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Early Cretaceous A-type Granites in the Dandong Area,NE China and its Geodynamical Implications

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Acta Geologica Sinica(English Edition) 2021年第5期95卷 1472-1482页

作者： SONG Yunhong hao libo YANG Fengchao Zhao Dongfang ZHANG Zhehuan Shenyang Center China Geological SurveyShenyang 110034China Key Laboratory of Black Soil Evolution and Ecological Effect Ministry of Natural ResourcesShenyang 110034China College of Geo-Exploration Science and Technology Jilin UniversityChangchun 130026China

A-type granites,as an important petrologic sign to build up environmental recognition,were mainly formed in extensional tectonic settings.A biotite syenogranite from the Fenghuangshan pluton in Dandong,Liaoning Province gave SHRIMP zircon U-Pb ages of 122.5±1.6 Ma,124.9±1.7 Ma and 126.9±1.1 *** monzogranites have SHRIMP zircon U-Pb ages of 118.2±1.6 Ma,128.1±1.7 Ma and 131.6±1.9 Ma,giving an emplacement age for the pluton in the Early ***_(2) is 65.48-74.49 wt%,whereas that of K_(2)O is 4.16-6.44 wt%,and that of Na_(2)O is 2.99-4.70 wt%.They also contain 13.24-15.76 wt% of Al_(2)O_(3),with an A/CNK ratio of 0.92-1.10,averaging *** alkalinity rate(AR)ranges from 2.68 to 5.12,and this range is within the AR of peraluminous type *** granites of Fenghuangshan pluton are characterized by high contents of Na and K and low contents of Ca(thermophile element)and Mg,which are features of A-type ***(Na_(2)O+K_(2)O)-Fe_(2)O_(3)^(*)×5-(CaO+MgO)×5 discrimination diagram also shows that Fenghuangshan pluton is an A2-type *** above granite has zircon ε_(Hf)(t)values ranging from-17.06 to-9.09,with single-stage Hf model ages(T_(DM))of 1141 Ma to 1498 Ma and two-stage Hf crustal model ages(T_(DM)^(C))of 1762 Ma to 2263Ma.A comprehensive analysis suggests that the Fenghuangshan pluton might have been formed from the lithospheric-plate sliding during the late stages of evolution of hot rift structures and might have been closely associated with the tectonic settings of Mesozoic Eurasia and the ancient Pacific Plate.

关键词： petrology peraluminous A-type granite zircon SHRIMP U-Pb zircon Hf isotope Yanshanian North China Craton

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噬菌体治疗在骨科植入物感染中的研究进展

中华外科杂志 2024年第1期62卷 81-85,21页

作者：祖力皮喀尔·买买提李倬徐驰付君郝立波刘亮陈继营柴伟首都医科大学附属北京潞河医院骨中心北京101199 南开大学医学院天津300074 解放军总医院第四医学中心骨科医学部北京100048

随着植入材料在骨科疾病治疗中的应用逐渐普及,植入物相关并发症日益增多,其中以感染为最为严重。采取手术取出感染植入物并延长抗菌药物用药时间已被视为根除感染的有效策略。然而,由于抗菌药物耐药和生物膜的存在,感染难以控制或复发... 详细信息

随着植入材料在骨科疾病治疗中的应用逐渐普及,植入物相关并发症日益增多,其中以感染为最为严重。采取手术取出感染植入物并延长抗菌药物用药时间已被视为根除感染的有效策略。然而,由于抗菌药物耐药和生物膜的存在,感染难以控制或复发的情况屡见不鲜,对患者健康构成严重威胁。最新研究结果显示,噬菌体不仅可以直接杀灭致病菌,还具备降解生物膜的能力。联合使用噬菌体和抗菌药物,在临床试验中展现出了良好的治疗效果,有望成为处理植入物相关感染的有效解决方案。

关键词：假体和植入物假体相关感染生物膜细菌感染噬菌体抗菌药物

宁夏沙坡头国家级自然保护区流动沙丘移动与固定沙地风蚀的研究

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湖南生态科学学报 2024年第3期11卷 11-18页

作者：何沐原郝丽波刘超张素娟赵爱国何兴东南开大学环境科学与工程学院天津300350 宁夏中卫沙坡头国家级自然保护区管理局宁夏中卫755099 中国科学院西北生态环境资源研究院兰州730000 南开大学生命科学学院天津300071

【目的】深入探究宁夏沙坡头国家级自然保护区流动沙丘营建植被后土壤风蚀抑制效率的定量关系,以期为我国干旱区制定合理的防风固沙方案提供理论依据。【方法】在宁夏沙坡头国家级自然保护区内3处流动沙丘各设置3个观测点,采取插钎法观... 详细信息

