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Journal of Systems Science & Complexity 2022年第4期35卷 1201-1224页

作者： HOU Wenhui zheng Yunwen liang liang LI Yongjun School of Management University of Science and Technology of ChinaHefei230026China

With the development of China’s economy,environmental pollution has become cumulatively *** primary source of environmental pollution is thermal power generation,which has attracted the attention of governments and academia in recent *** effectively reduce environmental pollution,research should study how to constrain the undesirable output of thermal power plants,that is,to limit the total undesirable output of the plants to a certain fixed ***,few studies have suggested that these undesirable outputs should be fixed-sum ***,no previous research publication about thermal power plants has analyzed their environmental performance *** address these gaps,a novel Malmquist-DEA approach is proposed for evaluate the environmental performance of thermal power plants in this *** approach generalizes the equilibrium efficient frontier DEA model with fixed-sum undesirable outputs and incorporates the model into the Malmquist productivity index(MPI).The authors apply this approach to the analysis of provincial thermal power plant environmental performance in China and analyze such plants’trends based on panel data from2011 to *** empirical research shows that the environmental performance of regional thermal power plants was positively affected by efficiency change and negatively affected by technical ***,the authors provide policy suggestions based on our findings.

关键词： Data envelopment analysis environmental performance fixed-sum undesirable outputs Malmquist productivity index thermal power plants

Identification of Self-Incompatibility Genotypes in Some Sand Pears (Pyrus pyrifolia Nakai) by PCR-RFLP Analysis

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Agricultural Sciences in China 2009年第2期8卷 154-160页

作者： GU Qing-qing ZHANG Qing-lin HU Hong-jü CHEN Qi-liang LUO zheng-rong Key Laboratory for Horticultural Plant Biology of Ministry of Education （MOE）/Huazhong Agricultural University Wuhan 430070 P.R. China Department of Horticulture Jiangxi Agricultural University Nanchang 330045 P.R.China Fruit-Tree and Tea Research Institute Hubei Academy of Agricultural Sciences Wuhan 430209 P.R.China

The identification of self-incompatibility genotype （S-genotype） will be useful for selection of pollinizers and design of crossing in cultivar improvement of sand pear. This paper reported the identification of self-incompatibility genotypes of seven Chinese and two Japanese sand pear cultivars using PCR-RFLP analysis and S-RNase sequencing. The Sgenotypes of these cultivars were determined as follows： Huali 1 S1S3, Shounan S1S3, Xizilti S1S4, Qingxiang S3S7, Sanhua S2S7, Huangmi （Imamuranatsu） S1S6, Huali 2 S3S4, Baozhuli S7S33, Cangxixueli S5S15. S-RNase alleles （S1 to S9） in sand pear could be identified effectively by PCR-RFLP analysis.

关键词： Pyrus pyrifolia Nakai self-incompatibility genotype S-allele S-RNase PCR-RFLP crossing experiment

Design,synthesis and evaluation of spermine-based pH-sensitive amphiphilic gene delivery systems: Multifunctional non-viral gene carriers

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Science China Chemistry 2011年第2期54卷 359-368页

作者： XU rongZuo LU zheng-rong Departments of Pharmaceutics and Pharmaceutical Chemistry University of Utah Salt Lake City Utah 84108 USA Department of Biomedical Engineering Case Western Reserve University Cleveland OH 44106 USA

Design and development of efficient non-viral gene delivery systems is critical to overcome various barriers for effective intracellular gene *** new spermine-based protonatable surfactants were designed,synthesized and evaluated as non-viral pH-sensitive gene *** carriers formed stable complexes with plasmid DNA at an N/P ratio as low as *** sizes of the carrier/pDNA nanoparticles (N/P = 12) were in the range of 90–130 nm,smaller than that of Lipofectamine2000/pDNA *** pDNA nanoparticles of the carriers exhibited substantially increased hemolysis when pH decreased from 7.4 to *** DNA nanoparticles had low cytotocixity,similar to that of Lipofectamine-2000/pDNA *** pH-sensitive gene carriers with no helper lipids resulted in much higher intracellular transfection and gene expression in U87 cells than Lipofectamine-2000.[N,N′-Bis(oleoylcysteinyl)(β-alanyl-α-lysyl)]-spermine monoamide (SKACO) resulted in the highest luciferase transfection efficiency,more than 400 times higher than that of Lipofectamine-2000,and GFP expression in 71% of transfected U87 *** was identified as a promising lead carrier for efficient gene *** spermine-based pH-sensitive amphiphilic carriers have a potential to be further developed as efficient non-viral multifunctional gene delivery systems.

