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Animal Nutrition 2021年第4期7卷 1173-1181页

作者： Li Zhe Lunxiang Yang Sen Lin Fangyuan chen Peng Wang Lourens Heres Yong Zhuo Jiayong Tang Yan Lin Shengyu Xu Xiaoling Zhang Xuemei Jiang Lingjie Huang Ruinan Zhang lianqiang che Gang Tian Bin Feng De Wu Zhengfeng Fang Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education Animal Nutrition InstituteSichuan Agricultural University211 Huimin RoadWenjiang DistrictChengdu611130China Sericultural&Agri-Food Research Institute Guangdong Academy of Agricultural Sciences 133 Dongguanzhuang Yiheng RoadGuangzhou510610China Sonac(China)Biology Co. LtdShanghai1668 Xiuyan RoadPudong New AreaShanghai200120China

This study was conducted to investigate the effects of spray-dried porcine plasma protein(SDPP)or spray-dried chicken plasma protein(SDCP)supplementation in diets without the inclusion of antibiotics and zinc oxide(ZnO)on growth performance,fecal score,and fecal microbiota in early-weaned piglets.A total of 192 healthy weaning piglets(Duroc×Landrace×Yorkshire,21 d old)were blocked by BW(6.53±0.60 kg)and randomly assigned to 4 dietary treatments:negative control(NC,basal diet),positive control(PC),basal diet+ZnO at 2 g/kg and antibiotics at 0.8 g/kg,SDPP(containing 5%SDPP),and SDCP(containing 5%SDCP).The experiment lasted 14 *** SDPP group had higher(Pched-chain fatty acids ratio than the PC and SDPP ***,SDPP was a promising animal protein for piglets in increasing feed intake,modifying gut microbiota profile,reducing gut protein fermentation and alleviating diarrhea frequency,thus promoting growth performance,under the conditions with limited in-feed utilization of antibiotics and ZnO.

关键词： Plasma protein Weaned piglet Growth performance Microbial community

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微流控肠道芯片研究进展

动物营养学报 2021年第4期33卷 1891-1900页

作者：李英洁张琛王蕾车炼强四川农业大学动物营养研究所成都611130 中国科学院过程工程研究所生化工程国家重点实验室北京100089 山东省食品药品检验研究院济南250101

近年来,微流控技术的出现为生物医学研究提供了新的体外试验平台。动物肠道与机体免疫、营养代谢等生理活动密切相关,但目前肠道功能研究受限于单一体外细胞培养技术。微流控肠道芯片的研发拓展了肠道功能研究方法与技术手段,成为当前... 详细信息

近年来,微流控技术的出现为生物医学研究提供了新的体外试验平台。动物肠道与机体免疫、营养代谢等生理活动密切相关,但目前肠道功能研究受限于单一体外细胞培养技术。微流控肠道芯片的研发拓展了肠道功能研究方法与技术手段,成为当前研究热点和前沿。本文概述了微流控技术和肠道芯片的发展历程与研究进展,阐述了微流控肠道芯片的结构与功能,比较了其较传统体外模型的优势,包括高度仿生性、高效性和精准可重复性等,并通过具体研究实例阐明了微流控肠道芯片在医学及营养学领域的应用,最后展望了微流控肠道芯片在动物营养学研究中的开发应用前景。

关键词：微流控肠道芯片仿生微生物

Mammary cell proliferation and catabolism of adipose tissues in nutrition-restricted lactating sows were associated with extracellular high glutamate levels

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Journal of Animal Science and Biotechnology 2019年第1期10卷 172-182页

作者： Heju Zhong Peng Wang Yumo Song Xiaoling Zhang lianqiang che Bin Feng Yan Lin Shengyu Xu Jian Li De Wu Qiaofeng Wu Zhengfeng Fang Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education Animal Nutrition InstituteSichuan Agricultural University Acupuncture and Moxibustion College Chengdu University of Traditional Chinese Medicine

