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Chemical Research in Chinese Universities 2011年第1期27卷 145-149页

作者： CHENG liang-liang ZHANG Yong shi Wen-fang CAS Key Laboratory of Soft Matter Chemistry Department of Polymer Science and Engineering University of Science and Technology of China Hefei 230026 P.. R. China

Dodecyl-benzophenone（DBP） and hexadecoxyl-benzophenone（HDBP） as type 11 photoinitiators used for radical photopolymerization systems were synthesized by Friedel-Crafts reaction, and characterized by 1H NMR and FTIR spectroscopy. The UV-Vis absorption spectra of DBP and HDBP, propitious to photopolymerization under a commercial mercury UV bulb are centered at 345 and 335 nm, respectively. HDBP has higher extinction coefficient than DBP, but lower photoinitiating efficiency. Their photoinitiating performances for EB605, a bisphenol A epoxy acrylate with 40%（mass fraction） tripropyleneglycol diacrylate （TPGDA）, resin consisting of bisphenol A epoxy acrylate and tripropyleneglycol diacrylate in the presence of triethanolamine as a coinitiator were investigated by photo-differential scanning calorimetry（photo-DSC）. DBP initiates the curing of acrylate more efficiently than HDBP, showing higher photopolymerization rate and unsaturation conversion, resulted from the poor compatibility of HDBP with the resin. The photoinitiating activity of DBP to epoxy acrylate resin is even higher than that of BP at lower loadings.

关键词： Macromolecular photoinitiator Benzophenone derivative Photopolymerization

Involvement of interstitial cells of Cajal in experimental severe acute pancreatitis in rats

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World Journal of Gastroenterology 2013年第14期19卷 2179-2186页

作者： liang-liang shi Ming-Dong Liu Min Chen Xiao-Ping Zou Department of Gastroenterology Medical Schoolthe Affiliated Drum Tower Hospital of Nanjing University

AIM:To observe the changes in interstitial cells of Cajal(ICC) in rats with experimental severe acute pancreatitis(SAP).METHODS:A total of twenty-four SD rats were randomly divided into two groups(n = 12),namely the sham(S) group and the SAP group;the SAP rat model was established by retrograde injection of 5% sodium taurocholate(1.0 mL/kg) into the pancreatic ***-four hours later intestinal motility was assessed by testing small intestinal propulsion rate,and then the rats were *** pancreas and jejunum were resected and underwent routine pathologic *** staining was used to detect c-kit-positive cells in the *** of c-kit mRNA was detected by real-time polymerase chain reaction,and the expression of c-kit protein was evaluated by Western *** of ICC was evaluated by transmission electron ***:There was bleeding,necrosis and a largeamount of inflammatory cell infiltration in pancreatic tissue in the SAP group,while in jejunal tissue we observed a markedly denuded mucosal layer,loss of villous tissue and a slightly dilated muscular *** small intestinal propulsion rate was 68.66% ± 2.66% in the S group and 41.55% ± 3.85% in the SAP *** with the S group,the rate of the SAP group decreased *** density of c-kit-positive cells in the SAP group was significantly lower than in the S group;the respective mean densities were 88.47 ± 10.49 in the S group and 56.11 ± 7.09 in the SAP *** levels of c-kit protein and mRNA were 0.36 ± 0.04 and 1.29 ± 0.91 in the SAP group,respectively,which were significantly lower than those in the S group(0.53 ± 0.06,0.64 ± 0.33,respectively).In the SAP group,ICC profiles showed the same change tendency,such as vacuolation of mitochondria,irregular vacuoles and loosened desmosome-like ***:Decreased c-kit-positive cells and ultrastructural changes in ICC resulting from blockade of the c-kit signaling pathway

关键词： Severe acute pancreatitis c-kit Interstitial cells of Cajal Real-time polymerase chain reaction Ultrastructure

Pure red cell aplasia due to parvovirus B19 infection after liver transplantation:A case report and review of the literature

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World Journal of Gastroenterology 2007年第13期13卷 2007-2010页

作者： Ting-Bo liang Dong-Lin Li Jun Yu Xue-Li Bai liang liang shi-Guo Xu Wei-Lin Wang Yan Shen Min Zhang Shu-Sen Zheng Department of Hepatobiliary and Pancreatic Surgery KeyLaboratory of Combined Multi-organ Transplantation Ministryof Public Health the First Affiliated Hospital of Medical CollegeZhejiang University Hangzhou 310003 Zhejiang Province China

