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Phase II study of novel orally PI3Kα/δinhibitor TQ-B3525 in relapsed and/or refractory follicular lymphoma

Signal Transduction and Targeted Therapy 2024年第5期9卷 2193-2201页

作者： Huaqing Wang Jifeng Feng Yanyan Liu Zhengzi Qian Da Gao Xuehong Ran Hui Zhou Lihong Liu Binghua Wang Meiyun Fang Hebing Zhou Zhenqian Huang Shi Tao Zhuowen Chen Liping su Hang su Yu Yang Xiaobao Xie Huijing Wu Ping sun Guoyu Hu Aibin liang Zhiming Li Department of Oncology Tianjin Union Medical Center of Nankai UniversityTianjin 300121PR China The Institute of Translational Medicine Tianjin Union Medical Center of Nankai UniversityTianjin 300121PR China Department of Medical Oncology Jiangsu Cancer HospitalThe Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009PR China Department of Medical Oncology Henan Cancer HospitalThe Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450003PR China Department of Medical Oncology Tianjin Medical University Cancer Institute and HospitalTianjin 300060PR China Department of Hematology The Affiliated Hospital of Inner Mongolia Medical College010050 HohhotPR China Department of Hematology Weifang People’s HospitalThe First Affiliated Hospital of Weifang Medical University261000 WeifangPR China Department of Lymphoma&Hematology Hunan Cancer HospitalThe Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University410013 ChangshaPR China Department of Hematology The Fourth Hospital of Hebei Medical University and Hebei Tumor Hospital050011 ShijiazhuangPR China Department of Lymphoma Weihai Central Hospital264400 WeihaiPR China Department of Hematology and Rheumatology The Affiliated Zhongshan Hospital of Dalian University116001 DalianPR China Department of Hematology Beijing Luhe Hospital101199 BeijingPR China Department of Hematology The First Affiliated Hospital of Guangzhou Medical University510120 GuangzhouPR China Department of Hematology The First Affiliated Hospital of Hainan Medical College570102 HaikouPR China Department of Hematology The First People’s Hospital of Foshan528000 FoshanPR China Department of Hematology Shanxi Cancer Hospital030013 TaiyuanPR China Department of Lymphoma Senior Department of HematologyThe Fifth Medical Center of Chinese PLA General Hospital100039 BeijingPR China Department of Lymphoma and Head and Neck Cancer Fujian Cancer Hospital350014 FuzhouPR China Department of Hematology The First People’s Hospit

This registration study assessed clinical outcomes of TQ-B3525,the dual phosphatidylinositol-3-kinase(PI3K)α/δinhibitor,in relapsed and/or refractory follicular lymphoma(R/R FL).This phase II study(*** *** March 27,2020)comprised run-in stage and stage 2.R/R FL patients after≥2 lines therapies received oral 20 mg TQ-B3525 once daily in a 28-day cycle until intolerable toxicity or disease *** endpoint was independent review committee(IRC)-assessed objective response rate(ORR).Based on results(ORR,88.0%;duration of response[DOR],11.8 months;progression-free survival[PFS],12.0 months)in 25 patients at run-in stage,second stage study was initiated and included 82 patients for efficacy/safety *** received prior-line(median,3)therapies,with 56.1%refractory to previous last therapies;73.2%experienced POD24 at *** stage 2,ORR was 86.6%(71/82;95%CI,77.3-93.1%),with 28(34.2%)complete *** control rate was 95.1%due to 7(8.5%)stable *** time to response was 1.8 *** 71 responders,median DOR was not reached;18-month DOR rate was 51.6%.with median follow-up of 13.3 months,median PFS was 18.5(95%CI,10.2-not estimable)*** overall survival(OS)was not reached by cutoff date;24-month OS rate was estimated as 86.1%.Response rates and survival data were consistent across all *** 3 or higher treatment-related adverse events were observed in 63(76.8%)cases,with neutropenia(22.0%),hyperglycemia(19.5%),and diarrhea(13.4%)being ***-B3525 showed favorable efficacy and safety for R/R FL patients after≥2 lines prior therapies.