Background: Persistent lactation,as the result of mammary cellular anabolism and secreting function,is dependent on substantial mobilization or catabolism of body reserves under nutritional ***,little is known about the biochemical mechanisms for nutrition-restricted lactating animals to simultaneously maintain the anabolism of mammary cells while catabolism of body *** present study,lactating sows with restricted feed allowance(RFA)(n = 6),24% feed restriction compared with the control(CON) group(n = 6),were used as the nutrition-restricted *** and mammary venous cannulas methods were used to monitor postprandial dynamic changes of metabolites in adipose and mammary ***: At lactation d 28,the RFA group showed higher(P 0.05) between ***,piglet performance and milk yield did not differ(P > 0.05) between *** would appear that activation of Notch signaling and adequate supply of glutamate might assist ***: Mammary cell proliferation and catabolism of adipose tissues i

关键词： Glutamate Insulin sensitivity Lipolysis Mammary cell proliferation

Cell replacement with stem cell-derived retinal ganglion cells from different protocols

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Neural Regeneration Research 2024年第4期19卷 807-810页

作者： Ziming Luo Kun-che Chang Spencer Center for Vision Research Byers Eye InstituteStanford University School of Medicine Department of Ophthalmology Louis J.Fox Center for Vision RestorationUniversity of Pittsburgh School of Medicine Department of Neurobiology Center of NeuroscienceUniversity of Pittsburgh School of Medicine

Glaucoma,characterized by a degenerative loss of retinal ganglion cells,is the second leading cause of blindness *** is currently no cure for vision loss in glaucoma because retinal ganglion cells do not regenerate and are not replaced after *** stem cell-derived retinal ganglion cell transplant is a potential therapeutic strategy for retinal ganglion cell degenerative *** this review,we first discuss a 2D protocol for retinal ganglion cell differentiation from human stem cell culture,including a rapid protocol that can generate retinal ganglion cells in less than two weeks and focus on their transplantation ***,we discuss using 3D retinal organoids for retinal ganglion cell transplantation,comparing cell suspensions and *** review provides insight into current knowledge on human stem cell-derived retinal ganglion cell differentiation and transplantation,with an impact on the field of regenerative medicine and especially retinal ganglion cell degenerative diseases such as glaucoma and other optic neuropathies.

关键词： cell clumps cell suspension cell transplantation differentiation direct-induced protocol glaucoma optic neuropathy regenerative medicine retinal ganglion cell retinal organoids stem cells

Effect of green forage on development of the reproductive organ and diversity of the gut microbiota in Meishan prepubertal gilts

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Effect of green forage on development of the reproductive or...

Numerical investigation of transient gas–solid heat transfer in a packed bed:Impact of intra-particle thermal diffusion

中国畜牧兽医学会动物微生态学分会第五届第十二次全国学术研讨会

作者： Meng Cao Pan Zhang Yang Li Shengyu Xu Yan Lin Jian Li Bin Feng lianqiang che Zhengfeng Fang De Wu Key Laboratory for Animal Disease-Resistant Nutrition of the Ministry of Education of China Animal Nutrition InstituteSichuan Agricultural University

This study was conducted to evaluate the effects of green forage on the onset of puberty and estrus cycle,the development of reproductive organ and diversity of the gut microbiota in Meishan prepubertal *** purebred prepubertal Meishan gilts(ages 93.3 ± 6.8 d;initial body weight 25.3 ± 0.8 kg)were randomly allocated to one of two groups with 10 repeats for each group:control(CON) and Green Forage group(GF).The control basal diets were formulated to meet or exceed Chinese Feeding Standard of Swine(2004).In Green Forage group we used Chinese cabbage instead of part of basal diet with almost iso-energetic and *** control group gilts fed 1.08 kg,1.30 kg,1.64 kg of basal diets(corn-soybean meal diets) per day at stage 1(20-3 0kg),stage 2(30-40kg) and stage 3(40kg to the fourth estrus),*** Green Forage group gilts were fed 1.2kg,1.8kg,2.4kg of Chinese cabbage,and1.02 kg,1.21 kg,1.54 kg of basal diets at stage 1(20-30kg),stage 2(30-40kg) and stage 3(40kg to the fourth estrus),*** age at first estrus of gilts fed green forage was delayed compared with the control gilts(152.4 d vs 135.2 d,P = 0.003).The number of large follicles(>5mm) were increased compared with the control gilts(16.4 vs 12.6,P = 0.041).The concentration of IGF-1 in follicular fluid was increased significantly compared with the control *** was no effect of green forage on estrus cycle and duration of *** gilts fed green forage had higher levels of intestinal microbial richness and biodiversity than the control *** study demonstrates that the green forage can promote the development of reproductive organ in Meishan prepubertal ***,this may be a hint that the improvement of the reproductive organs may be associated with the change of intestinal microorganism.

