degrees at 1 and 3 month post arriving at base camp（4400 m）. High altitude reduced EEG gravity frequency and power spectral entropy. Conclusion: In conclusions, acute exposure to high altitude could induce cognitive decline and acclimatization after prolonged stay may lead to cognitive function recovery. Neurophysiological evidences suggest the underlying mechanism of cognitive impairment at high altitude.

关键词： High altitude Cognitive impairment Electroencephalogram (EEG) Auditory evoked potential(AEP) Transcranial doppler sonography(TCD)

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Electrochemical Biosensor for Multiple Methylation-Locus Analysis Based on DNA-AuNPs and Bienzymatic Dual Signal Amplifications

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American Journal of Analytical Chemistry 2020年第2期11卷 61-74页

作者： Shasha Su Shu Zhang Jiang Huang Xi Chen Yan Li lichao fang Jun Deng Fei Mo Junsong Zheng Department of Clinical and Military Laboratory Medicine College of Medical Laboratory Science Army Medical University Shapingba District Chongqing China Department of Basic Clinical Laboratory Medicine School of Clinical Laboratory Science Guizhou Medical University Yunyan District Guiyang China Department of Clinical Laboratory Affiliated Hospital of Guizhou Medical University Guiyang China Department of Biochemistry Affiliated Hospital of Guizhou Medical University Guiyang China

DNA methylation plays a significant role in various biological events, and its precise determination is vital for the prognosis and treatment of cancer. Here, we proposed an ultrasensitive electrochemical biosensor for the quantitative analysis of multiple methylation-locus in DNA sequence via DNA anchoring the gold nanoparticles (DNA-AuNPs) and bienzyme dual signal amplifications. After the target DNA captured by the DNA-AuNPs of the biosensor, the methyl-CpG binding protein MeCP2 could specifically conjugate to the methylation-loci in the double-stranded DNA. Successively, the glucose oxidase (GOD) and horseradish (HRP) co-labeled antibody captured the His tagged MeCP2, which leads to a cascade enzymatic catalysis of the substrates to yield a detectable electrochemical signal. Both the two strategies, including the high content of DNA-AuNPs and the associated catalysis of bienzyme, dramatically enhanced the sensitivity of the biosensor. The response current elevated with the increasing numbers of methylation-locus, thus the multiple methylated DNA was identified by detecting the corresponding current signals. This method could detect the methylated target as low as 0.1 fM, and showed a wide linear range from 10 - 15 M to 10 - 7 M. Besides, the long-term stability and repeatability of the biosensor were also validated. The prepared electrochemical immunosensor exhibits ultrasensitivity through the bienzyme labeling process, which can be applied for the detection of DNA methylation with low concentration.

关键词： DNA Methylation Electrochemistry Biosensor AuNPs Bienzyme

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方差正则化的分类模型选择准则

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计算机科学与探索 2019年第3期13卷 457-467页

作者：房立超王钰杨杏丽李济洪山西大学数学科学学院太原030006 山西大学现代教育技术学院太原030006 山西大学软件学院太原030006

在传统的机器学习中,模型选择常常是直接基于某个性能度量指标的估计本身进行,没有考虑估计的方差,但是这样的忽略极有可能导致错误模型的选择。于是考虑在分类模型选择研究中添加方差的信息的方法,以提高所选模型的泛化能力,即将泛化... 详细信息

在传统的机器学习中,模型选择常常是直接基于某个性能度量指标的估计本身进行,没有考虑估计的方差,但是这样的忽略极有可能导致错误模型的选择。于是考虑在分类模型选择研究中添加方差的信息的方法,以提高所选模型的泛化能力,即将泛化误差性能度量指标的组块3×2交叉验证估计的方差估计作为正则化项添加到传统模型选择准则中,提出了一种新的方差正则化的分类模型选择准则。模拟和真实数据实验验证了在分类模型选择问题中,提出的模型选择准则相比传统方法选到正确分类模型的概率更大,验证了方差在模型选择中的重要性以及提出的模型选择准则的有效性。进一步,理论上证明了在二分类问题的模型选择中,该模型选择准则具有选择的一致性。

关键词：模型选择泛化误差组块3×2交叉验证方差正则化

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畜禽日粮中高铜的负面影响及其调整方法

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畜牧兽医杂志 2000年第2期19卷 16-19页

作者：方立超西南农业大学重庆北碚400716

铜是动物体必需的微量元素 ,具有广泛的生物学作用 ,而高铜则具有促进畜禽生长作用。

关键词：日粮铜负面影响高铜调整方法

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嗜酸乳杆菌合生元对抗生素相关腹泻大鼠肠道菌群和肠黏膜损伤的作用

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胃肠病学 2009年第2期14卷 88-91页

作者：杜丹方立超陈丙波魏泓济南军区总医院实验诊断科 250031 第三军医大学实验动物中心

背景：抗生素相关腹泻（AAD）是抗生素治疗最常见的不良反应。随着抗生素应用的日益广泛,AAD病例逐年增多。目的：探讨嗜酸乳杆菌与低聚异麦芽糖（IMO）组成的合生元对AAD大鼠肠道菌群和肠黏膜损伤的作用。方法：50只大鼠随机分为5组。... 详细信息