关键词： lymphoma assessed initiated

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Origin of the Disparity between the Stability of Transmutated Mix-Cation and Mix-Anion Compounds

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Chinese Physics Letters 2024年第5期41卷 53-60页

作者：野仕伟耿松源梁汉普张燮魏苏淮 Beijing Computational Science Research Center Beijing 100193China Advanced Materials Thrust Function HubHong Kong University of Science and TechnologyGuangzhou 511458China School of Materials Science and Engineering Northwestern Polytechnical UniversityXi’an 710072China

Transmutation is an efficient approach for material design. For example, ternary compound CuGaSe_(2) in chalcopyrite structure is a promising material for novel optoelectronic and thermoelectric device applications. It can be considered as formed from the binary host compound ZnSe in zinc-blende structure by cation transmutation(i.e., replacing two Zn atoms by one Cu and one Ga). While cation-transmutated materials are common, aniontransmutated ternary materials are rare, for example, Zn_(2)As Br(i.e., replacing two Se atoms by one As and one Br)is not reported. The physical origin for this puzzling disparity is unclear. In this work, we employ first-principles calculations to address this issue, and find that the distinct differences in stability between cation-transmutated(mix-cation) and anion-transmutated(mix-anion) compounds originate from their different trends of ionic radii as functions of their ionic state, i.e., for cations, the radius decreases with the increasing ionic state, whereas for anions, the radius increases with the increasing absolute ionic state. Therefore, for mix-cation compounds,the strain energy and Coulomb energy can be simultaneously optimized to make these materials stable. In contrast, for mix-anion systems, minimization of Coulomb energy will increase the strain energy, thus the system becomes unstable or less stable. Thus, the trend of decreasing strain energy and Coulomb energy is consistent in mix-cation compounds, while it is opposite in mix-anion compounds. Furthermore, the study suggests that the stability strategy for mix-anion compounds can be controlled by the ratio of ionic radii r3/r1, with a smaller ratio indicating greater stability. Our work, thus, elucidates the intrinsic stability trend of transmutated materials and provides guidelines for the design of novel ternary materials for various device applications.

关键词： stability stability ternary

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Antitumor efficacy and potential mechanism of FAP-targeted radioligand therapy combined with immune checkpoint blockade

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2936-2952页

作者： liang Zhao Yizhen Pang Yangfan Zhou Jianhao Chen Hao Fu Wei Guo Weizhi Xu Xin Xue Guoqiang su Long sun Hua Wu Jingjing Zhang Zhanxiang Wang Qin Lin Xiaoyuan Chen Haojun Chen Department of Nuclear Medicine and Minnan PET Center Xiamen Key Laboratory of RadiopharmaceuticalsThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Departments of Diagnostic Radiology SurgeryChemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and College of Design and EngineeringNational University of SingaporeSingaporeSingapore Clinical Imaging Research Centre Centre for Translational MedicineYong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Department of Radiation Oncology Xiamen Cancer CenterXiamen Key Laboratory of Radiation OncologyThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Department of Colorectal Tumor surgery Xiamen Cancer CenterXiamen Key Laboratory of Radiation OncologyThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Department of Cardiothoracic surgery Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingChina Nanomedicine Translational Research Program NUS Center for NanomedicineYong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Department of Neurosurgery and Department of Neuroscience Fujian Key Laboratory of Brain Tumors Diagnosis and Precision TreatmentXiamen Key Laboratory of Brain Centerthe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Institute of Molecular and Cell Biology Agency for ScienceTechnology and Research(A*STAR)SingaporeSingapore Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstituteChinese Academy of SciencesXiamenChina