【目的】深入探究宁夏沙坡头国家级自然保护区流动沙丘营建植被后土壤风蚀抑制效率的定量关系,以期为我国干旱区制定合理的防风固沙方案提供理论依据。【方法】在宁夏沙坡头国家级自然保护区内3处流动沙丘各设置3个观测点,采取插钎法观测流动沙丘的移动;同时在保护区3处固定沙地采集栽植沙柳地段、栽植樟子松地段与栽植油蒿、花棒、柠条地段的原状土和各自对照的原状土开展室内风洞实验,风洞内观测在不同风速下的吹蚀变化。【结果】宁夏沙坡头国家级自然保护区流动沙丘一个风季平均前移3.23 m。风洞内不同风速吹蚀下,栽植沙柳地段样地土样的风蚀模数与对照相比,在风速为15 m/s时减少96.78%,在风速为20 m/s时减少97.07%;在10、15、20 m/s的风速吹蚀下,栽植樟子松地段样地土样的风蚀模数分别比对照减少53.13%、99.61%、99.84%,栽植油蒿、花棒、柠条地段样地土样的风蚀模数分别比对照减少50.00%、65.01%、3.65%。【结论】流动沙丘采用机械草方格固定后栽植人工植被能够促进地表生物结皮形成,进而土壤风蚀大为减弱。在干旱半干旱区进行植物固沙工作时要高度重视生物结皮的防治土壤风蚀的作用,以促进我国的生态恢复。

关键词：固定沙地人工植被风洞实验宁夏沙坡头国家级自然保护区

3D bioprinting of a biomimetic meniscal scaffold for application in tissue engineering

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Bioactive Materials 2021年第6期6卷 1711-1726页

作者： Zhou Jian Tian Zhuang Tian Qinyu Peng Liqing Li Kun Luo Xujiang Wang Diaodiao Yang Zhen Jiang Shuangpeng Sui Xiang Huang Jingxiang Liu Shuyun hao libo Tang Peifu Yao Qi Guo Quanyi Medical School of Chinese PLA Beijing100853China Institute of Orthopedics The First Medical CentreChinese PLA General HospitalBeijing100853China Department of Joint Surgery Peking University Ninth School of Clinical MedicineBeijing Shijitan HospitalCapital Medical UniversityBeijing100038China School of Clinical Medicine Southwest Medical UniversityLuzhouSichuan646000China

Appropriate biomimetic scaffolds created via 3D bioprinting are promising methods for treating damaged ***,given the unique anatomical structure and complex stress environment of the meniscus,many studies have adopted various techniques to take full advantage of different materials,such as the printing combined with infusion,or electrospining,to chase the biomimetic meniscus,which makes the process complicated to some *** researchers have tried to tackle the challenges only by 3D biopringting,while its alternative materials and models have been *** this study,based on a multilayer biomimetic strategy,we optimized the preparation of meniscus-derived bioink,gelatin methacrylate(GelMA)/meniscal extracellular matrix(MECM),to take printability and cytocompatibility into account ***,a customized 3D bioprinting system featuring a dual nozzle+multitemperature printing was used to integrate the advantages of polycaprolactone(PCL)and meniscal fibrocartilage chondrocytes(MFCs)-laden GelMA/MECM bioink to complete the biomimetic meniscal scaffold,which had the best biomimetic features in terms of morphology and ***,cell viability,mechanics,biodegradation and tissue formation in vivo were performed to ensure that the scaffold had sufficient feasibility and functionality,thereby providing a reliable basis for its application in tissue engineering.

关键词： 3D bioprinting Tissue engineering Meniscus Scaffold

3D-printed cell-free PCL-MECM scaffold with biomimetic micro-structure and micro-environment to enhance in situ meniscus regeneration

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Bioactive Materials 2021年第10期6卷 3620-3633页

