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The influence of ^(18)F-fluorodeoxyglucose positron emission tomography/computed tomography on the N-and M-staging and subsequent clinical management of intrahepatic cholangiocarcinoma

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Hepatobiliary Surgery and Nutrition 2022年第5期11卷 684-695,I0002-I0007页

作者： Youpei Lin Huanhuan Chong Guohe Song Chenhao Zhang liangqing Dong Ling Aye Fei Liang Shuaixi Yang Mengsu Zeng Guangyu Ding Shu Zhang Jieyi Shi Aiwu Ke Xiaoying wang Jian Zhou Jia Fan Qiang Gao Department of Liver Surgery and Transplantation Liver Cancer InstituteZhongshan Hospitaland Key Laboratory of Carcinogenesis and Cancer Invasion(Ministry of Education)Fudan UniversityShanghaiChina Department of Radiology Zhongshan HospitalFudan UniversityShanghaiChina Department of Biostatistics Zhongshan HospitalFudan UniversityShanghaiChina Key Laboratory of Medical Epigenetics and Metabolism Institutes of Biomedical SciencesFudan UniversityShanghaiChina

Background:Intrahepatic cholangiocarcinoma(ICC)is a highly metastatic cancer.^(18)F-fluorodeoxyglucose positron emission tomography/computed tomography(^(18)F-FDG PET/CT)enables sensitive tumor and metastasis *** aim is to evaluate the influence of pre-treatment PET/CT on the N-and M-staging and subsequent clinical management in ICC ***:Between August 2010 and August 2018,660 consecutive ICC patients,without prior anti-tumor treatments nor other malignancies,were *** diagnostic performance of PET/CT on the N-and M-staging was compared with conventional imaging,and the preoperative staging accuracy and treatment re-allocation by PET/CT were retrospectively *** difference was compared between patients receiving PET/CT or not after propensity score ***:Patients were divided into group A(n=291)and group B(n=369)according to whether PET/CT was *** 291 patients with both PET/CT and conventional imaging for staging in group A,PET/CT showed significantly higher sensitivity(83.0%vs.70.5%,P=0.001),specificity(88.3%vs.74.9%,P<0.001)and accuracy(86.3%vs.73.2%,P<0.001)than conventional imaging in diagnosing regional lymph node metastasis,as well as higher sensitivity(87.8%vs.67.6%,P<0.001)and accuracy(93.5%vs.89.3%,P=0.023)in diagnosing distant ***,PET/CT improved the accuracy of preoperative staging from 60.1%to 71.8%(P<0.001),and modified clinical treatment strategy in 5.8%(17/291)of ICC patients,with unique roles in different tumor-node-metastasis(TNM)*** tumor-to-non-tumor ratio(TNR)predicted poor overall survival[hazard ratio(HR)=2.17;95%confidence interval(CI):1.49-3.15;P<0.001].Furthermore,patients performing PET/CT had longer overall survival compared with those without PET/CT(HR=0.74;95%CI:0.58-0.93;P=0.011)after propensity score ***:PET/CT was valuable for diagnosing regional lymph node metastasis and distant metastasis in ICC patients,and facilitated accura

关键词： Intrahepatic cholangiocarcinoma(ICC) staging positron emission tomography/computed tomography(PET/CT) clinical management

Epigenome-wide development and validation of a prognostic methylation score in intrahepatic cholangiocarcinoma based on machine learning strategies

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Hepatobiliary Surgery and Nutrition 2023年第4期12卷 478-494,I0001-I0006页

作者： Xing Chen liangqing Dong Lu Chen Yuan wang Jinpeng Du Lijie Ma Xiaokai Yan Jiwei Huang Mingheng Liao Xiangzheng Chen Dongming Liu Jin Li Bo Zhang Wen Teng Kefei Yuan Deqiang Sun Qiang Gao Yong Zeng Department of Liver Surgery&Liver Transplantation Laboratory of Liver SurgeryState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan University and Collaborative Innovation Center of BiotherapyChengduChina Department of Liver Surgery and Transplantation Liver Cancer InstituteZhongshan HospitalKey Laboratory of Carcinogenesis and Cancer Invasion of Ministry of EducationFudan UniversityShanghaiChina Key Laboratory of Medical Epigenetics and Metabolism Institutes of Biomedical SciencesFudan UniversityShanghaiChina Department of Hepatobiliary Cancer Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin’s Clinical Research Center for CancerTianjinChina The Fifth Affiliated Hospital State Key Laboratory of Respiratory DiseaseGuangzhou Medical UniversityGuangzhouChina Department of Research and Development Jiangsu Gaomei GenomicsNanjingChina Department of Oncology the Second Affiliated Hospital of Zunyi Medical UniversityZunyiChina Department of Cardiology Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina

Background:Clinical parameter-based nomograms and staging systems provide limited information for the prediction of survival in intrahepatic cholangiocarcinoma(ICC)*** this study,we developed a methylation signature that precisely predicts overall survival(OS)after ***:An epigenome-wide study of DNA methylation based on whole-genome bisulfite sequencing(WGBS)was conducted for two independent cohorts(discovery cohort,n=164;validation cohort,n=170)from three hepatobiliary centers in *** referring to differentially methylated regions(DMRs),we proposed the concept of prognostically methylated regions(PMRs),which were composed of consecutive prognostically methylated CpGs(PMCs).Using machine learning strategies(Random Forest and the least absolute shrinkage and selector regression),a prognostic methylation score(PMS)was constructed based on 14 PMRs in the discovery cohort and confirmed in the validation ***:The C-indices of the PMS for predicting OS in the discovery and validation cohorts were 0.79 and 0.74,*** the whole cohort,the PMS was an independent predictor of OS[hazard ratio(HR)=8.12;95% confidence interval(CI):5.48-12.04;P<0.001],and the C-index(0.78)of the PMS was significantly higher than that of the Johns Hopkins University School of Medicine(JHUSM)nomogram(0.69,P<0.001),the Eastern Hepatobiliary Surgery Hospital(EHBSH)nomogram(0.67,P<0.001),American Joint Committee on Cancer(AJCC)tumor-node-metastasis(TNM)staging system(0.61,P<0.001),and MEGNA prognostic score(0.60,P<0.001).The patients in quartile 4 of PMS could benefit from adjuvant therapy(AT)(HR=0.54;95%CI:0.32-0.91;log-rank P=0.043),whereas those in the quartiles 1-3 could ***,other nomograms and staging system failed to do *** analyses of potential mechanisms showed that the PMS was associated with tumor biological behaviors,pathway activation,and immune ***:The PMS could improve the prognostic accuracy and identify

关键词： Intrahepatic cholangiocarcinoma(ICC) prognostic methylation score(PMS) machine learning overall survival(OS) adjuvant therapy(AT)

本征导热聚合物研究:机理、结构与性能及应用

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化学进展 2023年第7期35卷 1106-1122页

作者：周文英王芳杨亚亭王蕴赵莹莹张亮青西安科技大学化学与化工学院西安710054 西安科技大学材料科学与工程学院西安710054

散热已成为制约超高频、大功率微电子器件和高电压电气绝缘设备日益微型化的技术瓶颈和发展面临的重要挑战,急需高性能的导热材料实现快速散热。相比导热高分子复合材料,本征结构的导热高分子材料因同步的高导热及高绝缘强度、优异柔韧... 详细信息

散热已成为制约超高频、大功率微电子器件和高电压电气绝缘设备日益微型化的技术瓶颈和发展面临的重要挑战,急需高性能的导热材料实现快速散热。相比导热高分子复合材料,本征结构的导热高分子材料因同步的高导热及高绝缘强度、优异柔韧性、轻质高强等优异的综合性能及优势受到了国内外学者的广泛研究和关注。本文首先讨论了聚合物的本征导热机理,系统深入地分析和评述了单体及分子链结构、结晶、取向、分子链间作用、交联、缺陷等结构因素,以及温度、压力、环境等因素对声子热传递及聚合物导热的影响机理,进一步归纳了本征导热聚合物的制备策略和途径。最后总结了当前本征导热聚合物研究面临的主要问题和挑战,展望了未来发展方向及其在众多领域的重要潜在应用。

关键词：导热聚合物声子传递有序结构取向氢键

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ⅡB期宫颈癌诊治中国专家共识(2024)

中华转移性肿瘤杂志 2024年第2期7卷 99-107页

作者：尧良清向阳王育林仲秋王平胡克中国医师协会妇产科医师分会妇科肿瘤学组中国医药教育学会妇科肿瘤专业委员会广州医科大学附属妇女儿童医疗中心妇瘤科广州510180 北京协和医院妇瘤中心北京100730 同济大学附属妇产科医院妇瘤科上海200040 中山大学孙逸仙纪念医院妇瘤科广州510120 四川大学华西第二医院妇科成都610044 北京协和医院放疗科北京100730 不详