Radiotherapy combined with immune checkpoint blockade holds great promise for synergistic antitumor *** radionuclide therapy delivers radiation directly to tumor ***1004 is a fibroblast activation protein(FAP)-targeting radiopharmaceutical,conjugated with the albumin binder Evans Blue,which has demonstrated enhanced tumor uptake and retention in previous preclinical and clinical ***,we demonstrate that^(68)Ga/^(177)Lu-labeled LNC1004 exhibits increased uptake and prolonged retention in MC38/NIH3T3-FAP and CT26/NIH3T3-FAP tumor *** therapy with^(177)Lu-LNC1004 induced a transient upregulation of PD-L1 expression in tumor *** combination of^(177)Lu-LNC1004 and anti-PD-L1 immunotherapy led to complete eradication of all tumors in MC38/NIH3T3-FAP tumor-bearing mice,with mice showing 100%tumor rejection upon ***,single-cell RNA sequencing(scRNA-seq),and TCR sequencing revealed that combination therapy reprogrammed the tumor microenvironment in mice to foster antitumor immunity by suppressing malignant progression and increasing cell-to-cell communication,CD8^(+)T-cell activation and expansion,M1 macrophage counts,antitumor activity of neutrophils,and T-cell receptor diversity.A preliminary clinical study demonstrated that^(177)Lu-LNC1004 was well-tolerated and effective in patients with refractory ***,scRNA-seq of peripheral blood mononuclear cells underscored the importance of addressing immune evasion through immune checkpoint blockade *** was emphasized by the observed increase in antigen processing and presentation juxtaposed with T cell *** conclusion,our data supported the efficacy of immunotherapy combined with^(177)Lu-LNC1004 for cancer patients with FAP-positive tumors.

关键词： immunity retention holds

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Alterations in Serum Lipids and Lipoproteins Induced by Neoadjuvant Chemotherapy in Patients with Osteosarcoma around the Knee Joint:A Retrospective Analysis

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Current Medical Science 2024年第4期44卷 741-747页

作者： su-guo WANG Yong-gang WANG Guo-wei QIAN Li-na TANG Xin ZHOU Dong-dong CHENG Chen-liang ZHOU Qing-cheng YANG Zan SHEN Gao-zhong HUANG Hong-tao LI Department of General Medicine Shenzhen Third People's HospitalShenzhen 518112China Department of VIP Clinic Shanghai Jiao Tong University Afiliated Sixth People's HospitalShanghai 200233China Department of Oncology Shanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai 200233China Cancer Research Institute of Jilin University the First Hospital of Jilin UniversityChangchun 130021China Department of Orthopedics Shanghai Jiao Tong University Afiliated Sixth People's HospitalShanghai 200233China

Objective To investigate the serum lipid profiles of patients with localized osteosarcoma around the knee joint before and after neoadjuvant *** After retrospectively screening the data of 742 patients between January 2007 and July 2020,50 patients aged 13 to 39 years with Enneking stage II disease were included in the *** lipid levels,including total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),lipoprotein-α[Lp(a)],and apolipoprotein A1,B,and E(ApoA1,ApoB,and ApoE),and clinicopathological characteristics were collected before and after neoadjuvant *** The mean levels of TC,TG,and ApoB were significantly increased following neoadjuvant chemotherapy(16%,38%,and 20%,respectively,*** values;Psurvival(DFS)was observed in patients with decreased TG and increased LDL-C following chemotherapy,although this difference was not statistically significant(P=0.23 and P=0.24,respectively).Conclusion Significant elevations in serum lipids were observed after neoadjuvant chemotherapy in patients with localized *** was no prognostic significance of pretreatment serum lipid levels on histologic response to neoadjuvant *** scale of increase in serum Lp(a)might have a potential prognostic role in *** with increased LDL-C or reduced TG after chemotherapy seem to exhibit a trend toward favorable DFS.

关键词： osteosarcoma neoadjuvant chemotherapy serum lipids

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Association between Low Ambient Temperature and the Severity of Acute Ischemic Stroke

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Journal of Clinical and Nursing Research 2024年第5期8卷 83-94页

作者： Xinyi Huang Liming Shu su Xiao Qiuhong Jiang Shiliang Yang Hualiang liang Hua Hong liang Luo Department of Critical Care Medicine The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen 518107GuangdongChina Department of Neurology The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510260GuangdongChina The Second Xiangya Hospital of Central South University Changsha 410011HunanChina Department of Neurology National Key Clinical Department and Key Discipline of NeurologyThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080GuangdongChina Department of General Practice Shenshan Central HospitalSun Yat-Sen Memorial HospitalSun Yat-Sen UniversityShanweiChina 516600GuangdongChina School of Public Health Sun Yat-sen UniversityGuangzhou 510080GuangdongChina