Pure red cell aplasia （PRCA） due to parvovirus B19 （PVB19） infectiori after solid organ transplantation has been rarely reported and most of the cases were renal transplant recipients, Few have been described after liver transplantation. Moreover, little information on the management of this easily recurring disease is available at present. We describe the first case of a Chinese liver transplant recipient with PVB19-induced PRCA during immunosuppressive therapy. The patient suffered from progressive anemia with the lowest hemoglobin level of 21 g/L. Bone marrow biopsy showed selectively inhibited erythropoiesis with giant pronormoblasts. Detection of PVB19-DNA in serum with quantitative polymerase chain reaction （PCR） revealed a high level of viral load. After 2 courses of intravenous immunoglobulin （IVIG） therapy, bone marrow erythropoiesis recovered with his hemoglobin level increased to 123 g/L. He had a lowlevel PVB19 load for a 5-too follow-up period without recurrence of PRCA, and finally the virus was cleared. Our case indicates that clearance of PVB19 by IVIG in transplant recipients might be delayed after recovery of anemia.

关键词： Pure red cell aplasia Parvovirus B19 Intravenous immunoglobulin Recurrence Livertransplantation

Finite element simulation of lower limb injuries to the driver in minibus frontal collisions

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Chinese Journal of Traumatology 2016年第3期19卷 146-150页

作者： liang-liang shi Chen Lei Kui Li Shuo-Zhen Fu Zheng-Wei Wu Zhi-Yong Yin College of Pharmaceutical and Biological Engineering Chongqing University of Technology Chongqing 400054 China Military Research Institute of Traffic Medicine Daping Hospital & Research Institute of Surgery Third Military Medical University Chongqing 400042 China School of Mechanical and Automotive Engineering Xiamen University of Technology Xiamen 361024 China

Purpose： This study aims to explore the biomechanical mechanism of lower limb injuries to the driver by establishing a finite element （FE） simulation model of collisions. Methods： First a minibus FE model was integrated with a seat belt system. Then it was used to rebuild two collisions together with the total human model for safety （THUMS） provided by Toyota Motor Corporation： a rear-end collision between a minibus and a truck and a head-on collision of a minibus to a rigid wall. The impact velocities of both collisions were set at 56 km/h. The vehicle dynamic response, vehicle deceleration, and dashboard intrusion in the two collisions were compared. Results： In the minibus rear-end truck collision, the peak values of the yon Mises equivalent stress at the tibia and the femur were 133 MPa and 126 MPa respectively; while in the minibus head-on rigid wall collision, the data were 139 MPa and 99 MPa. Compared with the minibus head-on rigid wall collision, the vehicle deceleration was smaller and the dashboard intrusion was larger in the minibus rear-end truck collision. Conclusion： The results illustrate that a longer dashboard incursion distance corresponds to a higher yon Mises equivalent stress at the femur. The simulation results are consistent with the driver＇s autopsy report on lower limbs injuries. These findings verify that FE simulation method is reliable and useful to analyze the mechanisms of lower limb iniuries to the driver in minibus frontal collisions.

关键词： BiomechanicsMinibus rear-end truckFinite element modelyon Mises equivalent stress

AQDS Enhances Degradation of BDE-47 by Promoting Shewanella oneidensis MR-1-mediated Fenton Reaction with Fe(III)-containing Minerals

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Journal of Earth Science 2025年

作者： Yongguang Jiang Siqi Zhu Zhou Jiang Yiran Dong liang shi School of Environmental Studies， China University of Geosciences State Key Laboratory of Biogeology and Environmental Geology， China University of Geosciences Hubei Key Laboratory of Yangtze Catchment Environmental Aquatic Science， China University of Geosciences State Environmental Protection Key Laboratory of Source Apportionment and Control of Aquatic Pollution， Ministry of Ecology and Environment， China University of Geosciences(Wuhan)

