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Recent Strategies and Advances in Hydrogel‑Based Delivery Platforms for Bone Regeneration

Nano-Micro Letters 2025年第3期17卷 389-439页

作者： Xiao Wang jia Zeng Donglin Gan Kun Ling Mingfang He jianshu Li Yongping Lu Scientific and Technological Innovation Center for Biomedical Materials and Clinical Research Guangyuan Key Laboratory of Multifunctional Medical HydrogelGuangyuan Central HospitalGuangyuan 628000People’s Republic of China jiangsu Collaborative Innovation Center of Biomedical Functional Materials Jiangsu Key Laboratory of Bio‑Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023People’s Republic of China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065People’s Republic of China

Bioactive molecules have shown great promise for effectively regulating various bone formation processes,rendering them attractive therapeutics for bone ***,the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in *** have emerged as ideal carriers to address these challenges,offering the potential to prolong retention times at lesion sites,extend half-lives in vivo and mitigate side effects,avoid burst release,and promote adsorption under physiological *** review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration,encompassing applications in cranial defect repair,femoral defect repair,periodontal bone regeneration,and bone regeneration with underlying ***,this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery,carrier-assisted delivery,and sequential ***,this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

关键词： Hydrogel Bone regeneration Bioactive molecules Drug delivery Nano-/microscale carriers

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Gut microbiota in antiviral strategy from bats to humans:a missing link in COVID-19

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Science China(Life Sciences) 2021年第6期64卷 942-956页

作者： jia Luo Shan liang Feng Jin Department of Psychology Sichuan Normal UniversityChengdu 610068China Key Laboratory of Microbial Physiological and Metabolic Engineering Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Key Laboratory of Mental Health Institute of PsychologyChinese Academy of SciencesBeijing 100101China

Bats are a potential natural reservoir for SARS-CoV-2 virus and other viruses detrimental to *** evidence has shown that,in their adaptation to a flight-based lifestyle,remodeling of the gut microbiota in bats may have contributed to immune tolerance to *** evidence from bats provides profound insights into the potential influence of gut microbiota in COVID-19 disease in ***,we highlight recent advances in our understanding of the mechanisms by which the gut microbiota helps bats tolerate deadly viruses,and summarize the current clinical evidence on the influence of gut microbiota on the susceptibility to SARS-CoV-2 infection and risk of COVID-19 leading to a fatal *** addition,we discuss the implications of gut microbiota-targeted approaches for preventing infection and reducing disease severity in COVID-19 patients.

关键词： COVID-19 SARS-CoV-2 gut microbiota bat anti-inflammatory antiviral

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Neuropeptide Y receptor Y8b(npy8br)regulates feeding and digestion in Japanese medaka(Oryzias latipes)larvae:evidence from gene knockout

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第7期25卷 605-616页

作者： Xiaodan jia Ke LU Xufang liang College of Fisheries Chinese Perch Research CenterHuazhong Agricultural UniversityWuhan 430070China Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt Ministry of EducationWuhan 430070China

Neuropeptide Y receptor Y8(NPY8R)is a fish-specific receptor with two subtypes,NPY8AR and *** in expression levels during physiological processes or in vivo regulation after ventricular injection suggest that NPY8BR plays an important role in feeding regulation;this has been found in only a few fish,at *** order to better understand the physiological function of npy8br,especially in digestion,we used clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)technology to generate npy8br-/-japanese medaka(Oryzias latipes).We found that the deletion of npy8br in medaka larvae affected their feeding and digestion ability,ultimately affecting their ***,npy8br deficiency in medaka larvae resulted in decreased feed intake and decreased expression levels of orexigenic genes(npy and agrp).npy8br-/-medaka larvae fed for 10 d(10th day of feeding)still had incompletely digested brine shrimp(Artemia nauplii)in the digestive tract 8 h after feeding,the messenger RNA(mRNA)expression levels of digestion-related genes(amy,lpl,ctra,and ctrb)were significantly decreased,and the activity of amylase,trypsin,and lipase also significantly *** deletion of npy8br in medaka larvae inhibited the growth and significantly decreased the expression of growth-related genes(gh and igf1).Hematoxylin and eosin(H&E)sections of intestinal tissue showed that npy8br-/-medaka larvae had damaged intestine,thinned intestinal wall,and shortened intestinal *** far,this is the first npy8br gene knockout model established in fish and the first demonstration that npy8br plays an important role in digestion.