关键词： gilts green forage reproductive organ intestinal microorganism

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Particuology 2024年第7期90卷 404-411页

作者： Hanqiao che Yuanhe Yue Zhaohua Jiang Duan Li School of Mechanical Engineering Guangxi UniversityNanningGuangxi530004China School of chemical Engineering University of BirminghamBirminghamB152TTUK Hebei Engineering Research Center of Advanced Energy Storage Technology and Equipment School of Energy and Environmental EngineeringHebei University of TechnologyTianjin300401China Hebei Key Laboratory of Thermal Science and Energy Clean Utilization School of Energy and Environmental EngineeringHebei University of TechnologyTianjin300401China School of Mechatronics and Vehicle Engineering Chongqing Jiaotong UniversityChongqing400074China School of Instrumentation and Opto-Electronic Engineering Beihang UniversityBeijing 100191China

The transient heat transfer behaviours in a packed bed have been studied using coupled computational fluid dynamics(CFD)and discrete element method(DEM).Intra-particle thermal diffusion,which is a crucial but rarely explored issue,is considered by introducing a one-dimensional diffusion equation in the DEM *** achieve a sufficiently long physical time of simulations,we further reduce the computational cost by applying periodic boundary condition to a small segment of the packed *** study demonstrates a shifting peak heat flow rate from the bottom to the top of the packed bed during the initial warming *** affirm that the influence of thermal diffusion within a particle is noteworthy only for particles exhibiting a high Biot number(e.g.,Bi=1.2).This insight enriches our understanding of heat transfer mechanisms in packed beds and their practical engineering applications.

关键词： Packed bed Intra-particle heat transfer CFD–DEM

Multi-timescale optimization scheduling of interconnected data centers based on model predictive control

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Frontiers in Energy 2024年第1期18卷 28-41页

作者： Xiao GUO Yanbo che Zhihao ZHENG Jiulong SUN Energy Power Electrical Automation and Information EngineeringTianjin UniversityTianjin 300072China

With the promotion of“dual carbon”strategy,data center(DC)access to high-penetration renewable energy sources(RESs)has become a trend in the ***,the uncertainty of RES poses challenges to the safe and stable operation of DCs and power *** this paper,a multi-timescale optimal scheduling model is established for interconnected data centers(IDCs)based on model predictive control(MPC),including day-ahead optimization,intraday rolling optimization,and intraday real-time *** day-ahead optimization stage aims at the lowest operating cost,the rolling optimization stage aims at the lowest intraday economic cost,and the real-time correction aims at the lowest power fluctuation,eliminating the impact of prediction errors through coordinated multi-timescale *** simulation results show that the economic loss is reduced by 19.6%,and the power fluctuation is decreased by 15.23%.

关键词： model predictive control interconnected data center multi-timescale optimized scheduling distributed power supply/landscape uncertainty

An innovative inertial parameters identification method for non-cooperative space targets based on electrostatic interaction

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CHINESE JOURNAL OF AERONAUTICS 2024年第9期37卷 417-432页

作者： Jing, Heng Zheng, Zixuan che, Dejia Yuan, Jianping Northwestern Polytech Univ Natl Key Lab Aerosp Flight Dynam Xian 710072 Peoples R China Northwestern Polytech Univ Sch Astronaut Xian 710072 Peoples R China

Inertial characteristics of non-cooperative targets are crucial for space capture and subsequent on-orbit servicing. Previous methods for identifying inertial parameters involve proximity operations, which are associated with the risk of collision with non-cooperative targets. This paper introduces a long-range, contactless method for identifying the inertial parameters of a noncooperative target during the pre-capture phase. Specifically, electrostatic interaction is used as an external excitation to alter the target's motion. A force estimation algorithm that uses measurements from visual and potential sensors is proposed to estimate the electrostatic interaction and eliminate the need for force sensors. Furthermore, a recursive estimation-identification framework is presented to concurrently estimate the coupled motion state, weak electrostatic interaction, and inertial parameters of the target. The simulation results show that the proposed method extends the identification distance to 170 times that of the previous method while maintaining high identification precision for all parameters.