ⅡB期宫颈癌在所有宫颈癌患者中占一定比例。由于妇科检查的主观性及影像学检查对宫旁组织受侵诊断的局限性,其诊断可能与临床分期存在分期升级或降级现象,因此选择同步放化疗还是手术治疗也成为临床上最大的困惑和争议。目前,关于ⅡB... 详细信息

ⅡB期宫颈癌在所有宫颈癌患者中占一定比例。由于妇科检查的主观性及影像学检查对宫旁组织受侵诊断的局限性,其诊断可能与临床分期存在分期升级或降级现象,因此选择同步放化疗还是手术治疗也成为临床上最大的困惑和争议。目前,关于ⅡB期宫颈癌的诊断和治疗在各国临床指南中尚存争议,对于不同患者的推荐治疗模式尚无统一共识。提高ⅡB期宫颈癌的精准诊断和个体化治疗是改善患者生存的关键。为此,编委会组织专家制订本共识,以期为ⅡB期宫颈癌诊断及治疗决策提供参考和借鉴。

关键词：子宫颈癌 ⅡB期诊断治疗同步放化疗根治性全子宫切除术

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多模终端待机低功耗设计

电讯技术 2017年第3期57卷 347-353页

作者：章梁晴王志功中兴通讯股份有限公司南京研究所南京210012 东南大学射频与光电集成电路研究所南京210096

如今的移动通信网络是由多种制式及多个频段融合而成的多模网络,对于商用终端而言,多种难题交织在一起,其中待机时长是必须要解决的一个关键问题。为此,不同于传统增大电池容量的方法,采用降低待机功耗的策略:时域的时隙控制、频域的电... 详细信息

如今的移动通信网络是由多种制式及多个频段融合而成的多模网络,对于商用终端而言,多种难题交织在一起,其中待机时长是必须要解决的一个关键问题。为此,不同于传统增大电池容量的方法,采用降低待机功耗的策略:时域的时隙控制、频域的电流控制、睡眠和唤醒的电源门控制、低频时钟高频化,其中高频时钟校准低频时钟是降低睡眠态功耗的关键措施。这一系列方案的实施,使得终端在多模实际网络环境下的待机电流小于5 m A,终端的待机低功耗达到了有竞争力的商用水平。

关键词：移动通信网络多模终端低功耗待机寻呼周期校准定时偏差

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半夏人工种茎质量标准的研究

中国中药杂志 2010年第11期35卷 1382-1385页

作者：叶双凤王沫刘良清张惠芝华中农业大学药用植物研究所湖北武汉430070

目的：制定半夏人工种茎的质量分级标准。方法：对组培快繁获得的成熟半夏人工种茎进行百粒重、含水量、发芽率、生活力、单粒径、净度等指标的测定和外观形态的观察,使用SPSS统计软件,分析出划分人工种茎等级的主要指标和参考指标,并... 详细信息

目的：制定半夏人工种茎的质量分级标准。方法：对组培快繁获得的成熟半夏人工种茎进行百粒重、含水量、发芽率、生活力、单粒径、净度等指标的测定和外观形态的观察,使用SPSS统计软件,分析出划分人工种茎等级的主要指标和参考指标,并制定半夏人工种茎质量分级标准。结果：生活力和发芽率是半夏人工种茎质量分级标准的主要指标,百粒重和直径大小是质量分级标准的重要参考指标。结论：1级半夏人工种茎的百粒重不低于10 g,含水量70%~80%,发芽率不低于80%,生活力不低于85%,单粒径不低于0.7 cm,净度不低于80%;2级人工种茎百粒重8~10 g,含水量70%~80%,发芽率60%~80%,生活力70%~85%,单粒径0.3~0.7 cm,净度75%~80%;含水量70%~80%且其他指标达不到2级人工种茎标准的为3级人工种茎。

关键词：半夏人工种茎质量分级标准

UbcH10在胃癌组织中的表达及其临床意义

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中华普通外科杂志 2014年第10期29卷 763-766页

作者：李良庆汪斌潘敦福建医科大学附属第一医院胃肠外科一区福州350005

目的研究胃癌组织中泛素偶联酶UbcH 10的表达与胃癌病理分级、临床分期及预后之间的关系.方法采用免疫组织化学方法检测有完整随访资料的117例胃癌组织中UbcH10、Ki-67及人表皮生长因子受体2的表达.用Real-time PCR和Western blot检... 详细信息