Objective:To explore the relationships among ambient temperature,ischemic stroke severity,and blood ***:Meteorological data(2005–2015)were collected from the Guangzhou Meteorological Data *** stroke patients from the Department of Neurology of the First Affiliated Hospital,sun Yat-sen University were retrospectively evaluated,each winter from 2005 to *** demographics,baseline measurements,and National Institute of Health Stroke Scale(NIHSS)score were ***:Three hundred sixty-two patients were *** median latency from symptom onset to admission was 2 d(IQR:1–3 d).During recruitment,the highest and lowest temperatures were 39℃and 1.3℃,*** was the most common comorbidity(75.1%).NIHSS scores at admission and discharge were higher in the cold-exposed group than in the controls regardless of the average temperature at *** addition,systolic and diastolic blood pressure values at admission were higher in the cold-exposed group than in the *** stratified by hypertensive status,the average and minimum temperatures at admission were negatively associated with systolic and diastolic blood pressure values in hypertensive *** in the average and minimum temperatures at symptom onset were associated with more severe ***:Ischemic stroke patients with symptom onset in winter had higher systolic blood pressure values and more serious neurologic deficits upon admission.

关键词： Low ambient temperature Stroke Blood pressure Severity

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Malignant glaucoma treated by low-dose laser cycloplasty: a 1-year multicenter prospective noncomparative study

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1248-1254页

作者： Hai-Shuang Lin Xiao-Ping Xu Xuan-Li Zheng Ji-Bing Wang su-Jie Fan Zuo-HongWu su-Mian Cheng Li-Jun Zhao Qin-Hua Cai Shao-Dan Zhang Shan-Shan Liu Ai-Guo Lyu Ying Zhang Hong Chen Dan-Ni Jiang Wu-liang Li Nathan Congdon Clement C Tham Ming-Guang He Yuan-Bo liang the Malignant Glaucoma TreatmentTrial Study(MGTT)Group Wenzhou Medical University Wenzhou 325027Zhejiang ProvinceChina Ningbo Eye Hospital Ningbo 315100Zhejiang ProvinceChina Weifang Eye Hospital Weifang 261000Shandong ProvinceChina Handan Eye Hospital Handan 056000Hebei ProvinceChina Aier Eye Hospital(Wuhan) Wuhan 430061Hubei ProvinceChina Hebei Eye Hospital Xingtai 054001Hebei ProvinceChina The Third People’s Hospital of Dalian Dalian 116033Liaoning ProvinceChina First Affiliated Hospital of suzhou University Suzhou 215031Jiangsu ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Glaucoma Research Institute Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Centre for Public Health Queen’s University BelfastBelfast BT71NNUK Orbis International New YorkUSA Department of Ophthalmology and Visual Sciences the Chinese University of Hong KongHong Kong SAR 999077China Centre for Eye Research Australia University of MelbourneRoyal Victorian Eye and Ear HospitalEast Melbourne 3000VICAustralia 不详

AIM:To report a one-year clinical outcomes of low-dose laser cycloplasty(LCP)among malignant glaucoma ***:In this prospective,multicenter,noncomparative clinical study,participants with malignant glaucoma were recruited and underwent LCP at eight ophthalmic centers in *** were followed up at 1wk,1,3,6,and *** pressure(IOP),number of glaucoma medications,anterior chamber depth(ACD),and complications were *** success was defined as the reformation of the anterior chamber based on slit-lamp *** was defined by the presence of a shallow orﬂat anterior chamber after initial recovery from ***:A total of 34 eyes received *** IOP and medications decreased from 36.1±11.5 mm Hg with 3.3±1.5 glaucoma medications pre-treatment to 20.9±9.8 mm Hg(Psuccess rate of 64.3%.Complications including anterior synechia(8.82%),choroidal/ciliary detachment(5.88%)and hypopyon(2.94%)were observed within ***:LCP is simple,safe,and effective in reforming the anterior chamber in malignant glaucoma.