关键词： Non-cooperative target Inertial parameters identifi- cation Electrostatic interaction Force estimation Dynamical coupling ATTITUDE-CONTROL ROBOT SATELLITE FORCES POSE

极低蛋白日粮补充不同形式氮营养素对生长猪回肠食糜菌群、代谢产物和屏障功能的影响

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南京农业大学学报 2019年第3期42卷 526-534页

作者：刘壮慕春龙彭宇彭燮车炼强朱伟云南京农业大学国家动物消化道营养国际联合研究中心/江苏省消化道营养与动物健康重点实验室/动物科技学院消化道微生物研究室江苏南京210095 四川农业大学动物营养研究所四川成都611130

[目的]本试验旨在研究极低蛋白(ELP)日粮下,补充不同形式氮营养素(氨基酸或酪蛋白)对生长猪回肠微生物、代谢产物和屏障功能的影响。[方法]试验选用80头PIC阉公猪(体质量约15.57 kg,48日龄),随机分为4组:中等蛋白组(MP)、低蛋白组(LP)... 详细信息

[目的]本试验旨在研究极低蛋白(ELP)日粮下,补充不同形式氮营养素(氨基酸或酪蛋白)对生长猪回肠微生物、代谢产物和屏障功能的影响。[方法]试验选用80头PIC阉公猪(体质量约15.57 kg,48日龄),随机分为4组:中等蛋白组(MP)、低蛋白组(LP)、极低蛋白+氨基酸组(ELP-AA)和极低蛋白+酪蛋白组(ELP-CAS),日粮粗蛋白(CP)水平分别为17%、15%、13%和13%。每个处理5个重复,每个重复4头仔猪。试验期28 d。MP和LP两组添加必需氨基酸(AA),ELP-AA组添加非必需AA以达到LP组日粮水平,ELP-CAS组使用3%酪蛋白部分替代ELP-AA组的单体AA,使其满足营养需要。于第29天每个重复挑选1头接近栏平均体质量的猪屠宰,采集回肠食糜和肠道组织样品,用于各项指标测定。[结果]与MP组相比,ELP-AA组回肠食糜中双歧杆菌属(Bifidobacterium)、乳酸杆菌属(Lactobacillus)和消化链球菌属(Peptostreptococcus)的数量显著降低(P0.05)。相关性分析结果表明,Lactobacillus数量与丁酸和生物胺含量、MUC-1、MUC-2和Occludin基因表达量显著正相关。[结论]饲喂极低蛋白日粮补充单体氨基酸对回肠微生物数量、代谢以及肠道组织屏障均产生不利影响,而补充酪蛋白能部分改善回肠有益微生物的生长并恢复部分肠道屏障相关基因的表达,提示在极低蛋白质水平下,补充酪蛋白对维持机体正常氮利用、肠道微生物生长代谢和肠道屏障功能具有重要作用。

关键词：蛋白水平氮营养素肠道微生物屏障功能

Electric Vehicle Charging Load Optimization Strategy Based on Dynamic Time-of-Use Tariff

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Energy Engineering 2024年第3期121卷 603-618页

作者： Shuwei Zhong Yanbo che Shangyuan Zhang Key Laboratory of Smart Grid of Education Ministry Tianjin UniversityTianjin300072China

Electric vehicle(EV)is an ideal solution to resolve the carbon emission issue and the fossil fuels scarcity problem in the ***,a large number of EVs will be concentrated on charging during the valley hours leading to new load peaks under the guidance of static time-of-use ***,this paper proposes a dynamic time-of-use tariff mechanism,which redefines the peak and valley time periods according to the predicted loads using the fuzzy C-mean(FCM)clustering algorithm,and then dynamically adjusts the peak and valley tariffs according to the actual load of each time *** on the proposed tariff mechanism,an EV charging optimization model with the lowest cost to the users and the lowest variance of the grid-side load as the objective function is ***,a weight selection principle with an equal loss rate of the two objectives is proposed to transform the multi-objective optimization problem into a single-objective optimization ***,the EV charging load optimization model under three tariff strategies is set up and solved with the mathematical solver *** results show that the EV charging load optimization strategy based on the dynamic time-of-use tariff can better balance the benefits between charging stations and users under different numbers and proportions of EVs connected to the grid,and can effectively reduce the grid load variance and improve the grid load curve.

关键词： Dynamic time-of-use tariff peak and valley time electric vehicle multi-objective optimization