目的研究胃癌组织中泛素偶联酶UbcH 10的表达与胃癌病理分级、临床分期及预后之间的关系.方法采用免疫组织化学方法检测有完整随访资料的117例胃癌组织中UbcH10、Ki-67及人表皮生长因子受体2的表达.用Real-time PCR和Western blot检测43例胃癌新鲜标本中UbcH10 mRNA和蛋白的含量.结果本组117例胃癌组织中UbcH10蛋白的阳性率为83％（97/117）,癌旁正常胃黏膜组织中阳性率为55％（64/117）,两者相比差异具有统计学意义（Rs=-0.397,P＜0.01）.胃癌组织中UbcH 10蛋白的表达与患者的性别、年龄、肿瘤部位、肿瘤直径无关（Rs =0.001、-0.084、0.052、-0.156,均P＞0.05）,但与肿瘤分化、浸润深度、淋巴结转移及TNM分期相关（Rs =0.369、-0.378、-0.276、0.421,均P＜0.05）.UbcH10与增殖抗原Ki-67、人表皮生长因子受体2表达呈正相关（Rs =0.834、0.281,均P＜0.01）.胃癌组织中UbcH10 mRNA的表达量高于癌旁正常组织（△Ct=32.2±5.19、△Ct=4.69±1.26,t=26.8,P＜0.01）,UbcH10蛋白在胃癌组织中的表达水平高于癌旁正常组织（0.74±0.45、0.11±0.04,t=8.09,P＜0.01）.UbcH10阳性表达胃癌患者5年生存率低于UbcH10阴性表达患者（χ^2=13.116,P＜0.01）.结论 UbcH10在胃癌组织中表达增强,UbcH10的表达可能与胃癌患者的预后有关.

关键词：胃肿瘤增殖细胞核抗原受体,人表皮生长因子预后

Siegesbeckia for Breast Cancer Pain Relief:Mechanisms and Potential Targets

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抗硫化返原剂KA9188对天然橡胶胶料性能的影响

中华医学会疼痛学分会第十九届学术年会

作者： Xinyi Li Yi Lin Chao wang Hao Jiang Ke He Xiaoming Xie liangqing Huang Huifeng Hao Guihua Tian Dongzhimen Hospital Beijing University of Chinese Medicine Peking University Cancer Hospital

Purpose Breast cancer(BC) is a prevalent malignancy often accompanied by significant ***,a widely used Chinese medicinal herb,has demonstrated therapeutic potential in various ***,its pharmacodynamic mechanisms and role in alleviating breast cancer-related pain remain to be *** study aims to investigate the mechanisms and potential targets of Siegesbeckia in the context of breast cancer pain management.

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橡胶工业 2022年第12期69卷 915-920页

作者：王辰冯林兆赖亮庆苏正涛中国航发北京航空材料研究院中国航空发动机集团减振降噪材料及应用技术重点实验室北京100095

研究抗硫化返原剂KA9188(简称KA9188)用量对硫黄用量分别为1.2和0.5份的K和S系配方天然橡胶(NR)胶料性能的影响。结果表明:S系配方NR胶料的硫化返原率远小于K系配方NR胶料,表明KA9188可以显著提升S系配方NR胶料的抗硫化返原性能;随着KA9... 详细信息

研究抗硫化返原剂KA9188(简称KA9188)用量对硫黄用量分别为1.2和0.5份的K和S系配方天然橡胶(NR)胶料性能的影响。结果表明:S系配方NR胶料的硫化返原率远小于K系配方NR胶料,表明KA9188可以显著提升S系配方NR胶料的抗硫化返原性能;随着KA9188用量的增大,K和S系配方NR硫化胶的交联密度、邵尔A型硬度和定伸应力增大,拉伸强度、拉断伸长率和撕裂强度减小,在玻璃化温度(T_(g))下K和S系配方NR硫化胶的损耗因子增大、动态剪切模量减小;与K系配方NR硫化胶的T_(g)相比,S系配方NR硫化胶的T_(g)向低温方向移动的趋势略大,这是因为KA9188分子中的亚甲基长链为NR硫化胶提供的交联网络柔顺性略好于单硫键和双硫键;K系配方NR硫化胶的交联密度大于S系配方NR硫化胶。

关键词：抗硫化返原剂天然橡胶交联密度拉伸性能玻璃化温度

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