关键词： gene delivery plasmid DNA pH sensitive multifunctional

Categorical computation

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Frontiers of physics 2023年第2期18卷 181-187页

作者： liang Kong Hao zheng Shenzhen Institute for Quantum Science and Engineering Southern University of Science and TechnologyShenzhen 518055China International Quantum Academy Shenzhen 518048China Guangdong Provincial Key Laboratory of Quantum Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Institute for Applied Mathematics Tsinghua UniversityBeijing 100084China Beijing Institute of Mathematical Sciences and Applications Beijing 101408China Department of Mathematics Peking UniversityBeijing 100871China

In quantum computing, the computation is achieved by linear operators in or between Hilbert spaces. In this work, we explore a new computation scheme, in which the linear operators in quantum computing are replaced by (higher) functors between two (higher) categories. If from Turing computing to quantum computing is the first quantization of computation, then this new scheme can be viewed as the second quantization of computation. The fundamental problem in realizing this idea is how to realize a (higher) functor physically. We provide a theoretical idea of realizing (higher) functors physically based on the physics of topological orders.

关键词： quantum computation categorical computation topological order

Precise gradient separation of nanoparticles using reduced graphene oxide-polyoxomolybdate membranes

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Science China Chemistry 2025年第01期 209-216页

作者： Yixin Yang Wanlei Zhao Ruoxuan zheng Hongqiang Li Wei Chen Yu-Fei Song State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Quzhou Institute for Innovation in Resource Chemical Engineering

The purification and size sieving of nanoparticles （NPs） represents a significant scientific ***,the r GO-polyoxometalates (POMs=PMo12,Mo132and Mo368) membranes were fabricated successfully via a simple and scalable POMsassisted in-situ photoreduction *** the mass ratio of r GO to PMo12was 1:30,the resultant r GO-PMo12membranes with highly ordered and uniform nanochannels of 1.0 nm can be obtained,which showed an accurate carbon quantum dots（CQDs） separation with a cut-off size approximately 1.0 *** increase of the size of the interlayered POMs from PMo12（1.0 nm）,{Mo132}（2.9 nm） to{Mo368}（3.8 nm）,the resultant r GO-PMo12,r GO-Mo132and r GO-Mo368exhibited precise gradient separation of CQDs and Au nanoparticles by size exclusion *** results pave a promising way to construct new twodimensional （2D） membranes for highly efficient size-selective separation.

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贻贝肽对厚壳贻贝稚贝生长发育及微生物群落结构的影响

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渔业科学进展 2025年第1期46卷 115-126页

作者：林倩李政杨金龙马蕃梁箫上海海洋大学水产与生命学院科技部海洋生物科学国际联合研究中心上海201306 上海市水产动物良种创制与绿色养殖协同创新中心上海201306 中国-葡萄牙星海“一带一路”联合实验室上海200120

为探究海洋生物活性肽对厚壳贻贝(Mytilus coruscus)生长发育的影响,本研究以厚壳贻贝稚贝为实验对象,通过投喂不同浓度的贻贝肽(0、7、9、10、70和90 mg/L),测定壳长、壳高、湿重等指标,以确定最适贻贝肽浓度,并对投喂前后的稚贝微生... 详细信息

为探究海洋生物活性肽对厚壳贻贝(Mytilus coruscus)生长发育的影响,本研究以厚壳贻贝稚贝为实验对象,通过投喂不同浓度的贻贝肽(0、7、9、10、70和90 mg/L),测定壳长、壳高、湿重等指标,以确定最适贻贝肽浓度,并对投喂前后的稚贝微生物群落进行分析,实验周期为56 d。结果显示,相较于未投喂贻贝肽的对照组,投喂9 mg/L的贻贝肽显著促进稚贝生长,且壳长、壳高和湿重分别提升了27.37%、32.35%和115.49%;同时发现,高浓度贻贝肽(70 mg/L和90 mg/L)对厚壳贻贝稚贝产生了致死效应。通过16S rRNA基因扩增和测序对比分析了28 d和56 d贻贝肽投喂组与未投喂组的厚壳贻贝稚贝微生物组群落结构变化。研究结果显示,投喂9 mg/L贻贝肽改变了稚贝微生物群落结构组成,提高了拟杆菌门(Bacteroidota)和变形菌门(Proteobacteria)的丰度,降低了放线菌门(Actinobacteriota)的丰度;同时,属水平分析发现,贻贝肽投喂组有效增加了鲁杰氏菌属(Ruegeria)、黏着杆菌属(Tenacibaculum)、居海杆菌属(Maribacter)、栖砂杆菌属(Arenibacter)、十八碳杆菌属(Octadecabacter)和希瓦氏菌属(Shewanella)等有益菌的物种丰度,显著减少了红球菌属(Rhodococcus)、气单胞菌属(Aeromonas)等潜在致病菌的丰度。综上,贻贝肽能有效促进厚壳贻贝的稚贝生长发育,并且可以优化厚壳贻贝微生物群落结构,研究成果将为后续开展贻贝肽等海洋生物活性肽对贝类稚贝中间培育以及海水贝类养殖可持续发展提供基础和数据支撑。

关键词：厚壳贻贝生长微生物群落结构贻贝肽

Cholesterol metabolism: physiological versus pathological aspects in intracerebral hemorrhage

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Neural Regeneration Research 2025年第4期20卷 1015-1030页

作者： Ruoyu Huang Qiuyu Pang Lexin zheng Jiaxi Lin Hanxi Li Lingbo Wan Tao Wang Department of Forensic Science School of Basic Medicine and Biological SciencesSuzhou Medicine College of Soochow UniversitySuzhouJiangsu ProvinceChina