关键词： Neuropeptide Y receptor Y8b(npy8br) Japanese medaka(Oryzias latipes) Knockout Feeding Digestion

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Traditional Chinese medicine for prevention and treatment of hepatocellular carcinoma: A focus on epithelial-mesenchymal transition

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Journal of Integrative Medicine 2021年第6期19卷 469-477页

作者： jia-jia Li Qing liang Guang-chun Sun Department of Pharmacy Shanghai Fifth People’s HospitalFudan UniversityShanghai 200240China

Hepatocellular carcinoma(HCC)is one of the most prevalent malignant cancers *** transition(EMT),which endows epithelial cells with mesenchymal properties,plays an important role in the early stages of *** cancer therapies have promising effects,but issues remain,such as high rates of metastasis and drug ***,exploring and evaluating new therapies is an urgent *** Chinese medicines(TCMs)have been acknowledged for their multi-target and coordinated intervention effects against *** evidence indicates that TCM can inhibit the malignancy of cells and the progression of EMT in ***,studies on the effects of TCM on EMT in HCC are *** this review,we summarized recent developments in anti-EMT TCMs and formulae,focusing on their underlying pharmacological mechanisms,to provide a foundation for further research on the exact mechanisms through which TCM affects EMT in HCC.

关键词： Traditional Chinese medicine Chinese medicine formulae Hepatocellular carcinoma Epithelial-mesenchymal transition Metastasis Cancer therapy

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Spin-orbit interaction induced Casimir-Lifshitz torque between two-dimensional electron gases

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 134-142页

作者： jia-Nan Rong liang Chen Kai Chang State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China School of Mathematics and Physics North China Electric Power UniversityBeijing 102206China School of Physics Zhejiang UniversityHangzhou 310027China College of Materials Science and Opto-electronic Technology University of Chinese Academy of SciencesBeijing 100049China

We investigate theoretically the Casimir interaction between two parallel two-dimensional electron gases(2DEGs)with Rashba and Dresselhaus spin-orbit interactions(SOIs),based on the quantum field *** derive an analytical expression for the polarization tensor and obtain the solution to the motion equation of the electromagnetic(EM)*** calculate the CasimirLifshitz torque(CLT)between two parallel 2DEGs with Rashba and Dresselhaus SOIs,which can be tuned by changing the relative strength between two *** anisotropic Casimir energy between 2DEGs caused by the interplay between the SOIs of 2DEGs offers a new origin of CLT and a new type of optoelectronic device.

关键词： Casimir torque two-dimensional electron gas spin-orbit interaction

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Intermittent Fault Diagnosability of Interconnection Networks

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Journal of Computer Science & Technology 2017年第6期32卷 1279-1287页

作者： jia-Rong liang Hao Feng Xiaojiang Du School of Computer and Electronic Information Guangxi University Nanning 530004 China Department of Computer and Information Sciences Temple University Philadelphia PA 19122 U.S.A.

An interconnection network＇s diagnosability is an important metric for measuring its self-diagnostic capability. Permanent fault and intermittent fault are two different fault models that exist in an interconnection network. In this paper, we focus on the problem pertaining to the diagnosability of interconnection networks in an intermittent fault situation. First, we study a class of interconnection networks called crisp three-cycle networks, in which the Chin-number （the number of common vertices each pair of vertices share） is no more than one. Necessary and sufficient conditions are derived for the diagnosability of crisp three-cycle networks under the PMC （Preparata, Metze, and Chien） model. A simple check can show that many well-known intereonnection networks are crisp three-cycle networks. Second, we prove that an intereonnection network S is a ti-fault diagnosable system without repair if and only if its minimum in-degree is greater than ti under the BGM （Barsi, Grandoni, and Masetrini） model. Finally, we extend the necessary and sufficient conditions to determine whether an interconnection network S is ti-fault diagnosable without repair under the MM （Maeng and Malek） model from the permanent fault situation to the intermittent fault situation.