关键词： anterior chamber reformation intraocular pressure low-dose laser cycloplasty malignant glaucoma anatomical success

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Magnetic-biased chiral molecules enabling highly oriented photovoltaic perovskites

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National Science Review 2024年第2期11卷 221-230页

作者： Jing Chen Caner Deger Zhen-Huang su Kai-Li Wang Guang-Peng Zhu Jun-Jie Wu Bing-Chen He Chun-Hao Chen Tao Wang Xing-Yu Gao Ilhan Yavuz Yan-Hui Lou Zhao-Kui Wang liang-Sheng Liao Institute of Functional Nano&Soft Materials(FUNSOM) Laboratory of Advanced Negative Carbon TechnologiesSoochow University Department of Physics Marmara University Shanghai Synchrotron Radiation Facility(SSRF) Shanghai Advanced Research InstituteChinese Academy of Sciences College of Energy Soochow Institute for Energy and Materials Innovations Soochow University Macao Institute of Materials Science and Engineering Macau University of Science and Technology

The interaction between sites A, B and X with passivation molecules is restricted when the conventional passivation strategy is applied in perovskite（ABX3） photovoltaics. Fortunately, the revolving A-site presents an opportunity to strengthen this interaction by utilizing an external field. Herein, we propose a novel approach to achieving an ordered magnetic dipole moment, which is regulated by a magnetic field via the coupling effect between the chiral passivation molecule and the A-site（formamidine ion） in *** strategy can increase the molecular interaction energy by approximately four times and ensure a well-ordered molecular arrangement. The quality of the deposited perovskite film is significantly optimized with inhibited nonradiative recombination. It manages to reduce the open-circuit voltage loss of photovoltaic devices to 360 mV and increase the power conversion efficiency to 25.22%. This finding provides a new insight into the exploration of A-sites in perovskites and offers a novel route to improving the device performance of perovskite photovoltaics.

关键词： perovskite photovoltaics magnetic moment A-site regulation chiral molecules

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High precision current mirror circuit based on two-dimensional material transistors

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Science China(Information Sciences) 2024年第8期67卷 353-354页

作者： Shiping GAO Chen PAN Pincheng su Xing-Jian YANGDONG Wentao YU Zhoujie ZENG Yu SHEN Jingwen SHI Yanwei CUI Pengfei WANG Yuekun YANG Cong WANG Bing CHENG Shi-Jun liang Feng MIAO Institute of Interdisciplinary Physical Sciences School of Physics Nanjing University of Science and Technology Institute of Brain-Inspired Intelligence National Laboratory of Solid State Microstructures School of PhysicsCollaborative Innovation Center of Advanced Microstructures

The emerging two-dimensional field-effect transistor(2DFET) is considered an important candidate device for driving future integrated circuit technology toward higher performance, lower power consumption, and more functionalities [1,2]. Among the integrated circuits, analog circuits play a crucial role as they are responsible for sampling, amplifying, and transmitting signals.

关键词： Timing circuits

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Efficacy and safety of Qingfei Huatan formula in the treatment of acute exacerbation of chronic obstructive pulmonary disease:A multi-centre,randomised,double-blind,placebo-controlled trial

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Journal of Integrative Medicine 2024年第5期22卷 561-569页

作者： Hui-zhi Zhu Cheng-yi Li liang-ji Liu Jia-bing Tong Zhi-hui Lan Shu-guang Tian Qiao Li Xiang-li Tong Ji-feng Wu Zhen-gang Zhu su-yun Li Jian-sheng Li Department of Respiratory Medicine the First Affiliated Hospital of Anhui University of Traditional Chinese MedicineHefei 230031Anhui ProvinceChina Graduate School Anhui University of Traditional Chinese MedicineHefei 230012Anhui ProvinceChina Department of Respiratory Medicine Affiliated Hospital of Jiangxi University of Traditional Chinese MedicineNanchang 330006Jiangxi ProvinceChina Department of Respiratory Diseases the First Affiliated Hospital of Henan University of Traditional Chinese MedicineZhengzhou 450000Henan ProvinceChina Department of Pulmonary Diseases Taihe Hospital of Traditional Chinese Medicine Affiliated to Anhui University of Traditional Chinese MedicineFuyang 236600Anhui ProvinceChina Department of Respiratory and Critical Care Medicine Jiangxi Province Hospital of Integrated Chinese and Western MedicineNanchang 330002Jiangxi ProvinceChina Department of Respiratory Medicine the First Affiliated Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300381China Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment and Chinese Medicine Development of Henan Province Zhengzhou 450046Henan ProvinceChina