背景：抗生素相关腹泻（AAD）是抗生素治疗最常见的不良反应。随着抗生素应用的日益广泛,AAD病例逐年增多。目的：探讨嗜酸乳杆菌与低聚异麦芽糖（IMO）组成的合生元对AAD大鼠肠道菌群和肠黏膜损伤的作用。方法：50只大鼠随机分为5组。四组模型组以盐酸林可霉素灌胃6d诱导AAD,之后其中一组予0.9%NaCl溶液灌胃7d作为自然恢复组,另三组分别予低、中、高剂量合生元灌胃7d。正常对照组仅予0.9%NaCl溶液灌胃7d。行肠道菌群分析后处死各组大鼠,行肠黏膜形态学观察和图像分析。结果：AAD模型大鼠肠道菌群失调,小肠黏膜水肿、糜烂、萎缩、坏死、脱落,绒毛排列紊乱、稀疏。不同剂量合生元组肠道菌群失调均有所改善,与正常对照组相比无明显差异;小肠黏膜病变均轻于自然恢复组,尤其是中、高剂量合生元组,小肠黏膜厚度、绒毛高度和隐窝深度较自然恢复组显著增加（P〈0.01）。结论：嗜酸乳杆菌合生元对AAD大鼠肠道菌群失调和肠黏膜损伤有一定治疗作用。

关键词：抗生素相关腹泻肠道菌群肠黏膜/损伤嗜酸乳杆菌异麦芽糖合生元

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多约束条件下的钻井液排量优选研究

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石油机械 2013年第8期41卷 13-16,27页

作者：梁奇敏侯本权方丽超中国石油大学(北京)石油工程教育部重点实验室中国石油北京油气调控中心中国石油大学(北京)机械与储运工程学院

在考虑环空携岩、地面机泵额定压力、钻井液当量循环密度、钻头水功率和井下动力钻具等因素的影响前提下对钻井液排量优选进行了研究。以新垦601井的基本数据为基础,采用不同约束条件下的钻井液排量计算模型对排量进行了计算。计算结果... 详细信息

在考虑环空携岩、地面机泵额定压力、钻井液当量循环密度、钻头水功率和井下动力钻具等因素的影响前提下对钻井液排量优选进行了研究。以新垦601井的基本数据为基础,采用不同约束条件下的钻井液排量计算模型对排量进行了计算。计算结果表明,环空携岩约束条件下优选出的排量值最小,地面机泵条件下确定的排量值最大;ECD可确定一个排量范围,保证井眼不坍塌、不破裂;井下动力钻具在最佳工作状态时也可确定一个排量范围。在实际钻井中,为使所设计的排量具有使用价值,须确保优选的钻井液排量满足所有约束条件。

关键词：钻井液排量优选优快钻井多约束环空携岩钻头水功率 ECD

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依达拉奉辅助脑苷肌肽对重症颅脑损伤患者的保护作用

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中华急诊医学杂志 2019年第3期28卷 319-323页

作者：方理超安堃华燕琴范诚王晓旻乔世刚苏州市相城人民医院重症医学科 215131 苏州科技城医院麻醉及围术期医学科 215153 南京医科大学附属苏州医院临床医学研究所 215153

目的探究依达拉奉辅助脑苷肌肽治疗重症颅脑损伤患者的作用效果以及与神经胶质纤维酸性蛋白(glial fiber acidic protein, GFAP)、泛素羧基末端水解酶-L1(ubiquitin carboxyl terminal-L1, UCH-L1)的影响。方法纳入苏州市相城人民医院于... 详细信息

目的探究依达拉奉辅助脑苷肌肽治疗重症颅脑损伤患者的作用效果以及与神经胶质纤维酸性蛋白(glial fiber acidic protein, GFAP)、泛素羧基末端水解酶-L1(ubiquitin carboxyl terminal-L1, UCH-L1)的影响。方法纳入苏州市相城人民医院于2016年1月至2017年12月期间收治的123例重症颅脑损伤患者。根据随机数字表法分为观察组和对照组,其中观察组61例,对照组62例。对照组给予脑苷肌肽治疗,观察组在对照组基础上给予依达拉奉治疗。比较两组患者的临床疗效,同时监测治疗前后血清丙二醇(malonaldehyde, MDA)、超氧化物歧化酶(superoxide dismutase, SOD)、髓过氧化物酶(myeloperoxidase, MPO)、基质金属蛋白酶-9(matrix metalloproteinases, MMP-9)、GFAP、UCH-L1水平及治疗过程中不良反应发生率。结果治疗后两组APACHEⅡ评分均降低(t=15.88,P=0.008;t=25.17,P=0.003),且观察组低于对照组,差异有统计学意义(t=15.95,P=0.013);治疗后两组日常生活能力(ADL)评分均升高(t=5.58,P=0.025;t=19.13,P=0.008),且观察组高于对照组,差异有统计学意义(t=11.24,P=0.012);治疗后两组MDA、SOD、MPO均升高,且观察组高于对照组,差异有统计学意义(t=11.41,P=0.024;t=2.03,P=0.22;t=7.16,P=0.038);治疗后两组MMP-9均下降,且观察组低于对照组,差异有统计学意义(t=16.25,P=0.012);治疗后两组GFAP(t=31.79,P=0.016;t=53.83,P=0.011)、UCH-L1(t=10.27,P=0.047;t=18.31,P=0.019)均下降,且观察组低于对照组,差异有统计学意义(t=43.90,P=0.014;t=15.31,P=0.035)。观察组不良反应总发生率为8.06%,对照组不良反应总发生率为9.83%,差异无统计学意义(χ^2=0.088,P=0.719)。结论依达拉奉辅助脑苷肌肽治疗重症颅脑损伤,可以有效保护神经细胞,改善神经功能,提高临床疗效,显著提高机体抗氧化能力,降低血清GFAP、UCH-L1水平,且安全性较好。

关键词：重症颅脑损伤依达拉奉神经胶质纤维酸性蛋白泛素竣基末端水解酶-L1

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