作者： Weimin Guo Mingxue Chen Zhenyong Wang Yue Tian Jinxuan Zheng Shuang Gao Yangyang Li Yufeng Zheng Xu Li Jingxiang Huang Wei Niu Shuangpeng Jiang Chunxiang hao Zhiguo Yuan Yu Zhang Mingjie Wang Zehao Wang Jiang Peng Aiyuan Wang Yu Wang Xiang Sui Wenjing Xu libo hao Xifu Zheng Shuyun Liu Quanyi Guo Department of Orthopaedic Surgery First Affiliated HospitalSun Yat-sen UniversityNo.58 Zhongshan Second RoadYuexiu DistrictGuangzhouGuangdong510080People’s Republic of China Institute of Orthopedics The First Medical CenterChinese PLA General HospitalBeijing Key Lab of Regenerative Medicine in OrthopedicsKey Laboratory of Musculoskeletal Trauma&War Injuries PLA.No.28 Fuxing RoadHaidian DistrictBeijing 100853People’s Republic of China Department of Orthopedic Surgery Beijing Jishuitan HospitalFourth Clinical College of Peking UniversityNo.31 Xinjiekou East StreetXicheng DistrictBeijing100035People’s Republic of China Department of Orthodontics Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityNo.56 Linyuan Xi RoadYuexiu DistrictGuangzhouGuangdong 510055People’s Republic of China Center for Biomaterial and Tissue Engineering Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing100871People’s Republic of China Department of Materials Science and Engineering College of EngineeringPeking UniversityBeijing 100871People’s Republic of China Musculoskeletal Research Laboratory Department of Orthopaedics and TraumatologyInnovative Orthopaedic Biomaterial and Drug Translational Research LaboratoryLi Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong KongPeople’s Republic of China Institute of Anesthesiology The First Medical CenterChinese PLA General HospitalNo.28 Fuxing RoadHaidian DistrictBeijing 100853People’s Republic of China Department of Orthopedic Surgery First Affiliated HospitalDalian Medical UniversityNo.222 Zhongshan RoadXigang DistrictDalian 116011China

Despite intensive effort was made to regenerate injured meniscus by cell-free strategies through recruiting endogenous stem/progenitor cells,meniscus regeneration remains a great challenge in *** this study,we found decellularized meniscal extracellular matrix(MECM)preserved native meniscal collagen and glycosaminoglycans which could be a good endogenous regeneration guider for stem ***,MECM significantly promoted meniscal fibrochondrocytes viability and proliferation,increased the expression of type II collagen and proteoglycans in ***,we designed 3D-printed polycaprolactone(PCL)scaffolds which mimic the circumferential and radial collagen orientation in native *** these two advantages together,a micro-structure and micro-environment dually biomimetic cell-free scaffold was *** cell-free PCL-MECM scaffold displayed superior biocompatibility and yielded favorable biomechanical capacities closely to native ***,neo-menisci were regenerated within PCL-MECM scaffolds which were transplanted into knee joints underwent medial meniscectomy in rabbits and sheep *** staining confirmed neo-menisci showed meniscus-like heterogeneous *** scores showed PCL-MECM scaffold could protect articular cartilage well,and knee X-ray examination revealed same *** magnetic resonance imaging(MRI)scanning also showed some neo-menisci in PCL-MECM scaffold *** conclusion,PCL-MECM scaffold appears to optimize meniscus *** could represent a promising approach worthy of further investigation in preclinical applications.

关键词： 3D printing Cell-free Decellularization Biomimetic scaffold Meniscus regeneration

辽宁白云金矿床稳定同位素地球化学特征及矿床成因

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吉林大学学报（地球科学版） 2017年第2期47卷 442-451页

作者：郝立波赵昕赵玉岩吉林大学地球探测科学与技术学院长春130026

白云金矿床是辽东地区的一个大型金矿床,其成矿物质来源及矿床成因一直存在争议。本文系统地研究了白云金矿床的氢、氧、硫和碳同位素地球化学特征。研究结果显示:成矿流体中δ^(18)OV-SMOW值变化范围为13.5‰15.9‰,δD_(V-SMOW)为-107... 详细信息

白云金矿床是辽东地区的一个大型金矿床,其成矿物质来源及矿床成因一直存在争议。本文系统地研究了白云金矿床的氢、氧、硫和碳同位素地球化学特征。研究结果显示:成矿流体中δ^(18)OV-SMOW值变化范围为13.5‰15.9‰,δD_(V-SMOW)为-107‰-83‰,表明成矿流体以岩浆水为主;矿石中黄铁矿的δ^(34)S_(V-CDT)为-8.3‰2.9‰,以富轻硫和贫重硫为特征,与辽河群围岩中黄铁矿的硫同位素组成(δ^(34)S_(V-CDT)为7.0‰18.7‰)有明显差异;矿石中方解石的碳同位素δ^(13)C_(V-PDB)为-2.2‰-0.4‰,类似于火成碳酸岩或地幔包体来源的碳同位素特征,也与辽河群大理岩的碳同位素组成明显不同。成矿元素特征对比也显示,成矿物质来源与辽河群没有必然联系。综合矿床地质特征和地球化学特征,认为白云金矿床是与深部岩浆流体活动有关的岩浆热液型金矿床。

关键词：辽宁白云金矿床稳定同位素地球化学岩浆热液型金矿床矿床成因

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高职工科类专业产教融合现状与实践困境研究

科教文汇 2023年第2期 154-157页

作者：郝丽波湖南机电职业技术学院湖南长沙410005

现代职教体系下的产教深度融合,是培养高素质技术技能人才、能工巧匠、大国工匠的根本途径。通过对高职工科类专业产教融合现状的调查和分析,提出当前工科类专业产教融合存在相关部门的支持力度不够,缺乏企业职场场景的学生职业规划、... 详细信息