Background Chronic obstructive pulmonary disease(COPD),a common respiratory disease,can be effectively treated by traditional Chinese medicine(TCM).Qingfei Huatan,a TCM formula,has been reported to effectively alleviate the clinical symptoms of COPD ***,there is a lack of multi-centre,randomised,double-blind,controlled clinical trials documenting the clinical efficacy and safety of this formula in the treatment of acute exacerbation of COPD(AECOPD).Objective This study evaluated the efficacy and safety of Qingfei Huatan formula in the treatment of AECOPD,thereby providing high-quality clinical ***,setting,participants and interventions A total of 276 patients with AECOPD were included in this multi-centre,randomised,double-blind,placebo-controlled trial and were randomised into treatment and control groups at a ratio of 1:*** in the treatment and control groups took Qingfei Huatan granules or simulated Qingfei Huatan granules twice a day,for 14 days,in addition to Western medicine *** patients were followed up for 3 *** outcome measures The primary outcome was time taken to symptom *** secondary outcomes included duration of antibiotic use,clinical symptom and sign score,TCM syndrome score,dyspnoea score,and quality of life(QOL)***,the safety of the formula was assessed through routine urine and stool tests,electrocardiograms,liver and kidney function tests,and the observation of adverse events throughout the *** The time taken for effective stabilisation(P<0.05)and obvious stabilisation(P<0.01),and the duration of antibiotic use(P<0.05)were significantly shorter in the treatment group than in the control *** days 6,9,12 and 14 of treatment,clinical symptom and sign score decreased in both groups,particularly in the treatment group(P<0.01).On days 9,12 and 14 of treatment,the TCM syndrome scores of both groups were reduced(P<0.01),with more significant reductions in the treatm

关键词： Acute exacerbation of chronic obstructive pulmonary disease Clinical trial Syndrome of phlegm-heat congesting lung Qingfei Huatan formula Traditional Chinese medicine

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Investigations on affinity law under gas–liquid conditions in multistage radial and mixed-flow multiphase pumps

International Journal of Fluid Engineering

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International Journal of Fluid Engineering 2024年第1期 56-70页

作者： liang Chang Chenyu Yang Xiaobin su Xiaoyu Dai Qiang Xu Liejin Guo State Key Laboratory of Multiphase Flow in Power Engineering Xi'an Jiaotong University

Affinity laws have been widely used in pump design and simulation under high-temperature and corrosive conditions. By applying such laws,it is possible to shorten development cycles and reduce test costs. However, current applications of affinity laws are still limited to liquid conditions. In this paper, expressions for affinity laws and their applicability are investigated for multistage radial and mixed-flow multiphase pumps under gas–liquid conditions. A high-pressure（30 MPa） gas–liquid experimental platform is constructed, and three-stage and 25-stage radial pumps and a 15-stage mixed-flow pump are investigated, with specific speeds of 107 and 216. With gas compressibility taken into account, the gas–liquid two-phase flow rate, head, and power, and the corresponding dimensionless hydraulic coefficients, are defined for multiphase pumps. The deterioration of gas–liquid pressurization performance is found to be divided into three processes with different dynamic mechanisms, corresponding to three flow patterns. The inlet gas volume fraction of pump is used to judge dynamic similarity. At the same inlet gas volume fractions λ1= λ2, when the gas–liquid flows in two pumps have the same flow pattern, dynamic similarity will be satisfied. The affinity law that is established shows good applicability to the three-stage radial multiphase pump, with goodness of fit R2larger than 0.9 for the two-phase Ψm–Φmand Πm–Φmperformance curves. Finally, experimental results indicate that the affinity law also has good applicability to multiphase pumps with different stage numbers and blade structures under gas–liquid conditions.

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