Electron shuttles are widespread in the environments and play important role in microbe-mineral interaction. This study investigated the effects of a model electron shuttle (i.e.， anthraquinone-2， 6-disulfonate， AQDS) on Shewanella oneidensis MR-1-mediated Fenton reaction and subsequent degradation of 2， 2′， 4， 4′-tetrabrominated diphenyl ether (BDE-47). Three Fe(III)-containing minerals， namely， ferrihydrite， goethite and nontronite， were used as electron acceptors and Fe(II) sources. With each mineral， additions of 0.01 – 1 mM AQDS in the reactions significantly enhanced Fe(III) reduction by S. oneidensis MR-1 and increased the amounts of Fe(II) produced in anoxic phase. As a result， the amounts of cumulative ·OH formed in oxic phase were increased by 10% – 287%. Regression analysis revealed that ·OH cumulation has significant linear correlation with sorbed Fe(II) but not aqueous and structural Fe(II). This finding may be ascribed to the higher reactivity of sorbed Fe(II) in oxygenation than the latter two types of Fe(II). With more ·OH， the degradation efficiency of BDE-47 was elevated by 31% – 173%. Collectively， AQDS enhances ·OH formation and BDE-47 degradation by promoting production of Fe(II)， particularly sorbed Fe(II) in S. oneidensis MR-1-mediated Fenton reaction with Fe(III)-containing minerals.

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黏蛋白型O-聚糖在人类肿瘤中的结构异常及生物学功能

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生物化学与生物物理进展 2010年第5期37卷 475-483页

作者：刘春亮吴士良苏州大学医学部生物化学与分子生物学系暨生化工程研究所苏州215123

黏蛋白是细胞表面的或分泌的、具有高度O-糖基化修饰的糖蛋白.在黏蛋白中,O-聚糖(O-glycan)是通过N-乙酰氨基半乳糖与丝氨酸或苏氨酸之间形成α连接,该结构即被称为黏蛋白型O-聚糖.黏蛋白型O-聚糖是由多肽∶N-乙酰氨基半乳糖转移酶(ppGa... 详细信息

黏蛋白是细胞表面的或分泌的、具有高度O-糖基化修饰的糖蛋白.在黏蛋白中,O-聚糖(O-glycan)是通过N-乙酰氨基半乳糖与丝氨酸或苏氨酸之间形成α连接,该结构即被称为黏蛋白型O-聚糖.黏蛋白型O-聚糖是由多肽∶N-乙酰氨基半乳糖转移酶(ppGalNAc-T)家族催化起始合成的,近年来,该酶的催化机制及结构特点已成为糖基转移酶研究的热点.在肿瘤中常常伴随着黏蛋白型O-聚糖结构上和数量上的改变,形成肿瘤特异聚糖结构(cancer-associated glycans),如肿瘤Tn和T抗原等.肿瘤特异聚糖使肿瘤细胞的抗原性和黏附能力发生改变,促进肿瘤细胞的恶性增生与转移.而这些肿瘤特异聚糖结构,也为肿瘤的诊断与抗肿瘤药物或疫苗开发提供了理论基础.

关键词：糖组学 O-聚糖多肽∶N-乙酰氨基半乳糖转移酶肿瘤特异聚糖

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提高挤压机产能的技术措施

轻合金加工技术 2016年第9期44卷 37-40页

作者：高振中肖亮梁世斌广东高登铝业有限公司广东佛山528000

提高单台挤压机的产能是铝挤压加工企业很想做的事情,特别是占地面积、厂房、设备都已定型的企业,想提高整个企业的产能只能靠提高单台挤压机的产能才能实现。从合理选择挤压筒内径、提高挤压速度、一模多孔挤压技术等三方面进行论述,... 详细信息

提高单台挤压机的产能是铝挤压加工企业很想做的事情,特别是占地面积、厂房、设备都已定型的企业,想提高整个企业的产能只能靠提高单台挤压机的产能才能实现。从合理选择挤压筒内径、提高挤压速度、一模多孔挤压技术等三方面进行论述,阐述提高挤压机产能的技术措施。

关键词：铝合金挤压单机产能,技术措施一模多孔

Metabolic reprogramming: a new option for the treatment of spinal cord injury

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Neural Regeneration Research 2025年第4期20卷 1042-1057页

作者： Jiangjie Chen Jinyang Chen Chao Yu Kaishun Xia Biao Yang Ronghao Wang Yi Li Kesi shi Yuang Zhang Haibin Xu Xuesong Zhang Jingkai Wang Qixin Chen Chengzhen liang Department of Orthopedics The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang ProvinceChina Orthopedics Research Institute of Zhejiang University Zhejiang UniversityHangzhouZhejiang ProvinceChina Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province HangzhouZhejiang ProvinceChina Clinical Research Center of Motor System Disease of Zhejiang Province HangzhouZhejiang ProvinceChina Qiandongnan Prefecture People’s Hospital KailiGuizhou ProvinceChina Department of Orthopedics Fourth Medical CenterChinese PLA General HospitalBeijingChina