Cholesterol is an important component of plasma membranes and participates in many basic life functions,such as the maintenance of cell membrane stability,the synthesis of steroid hormones,and *** plays a key role in the establishment and maintenance of the central nervous *** brain contains 20%of the whole body’s cholesterol,80%of which is located within myelin.A huge number of processes(e.g.,the sterol regulatory element-binding protein pathway and liver X receptor pathway)participate in the regulation of cholesterol metabolism in the brain via mechanisms that include cholesterol biosynthesis,intracellular transport,and *** brain injuries or diseases involving crosstalk among the processes above can affect normal cholesterol metabolism to induce detrimental ***,we hypothesized that cholesterol-related molecules and pathways can serve as therapeutic targets for central nervous system *** hemorrhage is the most severe hemorrhagic stroke subtype,with high mortality and *** cholesterol levels are associated with the risk of intracerebral ***,secondary pathological changes after intracerebral hemorrhage are associated with cholesterol metabolism dysregulation,such as neuroinflammation,demyelination,and multiple types of programmed cell *** cholesterol accumulation in the brain has been found after intracerebral *** this paper,we review normal cholesterol metabolism in the central nervous system,the mechanisms known to participate in the disturbance of cholesterol metabolism after intracerebral hemorrhage,and the links between cholesterol metabolism and cell *** also review several possible and constructive therapeutic targets identified based on cholesterol metabolism to provide cholesterol-based perspectives and a reference for those interested in the treatment of intracerebral hemorrhage.

关键词： cell death cholesterol metabolism intracerebral hemorrhage myelination therapeutic target

Intermolecular reductive coupling of aliphatic ketones with alkynes and alkenes by BCN photocatalysts

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Science China Chemistry 2025年第1期 181-185页

作者： Yanping Xia Luyang Sun Jiajia Cheng Sibo Wang Meifang zheng Xinchen Wang State Key Laboratory of Photocatalysis on Energy and Environment College of Chemistry Fuzhou University

A photocatalytic process was developed for intermolecular reductive coupling of aliphatic ketones with alkynes/alkenes to furnish tertiary alcohols. Mechanistic studies support that boron carbonitrides(BCN) promote the single electron reduction of unactivated aliphatic ketones to generate ketyl radicals with visible light irradiation, which then react with alkynes and alkenes to afford the allylic and aliphatic alcohols, respectively. The heterogeneous photocatalytic system is compatible with diverse substrates including pharmaceutical-related molecules(43 examples) with reusability and scale-up experiments, verifying the complementary synthetic utility of this method to the homogeneous catalysts.

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Non-abelian Collective Excitations in Nonlinear Quark-Gluon Plasma Media

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Chinese Physics Letters 2000年第9期17卷 643-645页

作者： zheng Xiao-Ping HOU De-Fu LIU liang-Gang LI Jia-rong Institute of Particle Physics Huazhong Normal UniversityWuhan 430079 Department of Physics Zhongshan UniversityGuangzhou 510275

We have studied the effect of the third-order density fluctuations in the medium on the collective excitations in quark-gluon *** show that the nonlinear response of a quark-gluon plasma medium leads to non-Abelian collective *** present two kinds of non-Abelian oscillation solutions which respectively correspond to weakly and strongly nonlinear coupling of field components in the color *** also show that the weakly nonlinear solution is similar to the Abelian-like one but has a frequency shift,which is of order g^(2)T,from the eigenfrequency.

关键词： space. weakly collective

Single-cell individualized electroporation with real-time impedance monitoring using a microelectrode array chip

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Microsystems & Nanoengineering 2020年第1期6卷 295-304页

作者： Zhizhong Zhang Tianyang zheng rong Zhu State Key Laboratory of Precision Measurement Technology and Instruments Department of Precision InstrumentTsinghua UniversityBeijing 100084China

The ability to precisely deliver molecules into single cells while maintaining good cell viability is of great importance to applications in therapeutics,diagnostics,and drug delivery as it is an advancement toward the promise of personalized *** paper reports a single-cell individualized electroporation method with real-time impedance monitoring to improve cell perforation efficiency and cell viability using a microelectrode array *** microchip contains a plurality of sextupole-electrode units patterned in an array,which are used to perform in situ electroporation and real-time impedance monitoring on single *** dynamic recovery processes of single cells under electroporation are tracked in real time via impedance measurement,which provide detailed transient cell states and facilitate understanding the whole recovery process at the level of single *** define single-cell impedance indicators to characterize cell perforation efficiency and cell viability,which are used to optimize *** applying the proposed electroporation method to different cell lines,including human cancer cell lines and normal human cell lines individually,optimum stimuli are determined for these cells,by which high transfection levels of enhanced green fluorescent protein(EGFP)plasmid into cells are *** results validate the effectiveness of the proposed single-cell individualized electroporation/transfection method and demonstrate promising potential in applications of cell reprogramming,induced pluripotent stem cells,adoptive cell therapy,and intracellular drug delivery technology.

关键词： impedance microelectrode monitoring