关键词： diagnosability intermittent fault PMC(Preparata,Metze,and Chien)model BGM(Barsi,Grandoni,and Masetrini)model MM(Maeng and Malek)model

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Limits on sequential sharing of nonlocal advantage of quantum coherence

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Science China(Physics,Mechanics & Astronomy) 2022年第6期65卷 26-35页

作者： Ming-liang Hu jia-Ru Wang Heng Fan School of Science Xi’an University of Posts and TelecommunicationsXi’an 710121China Institute of Physics Chinese Academy of SciencesBeijing 100190China CAS Center for Excellence in Topological Quantum Computation University of Chinese Academy of SciencesBeijing 100190China Songshan Lake Materials Laboratory Dongguan 523808China

Sequential sharing of nonlocal correlation is inherently related to its *** address the question as to how many observers can share the nonlocal advantage of quantum coherence(NAQC)in a(d×d)-dimensional state,where d is a prime or a power of a *** first analyze the trade-off between disturbance and information gain of the general d-dimensional unsharp *** in a scenario where multiple Alices perform unsharp measurements on one party of the state sequentially and independently and a single Bob measures coherence of the conditional states on the other party,we show that at most one Alice can demonstrate NAQC with *** limit holds even when considering the weak measurements with optimal pointer *** results may shed light on the interplay between nonlocal correlations and quantum measurements on high-dimensional systems and the hierarchy of different quantum correlations.

关键词： quantum coherence quantum correlation unsharp measurement

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Efficient Task Completion for Parallel Offloading in Vehicular Fog Computing

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China Communications 2019年第11期16卷 42-55页

作者： Jindou Xie Yunjian jia Zhengchuan Chen Zhaojun Nan liang liang Chongqing Key Laboratory of Space Information Network and Intelligent Information Fusion School of Microelectronics and Communication Engineering Chongqing University

In this paper,we investigate vehicular fog computing system and develop an effective parallel offloading *** service time,that addresses task offloading delay,task decomposition and handover cost,is adopted as the metric of offloading *** propose an available resource-aware based parallel offloading scheme,which decides target fog nodes by RSU for computation offloading jointly considering effect of vehicles mobility and time-varying computation *** on Hidden Markov model and Markov chain theories,proposed scheme effectively handles the imperfect system state information for fog nodes selection by jointly achieving mobility awareness and computation *** results are presented to corroborate the theoretical analysis and validate the effectiveness of the proposed algorithm.

关键词： parallel offloading vehicular fog computing task offloading HMM

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Bauschinger-Like Effect of AZ31 Magnesium Alloy Wide Sheet During the Straightening Process

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Acta Metallurgica Sinica(English Letters) 2021年第9期34卷 1255-1264页

作者： Fangkun Ning Qichi Le Yonghui jia liang Chen Key Laboratory of Electromagnetic Processing of Materials Ministry of EducationNortheastern UniversityShenyang 110819China

The Bauschinger-like effect, which showed up in the straightening process of the AZ31 magnesium alloy wide sheet, was investigated through the multi-pass discrete three-point bending–unloading–bending(BUB) experiments. The stress variable, anisotropy, and asymmetry of tension and compression on the straightening process were corresponding to the Bauschingerlike effect. The Bauschinger-like effect in the initial, intermediate, and end of the straightening process was dominated by the twinning, detwinning, and dislocation induced by pyramidal slip, respectively. Also, they were responsible for the transformation of the Bauschinger stress parameter(BSP) and Bauschinger energy parameter(BEP). Later, the anisotropic nonlinear kinematic hardening model(ANK model) to describe the Bauschinger-like effect was optimized and simplified.

关键词： Bauschinger-like eff ect Straightening Discrete experiments Anisotropic nonlinear kinematic hardening model(ANK model)

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Effective Identification and Annotation of Fungal Genomes

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Journal of Computer Science & Technology 2021年第2期36卷 248-260页

作者： jian Liu jia-liang Sun Yong-Zhuang Liu College of Computer Science Nankai UniversityTianjin 300350China School of Computer Science and Technology Harbin Institute of TechnologyHarbin 150001China

In the past few decades,the dangers of mycosis have caused widespread *** the development of the sequencing technology,the effective analysis of fungal sequencing data has become a *** the gradual increase of fungal sequencing data,there is now a lack of sufficient approaches for the identification and functional annotation of fungal chromosomal *** overcome this challenge,this paper firstly deals with the approaches of the identification and annotation of fungal genomes based on short and long reads sequenced by using multiple platforms such as Illumina and *** this paper develops an automated bioinformatics pipeline called PFGI for the identification and annotation *** experimental evaluation on a real-world dataset ENA(European Nucleotide Archive)shows that PFGI provides a user-friendly way to perform fungal identification and annotation based on the sequencing data analysis,and could provide accurate analyzing results,accurate to the species level(97%sequence identity).

关键词： fungal genome fungal identification bioinformatics pipeline

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