Spinal cord injuries impose a notably economic burden on society,mainly because of the severe after-effects they *** the ongoing development of various therapies for spinal cord injuries,their effectiveness remains ***,a deeper understanding of metabolism has opened up a new therapeutic opportunity in the form of metabolic *** this review,we explore the metabolic changes that occur during spinal cord injuries,their consequences,and the therapeutic tools available for metabolic *** spinal cord metabolism is characterized by independent cellular metabolism and intercellular metabolic ***,spinal cord injury results in metabolic disorders that include disturbances in glucose metabolism,lipid metabolism,and mitochondrial *** metabolic disturbances lead to corresponding pathological changes,including the failure of axonal regeneration,the accumulation of scarring,and the activation of *** rescue spinal cord injury at the metabolic level,potential metabolic reprogramming approaches have emerged,including replenishing metabolic substrates,reconstituting metabolic couplings,and targeting mitochondrial therapies to alter cell *** available evidence suggests that metabolic reprogramming holds great promise as a next-generation approach for the treatment of spinal cord *** further advance the metabolic treatment of the spinal cord injury,future efforts should focus on a deeper understanding of neurometabolism,the development of more advanced metabolomics technologies,and the design of highly effective metabolic interventions.

关键词： axons glycolysis metabolic reprogramming metabolism mitochondria neural regeneration neuroprotection oxidative phosphorylation spinal cord injury therapy

机遇、挑战与创新——谈《民办教育促进法》实施后民办高校的使命

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黄河科技大学学报 2004年第1期6卷 35-40页

作者：梁士亮西安外事学院陕西西安710077

《中华人民共和国民办教育促进法》于2003年9月1日起实施,给民办学校带来新的机遇和挑战,面对全国"促进"的大环境,民办高校只有立足创新,办出特色,才能实现新的腾飞。

关键词：《民办教育促进法》机遇挑战创新

不同取代率再生骨料混凝土硫酸根离子扩散试验

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科学技术与工程 2016年第31期16卷 275-280页

作者：张凯陈亮亮侍克斌宫经伟吴福飞新疆农业大学水利与土木工程学院乌鲁木齐830052

再生骨料混凝土能很好的解决城市建筑垃圾过多、天然骨料资源不足的问题。耐久性对于再生骨料混凝土在实际工程中的应用十分重要,混凝土常常会受到硫酸盐侵蚀而影响其耐久性。通过把0%、30%、50%、70%、100%取代率的再生骨料混凝土放入5... 详细信息

再生骨料混凝土能很好的解决城市建筑垃圾过多、天然骨料资源不足的问题。耐久性对于再生骨料混凝土在实际工程中的应用十分重要,混凝土常常会受到硫酸盐侵蚀而影响其耐久性。通过把0%、30%、50%、70%、100%取代率的再生骨料混凝土放入5%的硫酸钠溶液中,分别侵蚀2、4、6、8、10、12个月,每个侵蚀周期都对样品进行分层取样,采用EDTA络合滴定法检测硫酸根离子含量,从而得出侵蚀12个月后的不同取代率再生骨料混凝土硫酸根离子分布:0%取代率再生骨料混凝土硫酸根离子含量由初始值0.43%增加到2.24%,侵蚀深度为21 mm;30%取代率再生骨料混凝土硫酸根离子含量由初始值0.54%增加到2.66%,侵蚀深度为21 mm;50%取代率再生骨料混凝土硫酸根离子含量由初始值0.61%增加到3.40%,侵蚀深度为24 mm;70%取代率再生骨料混凝土硫酸根离子含量由初始值0.70%增加到3.98%,侵蚀深度为27 mm;100%取代率再生骨料混凝土硫酸根离子含量由初始值0.85%增加到5.02%,侵蚀深度为30 mm;若以0%取代率再生骨料混凝土硫酸根离子含量和侵蚀深度为基准,30%、50%、70%、100%取代率的再生骨料混凝土硫酸根离子含量同比分别增长17.13%、54.14%、81.22%、130.39%;30%、50%、70%、100%取代率的再生骨料混凝土侵蚀深度同比分别增长0%、14.29%、28.57%、42.86%。并结合试验结果,详细分析了不同取代率对于再生骨料混凝土硫酸根离子扩散影响的机理,为再生骨料混凝土在实际工程中的应用提供了借鉴。

关键词：取代率再生骨料混凝土硫酸盐侵蚀硫酸根离子分布