现代职教体系下的产教深度融合,是培养高素质技术技能人才、能工巧匠、大国工匠的根本途径。通过对高职工科类专业产教融合现状的调查和分析,提出当前工科类专业产教融合存在相关部门的支持力度不够,缺乏企业职场场景的学生职业规划、职业素养训练,师资队伍不能满足培养现代“新工科”人才,现代学徒制尚未真正实施等问题,提出了政府构建产业和教育统筹融合发展格局、强化工科企业重要主体作用、完善产教融合师资队伍建设机制、全面推进产教融合人才培养改革等建议,以促进专业内涵发展。

关键词：产教融合工科类专业实践困境

辽东三家子地区晚侏罗世花岗岩SHRIMP U-Pb年龄、Hf同位素特征及地质意义

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地质学报 2015年第10期89卷 1773-1782页

作者：杨凤超宋运红郝立波柴鹏吉林大学地球科学学院长春130061 中国地质调查局沈阳地质调查中心沈阳110034 吉林大学地球探测科学与技术学院长春130061 中国地质科学院地质研究所北京100037

辽东岫岩三家子矿化集中区位于青城子矿化集中区以西三家子一带,属于青城子矿化带西延部分。矿区内发育以洼岭二长花岗岩为代表的晚侏罗世侵入岩,应与本地区矿化作用有密切的关系。岩体锆石SHRIMP U-Pb年龄加权平均值为162.4±1.9Ma,代... 详细信息

辽东岫岩三家子矿化集中区位于青城子矿化集中区以西三家子一带,属于青城子矿化带西延部分。矿区内发育以洼岭二长花岗岩为代表的晚侏罗世侵入岩,应与本地区矿化作用有密切的关系。岩体锆石SHRIMP U-Pb年龄加权平均值为162.4±1.9Ma,代表岩浆结晶年龄,应为燕山期岩浆活动产物,是华北东部侏罗世花岗岩的一部分。全岩岩石化学分析结果显示,洼岭二长花岗岩为高钾钙碱性岩浆系列,其中SiO2(72.28%~75.61%)≥56%,Al2O3(14.37%~15.06%)≥15%(极少数低于此值),MgO小于3%制,A/CNK值1.035~1.083,均大于1,具有铝过饱和型特征。微量元素数据显示亏损重稀土元素,(La/Yb)N为18.06~22.66,Eu无负异常。具有高Sr(497×10-6~574×10-6),低Y(4.56×10-6~5.61×10-6)和Yb(0.47×10-6~0.62×10-6)特征,表现为具有埃达克质亲和性的I型花岗岩。岩体εHf(0)为负值,εHf(t)为负值(-28.9^-17.5),说明洼岭岩体形成时壳源物质成分占主导地位,单阶段Hf模式年龄(TDM)平均为1714Ma,两阶段Hf模式年龄(TDMC)平均为3704Ma。综上,洼岭岩体可能形成于从中侏罗世(160Ma)开始的多板块向东亚汇聚的构造背景,可能为加厚下地壳熔融的产物,同时是埃达克岩与铜成矿有密切关系的又一佐证。

关键词：辽东半岛洼岭岩体锆石SHRIMP U-Pb年龄 Hf同位素过铝质Ⅰ型花岗岩

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中酸性火山岩中造岩矿物含量的定量计算方法

岩石学报 2006年第2期22卷 480-484页

作者：郝立波赵洪振陆继龙赵玉岩时艳香吉林大学地球探测科学与技术学院长春130026

主要造岩矿物的含量是火山岩分类定名的主要依据。对于基质为微晶质、隐晶质的火山岩,采用常规的薄片显微镜统计矿物含量几乎是不可行的。目前已有的利用岩石化学成分计算矿物含量的方法均不适用于中酸性火山岩。因此,本文基于岩石与矿... 详细信息

主要造岩矿物的含量是火山岩分类定名的主要依据。对于基质为微晶质、隐晶质的火山岩,采用常规的薄片显微镜统计矿物含量几乎是不可行的。目前已有的利用岩石化学成分计算矿物含量的方法均不适用于中酸性火山岩。因此,本文基于岩石与矿物之间的化学成分质量平衡原理,提出了计算火山岩实际矿物含量的方法。该方法是利用实际矿物成分,采用最优化方法计算岩石中实际矿物的含量,在很大程度上避免了计算中的人为性。对中酸性火山岩实际样品计算表明,该方法使用简单方便,精度较高。

关键词：定量计算矿物含量岩石化学成分中酸性火山岩